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formoterol + fluticasone propionate (Abriff / Formoterol Combi / KRP108)

✓ Approved

Zambon · ADRB2 · 小分子

什么是 formoterol + fluticasone propionate？

formoterol + fluticasone propionate 是一种小分子，由Zambon研发。该药已获批，用于治疗相关适应症，给药途径：Inhaled。

药物档案

商品名Abriff, Formoterol Combi, KRP108
公司Zambon
药物类别小分子
分子靶点ADRB2, NR3C1
给药途径Inhaled
状态Approved
来源： ClinicalTrials.gov, Zambon

作用机制

分子靶点

formoterol + fluticasone propionate 作用于 2 个分子靶点：

ADRB2adrenoceptor beta 2 (B2AR, ARB2)
NR3C1nuclear receptor subfamily 3 group C member 1 (GR, GCCR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

formoterol + fluticasone propionate 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Respiratory, thoracic and mediastinal disordersAsthma✓ Approved
Respiratory, thoracic and mediastinal disordersChronic obstructive pulmonary diseasePhase III

相关研究文献

PubMedBioresource technology2026-07-27

Process optimization of continuous dark fermentative hydrogen production from food waste: effects of organic loading rate and feed disturbance strategies.

Hu Yangqing Y, Xue Shengrong S, Dong Jun J, Lv Guojun G et al.

Dark fermentative hydrogen production from organic waste simultaneously valorizes waste and generates clean energy, yet its practical application demands stable continuous operation under variable feeding conditions. This study systematically investigated the effects of organic loading rates (OLR) and feed disturbance strategies on continuous hydrogen production from food waste. The process was evaluated across three regimes: (i) stepwise OLR reduction from 40 to 5 gVS/L·d, (ii) constant high OLR (40 gVS/L·d), and (iii) disturbed feeding consisting of substrate addition (at OLRs of 60 and 40 gVS/L·d) alternating with intermittent inoculum-only shocks. Results showed that low OLR conditions resulted in poor hydrolysis and were unsuitable for long-term operation. High initial OLR (40 gVS/L·d) achieved a peak hydrogen production rate of 1.26  L/L·d within the first 48  h. However, constant high OLR led to gradual performance decline due to sustained low pH (average 4.71) and accumulation of hydrogen-consuming acids (propionate, valerate). In contrast, deliberately introduced feed disturbances successfully broke the steady inhibition state, reactivated hydrogen production, and achieved a high hydrogen yield (64.1 mL/g VSadded) along with stable hydrogen concentration (40-60%). These findings demonstrate that inoculum-mediated feast-famine perturbations, which consist of alternating substrate addition with pure inoculum shocks, not only overcome the limitations of constant high-rate fermentation but also achieve high hydrogen yield, providing a practical operational strategy for scaling up continuous dark fermentation systems.

PMID 42503355
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PubMedMetabolites2026-07-27

Effects of Compound Probiotic Fermented Feed on In Vitro Rumen Fermentation, In Situ Degradation, Rumen Microbiota and Metabolome, and Growth Performance of Beef Cattle.

Hu Haitao H, Cao Yuwa Y, Tian Mei M, Li Hongrui H et al.

Background/Objectives: This study evaluated the effects of a compound probiotic fermented feed (CPFF) containing Lactobacillus plantarum, Bacillus subtilis, yeast, and Aspergillus niger on rumen in vitro fermentation, in situ feed degradation, and growth performance in beef cattle. Methods: We established a control group (CON) and experimental groups with 2%, 4%, and 8% CPFF supplementation for in vitro fermentation. Results: The results indicated that the NH3-N concentration in the 4% CPFF group was significantly higher than in the other groups (p < 0.001). Similarly, microbial crude protein (MCP) production was significantly greater in the 4% CPFF group compared to the CON group (p = 0.016). The molar proportions of acetate, butyrate, isobutyrate, and valerate were significantly higher in the 2% and 4% CPFF groups than in the control group (p < 0.001), while propionate levels were significantly lower (p < 0.001). After 48 h, gas production was highest in the 4% CPFF group. Based on improvements in gas production, MCP synthesis, and fermentation intensity, the 4% inclusion level was determined to be optimal for further studies. We conducted an in situ degradation trial using 4% CPFF. Results showed that at 12 h, the neutral detergent fiber (NDF) degradation rate in the 4% CPFF group was significantly higher than in the CON group at 4, 8, 12, and 48 h (p < 0.05). At 48 h, the acid detergent fiber (ADF) degradation rate in the 4% CPFF group was also significantly higher than in the CON group (p < 0.001), and this group exhibited a significant increase in crude protein (CP) degradation (p = 0.030). We analyzed rumen fluid samples from both the CON and 4% CPFF groups after in vitro fermentation using 16S rRNA sequencing and untargeted metabolomics. Microbial community analysis revealed significantly increased abundances of functional bacterial groups such as Rikenellaceae_RC9_gut_group, Christensenellaceae_R-7_group, and UCG-002 in the 4% CPFF group (p < 0.05). Differential metabolites were primarily involved in pathways related to tryptophan metabolism, and tyrosine metabolism signaling. A feeding trial was conducted by adding 4% CPFF to the diet of Angus growing cattle. The results indicated that average daily gain (ADG) (p = 0.004) and average daily feed intake (ADFI) (p = 0.001) were significantly higher in the CPFF group than in the CON group. Conclusions: In conclusion, our results demonstrate that CPFF enhances rumen fermentation activity, optimizes the microbiota and metabolic profiles of rumen fluid, and improves the average daily gain of beef cattle. This research provides a valuable theoretical basis for applying CPFF in beef cattle breeding.

PMID 42506411
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PubMedJournal of mass spectrometry : JMS2026-07-26

Monitoring the Effect of Tributyltin Salicylate and Propionate, Retinoid X Receptor Ligands, on Heat Shock Protein Expression in MDA-MB-231 Cells by MALDI MS/MS.

Strouhalova Dana D, Macejova Dana D, Brtko Julius J, Bobalova Janette J

Organotin (IV) compounds are known to induce apoptosis via the intrinsic mitochondrial pathway, which is a key mechanism of effective anticancer therapy. Their ability to selectively promote apoptotic cell death highlights their potential as chemotherapeutic agents. In this study, the in vitro effects of two triorganotin compounds, tributyltin propionate and tributyltin salicylate, on the human breast cancer cell line MDA-MB-231 were evaluated. In addition to their proven antitumor activity, these compounds may act as synthetic ligands for nuclear retinoid X receptors. Protein expression profiles were examined using gel electrophoresis and MALDI-TOF mass spectrometry, with a particular focus on heat shock proteins (HSPs), which are commonly overexpressed in cancer cells and contribute to tumor progression and therapeutic resistance. Both triorganotin derivatives significantly reduced HSP expression, suggesting that HSPs could be a promising target in cancer therapy.

PMID 42503019
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PubMedAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2026-07-26

Pretransplant Gut Microbiome Signatures Predict Early Acute Rejection After Kidney Transplantation.

Kim Ji Eun JE, Cho Hyunjeong H, Lee Jangwook J, Park Ji In JI et al.

Early identification of rejection remains a critical unmet need in kidney transplantation, as conventional tools detect rejection only after irreversible allograft injury. The pre-transplant gut microbiome may provide novel predictive signals by modulating immune homeostasis. Pre-transplant stool samples underwent shotgun metagenomic sequencing. Composition, functional profiles, and networks were compared between rejection and non-rejection (protocol biopsy ≤ 2 weeks). A pre-specified SCFA biosynthetic KO panel was tested with FDR correction. Stepwise Random Forest models were developed with subgroup analyses and tested in a temporal validation cohort. Of 78 recipients, 26 (33.3%) developed biopsy-proven early acute rejection. Three taxa including Phascolarctobacterium faecium were FDR-significantly reduced. At the gene level, mcmB (a key propionate-biosynthetic enzyme) was the only KO reaching FDR significance in the pre-specified SCFA panel (q = 0.018). Network analysis revealed selective microstructural reorganization. AUC improved stepwise (0.565 → 0.681 → 0.765), was preserved across rejection subtypes (TCMR-spectrum 0.74; ABMR 0.85), and reached 0.721 in temporal validation with improved reclassification (NRI 0.11; IDI 0.055) and clinical net benefit at thresholds 0.2-0.5. Pre-transplant gut microbiome signatures were independently associated with early acute rejection. Microbiome-augmented models outperformed clinical-only models and remained robust in temporal validation, supporting microbiome-based pre-transplant risk stratification.

PMID 42501920
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PubMedInternational journal of biological macromolecules2026-07-26

Scleroglucan ameliorates dextran sulfate sodium-induced ulcerative colitis and gut microbiota dysbiosis in mice.

Zhao Yiyi Y, Wen Yanlong Y, Yin Dafang D, Yang Fuqin F et al.

β-1,3/1,6-Glucans exhibit significant potential as therapeutic agents for ulcerative colitis (UC); nevertheless, most existing studies have focused on yeast β-glucans. In the current research, we assessed the therapeutic effects of scleroglucan (SCL), a β-1,3/1,6-glucan produced from the fungus Sclerotium rolfsii, by using a dextran sulfate sodium (DSS)-induced mouse model. SCL treatment significantly attenuated DSS-induced body weight loss from 18.45% to 14.69%, reduced the disease activity index from 3.83 to 3.11, decreased colonic TNF-α and MPO levels, and restored IL-10 concentrations (p < 0.05). SCL also promoted goblet cell proliferation and upregulated Muc2 gene expression (p < 0.05), but had no significant effects on colon length and tight junction proteins. Additionally, SCL significantly increased cecal acetate to 10.82 μmol/g, propionate to 3.87 μmol/g, butyrate to 7.13 μmol/g, and valerate to 1.16 μmol/g, compared with the respective levels of 3.11, 1.61, 1.67, and 0.60 μmol/g in the DSS group. Consistently, enhanced colonic mRNA expression of GPR41, GPR43, and GPR109A was seen with the SCL group than the DSS group (p < 0.05). SCL also remodeled gut microbiota composition, and significantly elevated Bacteroidetes, Lactobacillus and Ruminococcus, and reduced Firmicutes (p < 0.05), a microbial profile associated with attenuated colitis severity. Taken together, these findings indicate that SCL effectively mitigated DSS-induced colitis, emphasizing its potential as a bioactive polysaccharide for developing functional foods to assist UC nutritional intervention.

PMID 42501847
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PubMedJournal of food science and technology2026-07-26

Development of multifunctional yeast probiotic effervescent tablets from bioconversion of mangosteen pericarp juice: a potential approach to enhance health benefits.

Di Menna Dalila D, Buranavanitvong Natthanan N, Paparella Antonello A, Prakitchaiwattana Cheunjit C

This study presents a potential approach to produce effervescent tablets with yeast probiotic and bio-converted mangosteen pericarp juice (MPEj), aiming to deliver both multifunctional health benefits and appealing color. The process involved fermenting MPEj with Saccharomyces cerevisiae var. boulardii to modify its composition and increase the yeast population. Subsequently, the bio-converted MPEj and yeast cells were separated to generate powdered forms for producing effervescent tablets. Through response surface methodology, varying MPEj and nitrogen source concentrations revealed the optimal condition: 20% MPEj and 0.5% nitrogen source, yielding a yeast viability of 8.67 ± 0.24 CFU/mL When scaling up yeast fermentation, both flask and bioreactor demonstrated similar trend, with bioreactor exhibiting notably enhanced growth rates in MPEj as well as significant changes in TSS, TTA, and pH during fermentation. After fermentation, MPEj displayed increased antioxidant activity, altered phenolic content, increased isoleucine levels, and presence of propionate, indicating biotransformation driven by yeast. Effervescent tablets met quality standards and demonstrated enhanced yeast survival in simulated gastrointestinal conditions. Moreover, surface property testing, specifically hydrophobicity, revealed improved adherence to intestinal cells, suggesting the potential for prolonged gastrointestinal retention. This study underscores promising application of MPEj fermentation with yeast probiotic in developing functional probiotic tablets with enhanced health benefits. The online version contains supplementary material available at 10.1007/s13197-025-06270-7.

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