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acellular pertussis + diphtheria + tetanus vaccine (Tribic / BK1301 / Torivic)

✓ Approved

Mitsubishi Tanabe Pharma Corporation · 细胞治疗 · 细胞治疗

什么是 acellular pertussis + diphtheria + tetanus vaccine？

acellular pertussis + diphtheria + tetanus vaccine 是一种细胞治疗，由Mitsubishi Tanabe Pharma Corporation研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名Tribic, BK1301, Torivic
公司Mitsubishi Tanabe Pharma Corporation
药物类别细胞治疗, 疫苗
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Mitsubishi Tanabe Pharma Corporation

治疗适应症

acellular pertussis + diphtheria + tetanus vaccine 针对 3 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsDiphtheria✓ Approved
Infections and infestationsPertussis✓ Approved
Infections and infestationsTetanus✓ Approved

相关研究文献

PubMedFrontiers in public health2026-10-27

An age-structured mathematical model of tetanus epidemiology, immunity, and vaccination across the life course.

Hounsell Rachel A RA, Norman Jared J, Silal Sheetal P SP

Tetanus remains a significant public health concern despite substantial reductions in incidence and mortality following the widespread introduction of tetanus-toxoid-containing vaccines (TTCVs). Because immunity is acquired only through vaccination and wanes over time, the World Health Organization recommends three booster doses throughout childhood and adolescence in addition to the three-dose infant primary series. However, few mathematical models explicitly represent the cumulative, dose-dependent nature of tetanus immunity needed to evaluate alternative vaccination strategies. We developed a novel age-structured model of tetanus epidemiology, immunity, and vaccination to address this gap. We developed a deterministic compartmental model stratified by age, vaccination history, and immunity status. The model incorporates environmental exposure, neonatal and non-neonatal tetanus, routine infant vaccination, booster doses, maternal immunization, and waning immunity. Unlike previous tetanus models, each TTCV dose is represented explicitly, allowing protection, waning, and booster responses to vary according to vaccination history. Model parameters were informed by published literature and expert consultation. Sensitivity analyses were conducted using Latin hypercube sampling and partial rank correlation coefficients, and model outputs were compared with published seroprevalence studies. The model reproduced expected patterns of vaccine-derived immunity and waning described in the literature and generated population protection estimates consistent with seroprevalence data from settings with different vaccination schedules. Sensitivity analyses identified the duration of vaccine-derived protection as a primary source of uncertainty, with vaccine effectiveness also substantially influencing population immunity. The framework successfully captured heterogeneous immunity profiles by age and vaccination history and the cumulative effects of primary series, booster doses, and maternal vaccination. This model provides a novel framework for representing cumulative TTCV-derived immunity across the life course. By explicitly tracking dose-specific protection and waning, it enables the evaluation of booster-dose strategies and maternal immunization programs and provides a platform for informing evidence-based tetanus vaccination policy.

PMID 42935852
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PubMedBMC infectious diseases2026-10-27

Epidemiology, vaccine effectiveness, and risk factors of pertussis in Xinjiang children: a retrospective study.

Ru Liang L, Zhu Hongtao H, Ma Xiangping X, Abuduhaer Abulaiti A et al.

Despite the high global vaccination coverage, the incidence of pertussis is rising in many countries. The epidemiological data on pertussis in children in the Xinjiang region are limited. This study aims to investigate the epidemiological characteristics of pertussis in this region, the protective effectiveness of vaccines, and the independent risk factors associated with the disease. A retrospective study was conducted among 2,250 children with suspected pertussis who presented to the Pediatric Center of the First Affiliated Hospital of Xinjiang Medical University from March 2024 to June 2025. Children aged ≤ 18 years who met the suspected case criteria of the Chinese Guidelines for Diagnosis, Treatment and Prevention of Pertussis (2024 edition) and underwent nasopharyngeal PCR testing were included. Demographic, clinical, vaccination, and laboratory data were collected. Bordetella pertussis DNA was detected using a fluorescence probe-based PCR method. The χ² test was used to compare the differences between groups, and univariate and multivariate logistic regression analyses were used to identify independent risk factors. The overall positivity rate of pertussis was 9.3%. The positivity rate was the highest during the months of July to September. Moreover, the positivity rate was the highest in infants younger than 6 months (17.4% in 0-2 months and 16.2% in 3-5 months). The vaccination coverage was 90.3%; however, 82.9% of the positive cases had been vaccinated. Among children aged ≥ 3 months (eligible for vaccination), vaccine effectiveness (VE) against laboratory-confirmed pertussis was 47.1% (95% CI: 9.4-69.1%) for ≥ 1 dose versus unvaccinated. Multivariate analysis showed that age, season, history of cough contact, and laboratory markers (lymphocytosis) were independent predictors of pertussis positivity. In the age-restricted multivariable analysis (≥ 3 months, n = 1,741 complete cases), summer was the strongest risk factor (adjusted odds ratio [aOR] = 5.25, 95% confidence intervals [CI]: 3.27-8.45). History of cough contact (aOR = 2.54) and lymphocytosis > 50% (aOR = 1.56) were significant risk factors. The age group of 1-2 years showed the strongest protective effect (aOR = 0.16, p = 0.006), reflecting a U-shaped age-risk curve. In this single-center retrospective study of suspected pertussis cases in Xinjiang, children who tested positive were more likely to present in summer, have paroxysmal cough, and report a history of cough contact. Despite 90.3% vaccination coverage, the overall positivity rate was 9.3%, with a U-shaped age distribution peaking in infants aged 0-5 months and children ≥ 6 years. These findings highlight the potential value of maternal immunization strategies and timely booster vaccination, though multi-center prospective studies are needed to confirm these observations. Not applicable.

PMID 42934535
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PubMedAmerican journal of ophthalmology case reports2026-10-27

Periocular reconstruction with acellular fish skin xenograft after severe thermal burn: A case report.

Brumaire Lynchel M LM, Gupta Lalita L

After a thermal burn the eyelids are highly susceptible to cicatricial forces. Donor sites for full-thickness skin grafts are limited in patients with large total body surface area burns. Acellular fish-skin xenografts are non-mammalian dermal substitutes that support neovascularization and granulation in burns and periocular defects. We report a case of a 47-year-old man who presented with approximately 50% total body surface area burns. He developed progressive cicatricial ectropion of all four eyelids and subsequent exposure keratopathy. Given the extent of his burns and limited donor sites, he underwent reconstruction of all four eyelids using fish-skin xenografts. Three surgeries using fish-skin xenografts achieved decreased scarring and restored lid-globe apposition. Subsequent full-thickness skin grafting was then performed. At final follow-up, the patient had a stable ocular surface, no recurrent ectropion or entropion, and only mild residual lagophthalmos. Acellular fish-skin xenografts are highly valuable for complex thermal burns with high contracture risk.

PMID 42936462
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PubMedLife (Basel, Switzerland)2026-10-27

Generalized Tetanus in a Four-Month-Old Labrador Retriever: Complete Recovery and One-Year Follow-Up in a Rare Canine Case.

Fernoagă Cristina C, Turbatu Raluca Mihaela RM, Neagu Alexandru Gabriel AG, Pavel Ruxandra R et al.

Tetanus is an infrequent, potentially fatal neurological disease in dogs, caused by tetanospasmin, the neurotoxin of Clostridium tetani, which reaches the central nervous system by retrograde axonal transport and blocks the release of the inhibitory neurotransmitters glycine and γ-aminobutyric acid. Dogs are comparatively resistant to the toxin, and canine reports remain scarce. This report describes generalized tetanus in a four-month-old, 13 kg male Labrador Retriever presented with an axillary wound sustained approximately one month earlier and neurological signs progressing over approximately seven days, from gait disturbance to generalized whole-body rigidity. On examination the dog showed trismus, risus sardonicus, cervical hyperextension, opisthotonos, third-eyelid protrusion, a sawhorse stance, hyperthermia and intermittent respiratory distress. The diagnosis was established clinically, following a structured neurological work-up and exclusion of the principal differentials, as confirmatory assays were unavailable. Total serum calcium was within the reference interval; serum creatine kinase was elevated; and venous blood-gas analysis indicated a mild, compensated metabolic acidosis. Management comprised metronidazole and clindamycin, equine tetanus antitoxin, diazepam, meloxicam and intensive nursing care in a low-stimulation environment. The dog improved from the first day of hospitalization and recovered without residual deficits, with no recurrence over one year of follow-up. The favorable outcome, in a young canine patient for which the literature would predict a guarded prognosis, is consistent with the absence of clinically detectable autonomic and cardiorespiratory dysfunction and with meticulous supportive care.

PMID 42942178
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PubMedInternational journal of molecular sciences2026-10-27

Micronized Acellular Dermal Matrix and Synthetic Polymers: Temporal Macrophage Transition as a Mechanistic Framework.

Jin Zhenyi Z, Jin Caijun C, Ding Zhiyuan Z, Hai Dang Truong DT et al.

Injectable biodegradable polymers and micronized acellular dermal matrix (mADM) have potentially complementary regenerative properties, but how their combination shapes the host response remains poorly defined. In many systems, polymers provide persistent material-associated stimulation that may sustain macrophage-driven foreign-body responses, whereas mADM provides tissue-derived extracellular matrix (ECM) cues that support cellular infiltration, vascularization, and remodeling, with persistence dependent on processing and host-mediated replacement. This narrative review evaluates whether changes in macrophage population states could help explain potential polymer-mADM synergy. Across the reviewed polymer-ECM hybrid studies, most evidence is indirect, and temporal sampling rarely resolves sequential state changes. No included study establishes temporal coupling as a causal mechanism. We therefore propose a temporal macrophage-switching model in which both components act from implantation and their relative contributions change over time; their spatiotemporal overlap may shape macrophage population trajectories and remodeling outcomes. We further define a functional macrophage polarization window using biological landmarks rather than fixed time points. The model remains a testable hypothesis whose applicability depends on material and tissue context. Validation requires polymer-only, mADM-only, and hybrid comparisons across independent mADM lots, with systematic variation in polymer persistence, mADM processing, component ratio, spatial organization, and degradation/remodeling kinetics.

PMID 42942009
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PubMedBiomedicines2026-10-27

Bivalent CD47 Immunotoxin for Targeted Therapy of Lung Cancer.

Ma Jihong J, Menon Dinoop Ravindran DR, Wang Zhaohui Z, Mintzlaff Danielle D et al.

Background/Objectives: Lung cancer is the leading cause of cancer-related death in the world, with ~2.5 million people diagnosed and ~1.5 million deaths each year. While the last two decades have yielded substantial progress, with systemic targeted and immune therapies improving treatment responses in subgroups of patients with advanced and refractory lung cancer, there is still a dire unmet clinical need to develop more effective therapies with durable responses. CD47 receptors are overexpressed on the surface of a variety of malignant tumor cells, including lung cancer. Although there has been increasing interest in developing targeting antibodies against CD47 for immunotherapy, they failed clinical trials due to their dose-limiting toxicities, primarily hematopoietic toxicity. Methods: Recently, using a unique diphtheria toxin-resistant Pichia pastoris yeast expression system, we developed a diphtheria toxin-based bivalent CD47 immunotoxin (bi-CD47-IT) for targeted therapy of CD47+ cancers. In this study, we extended application of the targeted therapy bi-CD47-IT to a solid tumor, specifically lung cancer. Results: Bi-CD47-IT demonstrated compelling preclinical efficacy in multiple non-small cell lung cancer (NSCLC) cell line-derived xenograft (CDX) and patient-derived xenograft (PDX) mouse models, including subcutaneous, orthotopic, metastatic, and humanized models. Conclusions: This study demonstrates the remarkable preclinical activity of bi-CD47-IT against various lung cancer models, making bi-CD47-IT a novel and promising therapeutic approach for NSCLC.

PMID 42939986
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