北京若生智能科技有限公司
Drug Database
MO

montmorillonite (Diarrafin)

✓ Approved

Beijing Holley-Cotec Pharma · 小分子 · 小分子

什么是 montmorillonite？

montmorillonite 是一种小分子，由Beijing Holley-Cotec Pharma研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Diarrafin
公司Beijing Holley-Cotec Pharma
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Beijing Holley-Cotec Pharma

治疗适应症

montmorillonite 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersDiarrhoea✓ Approved

相关研究文献

PubMedNanoscale2026-10-26

Programmable nanolaminate architectures enable superior corona resistance through synergistic erosion blocking and charge dissipation.

Guo Ning N, Dabaghian Marina M, Wei Dingxin D, Zhong Wesley W et al.

The rapid expansion of electrification technologies, including electric vehicles (EVs), more-electric aircraft (MEA), and high-voltage power systems, demands polymer dielectrics with enhanced resistance to corona-induced degradation. However, scalable strategies for mitigating corona aging remain limited. Here, we report a self-assembled montmorillonite/poly(vinyl alcohol) (MMT/PVA) nanocoating with a programmable nanolaminate architecture as a facile surface-engineering approach for corona-resistant polymer dielectrics. By regulating crosslinking-mediated organic-inorganic interactions, the interlayer spacing is reduced to ∼2.5 nm, producing a compact nano-laminate structure with increased inorganic-layer redundancy and improved thermal and chemical stability. Systematic investigations reveal that decreasing interlayer spacing simultaneously strengthens two synergistic protection mechanisms: enhanced barrier resistance against discharge-induced through-thickness erosion and improved lateral charge dissipation enabled by the highly aligned MMT nanosheet network. As a result, electric-field distortion is mitigated, the partial-discharge inception field increases, and high-energy discharge events are effectively suppressed. Under elevated electric fields, the average magnitude of high-energy discharges decreases to ∼60% of that in pristine films, resulting in a transition from localized crater-like erosion to more dispersed surface damage. Consequently, under corona aging at 100 MV m-1 and 50% relative humidity, the optimized nanocoating extends the characteristic lifetime of polyimide films to approximately 340% of that of the pristine polymer. These findings establish interlayer-spacing engineering as an effective strategy for simultaneously enhancing erosion resistance and charge dissipation, providing a scalable route to corona-resistant polymer dielectrics for harsh electrical environments.

PMID 42929314
阅读全文 →
PubMedEnvironmental science & technology2026-10-23

Molecular Fingerprint-Dependent Retention and Fractionation of Combustion-Derived Dissolved Organic Matter on Kaolinite and Montmorillonite.

Chen Weifeng W, Xu Yixin Y, Wang Yan Y, Si Youtao Y et al.

The environmental fate of combustion-derived dissolved organic matter (CDOM) at clay mineral interfaces remains poorly understood. We applied FT-ICR-MS, XPS, and other techniques to investigate the interfacial behavior of CDOM from coal, charcoal, pinewood, and maize straw on kaolinite and montmorillonite. Two distinct mechanisms were identified: ligand exchange on kaolinite (increasing binding energies by 1.2 ∼ 1.7 eV) and Ca2+/Mg2+-mediated cation bridging on montmorillonite (decreasing binding energies by 0.3 ∼ 1.8 eV). Maize straw-CDOM and charcoal-CDOM exhibited the highest adsorption on both clays, while pinewood-CDOM showed mineral-selective retention (montmorillonite only) and coal-CDOM showed negligible adsorption. Coal-CDOM (-SO3H-rich) with negligible adsorption was due to electrostatic repulsion and hydration steric hindrance. Pinewood-CDOM (phenolic) was retained only on montmorillonite via cation bridging, as its phenolic groups cannot undergo ligand exchange with kaolinite. Charcoal-CDOM (-NH2-rich) was retained on both clays primarily through electrostatic attraction of -NH3+, with additional contributions from Ca2+/Mg2+-mediated cation bridging and cation-π interactions on montmorillonite. Maize straw-CDOM (mixed -COOH, -NH2, -SO3H) was retained through synergistic ligand exchange, cation bridging, and electrostatic/H-bonding. Concentration-dependent fractionation shifted from H-bonding/electrostatic attraction (small polar molecules) to hydrophobic/cation-π interactions (large aromatic molecules) with increasing concentration. This framework provides mechanistic context for pyrogenic carbon sequestration and contaminant mobility in clay-rich environmental matrices.

PMID 42915992
阅读全文 →
PubMedLangmuir : the ACS journal of surfaces and colloids2026-10-23

Interfacial Hydration Improves Transport Capacity of Shale Oil within Montmorillonite Nanoconfinements.

Xu Peixing P, Yang Feng F, Liu Yasong Y, Kang Nong N et al.

Fluid transport within clay nanopores is governed by nanoscale interfacial interactions and can deviate from continuum flow theory because of strong adsorption and mineral-fluid friction. Here, nonequilibrium molecular dynamics simulations probe shale oil transport in Na-montmorillonite nanopores. Pure n-octane simulations quantify the effects of slit aperture, temperature, pressure, and driving pressure gradient, followed by a multicomponent mixture of methane, n-octane, toluene, pyridine, and asphaltene to characterize component fractionation. Interfacial water films are then introduced to evaluate hydration effects. Confined oil develops pronounced density layering near montmorillonite surfaces, while pore-center velocity profiles remain Poiseuille-like. Larger apertures expand the mobile region and substantially increase volumetric flow rate, although the relative contribution of interfacial slip decreases. Higher temperature weakens near-wall adsorption, lowers apparent viscosity, and enhances slip, whereas higher pressure compresses confined oil molecules, strengthens interfacial resistance, and reduces mobility. Flow rate increases approximately linearly with the driving pressure gradient, indicating quasi-Newtonian behavior over the simulated range. In multicomponent systems, pyridine, asphaltene, and toluene preferentially adsorb on montmorillonite, forming an immobile boundary layer that causes negative slip and increases apparent viscosity. This boundary-layer reconstruction reduces the effective hydraulic aperture and markedly increases the overall resistance compared with pure n-octane. Interfacial water films passivate active mineral adsorption sites, redistribute polar and heavy components toward the pore center, restore positive slip, and enhance multicomponent oil transport. These findings reveal the coupled effects of nanoconfinement, oil composition, and surface hydration governing shale oil transport in clay nanopores.

PMID 42917643
阅读全文 →
PubMedLangmuir : the ACS journal of surfaces and colloids2026-10-23

Surface-Engineered Organo-Montmorillonites as Tunable Urease Inhibitors: Interfacial Hydrophobic Anchoring and Conformational Regulation for Enhanced Soil Nitrogen Retention.

Shen Yuwen Y, Liu Bing B, Bian Wenfan W, Zhao Zichao Z et al.

Rapid urea hydrolysis in soil triggers substantial ammonia volatilization; it severely limits nitrogen use efficiency and increases greenhouse gas emissions. In this work, we describe a series of surface-engineered organo-montmorillonites that could achieve >80% suppression of urease activity through the hydrophobic interaction with urease. Kinetic analysis revealed a trend indicative of a chain-length-dependent transition from competitive-like inhibition to non-competitive-like inhibition driven by entropy-favored hydrophobic anchoring. Multi-technique characterizations combined with molecular dynamics simulations showed that long-chain surfactants induce partial unfolding of the urease secondary structure while rigidifying the flap domain of the active site. The optimal organo-montmorillonite exhibited 16-fold stronger binding (-1850 kJ/mol) than the native montmorillonite; it delayed urea conversion, increased wheat yield, and enhanced nitrogen uptake in field trials, matching the commercial urease inhibitor N-(n-butyl)thiophosphoric triamide. Metagenomic profiling confirmed that the organo-montmorillonite preserved microbial diversity while selectively enriching plant-beneficial taxa, such as Mesorhizobium. With the bridging of clay surface chemistry with enzyme structural mechanics, this study establishes a sustainable paradigm for regulating the conformational change of enzymes and managing nitrogen in agroecosystems.

PMID 42915186
阅读全文 →
PubMedCarbohydrate polymers2026-10-22

Lamellar-structured anisotropic sodium alginate/montmorillonite aerogels with mechanical robustness and flame-retardant thermal insulation.

Mu Junxiao J, Zou Fangxin F, Chen Xinyue X, Bo Yankai Y et al.

Lightweight, flame-retardant, and thermally insulating bio-based materials are required for thermal protection in buildings; however, sodium alginate (SA) aerogels are mechanically fragile and prone to drying shrinkage. Herein, anisotropic SA/montmorillonite (SA/MMT) aerogels were fabricated via freeze-casting, post-freeze ionic crosslinking in a low-temperature CaCl₂/EtOH bath, and air drying. The key innovation lies in the MMT-assisted stabilization of the freeze-cast lamellar skeleton, which preserves a highly porous framework during air drying while enhancing mechanical robustness and fire resistance. Increasing the MMT/SA ratio from 0 to 80 wt% reduced radial shrinkage from 13.6% to 4.2% while maintaining porosity above 95% and increased the axial specific modulus from 65.4 to 174.5 MPa cm3 g-1. The LOI increased from 29 to 81.2, whereas pHRR and THR decreased from 28.8 to 13.0 W g-1 and from 2.91 to 1.41 kJ/g, respectively. The optimized SA/MMT-80 aerogel exhibited a density of 0.09 g/cm3 and a thermal conductivity below 0.05 W/(m K). XPS and Raman analyses of the post-combustion residues revealed a stabilized carbonaceous-inorganic residual barrier, with the ID/IG ratio decreasing from 2.82 to 1.76, while TG-FTIR indicated a possible complementary gas-phase dilution effect associated with the released CO₂. These results establish a structurally stabilized air-drying route for multifunctional SA-based aerogels.

PMID 42907026
阅读全文 →
PubMedRSC advances2026-10-20

Montmorillonite-supported Ag/Sn@CeO2 via phyto-mechanochemical engineering: enhanced crystal violet adsorption and CO2 capture.

Rehman Mobeen Ur MU, Usman Muhammad M, Taj Muhammad Babar MB, Altowerqi Amal Marzoqi AM et al.

Crystal Violet (CV) dye and CO2 emissions represent two major environmental threats that demand cost-effective and multifunctional remediation materials. In this study, a silver/tin co-doped cerium oxide nanocomposite supported on montmorillonite (Mt-Ag/Sn@CeO2) was synthesized via continuous phyto-mechanochemical twin screw extrusion using Melothria scabra leaf extract as a green reducing agent. The composite was characterized by using FTIR, XRD, SEM, EDS, zeta potential, N2 adsorption-desorption isotherm, BJH pore size analysis, and ICP-OES. The adsorption performance of Mt-Ag/Sn@CeO2 and Ag/Sn@CeO2 toward CV dye was systematically evaluated by optimizing pH, contact time, adsorbent dose, initial dye concentration, and temperature. For CV dye removal, Mt-Ag/Sn@CeO2 achieved 96.08% removal compared with 89.22% for Ag/Sn@CeO2 (10 mg L-1 dye, 20 mg dose, pH 9, 298 K, 180 min). The maximum adsorption capacities, estimated from the Langmuir model, were 36.50 mg g-1 and 28.77 mg g-1, respectively. Adsorption data were best described by the Freundlich isotherm alongside the pseudo-second-order kinetic model, consistent with chemisorption on a heterogeneous surface with multilayer dye uptake. Thermodynamic analysis confirmed that the adsorption process is exothermic and spontaneous (ΔG° < 0 at all studied temperatures). Furthermore, Mt-Ag/Sn@CeO2 demonstrated CO2 adsorption capacity of 3.92 mmol g-1 at 298 K and 900 mmHg, surpassing several reported clay-based adsorbents. These results confirmed that the mechanochemically engineered Mt-Ag/Sn@CeO2 composite is an effective dual-function adsorbent with potential for simultaneous water and air remediation.

PMID 42899232
阅读全文 →

注册免费账户还可查看另外 5120 篇文献

免费注册查看全部文献 →

了解更多montmorillonite