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folic acid + vitamin B6 + vitamin B12 + primorine (Folmor)

✓ Approved

Zylera · 小分子 · 小分子

什么是 folic acid + vitamin B6 + vitamin B12 + primorine？

folic acid + vitamin B6 + vitamin B12 + primorine 是一种小分子，由Zylera研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名Folmor
公司Zylera
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Zylera

治疗适应症

folic acid + vitamin B6 + vitamin B12 + primorine 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Metabolism and nutrition disordersHypercholesterolaemia✓ Approved

相关研究文献

PubMedNutrients2026-10-27

Maternal Dietary Intake of Folic Acid, Vitamin B12, and Choline During Pregnancy and Lactation Alters DNA Methylation in Offspring.

Abell Alek J AJ, Schuler Lillian K LK, Jadavji Nafisa M NM

Maternal nutrition during pregnancy and lactation plays an important role in the neurodevelopment of offspring. One-carbon (1C) metabolism includes B-vitamins such as folic acid (vitamin B9) and vitamin B12, and the nutrient choline. Adequate dietary intake of B-vitamins and choline by women prior to getting pregnant and during pregnancy is essential for the neurodevelopment of the infant. The aim of this narrative review is to summarize the current findings on maternal diet intake of B-vitamins and choline and how their intake impacts DNA methylation levels in offspring. From our analysis of clinical and preclinical research, the evidence indicates that maternal intake of 1C nutrients during pregnancy is associated with DNA methylation in offspring during early life; however, it remains unknown whether these changes last past early life. Additionally, the impact on health outcomes requires further investigation. The studies included in our narrative review were heterogeneous and small, and future studies are needed to draw more definitive conclusions. To conclude the review, we discuss opportunities to enhance the scientific rigor of future studies in this field. One point to consider is the inclusion of both female and male offspring in all outcome assessments to facilitate a comprehensive understanding of potential sex-specific effects and to determine how each sex may be differentially impacted by maternal B-vitamin and choline intake during pregnancy and lactation. Additionally, increasing sample size appropriately and initiating multi-center preclinical randomized controlled trials (mpRCTs) could enhance scientific rigor.

PMID 42942877
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PubMedEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)2026-10-27

Dietary intake of vitamin B12 (cobalamin) and gastric cancer risk: a pooled analysis within the StoP Project.

Collatuzzo Giulia G, Santucci Claudia C, Pelucchi Claudio C, Bonzi Rossella R et al.

The effect of vitamin B12 (cobalamin) intake on gastric cancer is unclear. We investigated this association within the Stomach Cancer Pooling Project. Data from eight case-control studies within an international consortium were harmonized. Study-specific quartiles of dietary B12 intake (μg/day) were created using food frequency questionnaires and country-specific dietary composition tables. Odds ratios (ORs) and 95% confidence intervals (CIs) for the association between B12 and gastric cancer were calculated using multivariable logistic regressions adjusted by major sociodemographic and lifestyle factors. A random-effect meta-analysis pooling study-specific associations was also conducted. Secondary analyses were further adjusted for Helicobacter pylori (Hp) and dietary factors. Analyses stratified by anatomical subsite, histological type, sex, age, smoking, alcohol, and socioeconomic status (SES) were performed. The main analysis included 2228 cases and 7096 controls. A borderline positive association was observed between vitamin B12 intake and gastric cancer (OR = 1.04, 95% CI = 0.99-1.10 per quartile of intake). Results only slightly attenuated after adjusting for Hp and dietary factors. No statistical heterogeneity was found by histology and anatomical subsite, despite a higher risk being observed for the intestinal subtype (OR = 1.10, 95% CI = 1.02-1.19 per quartile of intake). Women, the elderly, never smokers, no-to-low alcohol consumers, and individuals from high SES had an increased risk of gastric cancer with increasing B12 intake, with no significant heterogeneity. Overall, dietary vitamin B12 intake was not associated with gastric cancer risk, while a positive association was observed for intestinal-type gastric cancer and within specific population subgroups.

PMID 42937461
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PubMedBiomolecules2026-10-27

Comprehensive Assessment of Peripheral Blood Biomarkers in Primary Pterygium: A Prospective Case-Control Study.

Vasović Dolika D DD, Rašić Dejan D, Spaić Dragan D, Simonović Jelena J et al.

Pterygium is a common ocular surface disorder linked to chronic ultraviolet exposure, local inflammation, and oxidative stress, yet no reliable circulating biomarker currently guides diagnosis, activity assessment, or recurrence risk. Peripheral-blood studies addressing this gap have produced inconsistent findings across hematological, inflammatory, and micronutrient domains, often using heterogeneous case definitions and isolated marker panels. In this prospective case-control study, 30 patients with newly diagnosed, clinically active primary pterygium and 17 healthy controls frequency-matched for age and sex underwent a comprehensive peripheral blood panel comprising 46 hematological, biochemical, iron-related, inflammatory, and vitamin/metabolic-bone parameters, including osteocalcin, ceruloplasmin, and immunoglobulin E. Lesions were graded using the Maheshwari and Tan classification systems, and group and severity-stratified comparisons were corrected for multiple testing using the Benjamini-Hochberg procedure. No parameter differed significantly between groups after correction. Nominal, uncorrected differences included higher total protein, albumin, and mean platelet volume in patients with pterygium, and severity-linked patterns of higher platelet count, plateletcrit, and ceruloplasmin, and higher vitamin B12, folic acid, and serum iron in less advanced lesions. None of these nominal differences survived correction, so no single marker distinguished pterygium from controls or tracked severity. Platelet indices and ceruloplasmin showed the most consistent severity-linked pattern, but this was nominal only and hypothesis-generating, warranting evaluation in larger, adequately powered cohorts.

PMID 42939658
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PubMedDiagnostics (Basel, Switzerland)2026-10-27

Yield of Low Serum Vitamin B12 Results in General Pediatric Outpatient Practice: Age-Specific Patterns and Associations with Testing Indications and Recorded Clinical Features.

Imdadoglu Timucin T, Altuncu Emel E, Keskin Cetinkaya Elif Betul EB, Yeniay Asli Ozturk AO et al.

Background/Objectives: Serum vitamin B12 testing is frequently ordered in pediatric outpatient practice, either routinely or incidentally as part of broad laboratory panels or in response to symptoms and nutritional concerns; however, how the yield of low serum vitamin B12 results varies across age groups and testing indications remains poorly defined. The primary focus was age-related variation in low serum vitamin B12 results, with recorded testing indications examined as a secondary question and symptom-specific analyses considered exploratory. Methods: This single-center retrospective study analyzed testing episodes from children aged 0-18 years attending general pediatric outpatient clinics in 2025. Outcomes were <200 pg/mL (primary) and <300 pg/mL (secondary). Two blinded physicians classified testing indications. Cluster-robust regression evaluated age, sex, and indication; 18 symptom indicators were evaluated in age- and sex-adjusted models with Benjamini-Hochberg correction. Results: Of 34,744 episodes, 34,721 were valid; 5.8% were <200 pg/mL and 27.5% were <300 pg/mL. Low-result yield (<200 pg/mL) showed a bimodal age pattern: 7.9% at ages 0-2 years, 2.3% at 3-5 years, and 10.6% at 15-18 years. The number of tests per low result ranged from 9.4 at ages 15-18 years to 42.8 at ages 3-5 years. Routine or incidental testing comprised 63.9% of episodes; crude yield by indication ranged from 4.9% to 7.3%. Compared with 6-11 years, adjusted odds were higher at 0-2 years (aOR 2.81, 95% CI 2.44-3.24) and 15-18 years (aOR 3.92, 95% CI 3.42-4.51). No indication independently predicted the primary outcome; no symptom remained significant for that outcome after false discovery rate correction. Conclusions: The yield of low serum vitamin B12 results was strongly age-dependent and bimodal, with higher-yield periods during the first two years of life and adolescence. Broad retrospectively recorded testing indications were not independently associated with results < 200 pg/mL after adjustment for age and sex. These findings support age-informed assessment alongside clinician-directed testing.

PMID 42938171
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PubMedAntioxidants (Basel, Switzerland)2026-10-27

Potential Role of Vitamin C in the Associations of Serum Per- and Polyfluoroalkyl Substances with Bilirubin and Albumin in U.S. Adolescents and Young Adults: NHANES 2011-2018.

Li Chan C, Zhu Kexin K, Niu Zhongzheng Z, Ochs-Balcom Heather H et al.

Research on per- and polyfluoroalkyl substances (PFAS) and biomarkers potentially related to oxidative stress in adolescents is limited. We investigated associations between serum PFAS and total bilirubin and albumin among 1474 participants aged 12-20 years using National Health and Nutrition Examination Survey 2011-2018 data. Six primary PFAS and two secondary measures, summed branched perfluorooctanesulfonic acid (Sm-PFOS) and total PFOS, were assessed. Survey-weighted linear regression with multiple imputation for missing covariates was used to assess associations and potential vitamin C effect modification. Bayesian kernel machine regression was used to evaluate PFAS mixture associations. After adjustment for multiple comparisons, perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), and perfluorodecanoic acid (PFDeA) were positively associated with bilirubin, and seven PFAS measures were positively associated with albumin. Albumin associations for PFOA, perfluorononanoic acid (PFNA), and PFDeA were stronger among vitamin C-deficient participants (<11.4 µmol/L), with significant interactions. For example, the PFOA-albumin association was stronger among vitamin C-deficient than non-deficient participants (β = 2.276 vs. 0.544; interaction q = 0.013). Mixture associations were positive for both biomarkers and consistent with the primary analysis. These findings suggest PFAS are associated with bilirubin and albumin; vitamin C findings are exploratory and limited by the small deficient group.

PMID 42939884
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PubMedAnimals : an open access journal from MDPI2026-10-27

Effects of Dietary 5-Aminolevulinic Acid Supplementation on Laying Performance, Immune Function, Intestinal Microbiota, and Serum Metabolomics in Laying Hens.

Yao Xianci X, Pan Chenkai C, Zheng Kaitian K, Shi Yonghao Y et al.

5-Aminolevulinic acid (5-ALA), a naturally occurring non-proteinogenic amino acid and a key precursor in heme biosynthesis, has attracted increasing attention as a potential functional feed additive in animal production. This study investigated the effects of dietary 5-ALA supplementation on 960 Fengda No. 1 laying hens (42 weeks of age) randomly assigned to four dietary treatments with 16 replicates per treatment (15 birds per replicate) and fed diets supplemented with 0, 250, 500, or 1000 mg/kg 5-ALA for 60 days. Results show that 500 mg/kg 5-ALA improved laying performance and enhanced liver antioxidant capacity (T-AOC, SOD, GSH-Px). It also enhanced serum immunoglobulin concentrations and reduced the concentrations of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6. Furthermore, 5-ALA supplementation was associated with changes in the abundances of specific cecal bacterial taxa. Metabolomic analysis revealed that vitamin B6 metabolism showed the highest differential abundance score, with increased 4-pyridoxic acid and 4-pyridoxolactone following 5-ALA supplementation. Collectively, these findings suggest that dietary 5-ALA, particularly at 500 mg/kg, has the potential to improve laying performance and physiological homeostasis, potentially through the modulation of antioxidant and immune functions, gut microbial composition, and metabolic pathways.

PMID 42939104
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