北京若生智能科技有限公司
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KH

KH-741 (KH 741 / KH741)

✓ Approved

Chengdu Kanghong Pharmaceutical · 小分子 · 小分子

什么是 KH-741？

KH-741 是一种小分子，由Chengdu Kanghong Pharmaceutical研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名KH 741, KH741
公司Chengdu Kanghong Pharmaceutical
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Chengdu Kanghong Pharmaceutical

治疗适应症

KH-741 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Psychiatric disordersBipolar I disorder✓ Approved

相关研究文献

PubMedNature communications2026-10-26

Record stack durability in industrial solid oxide steam electrolysis through operational control.

Bilalis Vasileios V, Sloth Olivia Fjord OF, Smitshuysen Thomas Erik Lyck TEL, Beyrami Javid J et al.

Solid oxide steam electrolysis offers the highest electrical efficiency for hydrogen production, yet wide-scale deployment remains constrained by durability. Here, we show that long-term stack durability can be strongly influenced by operating strategy, achieving 25,000 h of steam electrolysis operation in a full 70-cell solid oxide electrolysis cell stack under frequency-dependent electrochemical operation (AC:DC). This experiment represents, to our knowledge, the longest and lowest degradation operation reported for a full stack. The stack enters a stabilized regime with an average voltage degradation rate of 0.05 % kh⁻¹ (0.65 mV kh⁻¹ per cell) sustained for 22,000 h after initial conditioning. The behavior is evaluated against initial DC operation, prior full-stack benchmarks, impedance evolution, and post-test microstructural signatures. Periodic polarity inversion between electrolysis and fuel-cell modes modulates electrochemical polarization and heat generation, consistent with mitigating thermal and electrochemical gradients that develop during sustained DC electrolysis. Stack-level impedance evolution and post-mortem microstructural analysis demonstrate stabilization of electrochemical performance and suppression of degradation signatures commonly observed under DC operation, indicating that key degradation pathways are not activated under AC:DC operation. By shifting durability control from materials to operational strategy, AC:DC operation offers a scalable pathway toward long-lived solid oxide electrolysis for economically competitive green hydrogen production.

PMID 42928371
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PubMedGels (Basel, Switzerland)2026-10-26

Nano-SiO2/Polymer Composite Gel Fluid-Loss Reducer for High-Temperature, Salt-Resistant Water-Based Drilling Fluids: Performance and Mechanism.

Liu Luman L, Liu Jingping J, Geng Yuan Y, Wang Ren R et al.

Polymeric gel fluid-loss reducers for water-based drilling fluids often undergo performance deterioration under combined high-temperature and high-salinity conditions. In this study, an organic-inorganic nanocomposite gel fluid-loss reducer, SiO2@P-DAS, was synthesized through aqueous free-radical polymerization using N,N-dimethylacrylamide, 2-acrylamido-2-methylpropane sulfonic acid, sodium styrene sulfonate, and KH-570-modified nano-SiO2. The corresponding polymer gel without nano-SiO2, P-DAS, was used as the control. FTIR results were consistent with the presence of modified nano-SiO2 in the composite gel. Thermogravimetric analysis showed that its initial decomposition temperature increased from 245 °C for P-DAS to 252 °C for SiO2@P-DAS. At a concentration of 3.0 wt%, the post-aging API filtrate volume of SiO2@P-DAS was 3.8 mL, compared with 4.8 mL for P-DAS after aging at 220 °C for 16 h. Under HTHP conditions of 220 °C and 3.5 MPa, the corresponding filtrate volumes were 33.33 and 49.67 mL, respectively. SiO2@P-DAS also maintained lower fluid loss under NaCl and CaCl2 contamination. At 5 wt% CaCl2, its post-aging API filtrate volume was 6.8 mL, 58.0% lower than that of P-DAS. In weighted drilling fluids with densities of 1.4-2.0 g/cm3, the post-aging API and HTHP filtrate volumes remained within 2.4-3.2 and 24.6-26.2 mL, respectively. Zeta-potential, particle-size, and filter-cake observations suggest that polymer adsorption and hydration, together with the contribution of modified nano-SiO2 to particle packing and filter-cake continuity, improve filtration control. These results demonstrate the potential of SiO2@P-DAS as a nanocomposite gel fluid-loss reducer for high-temperature and salt-contaminated water-based drilling fluids.

PMID 42929929
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PubMedJournal of robotic surgery2026-10-26

Robot-assisted laparoscopic resection of paediatric retroperitoneal neurogenic tumours: a retrospective single-centre study of 117 patients.

Meng Jinwen J, Xiong Jieni J, Jia Xuan X, Zhang Lifeng L et al.

Although robot-assisted laparoscopic surgery (RALS) is increasingly used in paediatric surgery, evidence regarding its safety and feasibility in retroperitoneal neurogenic tumours (RNTs) remains limited. This study aims to evaluate perioperative and short-term oncological outcomes of RALS in children with RNTs. This single-centre retrospective study included all consecutive paediatric patients who underwent RALS for RNTs between May 2020 and May 2025. Patient demographics, tumour characteristics, perioperative outcomes, postoperative complications, and follow-up data were analysed. A total of 117 patients were included; 29 (24.8%) had a single IDRF (image-defined risk factors), and none had multiple IDRFs. Robotic resection was completed in 116 of 117 patients (99.1%). Subgroup completion rates were 100.0% (29/29) among IDRF-positive patients, 92.9% (13/14) among children younger than 5 months, 95.7% (22/23) among those weighing less than 10 kg, and 100.0% (16/16) among those with tumours > 6 cm. One infant required conversion following major haemorrhage during dissection of a tumour invading the inferior vena cava. Complete macroscopic excision was achieved in all patients. Median blood loss was 5.0 mL and median postoperative stay was 3.0 days. Grade IIIb and IVb complications occurred in one patient each, with no 30-day deaths. During a median follow-up of 741 days, one local recurrence and two deaths from systemic tumour progression occurred. RALS was feasible in carefully selected children with RNTs, with a high completion rate and infrequent serious complications. A selected single IDRF, low body weight, young age, or large tumour size should not alone be considered an absolute contraindication to RALS. Multicentre prospective comparative studies are needed to refine selection criteria and assess long-term outcomes.

PMID 42928072
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PubMedJournal of the American Heart Association2026-10-25

Residual Risk From Remnant Cholesterol and Inflammation Despite Lipid-Lowering Therapy and Association With Incident Peripheral Artery Disease in Type 2 Diabetes.

Liao Ruoxi R, Xiao Zhiwen Z, Huang Chixiong C, Chen Lin L et al.

Despite guideline-recommended lipid-lowering therapy, patients with type 2 diabetes retain a significant residual risk for peripheral artery disease (PAD). The contributions of remnant cholesterol (RC) and systemic inflammation in this treated population, particularly beyond achieved low-density lipoprotein cholesterol, remain incompletely understood. This prospective cohort study included 18 741 participants with type 2 diabetes from the UK Biobank who were free of PAD and were on lipid-lowering therapy at baseline. Plasma RC and hsCRP (high-sensitivity C-reactive protein) levels were measured at baseline. Incident PAD was ascertained over a median follow-up of 13.6 years. Multivariable Cox models were used to estimate hazard ratios after adjustment for demographic, clinical, metabolic, and treatment-related covariates, including low-density lipoprotein cholesterol and baseline coronary artery disease. During follow-up, incident PAD occurred in 1223 participants (6.5%). Elevated RC and hsCRP levels were each independently linked to an increased risk of PAD. Participants with concurrent elevations in both RC and hsCRP exhibited the highest risk of incident PAD. These associations remained robust across multiple sensitivity analyses, including exclusion of participants with baseline coronary artery disease, removal of events within the initial 2-year follow-up, elimination of individuals with hsCRP >10 mg/L, competing-risk analyses accounting for death, and further adjustment for detailed lipid-lowering therapy categories. Among patients with type 2 diabetes receiving lipid-lowering therapy for primary prevention of PAD, elevated RC and systemic inflammation are independently and jointly associated with future PAD risk. These findings highlight substantial residual risk beyond managed low-density lipoprotein cholesterol and support the need for further strategies targeting both remnant lipoproteins and inflammation in this high-risk population.

PMID 42924852
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PubMedSheng wu gong cheng xue bao = Chinese journal of biotechnology2026-10-24

[Identification of SPS family genes and regulation of photosynthetic pigment stability by PthSPS1/2/3 in Populus cv.741].

Xu Ziteng Z, Wang Zhi'an Z, Xu Yunjiao Y, Zhang Xiaoning X et al.

Solanesyl diphosphate synthases (SPSs), are key enzymes in the isoprenoid metabolic pathway, catalyze the biosynthesis of solanesyl diphosphate (SPP). In plants, the SPS family includes geranyl diphosphate synthase (GPS), farnesyl diphosphate synthase (FPS), geranylgeranyl diphosphate synthase (GGPPS), and SPS, catalyzing the stepwise condensation to form SPP. SPP is involved in the biosynthesis of solanesol and plastoquinone (PQ), both of which play important roles in plant growth, development, and the regulation of photosynthesis. Here, to elucidate the functions of the SPS subfamily in woody plants, we took 'Poplar 741' [Populus. alba×(Populus. davidiana+Populus. simonii)×Populus. tomentosa] as the experimental material. A total of 29 family members distributed across four subfamilies-PthSPS/PthFPS/PthGPS/PthGGPPS-related to the isoprenoid pathway were identified at the genome-wide level, located on 8 chromosome groups. Among them, 24 members were localized to chloroplasts and 5 to the cytoplasm. Three highly homologous PthSPSs were predicted as unstable hydrophilic proteins in chloroplasts. Subsequently, PthSPS1/2/3-edited mutant regenerated plants of 'Poplar 741' were generated via the CRISPR/Cas9 system. Phenotypic observation revealed three phenotypes: albino, green, and chimeric. PCR identification and sequencing analysis confirmed insertions and deletions (indels) at the target sites of PthSPS1/2/3. Physiological and biochemical analyses showed that the content of SPP, chlorophyll a, chlorophyll b, and carotenoids were significantly lower in the albino mutants (pthsps1/2/3) than in the wild type, indicating that PthSPS1/2/3 regulated the stability of photosynthetic pigments. These results provide a new direction for further dissecting the roles of the isoprenoid metabolic pathway in photosynthesis, growth, and development of woody plants.

PMID 42920224
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PubMedPlant physiology and biochemistry : PPB2026-10-23

Comparative transcriptome analysis reveals coordinated ABA, ROS, MAPK, and hormone-mediated regulatory networks underlying cold tolerance in noni (Morinda citrifolia L.).

Liu Xing-Di XD, Wang Xiang-She XS, Li Ming-Fang MF, Khanzada Hira H et al.

Low-temperature stress severely limits the cultivation and geographical distribution of noni (Morinda citrifolia L.), a tropical medicinal plant with high economic and pharmaceutical values. However, the molecular mechanisms underlying cold tolerance in noni remain largely unknown. We conducted an integrated physiological, biochemical, and comparative transcriptomic analysis of a cold-susceptible genotype, Sanya (SY), and a cold-tolerant genotype, Kanghan-4 (KH-4), to elucidate the molecular mechanisms underlying differential cold tolerance. Relative to SY, KH-4 exhibited superior membrane stability, enhanced proline accumulation, and stronger antioxidant enzyme activities under cold stress. Transcriptome analysis revealed that KH-4 activated 1025 more differentially expressed genes (DEGs) than SY during the early cold exposure, reflecting a rapid transcriptional response. Comparative analysis across genotypes and time points identified 4286 candidate genes associated with cold tolerance, demonstrating that cold adaptation in noni involves coordinated activation of multiple stress-responsive pathways rather than a single dominant mechanism. Genes associated with ABA-dependent and ABA-independent signaling, ROS signaling, MAPK cascades, and other hormone pathways were preferentially induced in KH-4. Among the identified candidates, Contig_2712 exhibited the strongest genotype-specific induction, while NAC, AHP, GID2, ERF1, and PSαT were consistently downregulated in KH-4. Notably, the canonical ICE1-CBF cold signaling pathway was not prominently induced; instead, the data point to a MAPKKK, MKK, MPK, CAMTA3 module as a candidate alternative regulatory axis for cold tolerance in noni. These findings provide a molecular framework for cold tolerance in noni and identify candidate genes and pathways for functional studies and molecular breeding of cold-tolerant cultivars.

PMID 42914796
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