epinephrine (Emerade)

✓ Approved

什么是 epinephrine？

epinephrine 是一种小分子，由Bausch + Lomb Corporation研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)。

药物档案

商品名	Emerade
公司	Bausch + Lomb Corporation
药物类别	小分子
给药途径	Injectable (Others)
状态	Approved

来源： ClinicalTrials.gov, Bausch + Lomb Corporation

治疗适应症

epinephrine 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域	疾病/病症	分期
Immune system disorders	Anaphylactic reaction	✓ Approved

相关研究文献

PubMedPharmaceuticals (Basel, Switzerland)2026-10-27

Nephron-Sparing Strategies for Tumor-Bearing Horseshoe Kidney: From Surgeries to Pharmaceuticals.

He Meng-Zhen MZ, Zhou Hui H

Background/Objectives: Horseshoe kidney (HSK) is a type of congenital renal fusion anomaly with extreme anatomic complexity. The malrotation of kidneys and ureters and malformation and altered isthmus and vascular supply may boost several renal and extrarenal complications. Organ preservation of tumor-bearing HSK is rather difficult and only available in a small minority of patients. Methods/Results: This review introduces new advances for nephron-sparing surgical strategies for tumor-bearing HSK, such as super-selective artery clamping, ultrasound-guided renal artery balloon catheter occluded hybrid partial nephrectomy, and focal therapies. It also puts forward novel pharmaceuticals for kidney function preservation to alleviate ischemia-reperfusion injury and medications for neoadjuvant therapies. Conclusions: HSK possesses unique etiology, complex anatomic characteristics, and hidden complications. Renal function preservation is extremely important for tumor-bearing HSK. For long-term high-quality lifespan, precise preoperative planning, surgeon's versatility with multiple surgical techniques, and novel pharmaceuticals to avoid IRI are promising strategies for nephron-sparing surgery.

PMID 42943357

阅读全文 →

PubMedPharmaceuticals (Basel, Switzerland)2026-10-27

Correction: Stasiowski et al. Postoperative Nausea and Vomiting Following Endoscopic Sinus Surgery Under the Guidance of Adequacy of Anesthesia or Pupillometry with Intravenous Propofol/Remifentanil. Pharmaceuticals 2024, 17, 2.

Stasiowski Michał J MJ, Zmarzły Nikola N, Grabarek Beniamin Oskar BO, Gąsiorek Jakub J

There was an error in the original publication [...].

PMID 42943364

阅读全文 →

PubMedJournal of the American Chemical Society2026-10-27

Grignard Reagents Unlock Three-Dimensional Nitrogen Heterocycles via Single-Carbon-Atom Insertion.

Koronatov Aleksandr A, Sakharov Pavel P, Kaushansky Alexander A, Fridman Natalia N et al.

Nitrogen heterocycles are an integral part of pharmaceuticals, catalysts, and materials, yet most accessible molecular scaffolds remain flat, aromatic rings with limited three-dimensionality. As medicinal chemistry increasingly seeks nonplanar, sp3-rich architectures to improve molecular performance and expand underexplored chemical space, methods that can remodel existing heterocycles into new 3D frameworks are of considerable interest. Here, we introduce a strategy for atom insertion that uses simple nucleophilic reagents─most notably, Grignard reagents─to insert a single carbon atom into azolium rings. This nucleophilic rearrangement converts planar triazolinium salts, derived from alkenes, into a previously inaccessible family of saturated three-dimensional 1,2,4-triazinanes. These underexplored compounds are 3D counterparts of planar 1,2,4-triazines well-represented in pharmaceuticals and bioactive molecules. The method is operationally simple, broadly applicable to cyclic, acyclic, natural, and highly functionalized alkenes, and remarkably tolerant of sensitive groups, including esters, amides, sulfonamides, acetals, phosphates, and alkynes. Mechanistic experiments and density functional theory computations reveal a unique nitrenium-centered pathway. By transforming readily available olefins into complex, nonplanar nitrogen heterocycles in just two steps, this work provides a powerful entry into new heterocyclic space and opens opportunities for late-stage diversification relevant to drug discovery, catalysis, and molecular design.

PMID 42938077

阅读全文 →

PubMedEnvironmental science and pollution research international2026-10-27

Investigating emerging contaminants in dams from the Vhembe District in Limpopo and, for the first time, in the Orlando Dam, Gauteng Province, South Africa.

Seshoka Mokgadi Flesher MF, van Dyk Jacobus J, Barnhoorn Irene Jane IJ

Endocrine-disrupting chemicals (EDCs), including certain organophosphate pesticides, herbicides, fungicides, and metals, as well as pharmaceuticals such as antiretroviral drugs (ARVs), are contaminants of increasing concern in freshwater sources in South Africa (SA). One surface water sample from each site was collected from dams in an urban area, Gauteng Province, and from a rural area, the Vhembe District in the Limpopo Province in SA. The water was tested for dolutegravir, nevirapine, tenofovir disoproxil, lamivudine, and efavirenz, human and veterinary pharmaceuticals, insecticides, herbicides, fungicides, and metals. Analytical methods included gas chromatography coupled to time-of-flight mass spectrometry (GC-TOF), liquid chromatography-time-of-flight mass spectrometry (LC-TOF) screening, and liquid chromatography with tandem mass spectrometry (LC/MS/MS). The metals were determined by a semi-quantitative inductively coupled plasma (ICP)-scan. The Orlando Dam screened positive for the five ARVs and two antibiotics, sulfamethoxazole and trimethoprim, and fourteen pesticides were present in the Orlando Dam, two at the Nandoni Dam, one at the TateVondo Dam, three at the Albasini Dam, and two at the Xikundu Weir from the rural area. From 68 metals measured, aluminium (Al), manganese (Mn), and (Zn) were above water quality guidelines. This is the first report of selected ARVs, organochlorine pesticides as EDCs, organophosphate pesticides, herbicides, fungicides, and metals in the Orlando Dam, Gauteng Province, SA.

PMID 42934473

阅读全文 →

PubMedJournal of the American Chemical Society2026-10-27

Enantioselective and Divergent Synthesis of Propargylamides and Allenamides from Alkynyl Diazoketones and Anilines via Organocatalytic Wolff Rearrangements.

Ji Xin X, Ni Yuhao Y, Yu Lu L, Wang Yuzhu Y et al.

Chiral allenes and alkynes are privileged scaffolds in natural products and pharmaceuticals. Although significant advances have been achieved in catalytic asymmetric synthesis from diazo compounds, selectively achieving high levels of both enantioselectivity and regioselectivity from the same starting materials remains challenging. Herein, we report a tunable organocatalytic strategy for the divergent synthesis of chiral allenamides and propargylamides via the Wolff rearrangement of alkynyl diazoketones. By modulating chiral bifunctional catalysts and Lewis acid additives, we achieved excellent control over site selectivity and enantioselectivity. The method features a broad substrate scope, scalability, and applications in late-stage modification of complex molecules, providing a versatile route to valuable enantioenriched building blocks.

PMID 42938006

阅读全文 →

PubMedMolecules (Basel, Switzerland)2026-10-27

Adsorption and Photocatalytic Activity of Covalent Organic Frameworks for Environmental Remediation: A Review of Density Functional Theory Studies.

Nurgaliyeva Damen D, Karibayev Mirat M, Aldongarov Anuar A, Kaisha Aitkazy A et al.

The contamination of water resources by heavy metals, radionuclides, and organic pollutants demands efficient materials for water treatment. Covalent organic frameworks (COFs) are promising candidates owing to their tunable porosity and functionalizable frameworks. This review examines density functional theory (DFT) studies of COFs for environmental remediation, distinguishing three frequently conflated processes: adsorptive capture, photocatalytic transformation, and combined adsorption-photocatalysis. Studies are analyzed across heavy metals, radionuclides, and organic pollutants, including antibiotics, pharmaceuticals, per- and polyfluoroalkyl substances (PFASs), dyes, pesticides, flame retardants, and others. Photocatalytic applications, including hydrogen peroxide (H2O2) production and others, are treated separately in terms of band alignment, charge separation, and reaction free energies. This review also assesses methodological limits of current DFT practice, including the incomparability of adsorption energies across functionals and model types, the distinction between adsorption energy and adsorption free energy, and the gap between computed energetics and experimental capacities.

PMID 42943765

阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

epinephrine (Emerade)

什么是 epinephrine？

药物档案

治疗适应症

相关研究文献

Nephron-Sparing Strategies for Tumor-Bearing Horseshoe Kidney: From Surgeries to Pharmaceuticals.

Correction: Stasiowski et al. Postoperative Nausea and Vomiting Following Endoscopic Sinus Surgery Under the Guidance of Adequacy of Anesthesia or Pupillometry with Intravenous Propofol/Remifentanil. Pharmaceuticals 2024, 17, 2.

Grignard Reagents Unlock Three-Dimensional Nitrogen Heterocycles via Single-Carbon-Atom Insertion.

Investigating emerging contaminants in dams from the Vhembe District in Limpopo and, for the first time, in the Orlando Dam, Gauteng Province, South Africa.

Enantioselective and Divergent Synthesis of Propargylamides and Allenamides from Alkynyl Diazoketones and Anilines via Organocatalytic Wolff Rearrangements.

Adsorption and Photocatalytic Activity of Covalent Organic Frameworks for Environmental Remediation: A Review of Density Functional Theory Studies.

了解更多epinephrine