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sodium ferrous citrate (SCF, Eisai / Ferromia / Nemiffero)

✓ Approved

Eisai Co., Ltd. · 小分子 · 小分子

什么是 sodium ferrous citrate？

sodium ferrous citrate 是一种小分子，由Eisai Co., Ltd.研发。该药已获批，用于治疗相关适应症。

药物档案

商品名SCF, Eisai, Ferromia, Nemiffero
公司Eisai Co., Ltd.
药物类别小分子
状态Approved
来源： ClinicalTrials.gov, Eisai Co., Ltd.

治疗适应症

sodium ferrous citrate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Blood and lymphatic system disordersAnaemia✓ Approved

相关研究文献

PubMedJournal of fungi (Basel, Switzerland)2026-07-27

Transporter Engineering for Enhancing Citric Acid Production in Aspergillus niger.

Li Jie J, Li Mingyang M, Song Yan Y, Xu Zeyu Z et al.

The efficient industrial production of citric acid by A. niger requires overcoming the limitations of substrate uptake and citrate export on the citrate synthesis efficiency. This study addresses these obstacles using a transporter engineering strategy, modifying the endogenous high-affinity glucose transporter MstF and citrate exporter CexA. The "push-pull" strategy was used to improve citric acid production by increasing glucose import and citrate export. A single overexpression of mstF improved citric acid production, reaching 179.35 g/L in the H7 strain. However, cexA high expression impaired dense mycelium pellet formation and affected the expression of key genes, resulting in reduced citric acid production. For balancing intracellular accumulation and secretion of citrate, simultaneous overexpression of mstF and cexA increased citric acid production and efficiency. In a 30 L fermenter, strain A5 achieved a citric acid titer of 185.91 g/L, a productivity of 3.21 g/h/L, and a shortened fermentation cycle. Collectively, these results provide a reference for the industrial production of citric acid and other organic acids.

PMID 42506234
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PubMedBiomimetics (Basel, Switzerland)2026-07-27

Long-Term Influence of Endodontic Irrigants on In Vitro Dentin Biomimetic Remineralization.

Taddei Paola P, Di Foggia Michele M, Spinelli Andrea A, Gandolfi Maria Giovanna MG et al.

Endodontic irrigant solutions act as crucial pretreatment conditioning agents in dentin biomimetic remineralization, preparing the collagen scaffold for calcium phosphate infiltration and subsequent tooth structure reconstruction. In this study, root dentin discs were exposed for 10 min to five irrigant solutions: sodium hypochlorite (NaClO, 3%), EDTA (17%), citric acid (CA, 10%), chlorhexidine (CHX, 2%), and an innovative experimental formulation containing citric acid (7%) and surfactants. Samples were then aged in Hank's Balanced Salt Solution (HBSS) at 37 °C for three months to simulate long-term clinical conditions. Physicochemical modifications of the collagen and apatite phases were assessed at each experimental stage using ATR-FTIR spectroscopy, with the ACaP/AAmide I and A870/ACaP absorbance ratios as markers of the degree of mineralization and apatite carbonate content, respectively. Results indicated that CHX- and EDTA-treated dentin exhibited the highest remineralization after ageing, while NaClO impeded remineralization due to collagen degradation. The experimental irrigant produced the most pronounced demineralization, followed by CA; however, it also facilitated significant remineralization, attributed to citrate-collagen binding and surfactant-enhanced apatite nucleation. NaClO selectively degraded collagen and increased apatite crystallinity; CA inhibited apatite nucleation through adsorbed citrate ions, and CHX and EDTA induced minimal alterations. These findings provide molecular-level evidence linking short-term irrigant effects to the long-term potential for dentin biomineralization, with direct implications for irrigant selection in regenerative endodontic protocols. It should be noted that this study was conducted on dentin discs obtained from a single tooth; all findings should therefore be regarded as preliminary and require confirmation in studies with larger, biologically independent sample sizes.

PMID 42505506
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PubMedGels (Basel, Switzerland)2026-07-27

Storage and Stability of AAV-Containing Fibrin Hydrogels for Retinal Gene Therapy.

Berger Aubrey A, Knudsen Travis T, Kopp Francesca F, Korda David D et al.

Subretinal and intravitreal injection of retinal gene therapy is associated with serious adverse events and poor efficacy. We sought to improve retinal gene therapy delivery by developing fibrin hydrogel encapsulated adeno-associated virus (FE-AAV). Here we investigate conditions for storage and stability for FE-AAV. FE-AAV containing 1.9 × 109 genome copies of AAV2/2-CMV-GFP was manufactured using fibrinogen reconstituted in 0.01 M sodium citrate, pH 7 (NaC) or phosphate-buffered saline containing 0.001% (v/v) Pluronic F68 (F68). Samples were stored at either -80 °C or 4 °C for up to 16 weeks. Changes in transduction efficiency, and mechanical and physical properties were evaluated. In vitro transduction was significantly (p < 0.05) reduced for FE-AAV manufactured with NaC. In contrast, we observed no change in transduction through 16 weeks for FE-AAV made with F68. Physical changes occurred in FE-AAV stored at -80 °C. In contrast to FE-AAV formulated with NaC, FE-AAV formulated with F68 and stored at 4 °C for 16 weeks was essentially equivalent to freshly made FE-AAV and retained the ability to transduce retinal pigment epithelial (RPE) cells in the pig eye. We conclude that FE-AAV formulated with F68 and stored at 4 °C is stable and shows potential for retinal gene therapy for at least 4 months following manufacture.

PMID 42505274
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PubMedZhonghua yi xue za zhi2026-07-27

[The impact of dietary sodium intake on therapeutic efficacy and short-term renal injury in patients after treatment for primary aldosteronism].

Deng Q R QR, Du Y Y, Zhong Z T ZT, Chen Z X ZX et al.

Objective: To evaluate the impact of dietary sodium intake on therapeutic efficacy and short-term renal injury in patients after treatment for primary aldosteronism(PA). Methods: A retrospective study was conducted on PA patients admitted between May 2017 and November 2024. Sodium intake was assessed via 24 h urinary sodium excretion before treatment. Patients were categorized into normal sodium (<6 g/d) and moderate-to-high sodium (≥6 g/d) groups. The baseline clinical characteristics of the two groups were compared. Spearman correlation analysis was used to analyze the correlations between sodium intake and baseline clinical indicators. The efficacy and renal function indicators were compared after 6 months of mineralocorticoid receptor antagonist (MRA) therapy or adrenalectomy. Restricted cubic spline model were used to analyze the nonlinear correlations between sodium intake and post-treatment urinary albumin-to-creatinine ratio (UACR). Results: A total of 239 patients were enrolled, including 122 males and 117 females with the age of (49.0±11.3) years. Among them, 72 patients were categorized into the normal sodium intake group and 167 into the moderate-to-high sodium intake group. Levels of UACR, urinary albumin excretion rate (UAER), 24 h urinary protein and 24 h urinary potassium were significantly higher in the moderate-to-high sodium intake group relative to the normal sodium intake group (all P<0.05). Spearman correlation analysis demonstrated that daily sodium intake was positively correlated with systolic blood pressure (SBP) (r=0.180), 24 h urinary potassium (r=0.375), UACR (r=0.224) and UAER (r=0.150) in patients with primary aldosteronism (all P<0.05). Following MRA pharmacotherapy, patients in the moderate-to-high sodium intake group exhibited higher SBP [130.0(120.0, 140.0) vs 120.0(119.0, 130.0) mmHg(1 mmHg=0.133 kPa), P=0.026] and a lower proportion of normotensive cases [65.6%(40/61) vs 90.9%(30/33), P=0.010] compared with the normal sodium intake group. After surgical intervention, the moderate-to-high sodium intake group achieved a greater reduction in SBP [-17.3(-26.5, -9.5) vs -7.0(-24.7, 1.7) mmHg, P=0.023], alongside a more prominent decline in UACR [-11.15(-35.75, 4.75) vs 0.10(-7.28, 7.33) mg/g, P=0.008] than the normal sodium intake group. Restricted cubic spline analysis revealed a "J-shaped" nonlinear association between baseline sodium intake and postoperative UACR. When sodium intake was ≥6.65 g/d, postoperative UACR increased progressively along with rising sodium intake. Conclusions: Moderate-to-high sodium intake is detrimental to blood pressure control and renal protection in patients with PA, while surgical treatment can partially alleviate the negative effects of moderate-to-high sodium intake on their blood pressure and kidneys. Sodium intake restriction should be an important component of comprehensive management for PA.

PMID 42503920
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PubMedGels (Basel, Switzerland)2026-07-27

Cobalt Oxide-Containing Glaze/CaAlg Hydrogel Membrane for Degradation of Orange G via Peroxydisulfate Activation.

Zhang Bin B, Wang Minglin M, Liu Yawen Y, Cui Jiabao J et al.

The sustained expansion of printing and dyeing operations has led to the discharge of large volumes of organic wastewater containing dyes. The resulting environmental pollution demands urgent solutions, making the development of efficient and eco-friendly methods for the elimination of dyeing wastewater critically important. The combination of alginate hydrogel membranes with advanced oxidation processes (AOPs) for water purification represents an emerging approach in the current field of water treatment. In this study, a calcium alginate membrane was loaded with a glaze containing highly active cobalt oxide to fabricate a glaze-calcium alginate (Glaze-CaAlg) composite membrane. The membrane achieved stable degradation of Orange G dye under optimal conditions, and a series of tests were conducted under varying conditions using pollutant concentrations close to those found in real water bodies. Under optimal conditions (glaze loading = 2.5 mL, PMS = 0.3 mmol/L, cross-flow filtration mode), the membrane achieved a 93.7% degradation efficiency of Orange G (10 ppm) within 45 min, with hydroxyl radicals (·OH, ~79%) identified as the predominant reactive species. The Glaze-CaAlg membrane also exhibited excellent reusability, maintaining a degradation efficiency of over 80% for Orange G across five consecutive cycles. Furthermore, sodium citrate was employed to react with the Glaze-CaAlg membrane, enabling the recovery and secondary application of the glaze. Membranes re-fabricated from the recovered glaze showed mechanical strength and catalytic efficiency comparable to those of the pristine membrane. The Glaze-CaAlg membrane possesses high catalytic activity and good stability. This work offers a sustainable, cost-effective, and recyclable catalytic membrane that converts a traditional ceramic material into an advanced functional material for wastewater remediation, with great potential for practical application in the treatment of refractory organic pollutants.

PMID 42505327
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PubMedBiosensors2026-07-27

Elucidating the Mechanism of Interactions Between Aminoglycosides and AuNPs: Why the Classical Colorimetric Assay May Falsely Report Aptamer Affinity.

Liang Yaning Y, Fang Shiyi S, Chen Zhuoer Z, Chen Yuzhuo Y et al.

Gold nanoparticles (AuNPs) are widely used in aptasensors because of their high extinction coefficient and aggregation-dependent color differences. However, recent studies have indicated that nonspecific interactions between target molecules and AuNPs may dominate the detection signal rather than aptamer-target specific binding. This study systematically investigated the interactions between 13 aminoglycoside antibiotics and AuNPs. We found that all aminoglycoside antibiotics interacted strongly with AuNPs, considerably reducing their salt stability. Furthermore, methoxy polyethylene glycol thiol reversed AuNP aggregation induced by aminoglycoside antibiotics, indicating that it occurs at the secondary minimum. Using density functional theory, we analyzed the molecular structures and charge distribution characteristics of the aminoglycoside antibiotics, elucidating that they replace citrate ions on AuNP surfaces via a ligand exchange mechanism, thereby inducing aggregation. Additionally, both aptamer targets and complementary DNA struggled to desorb the aptamer (KAN6-1) from the AuNP surfaces. Our study demonstrates that the label-free colorimetric assay based on aggregation of unmodified citrate-AuNPs is neither suitable for characterizing the binding affinity of aminoglycoside aptamers nor viable for constructing corresponding colorimetric sensors to detect this class of antibiotics. Thus, researchers should incorporate mechanistic verification and rigorous controls when employing this system to ensure reliable results.

PMID 42505464
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