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abuse-deterrent extended release tablet technology

✓ Approved

Inspirion Delivery Technologies · 治疗药物

什么是 abuse-deterrent extended release tablet technology？

abuse-deterrent extended release tablet technology 是一种治疗药物，由Inspirion Delivery Technologies研发。该药已获批，用于治疗相关适应症，给药途径：Others。

药物档案

公司Inspirion Delivery Technologies
给药途径Others
状态Approved
来源： ClinicalTrials.gov, Inspirion Delivery Technologies

治疗适应症

abuse-deterrent extended release tablet technology 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresOral appliance application✓ Approved

相关研究文献

PubMedActa parasitologica2026-07-27

Chemical Profile and Insecticidal Properties of Essential Oil Obtained from Algerian Artemisia herba-alba Leaves.

Benaceur Kenza K, Youcefi Mustapha Naceur MN, Benaceur Farouk F

Vector control is critical for reducing mosquito-borne diseases. Plant-derived insecticides offer a safer and environmentally friendly alternative to synthetic chemicals. This study aimed to evaluate the chemical composition and insecticidal efficacy of essential oil (EO) from Artemisia herba-alba against Culex pipiens. EO composition was determined using Gas Chromatography-Mass Spectrometry (GC/MS). Larvicidal, adulticidal, repellent, and oviposition deterrent activities were assessed through bioassays. Molecular docking analyses were conducted to investigate interactions between major EO components and mosquito enzymes involved in critical physiological processes. GC/MS revealed camphor (19.47%), 2-nonanone (16.96%), exo-fenchol (9.30%), and cis-thujone (8.18%) as the primary constituents. Larvicidal activity exhibited a dose- and time-dependent effect, with an LC₅₀ of 47.12 ppm at 72 h. Adulticidal activity was moderate. Repellency reached 92.92% at 6 µL/cm², and EO significantly reduced oviposition, with an Oviposition Activity Index of -0.85 at 7%. Docking studies indicated strong binding of cis-thujone and pinocarvone to glutathione S-transferase, chitinase h, and acetylcholinesterase. The EO of A. herba-alba demonstrated potent larvicidal, repellent, and oviposition deterrent effects, with active compounds potentially disrupting essential mosquito physiological functions. These findings support its potential application as a natural agent in integrated vector management programs.

PMID 42507277
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PubMedGels (Basel, Switzerland)2026-07-27

Protocol-Dependent Effects on Colloidal Characterization and Drug Loading/Release Analysis of Thermosensitive PNIPAM-co-COOH Microgels.

López-Molina José J, Garrido-Rodríguez Alba A, Tirado-Miranda María M, Bastos-González Delfi D et al.

This work analyzes protocol-dependent effects on the colloidal characterization and drug loading/release analysis of model thermosensitive PNIPAM-co-COOH microgels and shows how they can be quantified or minimized through targeted methodological refinements. Findings reveal that standard single-beam DLS underestimates the collapsed hydrodynamic radius by 18% at 43 °C due to thermal convection. After drift correction, 3D-DLS combined with SLS provides a consistent description of thermally induced collapse, pH-dependent swelling and core-corona structure. Regarding drug delivery, loading efficiency for Doxorubicin and 5-Fluorouracil is maximized near the volume phase transition temperature, where hydrophobic interactions are strongest. For release studies, dialysis is recommended, but free-drug blanks are required to account for membrane-induced delay and ensure accurate early kinetic profiles. By integrating TEM, AFM, SLS, DLS, NTA and LDE, this study establishes a robust framework for the colloidal characterization of thermosensitive microgels. These refinements reduce experimental bias and may be extended to related soft nanocarriers.

PMID 42505310
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PubMedGels (Basel, Switzerland)2026-07-27

Drug Delivery and Visual Monitoring of Nd(ATA)-GelMA Composite Hydrogels.

Qiu Tongyu T, Bian Fengyuan F, Meng Tong T, Zhou Wei W et al.

In this study, taking NdCl3 and 2-amino-1,4-benzenedicarboxylic acid (H2ATA) as raw materials, a novel lanthanide metal-organic framework, Nd(ATA), was synthesized by the coprecipitation method. After loading antibiotic levofloxacin (LEV), Nd(ATA) was combined with GelMA hydrogel to prepare a drug-loaded composite hydrogel, LEV@Nd(ATA)-Gel, which can emit near-infrared fluorescence under excitation at 808 nm and possesses improved mechanical properties compared to pure GelMA hydrogel. LEV@Nd(ATA)-Gel exhibited high bactericidal activity and low cytotoxicity, with cell viability increased by 35% compared to the control group. The release rate of the loaded LEV was found increasing with the pH decreasing from 7 to 3, and demonstrated a potential responsiveness to wound microenvironment. Furthermore, drug delivery studies revealed a significant correlation with the fluorescence intensity of the composite hydrogel and the drug release behavior, and the extent of drug release was quantitatively captured by an in vitro imaging technology. This study successfully integrated the drug release with fluorescent signal of carrier, providing a highly sensitive and visualizable strategy for the development of internal wound adhesive.

PMID 42505317
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PubMedNursing reports (Pavia, Italy)2026-07-27

Behind Closed Doors: Elder Abuse as an Overlooked Pandemic of Modern Times.

Filipska-Blejder Karolina K, Biercewicz Monika M, Jabłońska Renata R, Królikowska Agnieszka A et al.

Elder abuse is internationally recognized as a growing problem of the 21st century that requires urgent intervention and action. This review aimed to synthesize evidence on the prevalence and risk factors of elder abuse between 2010 and 2022. A total of 2875 articles were identified through database searches, of which 28 met the inclusion criteria and were included in the final analysis (24 cross-sectional studies, 3 prospective studies, and 1 descriptive study). Reported prevalence rates of elder abuse ranged from 2.2% to 81.2% overall, while studies conducted during the COVID-19 pandemic reported rates ranging from 1.6% to 44.7%. Psychological abuse was the most frequently reported form of violence. The most commonly identified risk factors included low income, low educational level, gender, disability, depression, and-during the COVID-19 pandemic-social isolation. Across most studies, individuals with lower education and women were statistically more likely to experience abuse. The findings indicate substantial variability in the prevalence of elder abuse both before and during the pandemic, with consistently high rates observed. These results highlight the urgent need for improved screening, education, and targeted interventions by healthcare and social service professionals.

PMID 42506036
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PubMedJournal of materials chemistry. B2026-07-27

Long-lasting antimicrobial surface coating.

Wang Jinquan J, Chan Shook Pui SP, Teong Siew Ping SP, Lim Diane D et al.

The increasing incidence of infectious diseases and persistent threat of pandemics have accentuated the urgent need for reliable antimicrobial technologies. This study presents a novel polymer composite coating technology offering long-term antimicrobial activity and durability. This transparent coating is clean, easy to apply, and effective on various hard surfaces. It is formulated using a sol-gel method that incorporates silane (Si(OR)4) precursors and hydroxyl-functionalized antimicrobial polymers, enabling sustained release of the active components. The antimicrobial efficacy was validated against clinically relevant microbes, and the coating demonstrated durable performance in real-world scenarios.

PMID 42506966
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PubMedFamily practice2026-07-27

Identifying clinical signs of child abuse in primary care: a systematic review.

Corsi Naïs N, Van der Windt Nolwenn N, Menage Quentin Q, Rouge Laure L et al.

Child abuse may be the cause of clinical signs that are often poorly understood, leading to an underestimation of violence. According to United Nations agencies, 1 billion children worldwide are victims of violence. The objective of this study was to identify the clinical signs of abused children during a consultation in primary care. A systematic review was conducted in the PubMed, Cochrane, PsycInfo, Embase, and CINAHL databases from 1996 to January 2024. The studies included focused on children aged 0-18 who were victims of abuse and presenting in primary care. Among the 3811 articles found in the databases, 19 were included in the review. Signs of physical trauma included fractures, bruises, burns, and genital and neurological injuries. Somatic symptoms in children may include abdominal pain, persistent nonspecific symptoms, and atopic manifestations such as eczema or asthma. The psychological symptoms identified were depression, despair, and anxiety. Abuse is also associated with behavioral disorders (externalizing or internalizing behaviors) and developmental delays (language, learning, and social interaction disorders). Few articles have investigated the clinical signs of child victims of violence presenting in primary care. These children may present with various clinical signs (physical trauma, pain, atopy, psychological disorders, behavioral disorders, developmental delays) that highlight the importance of considering abuse as the cause.

PMID 42503486
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