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prasterone (Mylis)

✓ Approved

Merck & Co. · AR · 小分子

什么是 prasterone？

prasterone 是一种小分子，由Merck & Co.研发。该药已获批，用于治疗相关适应症。

药物档案

商品名Mylis
公司Merck & Co.
药物类别小分子
分子靶点AR
状态Approved
来源： ClinicalTrials.gov, Merck & Co.

作用机制

分子靶点

prasterone 作用于 1 个分子靶点：

ARandrogen receptor (DHTR, AR8)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

prasterone 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresLabour induction✓ Approved

相关研究文献

PubMedNeurology. Education2026-09-06

Curriculum Innovation: Virtual Reality for Neuroanatomy Education Among Neurology Residents.

Gupta Ayush A, Bass Derek D, Barton Christopher R CR, Zhang Wanyu W et al.

Advanced neuroanatomy knowledge is essential for clinical reasoning in neurology, yet residency training offers limited time to reinforce concepts. This contributes to persistent gaps in topics frequently tested on the Residency In-service Training Examination (RITE). This study evaluated the feasibility and educational impact of a virtual reality (VR) neuroanatomy curriculum intended to enable residents to (1) identify and spatially integrate arterial, venous, and ventricular structures; (2) improve performance on assessments targeting commonly missed RITE concepts; and (3) assess usability, engagement, spatial presence, and perceived educational value. (1) To identify and label key neuroanatomical structures, (2) to describe spatial relationships relevant to clinical localization, (3) to apply neuroanatomy to clinical scenarios modeled after RITE items, and (4) to evaluate usability, engagement, and spatial presence of VR. A single-group, pre-post mixed-methods study among neurology residents at a single academic medical center. Participants completed a faculty-guided 40-minute VR session using Organon VR Anatomy on Meta Quest 3 headsets, focusing on cerebrovascular arterial supply, venous sinuses, ventricular anatomy, and key spatial relationships relevant to clinical localization. Knowledge was assessed using quizzes at baseline, postintervention, and at 2-week follow-up. Learner perceptions were measured using surveys, and data were analyzed using repeated-measures ANOVA and linear mixed-effects models, with mean differences and 95% confidence intervals reported. Thirty residents (mean age 30.5 years, SD 4.6; 50% female) completed all assessments. Mean scores increased from 8.57 (SD 2.75) at baseline to 11.37 (SD 2.27) immediately postintervention and were sustained at 11.20 (SD 3.07) at 2 weeks. The mean increase was 2.80 points (95% CI 1.45-4.15), representing an approximate 33% improvement, with sustained gains at follow-up (2.63 points; 95% CI 1.28-3.99). Participants reported high usability, engagement, and spatial presence. This study demonstrates the feasibility of an instructor-guided VR neuroanatomy curriculum and provides preliminary evidence of improved knowledge and short-term retention. Findings should be interpreted in the context of a single-group design and nonidentical assessments, which limit causal inference. VR seems to be a promising adjunct to traditional instruction, particularly when combined with guided teaching. Future controlled studies are needed to evaluate comparative effectiveness and long-term clinical impact.

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PubMedParasite (Paris, France)2026-09-04

Epidemiologic survey and genotyping of Enterocytozoon bieneusi in sika deer (Cervus nippon) in four provinces of China.

Zhuang Hong-Di HD, Xiang Wen-Tao WT, Li Ting T, Cui Bing-Bing BB et al.

Microsporidia are obligate intracellular parasites with a wide host range. To elucidate the relationship between Enterocytozoon bieneusi infection dynamics and evolution within China's sika deer population, 466 fresh fecal samples were collected from May to October 2024 across four provinces, Jilin, Liaoning, Heilongjiang, and Shandong. The ITS region of ribosomal RNA (rRNA) was amplified using nested PCR, enabling the identification and genotyping of E. bieneusi. The overall prevalence of E. bieneusi in sika deer was 44.4% (207/466). Province-specific prevalence was highest in Shandong (76.0%, 38/50) and Heilongjiang (75.3%, 67/89), followed by Jilin (38.7%, 65/168), and lowest in Liaoning (23.3%, 37/159). The prevalence in autumn (44.9%) was slightly higher than in summer (41.7%), and the prevalence in adult deer (48.7%) was found to be significantly higher than in young deer (31.6%). In this study, we identified a total of 11 E. bieneusi genotypes, including 9 known genotypes (BEB6, HND-II, LND-I, JLD-XIX, CHN-F1, HLJD-I, HLJD-III, Type IV, and COS-I) and 2 novel genotypes (named JL-D-4 and JL-D-5). Among them, BEB6 was the dominant genotype (38.7%, 80/207). This study enriches the genotype data of E. bieneusi, reveals the prevalence of E. bieneusi in some sika deer populations, and provides a reference for subsequent epidemiologic research as well as prevention and control efforts.

PMID 42696651
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PubMedBMJ connections surgery2026-09-04

Preliminary clinical experience using the Leica ARveo with MyVeo in neurosurgery: an IDEAL stages 1 and 2a observational study.

Matano Fumihiro F, Nounaka Yohei Y, Dan Hiroyuki H, Kitamura Takao T et al.

To report the initial clinical experience with the Leica ARveo system with MyVeo in neurosurgery, focusing on feasibility, ergonomics and visualisation characteristics during early clinical implementation. This observational study was conducted in accordance with the IDEAL framework (stages 1 and 2a: Idea/Development and Exploration). Department of Neurological Surgery, Nippon Medical School Hospital, Tokyo, Japan. Six patients undergoing neurosurgical procedures, including three aneurysm clippings, two microvascular decompressions and one superficial temporal artery-to-middle cerebral artery bypass for moyamoya disease. MyVeo was used either by the assistant (cases 1-3) or collaboratively by the primary surgeon and assistant (cases 4-6), reflecting staged clinical implementation. Feasibility, ergonomics, visualisation characteristics, operative workflow and intraoperative safety were assessed based on intraoperative observations and team feedback. All procedures were completed without intraoperative complications. MyVeo allowed flexible viewing and facilitated shared visualisation among surgical team members, with reported improvements in ergonomics and intraoperative collaboration. However, limitations were identified, including lower image resolution and depth perception compared with conventional microscopes as well as neck fatigue and workflow challenges related to cable management. The system required adaptation during use, particularly in the early phase. The use of Leica ARveo with MyVeo was feasible in this small case series and provided ergonomic and collaborative advantages in selected scenarios. However, given its current limitations in visualisation performance and system integration, it should be considered a complementary tool rather than a replacement for conventional operating microscopes. Further studies with objective outcome measures are required to define its clinical role.

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PubMedEuropean journal of obstetrics, gynecology, and reproductive biology2026-08-26

Intravaginal radiofrequency versus local estrogen and prasterone for genitourinary syndrome of menopause: a comparative study of clinical outcomes.

Llaneza Iris Porcel IP, Parugues Beatriz Duplá BD, de la Noval Begoña Díaz BD, Aldecoa Álvarez M Belén MB et al.

Genitourinary syndrome of menopause (GSM) causes vulvovaginal and urinary symptoms due to estrogen deficiency. While local estrogen therapy is a standard treatment, non-hormonal alternatives such as intravaginal radiofrequency (RF) are under investigation. To compare the effectiveness of intravaginal RF with local estriol and prasterone in postmenopausal women with clinically significant GSM. Prospective, multicenter, quasi-experimental, non-randomized study with sequential allocation (2:2:1) to estriol, prasterone, or RF (three monthly sessions). Primary outcome was defined as favorable response in vaginal dryness, while secondary outcomes included patient satisfaction and favorable response in: pruritus/pain, dyspareunia, vaginal cytology, pH, Bladder Control Self-Assessment Questionnaire (B-SAQ) score, International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF) score and urinary symptoms. Of 146 women allocated, 131 completed follow-up (estriol n = 54; prasterone n = 52; RF n = 25). RF showed comparable outcomes in selected urinary endpoints, including recurrent urinary tract infections, nocturia, urinary incontinence, and patient satisfaction compared with estriol. In adjusted analyses controlling for baseline pollakiuria, prasterone was associated with higher odds of favorable response in vaginal dryness compared with RF (OR 7.50; 95% CI 2.22-25.32; p = 0.001). RF showed lower favorable-response proportions for vaginal dryness and vaginal cytology, although only the comparison with prasterone for vaginal dryness reached statistical significance in adjusted analyses. RF showed partial clinical effectiveness and may be considered a non-hormonal option for selected women, particularly when urinary symptoms are prominent or hormonal therapy is not suitable. However, local estriol and prasterone showed greater benefit for vaginal dryness, dyspareunia, and epithelial outcomes.

PMID 42648084
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PubMedJournal of Nippon Medical School = Nippon Ika Daigaku zasshi2026-08-26

Periodontal Disease is a Risk Factor for Placenta-Mediated Pregnancy Complications.

Kikuchi Eriko E, Suzuki Asami A, Hayashi Masako M, Sekiguchi Atsuko A et al.

Although periodontal disease is known to be associated with obstetric complications, evidence is limited regarding the relationship with placenta-mediated pregnancy complications (PMPCs), a major cause of maternal and fetal morbidity and mortality. This study investigated whether periodontal disease is a risk factor for PMPCs. We conducted a retrospective case-control study of inpatients with singleton pregnancies who underwent perinatal dental examinations at Nippon Medical School Tama Nagayama Hospital between September 2012 and August 2015. Medical records were reviewed for incident PMPCs, including preterm birth, preeclampsia, small for gestational age birth, placental abruption, and late pregnancy loss. Associations of periodontal disease with PMPCs were assessed using univariate and multivariate logistic regression analyses. Among 262 inpatients, 130 (49.6%) developed PMPCs. The prevalence of periodontal disease was significantly higher among women with PMPCs than among those without PMPCs (90.0% vs. 75.0%, P = 0.002). Multivariate logistic regression analysis identified periodontal disease as an independent risk factor for PMPCs (adjusted odds ratio [aOR], 2.89; 95% confidence interval [CI], 1.41-5.88). Younger maternal age (<35 years; aOR, 1.75; 95% CI, 1.04-2.92) and a past history of PMPCs (aOR, 3.27; 95% CI, 1.47-7.27) were also significantly associated with PMPCs. Periodontal disease was independently associated with increased risk of PMPCs. Management of periodontal disease during pregnancy may help prevent PMPCs.

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PubMedCureus2026-08-24

Exploratory Clinical and Cost Evaluation of Robot-Assisted Adrenalectomy Using the hinotori™ Surgical Robotic System: A Single-Center Retrospective Study.

Obayashi Kotaro K, Nishino Takuya T, Takadate Mami M, Hasegawa Hiroya H et al.

Although the hinotori™ surgical robotic system is Japan's first domestically developed platform, evidence regarding its clinical feasibility remains limited. Because adrenalectomy is a standardized minimally invasive procedure with well-defined perioperative outcomes, it provides an appropriate model for evaluating newly introduced robotic platforms. We evaluated the clinical outcomes and medical costs of robot-assisted adrenalectomy (RAAD) using the hinotori™ system (H-RAAD) and compared them retrospectively with those of da Vinci Xi™-assisted RAAD (D-RAAD). We retrospectively examined patients who underwent RAAD at Nippon Medical School Hospital between September 2023 and May 2025. Baseline demographic characteristics, perioperative variables, postoperative outcomes, pathological findings, and medical costs extracted from the Diagnosis Procedure Combination (DPC) database were evaluated. We evaluated 12 patients (H-RAAD, n = 5; D-RAAD, n = 7). Baseline characteristics were comparable between the groups, although the median tumor diameter was numerically smaller in the H-RAAD group. The median anesthesia, operative, and console times in the H-RAAD group were 264 (253-307, U = 10.0, p = 0.22), 189 (156-264, U = 10.0, p = 0.29), and 108 (71-180, U = 14.0, p = 0.57) minutes, respectively, comparable with those in the D-RAAD group. Total medical costs per case were similar between the D-RAAD ($6,333.1) and H-RAAD ($6,398.4) groups (U = 23.0, p = 0.34). In this small cohort, H-RAAD was completed safely without conversion or major complications, demonstrating perioperative outcomes similar to those of D-RAAD. Although individual cost components varied, total reimbursed medical costs under the DPC system were comparable. Given the limited sample size and exclusion of robotic system capital and maintenance costs, these findings remain exploratory.

PMID 42634690
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