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folic acid + vitamin B6 + vitamin B12 + primorine (Folmor)

✓ Approved

Zylera · 小分子 · 小分子

什么是 folic acid + vitamin B6 + vitamin B12 + primorine？

folic acid + vitamin B6 + vitamin B12 + primorine 是一种小分子，由Zylera研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名Folmor
公司Zylera
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Zylera

治疗适应症

folic acid + vitamin B6 + vitamin B12 + primorine 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Metabolism and nutrition disordersHypercholesterolaemia✓ Approved

相关研究文献

PubMedJournal of medicinal food2026-09-11

Effects of Lactiplantibacillus plantarum HY7715 Supplementation on Lower Limb Muscle Strength and Power in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.

Hong Dong-Ki DK, Jeon Soomin S, Woo Seonwook S, Shin Sangyeon S et al.

Age-associated reductions in muscle strength and physical function have become an important public health concern among older adults, and gut microbiome-targeted interventions have emerged as a potential strategy to mitigate these declines. We evaluated the effects of Lactiplantibacillus plantarum HY7715 (L. plantarum HY7715) on lower-limb muscle function, serum vitamin B2, and gut microbiome profiles in older adults exhibiting reduced muscle strength. In this 12-week, randomized, double-blind, placebo-controlled trial, 100 adults aged 50-85 years were assigned to receive HY7715 (5.0 × 109 CFU/day) or placebo. Compared with placebo, HY7715 supplementation was associated with greater increases in multiple measures of quadriceps strength, with the left and bilateral mean measures remaining significant after baseline adjustment. Selected hamstring strength and quadriceps muscle power outcomes also showed significant improvements in the unadjusted analyses. Overall, the most consistent findings were observed for quadriceps strength, whereas the hamstring strength and quadriceps muscle power findings were less consistent after baseline adjustment. Serum vitamin B2 concentration increased significantly following HY7715 supplementation, and the between-group difference remained significant after adjustment for baseline dietary riboflavin intake. Microbiome analyses demonstrated increased Chao1 alpha diversity, significant within-group shifts in beta diversity, and increased relative abundances of Lactiplantibacillus and L. plantarum. HY7715 supplementation was associated with greater increases in selected quadriceps strength measures and serum vitamin B2 concentrations in adults with reduced muscle strength.

PMID 42723314
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PubMedFrontiers in surgery2026-09-11

Association of preoperative serum 25-hydroxyvitamin D levels with deep vein thrombosis after total knee arthroplasty: a hypothesis-generating analysis of coagulation function mechanisms.

Shang He H, Li Jun J, Ma Tao T, Wei Yuan Y et al.

This hypothesis-generating study aimed to explore the association of preoperative serum 25-hydroxyvitamin D [25(OH)D] levels with deep vein thrombosis (DVT) risk after total knee arthroplasty (TKA) and clarify the potential coagulation-related mechanisms. A total of 193 patients undergoing primary unilateral TKA in a single center were stratified into 25(OH)D deficiency (<20 ng/mL, n = 106), insufficiency (20-29 ng/mL, n = 47), and sufficiency (≥30 ng/mL, n = 40) groups. Postoperative DVT (detected via day 5-7 venous ultrasonography) and coagulation indices [D-dimer, prothrombin time (PT)] were compared across groups. Univariate and multivariate logistic regression were used to screen DVT-related factors, and Firth's penalized logistic regression was applied for a sparse-data sensitivity analysis. The overall postoperative DVT incidence was 13.5% (26/193). A bivariate analysis revealed a markedly higher DVT rate in the deficiency group (18.9%) than in the sufficiency group (2.5%), with a crude 2 × 2 odds ratio (OR) of 9.070 [95% confidence interval (CI): 1.198-68.542, P = 0.015]; this estimate was unstable due to only one DVT case in the sufficiency group. To provide a more stable estimate, a secondary binary logistic regression model (deficiency vs. non-deficiency) was performed, which identified preoperative 25(OH)D deficiency as significantly correlated with postoperative DVT (OR = 3.140, 95% CI: 1.200-8.212, P = 0.020). After analysis of covariance adjustment for baseline levels, the deficiency group maintained significantly higher postoperative D-dimer and shorter PT than the sufficiency group (both P < 0.001). A univariate analysis identified 25(OH)D deficiency and elevated postoperative D-dimer as DVT-related risk factors. In the secondary exploratory model adjusting for postoperative D-dimer (a potential mediator), the association between vitamin D deficiency and DVT was attenuated (OR = 2.576, 95% CI: 0.941-7.049, P = 0.065), indicating a possible mediating effect rather than confounding bias. Firth's sensitivity analysis on the binary model further verified the robustness of this finding (OR = 2.918, 95% CI: 1.142-7.456, P = 0.025). Preoperative 25(OH)D deficiency is associated with elevated postoperative DVT risk after TKA in univariate analyses. Abnormal postoperative D-dimer and PT levels suggest that vitamin D status may modulate coagulation-fibrinolysis balance. The attenuated association after D-dimer adjustment supports a potential mediating mechanism. As a hypothesis-generating analysis, these preliminary findings require further validation in large-scale prospective studies to confirm the independent predictive value of preoperative vitamin D deficiency for post-TKA DVT.

PMID 42723925
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PubMedHypertension in pregnancy2026-09-11

A preeclampsia prediction model incorporating methylenetetrahydrofolate reductase, vitamin D receptor, and uterine artery pulsatility index.

Xu Mei M, Yang Ge G, Zhong XingBo X, Jin Zhao Z et al.

This study evaluated the predictive value of methylenetetrahydrofolate reductase (MTHFR) rs1801133 and vitamin D receptor (VDR) FokI rs2228570 polymorphisms combined with uterine artery pulsatility index (PI) for preeclampsia (PE), and explored mediating pathways underlying genetic risk. A two-phase prospective study was conducted. Phase I (n = 73) screened PE-related single nucleotide polymorphisms (SNPs) via targeted sequencing; Phase II (n = 195) validated the candidates and collected clinical and ultrasound metrics. Independent predictors were identified by multivariate logistic regression to build a nomogram, and the nomogram was evaluated by receiver operating characteristic (ROC) curve, calibration, and decision curve analyses. Mediation analysis was performed to quantify the contribution of serum biomarkers. The T allele of MTHFR rs1801133 showed a marginal association with PE risk under dominant model (OR = 1.82, 95% CI: 0.96-3.44, P = 0.067), while VDR rs2228570 was not significantly associated (OR = 1.74, 95% CI: 0.89-3.39, P = 0.104). Pre-pregnancy body mass index (BMI) ≥25 kg/m² (OR = 2.75, 95% CI: 1.45-5.21, P = 0.002) and elevated uterine artery PI (OR = 4.75, 95% CI: 1.38-16.41, P = 0.014) were independent risk factors. The nomogram achieved an area under the curve (AUC) of 0.711 (95% CI: 0.640-0.783), with sensitivity of 75.53% and specificity of 59.41%. Asymmetric dimethylarginine (ADMA) and 8-iso-PGF2α mediated 77.5% and 26.0% of the effect of MTHFR on PE risk, respectively. Pre-pregnancy BMI and uterine artery PI are independent predictors of PE. The integrated model offers moderate predictive value. ADMA-mediated endothelial dysfunction may be involved in MTHFR-related PE risk.

PMID 42723529
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PubMedFrontiers in pharmacology2026-09-11

Therapeutic drug monitoring of zonisamide in children with epilepsy: development and validation of a precise binary prediction model.

Li Huiying H, Tang Xiaoling X, Li Fashuang F, Zong Jing J et al.

This study aimed to investigate the key factors influencing the failure to achieve steady-state trough concentrations of zonisamide in pediatric patients with epilepsy. Furthermore, we sought to construct and validate a binary machine learning prediction model for zonisamide concentration attainment to provide an objective reference for therapeutic drug monitoring in clinical practice. A retrospective analysis was conducted on 958 pediatric patients with epilepsy who received zonisamide treatment at the Department of Neurology, Kunming Children's Hospital, from May 2022 to January 2026. Multi-dimensional feature screening was performed on the training set using spearman correlation analysis, variance inflation factor multicollinearity diagnosis, univariate analysis, lasso regression, boruta algorithm, and 500-iteration bootstrap resampling. Subsequently, 17 machine learning classification models were developed. Hyperparameter optimization was achieved through grid search combined with 10-fold cross-validation. Model performance was comprehensively evaluated in terms of discrimination, calibration, and clinical net benefit using 500-iteration bootstrap resampling. Finally, SHAPley additive exPlanations analysis and a visualized decision tree were employed to interpret the feature contribution and intrinsic decision logic of the optimal model. Following multi-stage screening, six core predictive variables were identified: dosage, uric acid, age, total bilirubin, vitamin D, aspartate aminotransferase, and gender. A comparative analysis of the 17 machine learning models revealed that the classification and regression tree model exhibited the best comprehensive predictive performance, demonstrating superior stability and robustness under resampling validation. The area under the curve values for the internal test set and the time-split internal validation set were 0.82 and 0.87, respectively. Calibration curves and decision curve analysis confirmed ideal calibration and a wide range of clinical net benefit. SHAPley additive exPlanations analysis and decision tree results confirmed that dosage is the primary determinant of the probability of achieving target ZNS concentrations. Sex, liver and kidney function, and nutrition-related indices collectively modulate the processes of drug absorption, metabolism, and clearance, thereby influencing the risk of failing to achieve target concentrations. The machine learning prediction model constructed using the CART algorithm can accurately and stably predict whether steady-state trough concentrations of zonisamide reach the target therapeutic range in pediatric patients with epilepsy.

PMID 42724114
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PubMedAnnals of medicine and surgery (2012)2026-09-11

How cholecystectomy and gastrectomy contribute to pancreatic cancer development: a review.

Jha Rahul R, Ghimire Sabin Kumar SK, Jaiswar Mukesh M, Prasad Rishika R

Despite advances in diagnostic tools and management, the 5-year survival rate of pancreatic cancer ranges from 2% to 9%. Given the poor prognosis and low survival rates, a better understanding of modifiable risk factors is essential for the prevention of this disease. The low survival rate is attributed to the fact that only 20% of patients present at an early, surgically resectable stage. A literature review was conducted to evaluate the role of cholecystectomy and gastrectomy in the development of pancreatic cancer. PubMed, Google Scholar, Web of Science, and Embase were searched from each database's inception through the final search date, and all eligible studies were included. The concentrated bile released from the gallbladder exerts negative feedback on intestinal cholecystokinin (CCK) release. After cholecystectomy, there is a continuous flow of unconcentrated hepatic bile into the intestine, which disrupts this feedback inhibition, increasing CCK levels and causing sphincter of Oddi relaxation with subsequent bile reflux into the pancreatic duct, which may contribute to the development of pancreatic cancer. Similarly, gastrectomy may promote pancreatic carcinogenesis by increasing the formation of carcinogenic N-nitroso compounds, enhancing CCK release due to rapid gastric emptying, and impairing the absorption of vitamin D and magnesium, thereby creating a procarcinogenic environment. Cholecystectomy and gastrectomy should be performed only when clinically indicated to maximize patient benefit and minimize unnecessary risks. Careful patient selection and adherence to established clinical guidelines are essential when determining the need for either procedure.

PMID 42724911
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PubMedCureus2026-09-11

Posterior Lumbar Arthrodesis Using a Stand-Alone Hydrophilic Synthetic Bone Graft in the Setting of Postoperative Osteomyelitis/Discitis: A Case Report.

Smith Micah M

This single-patient case report describes an all-posterior salvage reconstruction of multilevel lumbar osteomyelitis using a stand-alone hydrophilic synthetic bone graft (HPSBG; OsteoFlo® HydroFiber™, SurGenTec, LLC, Boca Raton, FL) packed transpedicularly as the sole intervertebral graft material. Postoperative osteomyelitis with progressive vertebral body destruction commonly involves combined anterior-posterior reconstruction with corpectomy and structural cage placement, which is technically demanding and morbid in patients with poor bone quality and adjacent prior fractures. Hydrophilic synthetic bone grafts engineered to support fusion in compromised environments may permit less invasive salvage strategies. A 59-year-old woman with persistent L1-L2 osteomyelitis after a prior L2-L5 fusion for an L3 burst fracture, complicated by osteoporosis and low vitamin D levels (25-hydroxyvitamin D 15.6 ng/mL), underwent posterior-only salvage reconstruction. Through an all-posterior approach, transpedicular partial corpectomies of L1 and L2 were performed through the existing erosive defects. Intraoperative cultures grew Pseudomonas aeruginosa. The void was packed with HPSBG as the sole intervertebral graft material, with no anterior cage. Long-segment T10-pelvis fixation with a quad-rod construct provided posterior stabilisation. Computed tomography (CT) at eight months postoperatively demonstrated bridging bone through the L1-L2 defect, consistent with early anterior column consolidation, and repeat CT at 12 months showed bridging trabecular bone across the defect with continuity to the host endplates. Patient-reported outcomes improved at 12 months, and the patient returned to her preoperative activities. This case suggests that a stand-alone hydrophilic synthetic graft may support anterior column consolidation when used without an interbody cage in an infected, biologically hostile environment, potentially reducing the need for morbid anterior reconstruction in selected salvage cases. Larger comparative studies are warranted.

PMID 42724889
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