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zinc acetate dihydrate (Wilzin / Wilzin)

✓ Approved

Recordati S.p.A. · 小分子 · 小分子

什么是 zinc acetate dihydrate？

zinc acetate dihydrate 是一种小分子，由Recordati S.p.A.研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名Wilzin, Wilzin
公司Recordati S.p.A.
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Recordati S.p.A.

治疗适应症

zinc acetate dihydrate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Congenital, familial and genetic disordersHepato-lenticular degeneration✓ Approved

相关研究文献

PubMedBMC veterinary research2026-09-11

Integrated endocrine-oxidative-metabolic and trace element responses to heat and cold stress in dromedary camels (Camelus dromedarius).

Zaki Mariam Gamal MG, Ramadan Eman Shawky ES, Oraby Mohamed Ibrahim MI, Ryad Noha Mahmoud NM

The dromedary camel (Camelus dromedarius) possesses remarkable physiological adaptations to withstand harsh desert conditions, including heat stress and drought. This study aimed to evaluate the effects of heat and cold stress on oxidative stress biomarkers, hormones, lipid, and mineral concentrations in dromedary camels. A total of 45 apparently healthy adult male dromedary camels were included in the study. Blood samples were collected, plasma and serum were separated for the determination of oxidative stress biomarkers, hormones, metabolic, and trace mineral parameters. During heat stress, cortisol, zinc, and copper concentrations increased significantly (p < 0.05), whereas total antioxidant capacity (TAC), triiodothyronine (T3), glucose, and triglyceride concentrations decreased significantly (p < 0.05). In contrast, cold stress was associated with significant (p < 0.05) increases in catalase (CAT), malondialdehyde (MDA), T3, glucose, and cortisol concentrations, while TAC, triglycerides, and copper concentrations decreased significantly (p < 0.05). Strong positive (p < 0.01) correlation between T3 and thyroxine (T4), whereas a strong negative (p < 0.01) correlation was observed between zinc and cholesterol. Positive (p < 0.05) correlations were also detected between glucose and MDA, cortisol and CAT, and copper and TAC. Conversely, negative (p < 0.05) correlations were found between triglycerides and CAT, triglycerides and T4, triglycerides and cortisol, zinc and triglycerides, cholesterol and glucose, and copper and MDA. During summer, positive correlations were observed between glucose and MDA, T3 and T4, as well as between cholesterol and both T3 and T4. In contrast, glucose showed negative correlations with both T3 and T4, while zinc was negatively correlated with copper. During autumn, positive correlations were detected between CAT and TAC, T3 and T4, and glucose and zinc. Conversely, negative correlations were observed between triglycerides and TAC, cortisol and T4, glucose and cholesterol, and zinc and cholesterol. During winter, T3 was positively correlated with zinc but negatively correlated with TAC. Cold stress exerted a more pronounced effect on oxidative balance and metabolic activity in dromedary camels than heat stress. Regular monitoring of these parameters is recommended for the early detection of physiological disturbances during the cold season.

PMID 42723058
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-09-11

Synergistic Regulation of Deep-Cycling-Induced Zn Pulverization and Resting Galvanic Corrosion in Practical Lean Zinc Anodes.

Xu Jing J, Li Haolin H, Jing Qiyin Q, Zhao Lingfei L et al.

Scaling up aqueous zinc (Zn)-ion batteries with long cycling stability and calendar life (i.e., long rest periods at open-circuit potential) remains challenging, particularly with the use of a thick Zn foil anode. A more practical and scalable approach involves adopting a lean-Zn configuration with a current collector. Due to the limited Zn availability, lean Zn anodes experience different failure mechanisms, manifested as Zn pulverization in cycle life and galvanic corrosion during calendar life. Unfortunately, these issues have long been overlooked. Herein, we introduce benzotriazole (BTA), a well-known corrosion inhibitor, as an electrolyte additive in aqueous zinc sulfate (ZnSO4) electrolytes. BTA modifies the electric double layer (EDL) structure on the Zn anode, alleviating the mismatch between Zn2 + mass transport and reduction kinetics. This leads to the formation of dense, flat zinc deposits rather than the Zn pulverized structures, significantly reducing contact loss during stripping. On the other hand, the strong chemisorption of BTA on the Cu substrate effectively blocks electron transfer pathways responsible for galvanic corrosion, reducing capacity fade during calendar aging. When paired with a MnO2 cathode, the lean-Zn anode enables the full cell to retain 90.3% of its capacity over 600 cycles at a negative: positive (N:P) ratio of 3:1.

PMID 42723211
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-09-11

Fe-Regulated Coupled 2e-/4e- ORR Pathway in a Conductive Co-Fe HITP Framework for Rechargeable Zinc-Air Batteries.

Xu Qiucheng Q, Fang Xiaoyu X, Ou Wenhan W, Cheng Tianyi T et al.

Zinc-air batteries based on non-precious-metal catalysts are promising for sustainable energy conversion, yet their performance is hindered by sluggish oxygen reduction reaction (ORR) kinetics and limited understanding of pathway regulation in metal-organic framework (MOF)-based catalysts. Herein, we report a bimetallic electron-conductive Co-Fe framework based on 2,3,6,7,10,11-hexaiminotriphenylene (HITP), in which Fe incorporation shifts the ORR toward a greater four-electron contribution. Structural, electrochemical, and density functional theory (DFT) analyses reveal complementary dual-site roles: Co sites favor peroxide formation via the 2e- pathway, whereas Fe sites promote O─O bond activation and subsequent reduction of peroxide intermediates. Peroxide intermediates generated on Co sites can be further converted to OH- at Fe sites. As a result, the Co2.2Fe0.8(HITP)2 catalyst exhibits enhanced ORR activity and enables a rechargeable zinc-air battery with an open-circuit voltage of 1.37 V, a peak power density of 154.2 mW cm-2, and a high specific capacity of 843 mAh gZn -1 along with enhanced cycling stability. This work establishes electron-conductive MOFs as a well-defined platform for probing ORR mechanisms and highlights dual-metal site engineering as an effective strategy for modulating ORR pathways and improving electrocatalytic performance.

PMID 42723395
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-09-11

Facilitated Zn2+ Transport and Preferential Zn (100) Deposition Enabled by Amorphous ZrOx-C Hybrid Thin Film for High-Performance Aqueous Zinc-Ion Batteries.

Kim Dongbeom D, Lee Yubeen Y, Ryu Sangmin S, Moon Huisim H et al.

Although aqueous zinc-ion batteries (AZIBs) are emerging as promising candidates for large-scale energy storage due to their intrinsic safety and cost-effectiveness, the practical deployment of metallic zinc (Zn) anodes is still plagued by uncontrolled dendrite growth, corrosion, and competing hydrogen evolution reaction (HER) at the Zn/electrolyte interface. Surface/interface engineering with organic-inorganic hybrid layers has recently proven effective in homogenizing Zn2+ flux and suppressing parasitic reactions. In parallel, ultrathin inorganic oxide coatings such as ZrO2 have been shown to enable dendrite-free cycling in aqueous media.​ In this study, an amorphous zirconium oxide-carbon (a-ZrOx-C) hybrid thin film is engineered on the Zn anode surface via ultraviolet-ozone treatment, yielding an interphase with a dense ZrOx outer layer and an underlying Zr-O-C network. Such a gradient organic-inorganic architecture is designed to facilitate selective Zn2+ ion transport while simultaneously blocking direct contact between Zn and the electrolyte, thereby mitigating corrosion, HER, and tip-enhanced dendritic growth. The optimized a-ZrOx-C coating layer (30 nm in thickness) on the Zn anode delivers a prolonged cell lifespan of over 1200 h at 1 mA cm-2, and the corresponding Zn||NH4V4O10 full cell maintains a high discharge capacity of 222 mAh g-1 after 300 cycles under 0.3 A g-1.

PMID 42723408
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-09-11

Tri-Functional Electrocatalysis for Zinc-Air Battery Coupled Water Splitting: A Catalyst-Electrode-Device-System Perspective.

Di Xixi X, Duan Chao C, Li Shuzhen S, Che Yiyang Y et al.

Tri‑functional electrocatalysis is crucial for coupling rechargeable zinc‑air batteries with water splitting (WS), enabling self‑powered hydrogen production and versatile energy conversion. Although numerous catalysts demonstrate excellent half-cell activities toward the hydrogen evolution reaction, oxygen evolution reaction, and oxygen reduction reaction, their practical application in battery-driven water electrolysis remains challenging. The major bottleneck is multiscale mismatch, which involves conflicting adsorption energetics at atomic sites, unstable gas‑liquid‑solid interfaces at electrodes, device degradation under alternating charge‑discharge and electrolysis modes, and voltage‑power imbalances at the system level. This review goes beyond conventional material summaries by constructing a catalyst-electrode-device-system framework to systematically examine how electronic modulation, defect engineering, heterostructure design, single-atom site tuning, and self-supported electrode construction influence intrinsic activity, mass transport, interfacial durability, and overall cell performance. Importantly, the actual operating point of the coupled system is determined by the intersection of the battery discharge curve and the electrolyzer polarization curve, rather than by isolated half‑cell metrics alone. Finally, we highlight future opportunities including operando characterization techniques, AI‑driven catalyst screening, standardized device evaluation protocols, and system-level co‑design for practical renewable energy devices.

PMID 42723203
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PubMedExperimental & molecular medicine2026-09-11

Pharmacological modulation of GPR84 revealed by dual states structures and immune functional assays.

Choi Myung Kyung MK, Park Dong Jin DJ, Kim Pankyung P, Choi Hee Seong HS et al.

G-protein-coupled receptor 84 (GPR84) is an orphan class A GPCR selectively activated by medium chain fatty acids and highly expressed in immune cells, where it modulates pro-inflammatory signaling. The structural basis of GPR84 inactivation and antagonism has remained unclear, limiting the rational design of pathway-selective modulators despite its clinical relevance in metabolic inflammation and fibrotic diseases. Here, we report cryo-electron microscopy structures of human GPR84 in inactive and active states. The 3.5 Å inactive structure bound to the antagonist GLPG1205 reveals a lid-like conformation of extracellular loop 2 and an inward reorientation of Arg172, with the antagonist head group blocking the allosteric sodium-binding site. Molecular dynamics simulations further support these findings, identifying an aberrant TM5, TM6 lateral entry gate. By contrast, the 3.17 Å agonist ZQ-16, Gαi complex, shows a rearranged toggle switch and comparative analyses highlight extracellular loop 2 conformational plasticity. Immune functional assays in THP-1 cells demonstrated that ZQ-16 elicited GPR84-dependent activation and cytokine production, which were effectively abrogated by GLPG1205. Mutagenesis combined with functional assays validates key ligand interactions, providing a framework for the rational design of pathway selective GPR84 modulators.

PMID 42722702
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