北京若生智能科技有限公司
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zinc acetate dihydrate (Wilzin / Wilzin)

✓ Approved

Recordati S.p.A. · 小分子 · 小分子

什么是 zinc acetate dihydrate？

zinc acetate dihydrate 是一种小分子，由Recordati S.p.A.研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名Wilzin, Wilzin
公司Recordati S.p.A.
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Recordati S.p.A.

治疗适应症

zinc acetate dihydrate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Congenital, familial and genetic disordersHepato-lenticular degeneration✓ Approved

相关研究文献

PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-10-27

Pluripotent Hydrogels With Ion-Tempered Mechanical Properties.

Lu Jianlei J, Guan Xin X, Jia Jiangpeng J, He Xinyue X et al.

Functional soft materials have a wide application prospect in many fields. However, these materials often have elaborately designed polymer network structures to generate unique performance for specific applications. In this work, we present a versatile strategy for adjusting the mechanical properties and thermoresponsive behaviors of hydrogels by ion-tempering, enabling their application in diverse scenarios. Thermoresponsive hydrogels with versatile applications are prepared by treating non-thermoresponsive poly(acrylic acid) (PAA) hydrogels with acetate solutions containing metal ions of Mg2+, Ca2+, Sr2+, Mn2+, Ni2+, and Zn2+, respectively. Except for poly(acrylic acid)/ magnesium acetate (PAA/MgAc), all the other hydrogels exhibit thermo-induced phase separation behavior and shape memory properties with tunable hysteresis ratios. By exploiting the controllable recovery behavior of stretch-programmed hydrogels, the poly(acrylic acid)/ manganese acetate (PAA/MnAc) hydrogel could be applied as artificial muscles and generate effective contractile actuation. Furthermore, the strong ionic bonds within the poly(acrylic acid)/zinc acetate (PAA/ZnAc) hydrogel provide remarkable energy dissipation capability, rendering it ideal for damping and impact protection applications.

PMID 42935001
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PubMedInternational journal of molecular sciences2026-10-27

Effects of Zinc Deficiency and Supplementation on Hippocampal ZnT3, NOGO-A, IL-6, and SESN2 Expression and Oxidative Stress Markers in a Cuprizone-Induced Toxic Demyelination Model.

Atacak Adem A, Gulbahce-Mutlu Elif E, Acar Gozde G, Baltaci Saltuk Bugra SB et al.

This study investigated the effects of zinc deficiency and supplementation on oxidative stress markers and the expression of ZnT3, NOGO-A, IL-6, and SESN2 in hippocampal tissue within a cuprizone (CPZ)-induced toxic demyelination model. Methods: Forty-six adult male Wistar rats were divided into five groups: Control (n = 6), Sham (n = 10), CPZ (n = 10), CPZ + zinc-deficient diet (n = 10), and CPZ + zinc supplementation (5 mg/kg/day, i.p., n = 10). Toxic demyelination was induced by continuous cuprizone administration for eight weeks. At the end of the experimental period, hippocampal malondialdehyde (MDA) and glutathione (GSH) levels were measured; additionally, hippocampal ZnT3, NOGO-A, IL-6, and SESN2 mRNA expression levels were analyzed using quantitative real-time PCR. Cuprizone administration led to significant hippocampal oxidative stress, characterized by increased MDA levels and decreased GSH concentrations (p < 0.05); these oxidative changes were further exacerbated in CPZ-treated animals fed a zinc-deficient diet (p < 0.05). Furthermore, CPZ-induced demyelination suppressed ZnT3 expression in hippocampal tissue while significantly increasing NOGO-A, IL-6, and SESN2 mRNA expression (p < 0.05). These molecular alterations were more pronounced in the zinc-deficient CPZ group (p < 0.05). Intraperitoneal zinc supplementation effectively mitigated these changes by suppressing oxidative stress, attenuating the upregulation of NOGO-A, IL-6, and SESN2 transcripts, and restoring ZnT3 expression to levels comparable to controls (p < 0.05). While dietary zinc deficiency exacerbated hippocampal oxidative stress, neuroinflammatory transcripts, and molecular markers associated with neurodegeneration in the cuprizone model, zinc supplementation restored oxidative balance; increased ZnT3 expression; and suppressed the upregulation of NOGO-A, IL-6, and SESN2. These findings suggest that zinc homeostasis significantly modulates cuprizone-induced hippocampal damage and that zinc supplementation may exert protective transcriptional and antioxidant effects during toxic demyelination.

PMID 42942096
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PubMedVirulence2026-10-27

PmZapA orchestrates zinc homeostasis and pleiotropic stress responses to drive pathogenicity in Talaromyces marneffei.

Shen Qi Q, Nong Yuan Y, Miao Zhengqiang Z, Ma Jianwei J et al.

Zinc homeostasis is critical for pathogenic microbes during their interactions with hosts. In Aspergillus nidulans, the transcription factor ZapA serves as a key regulator of zinc uptake. However, the function of ZapA in the thermally dimorphic pathogen Talaromyces marneffei remains largely unexplored. In this study, we identified and characterized the ZapA homolog in T. marneffei. Our results demonstrate that PmZapA acts as a master regulator of zinc homeostasis by directly controlling the expression of the zinc transporter encoding genes. Deletion of PmzapA severely impaired growth under Zinc - conditions and reduced pigment production. Notably, in a Galleria mellonella larval infection model, the ΔPmzapA strain exhibited significantly attenuated virulence. However, the reduced pathogenicity was not solely attributable to defective zinc transport, as additional pleiotropic effects were detected. Specifically, the ΔPmzapA strain showed impaired reactive oxygen species (ROS) clearance capability, as well as increased susceptibility to cell wall stress and alkaline pH. Integrated RNA-seq and ChIP-seq analysis revealed that PmZapA governs a broad regulatory network, directly and indirectly modulating pathways involved in redox homeostasis, secondary metabolite biosynthesis, as well as carbon metabolism. Collectively, our work identifies PmZapA as a novel virulence determinant in T. marneffei.

PMID 42944568
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PubMedPreventive nutrition and food science2026-10-27

Formulation, Characterization, and In Vitro Simulated Digestion Studies of Emulsified Zinc-Fortified Cupcake Formulations.

Ayesha, Nadeem Muhammad M, Khalid Nauman N

Zinc is a crucial micronutrient that plays multiple essential physiological roles in human health. This study aimed to formulate emulsion-based zinc-fortified cupcakes. Zinc-based water-in-oil emulsions containing canola oil were prepared using a two-step homogenization process. Before product development, different emulsion formulations were formulated, where formulation E1 exhibited the best physical stability. Four cupcake formulations (C0, C1, C2, and C3) with varied amounts of the selected emulsion (E1) were formulated and evaluated based on height, width, baking loss, color, texture, and sensory attributes. There were no significant differences in height, width, and baking loss (P>0.05). The mean weight loss after baking ranged from 11.56±0.31% to 12.89±0.27%. Furthermore, the results showed a significant (P<0.05) effect of emulsion incorporation on textural attributes, except for a non-significant effect on hardness (P=0.441). Emulsion incorporation affected the crumb with a non-significant effect (P>0.05) on color, with the sole exception of lightness. Sensory evaluation identified C2 as the most acceptable formulation based on flavor, texture, appearance, odor, sweetness, and overall acceptability, scoring 7.62±0.74. The best formulation was selected for in vitro simulated digestion, which affects consumer preference. In vitro digestion of C2 exhibited a zinc bioaccessibility of 53.97±1.69% in the intestinal phase and 39.03±8.55% in the gastric phase. Conclusively, the formulated product achieved sensory acceptability and appreciable zinc bioaccessibility, demonstrating a workable strategy to address zinc deficiency. However, verification through in vivo digestion is required, as current findings cannot be considered direct evidence in human subjects.

PMID 42935662
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PubMedAntonie van Leeuwenhoek2026-10-27

Therapeutic potential of the exometabolic crude ethyl acetate extract of an endophytic Bacillus sp. against multidrug-resistant pathogens associated with cancer patients.

Elebiary Deyaa M DM, El-Sherbiny Gamal M GM, Sharaf Mohamed H MH, Elnady Maha S MS et al.

The alarming emergence of multidrug-resistant bacterial pathogens (MDRBPs), esp.ecially associated with cancer patients, necessitates the exploration of novel biological agents as endophytic microorganisms that are natural reservoirs of bioactive substances. The purpose of the present study was to isolate endophytic bacteria and evaluate the exometabolic crude ethyl acetate extract against MDRBPs in vitro and in vivo, study their effects on cancer cells and wound recovery, and elucidate some mechanisms supporting their efficacy. In our study, a bacterium was isolated from Sp.inacia oleracea and identified as a Bacillus isolate closely related to Bacillus amyloliquefaciens and deposited in GenBank as PX736878. The exometabolic crude ethyl acetate of Bacillus sp. exhibited a strong antibacterial activity against MDRBPs, and the highest activity was against Klebsiella pneumoniae (21.2 mm). The MIC values showed its efficacy, particularly at 500 µg/ml. The extract also exhibited significant anti-biofilm activity sp.ecifically against K. pneumoniae. The cytotoxicity assays showed a selective toxicity of Bacillus sp. extract against the cancer cell lines (HCT116 and MCF7). In vivo, significant wound healing potential of the exometabolic crude ethyl acetate of Bacillus sp. was demonstrated by histological evidence of near-normal tissue regeneration. The strong activities exometabolic crude ethyl acetate of Bacillus sp. were due to the high antioxidant capacity. GC-MS analysis further supported our results and identified diverse bioactive compounds in the exometabolic crude ethyl acetate of Bacillus sp., including Diketopyrazine, fatty acids, and dipeptides. In conclusion, the extract of exometabolic crude ethyl acetate extract of Bacillus sp. is a promising multifunctional agent with strong antibacterial, anti-biofilm, antioxidant, and anticancer properties. This could be a new way to fight MDRBPs and aid damaged tissue to heal.

PMID 42934348
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-10-27

Molecular Engineering of a Weakly Coordinating Additive for Multiscale Stabilization of Zinc Metal Anodes.

Liu Xuekun X, Lu Yanmin Y, Xu Hongfei H, Wan Zihao Z et al.

Aqueous zinc metal batteries are promising energy‑storage systems due to their high safety, low cost, and abundant zinc resources. However, their practical application is significantly constrained by persistent challenges at the zinc anode, including dendrite growth, hydrogen evolution, and corrosion in aqueous electrolytes. To overcome these limitations, we propose ethyl maltol (EM) as a weakly coordinating, small‑molecule additive that implements a synergistic strategy integrating solvation‑structure regulation, interfacial desolvation promotion, and defect‑site passivation. Theoretical and experimental results reveal that EM participates in the Zn2+ solvation sheath and restructures the hydrogen-bond network of water, thereby lowering water activity and retarding proton transport. Its weak coordination facilitates Zn2+ desolvation at the interface, while its preferential adsorption on active Zn surface sites suppresses both hydrogen evolution and corrosion, enabling uniform and dendrite‑free Zn deposition. Benefiting from this synergistic regulation, Zn||Zn symmetric cells achieve stable cycling for over 3500 h at 1 mA cm-2/1 mAh cm-2, and 771 h at 5 mA cm-2/5 mAh cm-2; the Zn||V2O5 full cell maintains a reversible capacity of 123.48 mAh g-1 after 5000 cycles at 5 A g-1. This work offers a rational molecular‑design strategy for developing multifunctional electrolyte additives toward highly stable aqueous zinc metal batteries.

PMID 42934962
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