北京若生智能科技有限公司
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PT-007

✓ Approved

Pediatrix Therapeutics · 未知 · 未知

什么是 PT-007？

PT-007 是一种未知，由Pediatrix Therapeutics研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

公司Pediatrix Therapeutics
药物类别未知
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Pediatrix Therapeutics

治疗适应症

PT-007 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Congenital, familial and genetic disordersHereditary haemochromatosis✓ Approved

相关研究文献

PubMedAngewandte Chemie (International ed. in English)2026-09-11

Resolving Swelling by Swelling: Water-Mediated Interface Regulation for Ultralow-Pt Membrane Electrode Assemblies.

Zhao Guangyao G, Fan Hua H, Yang Qimei Q, Zheng Tangfei T et al.

Anisotropic swelling of ion-exchange membranes (IEMs)-a phenomenon that is both physically inevitable and operationally detrimental-poses disproportionately severe interfacial instability challenges in ultralow-Pt membrane electrode assemblies (MEAs). Here, we report a counterintuitive yet effective strategy, termed resolving swelling by swelling, in which the catalyst layer/IEM (CL/IEM) interface is constructed directly on a fully preswollen membrane. By exploiting the dynamic interplay between interchain hydrogen bonding and intrachain elastic contraction inherent to the membrane network, this approach harnesses controlled swelling to drive the in situ optimization of a three-dimensional interpenetrating CL/IEM interface. The resulting interface exhibits reinforced interfacial stability under operating conditions, a water-mediated active area resistant to ionomer poisoning, and enhanced gas and ion transport pathways. MEAs fabricated via this strategy deliver a peak power density of 1.22 W cm-2 under H2/Air conditions at an ultralow cathode Pt loading of 0.05 mgPt cm-2, representing a 1.68-fold improvement over conventionally fabricated proton exchange membrane fuel cells, alongside a record-breaking cathode Pt utization of 24.4 kW gPt -1. These MEAs sustain excellent electrochemical performance under low-humidity operating conditions, long-term durability and 10 000 wet-dry cycles. The broad applicability of this strategy is further validated by its successful extension to anion exchange membrane fuel cells.

PMID 42723348
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PubMedNature chemistry2026-09-11

Nanoscale visualization of plasmon-enhanced hydrogen activation on a Pt(111) surface.

Cai Zhen-Feng ZF, Manae Meghna A MA, Tang Zi-Xi ZX, Zhang Jun-Xian JX et al.

Efficient H2 activation under mild conditions is crucial for achieving energy-efficient catalytic hydrogenation, but this remains a major challenge. Here we demonstrate nanoscale visualization of plasmon-enhanced H2 activation on Pt(111) at room temperature under visible light by employing a combination of spectroscopic and modelling methods. In situ tip-enhanced Raman spectroscopy tracked H2 activation through H-assisted desorption of an oligomeric phenylene-ethynylene thiolate reporter, while hyperspectral imaging revealed ~20% enhancement in the 180-300 nm region around the near field. Spectroscopic evidence and finite element method simulations excluded the plasmonic heating effect, whereas quantum calculations showed that hot electrons generated in the tip-enhanced Raman spectroscopy near field can efficiently drive H2 dissociation via an indirect transfer mechanism. Notably, we found that activated H atoms propagate hundreds of nanometres beyond the near field through a collective crowd effect. These findings provide mechanistic insights into plasmon-enhanced H2 activation on Pt surfaces and suggest future opportunities for energy-efficient catalytic hydrogenation.

PMID 42722739
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PubMedFrontiers in surgery2026-09-11

Association of preoperative serum 25-hydroxyvitamin D levels with deep vein thrombosis after total knee arthroplasty: a hypothesis-generating analysis of coagulation function mechanisms.

Shang He H, Li Jun J, Ma Tao T, Wei Yuan Y et al.

This hypothesis-generating study aimed to explore the association of preoperative serum 25-hydroxyvitamin D [25(OH)D] levels with deep vein thrombosis (DVT) risk after total knee arthroplasty (TKA) and clarify the potential coagulation-related mechanisms. A total of 193 patients undergoing primary unilateral TKA in a single center were stratified into 25(OH)D deficiency (<20 ng/mL, n = 106), insufficiency (20-29 ng/mL, n = 47), and sufficiency (≥30 ng/mL, n = 40) groups. Postoperative DVT (detected via day 5-7 venous ultrasonography) and coagulation indices [D-dimer, prothrombin time (PT)] were compared across groups. Univariate and multivariate logistic regression were used to screen DVT-related factors, and Firth's penalized logistic regression was applied for a sparse-data sensitivity analysis. The overall postoperative DVT incidence was 13.5% (26/193). A bivariate analysis revealed a markedly higher DVT rate in the deficiency group (18.9%) than in the sufficiency group (2.5%), with a crude 2 × 2 odds ratio (OR) of 9.070 [95% confidence interval (CI): 1.198-68.542, P = 0.015]; this estimate was unstable due to only one DVT case in the sufficiency group. To provide a more stable estimate, a secondary binary logistic regression model (deficiency vs. non-deficiency) was performed, which identified preoperative 25(OH)D deficiency as significantly correlated with postoperative DVT (OR = 3.140, 95% CI: 1.200-8.212, P = 0.020). After analysis of covariance adjustment for baseline levels, the deficiency group maintained significantly higher postoperative D-dimer and shorter PT than the sufficiency group (both P < 0.001). A univariate analysis identified 25(OH)D deficiency and elevated postoperative D-dimer as DVT-related risk factors. In the secondary exploratory model adjusting for postoperative D-dimer (a potential mediator), the association between vitamin D deficiency and DVT was attenuated (OR = 2.576, 95% CI: 0.941-7.049, P = 0.065), indicating a possible mediating effect rather than confounding bias. Firth's sensitivity analysis on the binary model further verified the robustness of this finding (OR = 2.918, 95% CI: 1.142-7.456, P = 0.025). Preoperative 25(OH)D deficiency is associated with elevated postoperative DVT risk after TKA in univariate analyses. Abnormal postoperative D-dimer and PT levels suggest that vitamin D status may modulate coagulation-fibrinolysis balance. The attenuated association after D-dimer adjustment supports a potential mediating mechanism. As a hypothesis-generating analysis, these preliminary findings require further validation in large-scale prospective studies to confirm the independent predictive value of preoperative vitamin D deficiency for post-TKA DVT.

PMID 42723925
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PubMedFrontiers in psychology2026-09-11

AI literacy for self-regulated learning among pre-service teachers: development and validation of a scale of ethical use, monitoring, motivation, regulation, and evaluation.

Kaya Ismet I, Meylani Rusen R

Existing AI-literacy measures often emphasize broad knowledge, attitudes, application, or ethical awareness rather than how learners use AI within self-regulated academic learning. This study developed and validated the Multidimensional Aspects of AI Literacy Scale for Pre-Service Teachers (MAILS-PT), which assesses Ethical Use, Metacognitive Monitoring (Monitor), Motivational Regulation (Motivate), Behavioral Regulation (Regulate), and Critical Evaluation (Evaluate). An initial 60-item pool was reduced to 40 items through expert content review. The scale was administered to 420 pre-service teachers recruited in Spring 2025 for exploratory factor analysis and to a separately recruited sample of 684 in Fall 2025 for confirmatory and validation analyses. Ordinal-data methods, reliability analysis, assessment of convergent and discriminant validity, and gender measurement-invariance testing were conducted. A 15-item AI-Assisted Learning Judgment Quiz was used to examine preliminary concurrent associations with a framework-aligned judgment measure. Exploratory factor analysis retained 30 items, six per dimension; the five-factor solution explained 58.3% of the variance, with primary loadings ranging from 0.639-0.829. Confirmatory factor analysis supported the structure, χ 2 (395) = 522.90, p < 0.001, CFI = 0.988, TLI = 0.986, RMSEA = 0.022, 90% CI [0.016, 0.027], SRMR = 0.037. Subscale omega values ranged from 0.851-0.889 in the exploratory sample and 0.848-0.874 in the confirmatory sample. AVE values ranged from 0.522-0.583 and HTMT values from 0.029-0.272. Configural, loading, and threshold invariance across gender were supported under the specific ordered-categorical JASP/lavaan parameterization. Ethical Use showed near-zero relationships with the other dimensions. The five subscales jointly explained 41.3% of judgment-quiz variance, R = 0.643, R 2 = 0.413, adjusted R 2 = 0.409, F (5, 678) = 95.48, p < 0.001. MAILS-PT provides preliminary psychometric support for five distinguishable aspects of learning-related AI literacy among pre-service teachers. Subscales should be interpreted separately, with Ethical Use treated as a distinct yet related domain of responsible academic AI use. Quiz associations provide preliminary framework-aligned concurrent evidence, not independent criterion or predictive validity. Further validation across institutions, cultures, and behavioral or longitudinal criteria is needed.

PMID 42724067
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PubMedTranslational cancer research2026-09-11

Inflammation-coagulation biomarkers predict catheter-related thrombosis following peripherally inserted central catheter placement in patients with hematologic malignancies: a retrospective cohort study.

Zhang Lifeng L, Gao Wen W, Chang Xin X, Lu Fengni F et al.

Patients with hematologic malignancies are at high risk of developing catheter-related thrombosis (CRT) following peripherally inserted central catheter (PICC) placement; however, reliable prediction tools based on inflammation and coagulation biomarkers remain limited. This study aimed to investigate inflammation and coagulation biomarkers associated with CRT and to construct an individualized risk prediction model. This retrospective study enrolled 172 patients with hematologic malignancies who underwent PICC placement (April 2022-December 2023). Inflammatory [white blood cell count, C-reactive protein (CRP), interleukin (IL)-6, IL-1β] and coagulation [fibrinogen (FIB), D-dimer (D-D), international normalized ratio (INR), activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT)] indicators were collected. Patients were classified into the CRT and non-CRT groups according to the occurrence of CRT, defined as both symptomatic and asymptomatic thrombi detected by scheduled upper-extremity duplex ultrasound following PICC placement. Least absolute shrinkage and selection operator (LASSO) regression and multivariate logistic regression were used to identify independent risk factors. A nomogram was built and validated internally using receiver operating characteristic (ROC) curves, decision curve analysis (DCA), calibration curves, and bootstrap. Overall CRT, including both symptomatic and asymptomatic events detected by scheduled upper-extremity ultrasound screening following PICC placement, occurred in 58 patients (33.7%; 15 symptomatic and 43 asymptomatic). The median time to thrombus was 17.5 days [interquartile range (IQR), 12.5-28.0 days]. Platelet count (PLT), IL-1β, CRP, IL-6, FIB, D-D, PT, and TT were higher in the CRT group (all P<0.05). Multivariate analysis identified PLT [odds ratio (OR) =0.936], IL-1β (OR =1.375), CRP (OR =1.367), IL-6 (OR =1.134), FIB (OR =1.870), and D-D (OR =1.005) as independent risk factors (all P<0.05). The nomogram achieved an area under the receiver operating characteristic curve (AUC) of 0.947 [95% confidence interval (CI): 0.909-0.986] with good calibration. PLT, IL-1β, CRP, IL-6, FIB, and D-D are independently associated with CRT following PICC placement in patients with hematologic malignancies. The prediction model performed well internally but requires external multi-center validation before clinical application.

PMID 42724952
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PubMedJournal of pathology and translational medicine2026-09-11

Ki-67 index and galectin-3 as surrogate markers for predicting disease-free survival in luminal-type breast carcinoma treated with neoadjuvant chemotherapy.

Lee Ho-Chang HC, Han Wonshik W, Im Seock-Ah SA, Park In Ae IA

Residual cancer burden (RCB) is an important marker for patients with breast carcinoma treated with neoadjuvant chemotherapy (NACT). However, the association between RCB and prognosis is relatively less significant in residual luminal-type breast carcinoma (LTBC). Associations between clinicopathological variables, including RCB class, and immunohistochemical (IHC) markers with disease-free survival (DFS) were analyzed. Expression of Ki-67, calreticulin, clusterin, galectin-3, mucin-1, and p27 was assessed in tissue microarray slides of 55 post-NACT resection specimens from LTBC patients treated with docetaxel and doxorubicin. Patients' age, pre-NACT progesterone receptor status, lymphovascular invasion, histologic grade, ypT category, ypN category, RCB class, and IHC markers were analyzed for their association with DFS using Kaplan-Meier analysis and Cox proportional hazards models. Twenty of the 55 patients developed recurrence or distant metastasis. A Ki-67 index > 2.7% and high galectin-3 expression were associated with shorter DFS on Kaplan-Meier analysis (p < .001 and p = .018, respectively). Other clinicopathological and IHC markers were not significantly associated with DFS. In the multivariate Cox proportional hazards model, a Ki-67 index > 2.7% (hazard ratio, 7.23; p < .001) and high galectin-3 expression (hazard ratio, 4.51; p = .007) remained independent predictors of shorter DFS. The Ki-67 index and high galectin-3 expression in post-NACT resection specimens may serve as surrogate markers for predicting recurrence in LTBC.

PMID 42723306
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