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sodium ferrous citrate (SCF, Eisai / Ferromia / Nemiffero)

✓ Approved

Eisai Co., Ltd. · 小分子 · 小分子

什么是 sodium ferrous citrate？

sodium ferrous citrate 是一种小分子，由Eisai Co., Ltd.研发。该药已获批，用于治疗相关适应症。

药物档案

商品名SCF, Eisai, Ferromia, Nemiffero
公司Eisai Co., Ltd.
药物类别小分子
状态Approved
来源： ClinicalTrials.gov, Eisai Co., Ltd.

治疗适应症

sodium ferrous citrate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Blood and lymphatic system disordersAnaemia✓ Approved

相关研究文献

PubMedInternational journal of molecular sciences2026-10-27

Association of Circulating microRNAs in Plasma with Coronary Collateral Circulation in Patients with Chronic Total Occlusion.

Kiseleva Anna A, Sotnikova Evgeniia E, Zharikova Anastasia A, Vasilev Dmitry D et al.

Chronic total occlusion (CTO) occurs in 16-52% of patients with coronary artery disease (CAD) and is often accompanied by variable development of coronary collateral circulation (CCC). The aim of this work was to study the associations between circulating plasma microRNAs (miRNAs) and the development of CCC in patients with CTO. This exploratory study included 43 patients: a control group-patients without significant coronary artery stenosis (n = 20), and two CTO groups with good (n = 13) and poor (n = 10) CCC based on the Rentrop classification. The study was performed simultaneously on two types of plasma samples (K2EDTA and sodium citrate). Total RNA was isolated using the miRNeasy Serum/Plasma Advanced Kit. Libraries were prepared using the QIAseq miRNA UDI Library Kit and then sequenced on the NextSeq 550 using a 1 × 75 bp protocol. A total of 18 miRNAs were found to be differentially expressed (DE) in EDTA plasma and 13 in citrate plasma; only one miRNA in citrate plasma (hsa-miR-92a-3p) was differentially expressed between the good and poor CCC groups. However, given the limited sample size, the findings should be considered hypothesis-generating, and further studies are required for validation in larger, independent cohorts and to establish the roles of these miRNAs in CCC development.

PMID 42941886
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PubMedClinical kidney journal2026-10-27

Short-term effects of an SGLT2 inhibitor on divalent ions in autosomal dominant polycystic kidney disease: a randomized crossover trial.

Roth Lorena L, Harmacek Dusan D, Schachtner Thomas T, George Britta B et al.

Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a cornerstone of chronic kidney disease therapy, reducing disease progression, cardiovascular events, and mortality. Autosomal dominant polycystic kidney disease (ADPKD) patients were excluded from major trials, and data on electrolyte handling with SGLT2 inhibitors, in combination with tolvaptan, are lacking. SIDIA was a randomized, double-blind, placebo-controlled, two-period crossover trial in 15 adults with ADPKD (mean estimated glomerular filtration rate (eGFR) 68 ml/min/1.73 m²; median age 43 years). Participants received empagliflozin 10 mg or placebo for 14 days, separated by a 2-week washout. The primary endpoint was 24 h urinary and fractional excretion of phosphate, calcium, and magnesium. Exploratory secondary endpoints included markers of kidney stone propensity, inflammation, vitamin D metabolism, and tolerability. Treatment effects were estimated using generalized linear mixed models. Given the small sample size, analyses were exploratory and focused on effect estimation. For the primary endpoint, neither 24 h urinary nor fractional excretion of phosphate, calcium, or magnesium differed between empagliflozin and placebo. Empagliflozin lowered serum uric acid (-26%), increased serum magnesium (+5.7%) and urinary citrate (+78.6%), and reduced blood pressure (-4/-7 mmHg). An expected decline in eGFR (-7.1%) was observed, with no major short-term safety signals observed. Copeptin levels increased with empagliflozin (+26%). In this exploratory mechanistic trial, no substantial short-term difference in urinary or fractional excretion of divalent ions were detected with empagliflozin. The observed changes in serum magnesium, urinary citrate, uric acid, and copeptin are hypothesis-generating and require confirmation in larger, longer-term studies.

PMID 42936265
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PubMedJournal of the American Chemical Society2026-10-27

Elucidating the Role of Energy- and Electron-Transfer Processes and the Route to Highly Reduced Products in the Dual IrIII/FeIII Photocatalyzed CO2 Reduction Reaction.

DiLuzio Stephen P SP, Hwang Keon Ha KH, Luedecke Kaitlin M KM, Sutcliffe Erica E et al.

Mechanistic elucidation of a photochemically driven CO2 reduction reaction (CO2RR) using an IrIII photosensitizer and an iron metalloporphyrin reduction catalyst, which has been proposed to transform CO2 into CH4, has been conducted using various steady-state and time-resolved absorption and emission spectroscopic methods, cyclic voltammetry, reaction kinetics, quantum yield measurements, spectroelectrochemistry, and isotope-labeling experiments. A dynamic reactivity landscape was subsequently uncovered where the key photochemical mechanistic steps are altered as a function of reaction progress from an initial photoinduced single electron transfer to an energy transfer mechanism, which is supported by the in situ generation of a ferrous-carbonyl intermediate that was subjected to Stern-Volmer analysis and transient absorption spectroscopy to determine the overall photochemical mechanism using a select IrIII photosensitizer. This alteration of the photochemical mechanistic steps stymies further photoinduced reduction of the ferrous-carbonyl intermediate, which is a proposed on-cycle step toward the photoevolution of CH4. Instead, cyclic voltammetry experiments implicated a plausible CH4 evolution mechanism involving degradation of the porphyrin structure through attack of a second equivalent of the reduced metalloporphyrin catalyst. This mechanistic picture is consistent for the observed formation of ethane under steady-state irradiation conditions, which also does not arise from the CO2RR but instead represents a degradation product of the sacrificial electron donor, triethylamine, following single electron oxidation.

PMID 42937862
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PubMedMaterials (Basel, Switzerland)2026-10-27

Application and Adaptation of Arc-Based Welding Processes to Wire Arc Additive Manufacturing: A Review.

Elalem Ahmed Nabil AN, Alrehaili Husam H, Alam Mohammad Azad MA, Raja Sufian S et al.

Wire Arc Additive Manufacturing (WAAM) has emerged as one of the most industrially scalable arc-based metal additive manufacturing (AM) technologies, using established Gas Metal Arc Welding (GMAW), Gas Tungsten Arc Welding (GTAW), and Plasma Arc Welding (PAW) processes to deposit metallic material layer-by-layer into near-net-shape components. This review presents a physics-based examination of the adaptation of traditional welding processes for AM applications, with emphasis on: (i) the thermodynamic and metallurgical principles governing melt pool formation, solidification, and solid-state transformations; (ii) the thermal and solidification features that WAAM shares with multi-pass welding and those that are distinctive to WAAM, with particular attention to the temperature gradient-to-solidification-rate ratio (G/R) and its role in controlling grain morphology; (iii) deposition path strategies and their influence on heat distribution and microstructural homogeneity; (iv) arc metal transfer modes and their thermal implications for AM; and (v) mechanisms of defect formation including porosity, solidification cracking, residual stress, and geometric deviation. Unlike general WAAM reviews, this article specifically positions conventional arc welding processes as the metallurgical and thermal foundation of WAAM and critically examines how their operating principles are transformed under repeated layer-by-layer deposition. Key governing equations linking process parameters to microstructure and properties are presented. Among GMAW variants, Cold Metal Transfer (CMT) provides low heat input, controlled droplet transfer, and low spatter, whereas GTAW and PAW allow wire feed and arc power to be set independently; the preferred process therefore depends on the alloy, required deposition rate, geometry, and surface quality. A synthesis of findings across ferrous and non-ferrous alloy systems is presented, together with knowledge gaps and future directions toward closed-loop adaptive WAAM systems.

PMID 42941102
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PubMedJournal of the American Chemical Society2026-10-27

Online Quantification of Lattice Sodium for O3-Type Cathode Diagnostics during Scalable Manufacturing.

Su Xiao-Chuan XC, Jin Ruo-Xi RX, Qi Xiaodong X, Chen Hao-Ran HR et al.

The precise control of lattice sodium stoichiometry in cathodes is paramount for sodium-ion battery performance, as it constitutes the sole charge carrier inside the battery during the charge/discharge process. However, precisely tracking the lattice sodium inventory within Na-layered oxide cathodes, particularly during manufacturing, remains a significant challenge. Here, we propose a reliable descriptor, the diffraction peak intensity ratio (α = I(003)/I(104)), which allows the rapid, accurate, and nondestructive quantification of lattice sodium and distinguishes it from inactive sodium. In particular, a rational correlation can be established among the α value, lattice sodium content, and electrochemical properties to enable the α value to predict the electrochemical performance of the as-prepared Na-layered oxides. To achieve continuous and scalable online lattice sodium quantification during manufacturing, we design an industrial automated testing platform applicable to the cathode material production lines with high efficiency and accuracy. Our work provides a universal solution for the prediction and adjustment of material performance during the synthesis and processing, which ultimately accelerates the sustainable development of sodium-ion batteries.

PMID 42938015
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PubMedThe journal of poultry science2026-10-27

Effects of Cyclic High Ambient Temperature on Tricarboxylic Acid Cycle Intermediates and Orotate Levels in the Liver and Breast Muscle of Broiler Chickens.

Katafuchi Ayumi A, Shimamoto Saki S, Tomonaga Shozo S, Kamimura Miyu M et al.

Heat stress alters tricarboxylic acid (TCA) cycle metabolism in broiler chickens; however, quantitative changes in TCA cycle-related metabolites remain poorly understood. This study determined the effects of heat exposure on TCA cycle intermediate (citrate, isocitrate, α-ketoglutarate, succinate, fumarate, and malate) and orotate levels in the liver and breast muscle of broiler chickens. Twelve 14-day-old male broiler chickens were assigned to either a control group (25 ± 1 °C) or a cyclic high ambient temperature group (35 ± 1 °C for 8 h/day) and reared under these conditions for 4 days. Heat exposure increased liver levels of citrate, α-ketoglutarate, fumarate, and malate, while decreasing succinate and orotate. Heat exposure also decreased the mRNA expression of isocitrate dehydrogenase 3A (IDH3A) and oxoglutarate dehydrogenase, key TCA cycle regulatory enzymes, as well as dihydroorotate dehydrogenase and ubiquinol-cytochrome c reductase Rieske iron-sulfur protein 1 (UQCRFS1), which are involved in mitochondrial electron transport. Heat exposure increased breast muscle levels of succinate, fumarate, and malate, while reducing IDH3A and UQCRFS1 mRNA expression. These findings suggest that heat exposure impairs TCA cycle metabolism in broiler chickens, possibly by reducing the utilization of TCA cycle intermediates through impaired electron transfer in mitochondrial complex III.

PMID 42936156
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