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doxycycline (Perio Product / Atridox / doxycycline, Atrix)

✓ Approved

Pharmascience, Inc. · 小分子 · 小分子

什么是 doxycycline？

doxycycline 是一种小分子，由Pharmascience, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)、Topical。

药物档案

商品名Perio Product, Atridox, doxycycline, Atrix
公司Pharmascience, Inc.
药物类别小分子
给药途径Oral (PO), Topical
状态Approved
来源： ClinicalTrials.gov, Pharmascience, Inc.

治疗适应症

doxycycline 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsPeriodontitis✓ Approved

相关研究文献

PubMedAntibiotics (Basel, Switzerland)2026-10-27

Therapeutic Outcomes of Oral Antibiotics for the Treatment of Methicillin-Resistant Staphylococcus aureus Urinary Tract Infections: A Multisite, Retrospective Cohort Study of Linezolid, Trimethoprim-Sulfamethoxazole and Doxycycline.

McCall Ryan R, Gatskevich Elena E, Fiester Steven E SE, Floren Michael M et al.

Methicillin-resistant Staphylococcus aureus (MRSA) urinary tract infections (UTIs), while relatively uncommon, pose a unique challenge in treatment as only specific intravenous (IV) options are typically utilized, with the efficacy of oral antimicrobials being poorly defined. The multi-site retrospective cohort study described herein therefore aims to characterize outcomes associated with oral administration of linezolid, trimethoprim-sulfamethoxazole (TMP-SMX), or doxycycline for the treatment of MRSA UTIs. Study participants were adults with culture-positive MRSA UTIs receiving one of the three oral therapies. Exclusion criteria included polymicrobial UTI, concomitant MRSA outside the urinary tract, receipt of non-study anti-MRSA agents for greater than or equal to 50% of treatment, less than 48 h of the oral study drug, and/or prostatitis. The primary outcome was clinical cure defined as a composite of symptom resolution, no readmission within 30 days of discharge attributable to UTI, and no change in therapy due to treatment failure. Secondary outcomes included antibiotic discontinuation because of adverse effects (AEs). Overall, patients attained a clinical cure rate from MRSA UTI of 78.8%, 80.0%, and 94.4% when treated with linezolid, TMP-SMX, or doxycycline, respectively. While there were no observed differences between the clinical cure rates of the three antimicrobials studied, the high clinical cure rate coupled with low rates of AEs may support these oral therapies for the treatment of MRSA UTIs, but further investigation is required.

PMID 42938697
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PubMedAIDS (London, England)2026-10-27

Impact of doxycycline postexposure prophylaxis on sexually transmitted infections within a statewide community healthcare system.

Burch Sarah S, Alqahtani Zuhair Z, Brown Bethanne B

This study evaluated the impact of doxycycline postexposure prophylaxis (DoxyPEP) prescribing on sexually transmitted infection (STI) incidence proportion in an underserved population receiving care from a statewide community healthcare system. Retrospective cohort study was conducted using pharmacy and electronic health records data between 4 May 2021 and 1 April 2025. Primary outcome was the overall STI incidence proportion during 12 months prior to and following DoxyPEP initiation. Secondary outcomes included categorizing bacteria and site-specific STIs and exploring the association between DoxyPEP, preexposure prophylaxis (PrEP), and STI incidence proportion. Pharmacy dispensing reports and patient demographic information were combined with EHR laboratory-confirmed STI results for review and analysis. Patient data were included if the DoxyPEP prescription was written by an Equitas Health provider and dispensed by the in-house pharmacy, and at least one documented STI test during the 12 months before and after the DoxyPEP initiation. Data were excluded if the prescription originated from an outside provider or was sold after 1 April 2025. Overall STI incidence proportion decreased from 30.5% preintervention to 17.6% postintervention (P < 0.001) for the 1,111 included patients. Reductions were observed in chlamydia (17.3-3.1%, P < 0.001) and syphilis (3.5-0.6%, P < 0.001), while gonorrhea incidence decreased slightly (16.9-15.2%, P = 0.24). Rectal and urine chlamydia infections experienced the largest decline, and no association was found with PrEP use. DoxyPEP use was associated with a significant reduction in overall STI incidence proportion in a high-risk population, supporting this prevention strategy.

PMID 42937323
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PubMedInfection and immunity2026-10-27

The Aspergillus fumigatus septation components Bud4 and Rho4 are essential for virulence.

Guruceaga Xabier X, Thorn Harrison I HI, Perez-Cuesta Uxue U, Martin-Vicente Adela A et al.

Aspergillus fumigatus is the primary etiologic agent of pulmonary mold infections, the most severe of which is invasive pulmonary aspergillosis (IPA). As the currently approved antifungal drugs are threatened by growing resistance rates and host toxicity, novel therapeutic options are urgently needed. Our recent work suggests that septation inhibition may be one such strategy, as aseptate strains of A. fumigatus are hypersusceptible to the echinocandin antifungal drugs and display significantly reduced virulence in animal models of IPA. In the current study, we expand upon our understanding of the anillin-like protein, Bud4, and Rho GTPase, Rho4, which regulate septation in Aspergillus nidulans and A. fumigatus, respectively. Whereas AnBud4 is not essential for septation in A. nidulans, deletion of the A. fumigatus ortholog (∆bud4) resulted in complete loss of septation. A similar phenotype was also observed in ∆rho4, consistent with previous studies. Supporting a critical role for hyphal septation in the establishment of invasive aspergillosis, we find that ∆bud4 and ∆rho4 display avirulence in a mouse model of IPA characterized by a loss of tissue-invasive growth. Furthermore, both deletion mutations were able to convert anti-Aspergillus echinocandin activity from static to cidal. Through titratable bud4 expression using a doxycycline-repressible promoter system, we also find that even partial repression of septation significantly increases echinocandin susceptibility. Taken together, these studies support a therapeutic strategy which could incorporate a septation inhibitor in combination with echinocandins to reduce tissue-invasive growth and improve antifungal susceptibility.

PMID 42937459
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PubMedMedicina (Kaunas, Lithuania)2026-10-27

The Role of Hysteroscopy in Reproductive Medicine and Subfertility: A Critical Narrative Review.

Tsonis Orestis O, Paschopoulos Ioannis I, Paschopoulou Kasmiria Ioanna KI, Deligeoroglou Evangelia E et al.

Background and Objectives: Hysteroscopy permits direct assessment and treatment of the uterine cavity, but diagnostic yield does not necessarily translate into improved fertility. This narrative review examines its role in subfertility and reproductive medicine. Materials and Methods: The original literature search covered PubMed/MEDLINE, Scopus and the Cochrane Library through February 2026. Targeted checks during revision added the 2026 chronic endometritis consensus and the full CERM trial report; these updates do not represent a new comprehensive search. Evidence was interpreted by study design, population, outcome and precision, without formal risk-of-bias assessment or meta-analysis. Results: Large randomised trials do not support routine hysteroscopy before first IVF or after repeated IVF failure when ultrasonography is normal. Polypectomy has evidence of improved pregnancy rates in women planning IUI, although spontaneous pregnancies contributed to that result and live-birth benefit remains uncertain. Hysteroscopic myomectomy may improve clinical pregnancy in women with cavity-distorting fibroids; evidence for live birth is less secure. Adhesiolysis restores cavity anatomy, but reproductive estimates largely derive from observational series. The small TRUST trial did not demonstrate a live-birth advantage from septum resection and cannot establish equivalence. Hysteroscopy may guide biopsy for chronic endometritis but does not replace histological assessment. CERM found no improvement with doxycycline in its composite of cumulative live births and ongoing pregnancies at ≥24 weeks among women with recurrent miscarriage and CD138-defined endometritis. Fertility-sparing endometrial cancer treatment requires oncological selection, progestin therapy and histological surveillance. Conclusions: Hysteroscopy should address a defined diagnostic or therapeutic question. Decisions should distinguish spontaneous conception, IUI and IVF/ICSI and acknowledge uncertainty in live-birth outcomes.

PMID 42942536
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PubMedPharmaceuticals (Basel, Switzerland)2026-10-27

Comparative Pharmacological Effects of Tetracycline Derivatives on Osteoclast- and Osteoblast-Related Phenotypes and Skeletal Accumulation.

Shimochi Saeka S, Hrovat Katja K, Sarwar Uruj U, Bergara-Muguruza Leire L et al.

Background/Objectives: Tetracycline (TC) derivatives possess biological activities beyond their antimicrobial effects and exhibit affinity for mineralized tissues. However, direct comparisons of clinically established TC derivatives across bone-related experimental systems remain limited. This study comparatively evaluated TC, oxytetracycline (OC), doxycycline (DC), and minocycline (MC) to characterize their compound- and concentration-dependent effects on bone-related cellular phenotypes and skeletal accumulation. Methods: TC, OC, DC, and MC were evaluated using primary human osteoclasts, primary human mesenchymal stem cell (MSC)-derived osteoblasts, MG-63 osteoblast-like cells, and zebrafish embryos. Osteoclast formation and resorption, ALP-positive area, cellular metabolic activity, extracellular matrix mineralization, and compound localization were assessed. Results: All four derivatives were associated with concentration-dependent reductions in osteoclast formation, multinucleation, and resorptive activity, with DC showing pronounced effects. At 10 μg/mL, TC, OC, and MC reduced resorption pit volume to approximately 10-20% of untreated control values, while DC markedly reduced resorption even at 5 μg/mL. In primary MSC-derived osteoblasts, treatment with all four derivatives was associated with concentration-dependent reductions in ALP-positive area. In MG-63 cells, none reduced WST-8 metabolic activity at concentrations up to 20 μg/mL, whereas extracellular matrix mineralization showed compound- and concentration-dependent responses. All four derivatives preferentially localized to mineralized matrices in vitro and accumulated in developing skeletal structures in zebrafish, where increasing concentrations were associated with reduced mineralization intensity. Conclusions: Clinically established TC derivatives exhibit distinct compound- and concentration-dependent pharmacological profiles across bone-related experimental models and preferential affinity for mineralized tissues. These findings provide a comparative framework for future mechanistic studies of the bone-related biological effects and skeletal accumulation of TC derivatives.

PMID 42943307
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PubMedHealth science reports2026-10-27

Bacterial Agents and Their Multidrug-Resistance Profile Among Patients Suspected of Bacterial Infections in Hakim Gizaw Hospital, Debre Berhan, Ethiopia: A Cross-Sectional Study.

Zelelie Tizazu Zenebe TZ, Endewunetu Ermias E, Temesgen Yosef Y, Gebreyes Demissew Shenkute DS et al.

Antimicrobial resistance is a global threat. Bacteria showed higher resistance in Ethiopia, and up-to-date data on it is urgently required for effective interventions. This study aimed to determine occurrence of multi-drug-resistant (MDR) bacterial isolates among patients presented to Hakim Gizaw Hospital (HGH). A health-facility based cross sectional study was conducted in HGH, Debre Berhan, Ethiopia. All patients presented to HGH and diagnosed bacterial infections were eligible for the study. Depending on the clinical presentation of the patient, different clinical samples were investigated in microbiology laboratory following standard operating procedures. The analysis was carried out using SPSS version 27. A total of 252 study participants were included in the analysis. The gender distribution was nearly equal, with 128 (50.8%, 128/252) females. Among all participants, 103 (40.9%, 103/252) were culture positive, irrespective of whether one or two bacterial isolates (polymicrobial) were identified. The prevalence of Gram-positive and Gram-negative bacteria was 26% (65/252) and 20% (50/252), respectively. Among all bacteria, S. aureus (40%, 46/115) was the predominant followed by E. coli (11.3%, 13/115). E. coli showed higher resistant to Ciprofloxacin (CIP), Doxycycline (DOX), Trimethoprim-sulfamethozole (SXT), Cefoxitin (FOX), and Ceftaroline (CTR) (all ≥ 61.5%). K. pneumonia showed resistant from 27.3%-90.9%, with low resistant against GM and high resistant against Ampicillin (AM, 90.9%) and Amoxicilin-clavulanate (AMC, 90.9%). S. aureus showed higher resistant against CIP (58.7%), SXT (60.9%), and Erythromycin (E, 67.4%). MDR rate was 66.1% (72/109). Among Gram-negative bacteria, the prevalence of ESBLs and carbapenemase production was 66% (33/50) and 44% (22/50), respectively. Only age greater than 18 years old was significantly associated with MDR positive. Many bacterial infections were linked with high MDR bacterial isolates. However, few patient characteristics were shown statistical significance association. Thus, diagnosis and treatment of patients must be evidence based.

PMID 42936457
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