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sodium ferrous citrate (SCF, Eisai / Ferromia / Nemiffero)

✓ Approved

Eisai Co., Ltd. · 小分子 · 小分子

什么是 sodium ferrous citrate？

sodium ferrous citrate 是一种小分子，由Eisai Co., Ltd.研发。该药已获批，用于治疗相关适应症。

药物档案

商品名SCF, Eisai, Ferromia, Nemiffero
公司Eisai Co., Ltd.
药物类别小分子
状态Approved
来源： ClinicalTrials.gov, Eisai Co., Ltd.

治疗适应症

sodium ferrous citrate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Blood and lymphatic system disordersAnaemia✓ Approved

相关研究文献

PubMedBiophotonics discovery2026-09-11

Temperature-induced hemoglobin dynamics: oxygenation-dependent evolution of hemoglobin spectral response in the near-infrared.

Bossi Alessandro A, Negretti Fabio F, Saccomandi Paola P, Pifferi Antonio A

Monitoring thermally induced optical changes can guide thermal therapies, but these signals depend strongly on hemoglobin oxygenation, leading to different spectral responses under ex vivo and in vivo conditions. Clarifying these effects is essential for interpreting absorption measurements during treatment. We characterized near-infrared absorption spectra of hemoglobin during heating under controlled oxygenated and deoxygenated conditions and related the signatures to hemoglobin chemistry. Using time-domain diffuse optical spectroscopy, we measured 680- to 1110-nm absorption spectra of blood phantoms containing oxyhemoglobin (oxyHb) or deoxyhemoglobin (deoxyHb) during controlled heating. Multi-concentration measurements yielded extinction coefficients for native and thermally denatured species. Heating oxyHb caused a broad absorption rise consistent with autoxidation of ferrous ( Fe 2 + ) heme to ferric ( Fe 3 + ) forms, similar to methemoglobin and hemichromes. Heated deoxyHb showed distinct peaks at 774 and 874 nm that disappeared upon re-oxygenation, after which spectra converged to treated oxyHb. The oxygen-dependent kinetics of the 774/874 nm bands support a ferrous-denatured intermediate that converts to ferric hemichromes when oxygen becomes available. Thermal denaturation of hemoglobin follows distinct oxygenation-dependent spectroscopic pathways. The extracted extinction coefficients provide essential inputs for optical models of laser-based ablation and improve diffuse optical monitoring of thermal therapies.

PMID 42724164
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PubMedJournal of thoracic disease2026-09-11

Uncovering sodium overload-associated gene signatures in chronic obstructive pulmonary disease through integrated bioinformatics and machine learning.

Zou Zhongzhou Z, Chen Jietao J, Mai Zutong Z, Wu Ningcheng N et al.

Airway epithelial cells depend on tightly regulated ion transport, and disturbed sodium handling has been linked to mucus dehydration, oxidative stress and epithelial injury in obstructive lung disease. How sodium/ion-homeostasis-related transcription is organised in chronic obstructive pulmonary disease (COPD), and whether it converges with the disease's broader expression architecture, has not been systematically examined. This study aimed to identify sodium-overload-associated genes in COPD and evaluate a compact epithelial gene panel across multiple validation platforms. Two bulk lung-transcriptomic cohorts were integrated and analysed with differential expression, weighted gene co-expression network analysis (WGCNA) and a locked sodium-overload-related gene (SORG) set defined a priori from GeneCards. Candidate genes were characterised by functional enrichment and protein-protein interaction analysis, benchmarked across twelve machine-learning algorithms, and then examined in an independent external cohort, a mucus-score sensitivity analysis, single-cell RNA sequencing and quantitative polymerase chain reaction (qPCR; 13 COPD and 12 non-COPD controls). Seven genes lay at the intersection of differential expression, the COPD-associated co-expression module and the sodium-overload set, enriched for xenobiotic-metabolism and oxidative-stress pathways. A reduced three-gene panel (ALDH3A1, MUC5AC and PHEX) gave moderate but reproducible discrimination [area under the curve (AUC) 0.686], with acceptable calibration and positive net benefit over the threshold range examined, and reached an AUC of 0.809 in the external cohort. The three genes co-varied with multiple immune-cell fractions without implying direction. Single-cell analysis and qPCR localised the changes mainly to airway epithelial cells: ALDH3A1 and MUC5AC were consistently higher in COPD across datasets, whereas PHEX showed directional heterogeneity across platforms. Sodium/ion-homeostasis-related transcription is associated with a stressed airway-epithelial state in COPD. The three-gene panel is best read as a compact, biologically interpretable framework-annotation-guided rather than evidence of causal sodium overload, and not a stand-alone diagnostic-that warrants validation in larger, prospectively matched cohorts.

PMID 42724664
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PubMedFrontiers in medicine2026-09-11

Severe recurrent hypernatremia and probable lithium-associated nephrogenic diabetes insipidus following pancreatectomy in a patient with schizophrenia: a case report.

He Yanfei Y, Jin Liuyin L, Xu Xiaolei X, Xia Qing Q

Nephrogenic diabetes insipidus (NDI) is characterized by impaired renal responsiveness to arginine vasopressin, causing defective urinary concentration and large volumes of dilute urine. Long-term lithium exposure is an important acquired cause. Perioperative fasting, restricted free-water intake, and ongoing fluid losses may unmask compensated lithium-associated urinary concentrating dysfunction and precipitate severe hypernatremia. A 61-year-old man underwent laparoscopic resection of a pancreatic tail lesion. His history included schizophrenia, type 2 diabetes mellitus, impaired renal function, long-term lithium therapy, and preoperative polyuria, nocturia, and polydipsia. Preoperative serum sodium was 147.1 mmol/L, creatinine 174.4 μmol/L, and eGFR 35.6 mL/min. Postoperatively, restricted free-water intake was followed by progressive polyuria, persistent negative fluid balance, altered mental status, and worsening renal function. Urine output peaked at 7,900 mL/24 h and serum sodium at 165.5 mmol/L. Despite marked hypernatremia and hypertonicity, urine specific gravity remained ≤1.005. Serum lithium before discontinuation was 0.90 mmol/L. Based on long-term lithium exposure, preoperative symptoms, persistent polyuria, recurrent severe hypernatremia, and low urine specific gravity, probable lithium-associated NDI was considered. Because urine osmolality and a standardized desmopressin response test were unavailable, NDI could not be biochemically confirmed and central diabetes insipidus could not be definitively excluded. Hyperglycemia, gastrointestinal fluid losses, and renal dysfunction may also have contributed. Lithium was discontinued after psychiatric and multidisciplinary consultation, and hydrochlorothiazide was initiated. Treatment included gradual free-water replacement, intravenous fluid adjustment, sodium restriction, enteral free water administered separately from enteral nutrition, and close monitoring of serum sodium, potassium, renal function, urine output, glucose, and mental status. The retrospectively estimated free-water deficit was approximately 7.5 L. With combined management, serum sodium, urine output, and consciousness gradually improved. At 12 weeks, serum sodium was 142.3 mmol/L. At 13 months, urine specific gravity remained 1.004, although persistent NDI could not be confirmed. In patients receiving long-term lithium, postoperative polyuria, recurrent hypernatremia, and low urine specific gravity should prompt consideration of lithium-associated urinary concentrating dysfunction while other causes of water loss are assessed. Careful perioperative medication review, sodium and fluid-balance monitoring, individualized fluid management, and multidisciplinary collaboration are essential.

PMID 42723773
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PubMedJournal of microencapsulation2026-09-11

Cross-linked alginate/pozzolan (Alg@PZ) microcapsules for sodium diclofenac removal as emerging contaminant.

Drai Ikram I, Bachir Cherifa C, Bailiche Zohra Z, Rodríguez Juan Francisco JF et al.

This study investigates the adsorption of sodium diclofenac (SDF) onto Alginate/Pozzolan (Alg@PZ) microcapsules to address pharmaceutical contamination in aquatic systems. The Alg@PZ composite was synthesised via CaCl2 cross-linking by varying the Sodium Alginate (S-Alg)/Pozzolan (PZ) mass ratio from 0.625 to 3.25. Successful PZ incorporation into the S-Alg matrix was confirmed by FTIR, XRD and SEM analyses, revealing hydrogen and electrostatic bonding alongside a near-uniform spherical porous morphology of 1.73 mm diameter. TGA revealed optimal PZ encapsulation of 63.87% at a S-Alg/PZ ratio of 0.625, with high thermal stability. Adsorption experiments in a shallow-bed system demonstrated rapid SDF removal, best described by a PSO kinetic model reaching equilibrium after 45 minutes, with a qmax= 21.85 mg.g - 1. Thermodynamic analysis showed that the reaction was spontaneous and exothermic. However, Alg@PZ0.625 represents a scalable, eco-friendly and cost-effective alternative to conventional adsorbents for removing persistent pharmaceutical compounds from aqueous systems.

PMID 42723228
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PubMedBiotechnology journal2026-09-11

Metabolic Footprint of Drosophila S2 Cells: Findings During the Production of a Recombinant Rabies Virus Glycoprotein.

Decarli Monize Caiado MC, Dos Santos Diogo Peres DP, Correia Daniela Matilde DM, de Azevedo Amadeus Gomes AG et al.

Over the past 50 years, the Drosophila melanogaster S2 cells have been valued for their ability to synthesize therapeutic molecules at high yield. To further increase protein expression, it is imperative to improve cellular performance, which is intrinsically linked to cell metabolism. Nevertheless, information on S2 metabolism, including pathways, components, and cellular compartments, remains limited, hindering advances in S2 cellular performance. Herein, using a genetically modified S2 cell line expressing the recombinant rabies virus glycoprotein (RVGP), we investigated the stress caused by RVGP production on S2 cells. Batch cultures using wild- and rec-types were performed, and 27 compounds were quantified over 192 h. The extracellular metabolome affected the rec-S2 growth kinetics after RVGP expression was activated. Although RVGP was produced in high amounts, we identified a substrate limitation for rec-S2 cell growth (glutamine), changes in amino acid routes due to RVGP biosynthesis (leucine, serine, glycine, and valine), and metabolites that might be affecting rec-S2 cell growth (acetate, pyruvate, citrate, and malate). Organic acid analysis indicated that malate and acetate production are correlated with RVGP production. This work revealed metabolic correlations in S2 cells that may have direct implications for media optimization and yield maximization, thereby improving S2 performance for scale-up.

PMID 42723328
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PubMedFrontiers in pediatrics2026-09-11

Development and validation of a predictive model for myocardial injury in children with pneumonia based on interpretable machine learning.

Zhang Shuai S, Zhang Jianming J

This study aimed to identify independent factors for pneumonia-related myocardial injury in children, and construct and validate a risk prediction model and stratification system to enable early screening of high-risk patients and guide individualized clinical interventions. A total of 222 children hospitalized with pneumonia from January 2023 to May 2026 were enrolled in this retrospective study and equally divided into myocardial injury and non-injury groups (111 cases per group). Admission baseline clinical and laboratory data were collected. Core predictive variables were screened via univariate analysis and LASSO regression. Restricted cubic spline regression was performed to explore the nonlinear relationships between variables and myocardial injury. Multivariate logistic regression was used to identify independent risk and protective factors, while the SHAP algorithm validated variable importance and effect directions. We further analyzed variable interactions and established a nomogram model. Model performance was evaluated using ROC curves, bootstrap calibration, and DCA. Subgroup analysis and a three-tier risk stratification system were conducted for systematic verification. Univariate analysis screened 11 differential variables, which were compressed to seven core predictors by LASSO regression. Multivariate analysis identified AST (OR = 1.11) and TP (OR = 1.12) as independent risk factors, while serum sodium (OR = 0.81), carbon dioxide combining power (OR = 0.86), and urea (OR = 0.67) were protective factors (all P < 0.05), consistent with SHAP validation results. Significant synergistic interaction was found between AST and TP (S = 1.32), whereas AST exerted antagonistic interactions with sodium (S = 0.74) and carbon dioxide combining power (S = 0.78). The nomogram yielded AUCs of 0.902 (training set) and 0.822 (validation set), with calibration errors of 0.021 and 0.035. DCA demonstrated favorable clinical net benefit, and all subgroup AUCs exceeded 0.85. The three-tier stratification system presented significantly different myocardial injury rates (6.12%, 25.36%, and 62.79% for low-, medium-, and high-risk groups, P < 0.001). AST, TP, serum sodium, carbon dioxide combining power, and urea independently affect the risk of pediatric pneumonia-associated myocardial injury with distinct synergistic and antagonistic interactions. The validated nomogram and risk stratification system serve as accurate and stable bedside tools for early risk assessment, facilitating timely clinical intervention and optimized medical resource allocation.

PMID 42723900
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