若生智能
Drug Database
DO

doxycycline (Perio Product / Atridox / doxycycline, Atrix)

✓ Approved

Pharmascience, Inc. · 小分子 · 小分子

什么是 doxycycline？

doxycycline 是一种小分子，由Pharmascience, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)、Topical。

药物档案

商品名Perio Product, Atridox, doxycycline, Atrix
公司Pharmascience, Inc.
药物类别小分子
给药途径Oral (PO), Topical
状态Approved
来源： ClinicalTrials.gov, Pharmascience, Inc.

治疗适应症

doxycycline 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsPeriodontitis✓ Approved

相关研究文献

PubMedJournal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG2026-07-27

Effect and length of doxycycline administration in elderly patients with bullous pemphigoid.

Merkel-Ropele Alena A, Salmhofer Wolfgang W, Wolf Peter P

Bullous pemphigoid (BP) is the most common autoimmune blistering disease and primarily affects the elderly. Systemic corticosteroids and immunosuppressive drugs are the standard treatment, but side effects often restrict their use. Doxycycline has been proposed as an alternative, but there is limited long-term, real-world data on its efficacy and tolerability. We aimed to evaluate the effectiveness and length of doxycycline treatment in BP patients. This retrospective, single-center study analyzed data from patients with a confirmed BP diagnosis treated with doxycycline. The comprehensive dataset included information on disease severity, concomitant therapies, and treatment response. Treatment duration was analyzed using the Kaplan-Meier method. The cohort comprised 102 patients with a mean age of 79 (range 51-95) years. A clinical response (an improvement of 1 or 2 on the PGA score, which ranges from 2 to -2) was observed in 85 patients (83.3 %), many of whom received combination therapy with other drugs (67.7 %). The median length of doxycycline treatment was 122.7 weeks. Adverse events, mainly of gastrointestinal origin, were rare, non-serious and manageable. Doxycycline proved to be an effective and well-tolerated long-term treatment for elderly patients with BP, when used either as monotherapy or in combination.

PMID 42504029
阅读全文 →
PubMedMarine drugs2026-07-27

A Structure-Activity Relationship Study of Trypargine and Opacaline β-Carbolines.

Chen Dan D, Rouvier Florent F, Brunel Jean Michel JM, Copp Brent R BR et al.

The marine environment represents a rich source of novel antimicrobial compounds. This study investigated the isolation and synthesis of antimicrobial agents from the New Zealand ascidian Pseudodistoma opacum to identify natural products and derivatives with potential pharmacological applications. Screening of a marine natural product library and related synthetic analogues revealed several compounds exhibiting antibiotic-potentiating activity in combination with doxycycline against Pseudomonas aeruginosa. To further explore these findings, the most active natural product, opacaline A (1), was synthesized, and a structure-activity relationship (SAR) study was conducted to identify key structural features required for activity. This work reports the first total synthesis of opacaline A (1) and racemic 7-bromohomotrypargine (3). Biological evaluation demonstrated that the presence of a bromine substituent and a free amine or guanidine group is essential for both intrinsic antimicrobial activity and antibiotic potentiation. Additionally, both oxidation states of the β-carboline ring (aromatic and tetrahydro-) were found to retain activity. These findings provide insight into the structural requirements for activity and support further development of these compounds as antimicrobial adjuvants.

PMID 42505988
阅读全文 →
PubMedTropical medicine and infectious disease2026-07-27

A Rare Cause of Folliculitis by Dermatophilus congolensis in a Tropical Martial Arts Fighter.

Martínez-Carrión Guillermo G, Fernández-Ciriza Leire L, Razquin Iosu I, Río-Poza María Ángeles Del MÁD et al.

Dermatophilus congolensis, a Gram-positive actinomycete, is a well-known animal pathogen but a rare cause of human skin infections. Human dermatophilosis is an infection associated with tropical environments and animal contact that remains frequently underdiagnosed. We report a case of recurrent folliculitis in a 34-year-old male Muay Thai fighter returning from Thailand to Spain. The patient presented with pustular lesions on his lower limbs following frequent leg shaving and close physical contact during training. Microbiological culture from skin swabs yielded beta-hemolytic colonies, identified as D. congolensis by MALDI-TOF MS. Identification was confirmed through Whole-Genome Sequencing (WGS), which also revealed an absence of antimicrobial resistance genes. Despite the lack of established EUCAST breakpoints, the isolate showed low MICs for most tested antibiotics. The patient was treated with doxycycline, although clinical follow-up was not possible due to travel. This case highlights D. congolensis as an emerging differential diagnosis for persistent folliculitis in travelers and athletes. Our findings suggest a potential horizontal transmission route through contact sports and fomites (e.g., mats) in high-humidity settings.

PMID 42506766
阅读全文 →
PubMedAnalytical methods : advancing methods and applications2026-07-27

Smartphone-based fluorescence sensing platform for tetracycline determination based on a high quantum yield europium metal-organic framework with a dual-ligand strategy.

Cheng Shuang S, Song Jintian J, Wen Yue Y, Xu Yijia Y et al.

Ultrasensitive and visual detection of tetracyclines (TCs) is of great significance to public health and environmental safety. Herein, we synthesized a dual-ligand europium metal-organic framework (Eu-phen-MOF) via a one-step solvothermal method for the fluorescence detection of TCs. Compared with the Eu-MOF without 1,10-phenanthroline, Eu-phen-MOF exhibits superior stability, lower LOD and higher quantum yield. It delivers superior TC sensing performance and anti-interference, enabling high-accuracy detection with limits of 152.0 nmol L-1, 249.4 nmol L-1, 171.0 nmol L-1 and 277.7 nmol L-1 for tetracycline (TC), oxytetracycline (OTC), doxycycline hydrochloride (DOX), and chlortetracycline (CTC), respectively. Eu-phen-MOF was used for the quantitative detection of TC, OTC, DOX, and CTC in real samples (milk, eggs, and river water) and recoveries ranging from 94.64% to 105.37% were achieved. Finally, a portable fluorescence sensing platform integrating a smartphone and the Eu-phen-MOF fluorescent hydrogel was constructed, enabling convenient, rapid, and low-cost detection of TCs. This work not only highlights the significance of the dual-ligand strategy for fabricating an efficient TC sensor, but also develops a rapid and visual method for TC detection.

PMID 42504902
阅读全文 →
PubMedFood science & nutrition2026-07-27

Global Distribution and Comparative Resistance Profiles of Escherichia coli Isolated From Bovine Meat and Meat Products: Evidence From Network Meta-Analysis.

Khorram Del Yaser Y, Mahmoudi Peyman P, Rashidi Amir A, Idrees Hama Faraj Skala S et al.

Escherichia coli is a pivotal indicator organism for monitoring antimicrobial resistance (AMR) in the food chain. This study investigates global resistance profiles in E. coli isolates recovered from bovine meat and its derivatives employing a network meta-analysis (NMA). A Bayesian NMA was created by collating 100 studies from 41 countries that included 221,420 E. coli isolates. Resistance to 39 different antimicrobials was analyzed using the Surface Under the Cumulative Ranking Curve (SUCRA) and odds ratios (OR). Node-splitting was used to assess inconsistency between studies, and future trends were estimated using the Prophet time series forecasting method. The results of the NMA indicate that carbapenems and fourth-generation cephalosporins had the largest SUCRA values of 0.0008 and 0.1170, respectively, showing the least amount of resistance to imipenem and meropenem. Conversely, highest resistance levels were documented for penicillins (SUCRA = 0.974) and diaminopyrimidines (SUCRA = 0.908) classes, with penicillin (0.999), doxycycline (0.951), and amoxicillin (0.942). Pathogenic strains had a significantly higher proportion of resistance (32.35%) compared with commensal strains (24.09%). In addition, developing countries had nearly twice the percentage of resistance (31.73%) as did developed countries (17.03%). Estimates for resistance at the global level indicate that resistance will increase from 32% to 63.44% by 2040. The ability of widely used antimicrobials to maintain their effectiveness compared with a large number of common agricultural antimicrobials that have very high failure rates illustrates the importance of selective pressure and regulatory oversight. Strengthening of international stewardship and surveillance to prevent further spread of resistant foodborne pathogens is critical.

PMID 42504196
阅读全文 →
PubMedGels (Basel, Switzerland)2026-07-27

Structure-Property Relationships Governing Encapsulation and Release of Antibiotics from Calcium-Alginate Hydrogels.

Hebip İbrahim İ, Toprakçı İrem İ, Bozkurt Rabia Nur RN, Kurtulbaş Ebru E et al.

Understanding mass transport of structurally different drugs within ionically crosslinked hydrogel networks remains an important challenge in polymer-based delivery systems. In this study, hydrophilic amoxicillin (AMOX) and amphiphilic doxycycline (DOX) were encapsulated into calcium-alginate beads, respectively. A three-factor and three-level Box-Behnken design was utilized to examine the influences of alginate concentration (2-5%, w/v), CaCl2 concentration (1-3%, w/v), and gelation time (15-45 min) on encapsulation efficiency (EE). EE exhibited considerable variability for both AMOX (10-86%) and DOX (10-63%). Optimal EE values were achieved at almost 3.5% alginate and 3% CaCl2. The optimized gelation times differed between AMOX (45 min) and DOX (15 min), which is likely associated with differences in their physicochemical properties, although additional intermediate gelation times could further refine the optimal conditions. ANOVA identified CaCl2 concentration and the quadratic effect of alginate as the most influential parameters. Furthermore, both models demonstrated robust predictive capability (R2 > 0.98). In vitro release experiments demonstrated minimal drug diffusion in simulated gastric fluid (SGF) and significantly accelerated release in simulated intestinal fluid (SIF). These findings indicate a pH-responsive release behavior under simulated gastrointestinal conditions. The release profile was best represented by Higuchi and Korsmeyer-Peppas kinetic models. SEM and optical microscopy revealed uniform spherical beads with drug-dependent microstructural differences: hydrophilic AMOX produced smoother, wrinkled surfaces, whereas amphiphilic DOX induced localized cracking and heterogeneous microdomains. Furthermore, DLS and zeta potential measurements of the released fractions indicated nanoscale particle populations (≈190-225 nm) with moderate negative surface charge (≈-21 mV), suggesting stable colloidal dispersion during intestinal-phase release.

PMID 42505318
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多doxycycline