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meningococcal AC/Haemophilus influenzae B type vaccine (Hi Becam / HibACon)

✓ Approved

Chongqing Zhifei Biological · 疫苗 · 疫苗

什么是 meningococcal AC/Haemophilus influenzae B type vaccine？

meningococcal AC/Haemophilus influenzae B type vaccine 是一种疫苗，由Chongqing Zhifei Biological研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection。

药物档案

商品名Hi Becam, HibACon
公司Chongqing Zhifei Biological
药物类别疫苗
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved
来源： ClinicalTrials.gov, Chongqing Zhifei Biological

治疗适应症

meningococcal AC/Haemophilus influenzae B type vaccine 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsMeningococcal bacteraemia✓ Approved

相关研究文献

PubMedPharmaceuticals (Basel, Switzerland)2026-10-27

Adjunctive Corticosteroids in Pediatric Meningitis: Current Evidence, Clinical Controversies, and Future Directions.

Zambelli Giulia G, Masetti Marco M, Diona Sonia S, Bonacorsi Lorenzo L et al.

Background: Pediatric bacterial meningitis remains an important cause of death and long-term neurological disability despite advances in vaccination, antimicrobial therapy, and supportive care. Because host inflammation contributes substantially to secondary neuronal injury, adjunctive corticosteroids have been investigated as a strategy to reduce inflammation-mediated complications. This narrative review aims to critically evaluate the current evidence on corticosteroid therapy in pediatric meningitis, with particular emphasis on acute bacterial meningitis, major clinical and neurological outcomes, treatment timing, pathogen-specific effects, and the impact of changing post-vaccination epidemiology. Methods: A structured search of PubMed/MEDLINE, Scopus, and Web of Science was conducted for relevant publications available up to June 2026. Randomized controlled trials, observational studies, systematic reviews, meta-analyses, and international guidelines involving patients aged 0-18 years were considered. Evidence was synthesized narratively, focusing on mortality, hearing loss, neurological sequelae, long-term outcomes, safety, causative pathogen, and timing of corticosteroid administration. Results: Adjunctive dexamethasone has not demonstrated a consistent mortality benefit, while evidence concerning hospital stay, intensive care utilization, and healthcare costs remains limited. Its most reproducible benefit is a reduction in sensorineural hearing loss, particularly in Haemophilus influenzae type b (Hib) meningitis. Benefits in pneumococcal meningitis are less consistent, and evidence supporting routine use in meningococcal disease remains limited. Efficacy appears greatest when dexamethasone is administered before or with the first antibiotic dose and may be less pronounced in the post-vaccination era. In tuberculous meningitis, corticosteroids improve survival, whereas routine use is not supported in uncomplicated viral meningitis or cryptococcal meningitis. Conclusions: Adjunctive dexamethasone should be used selectively in pediatric meningitis, with its clearest benefit being hearing preservation in early-treated Hib meningitis. Treatment decisions should account for pathogen, timing, and epidemiological context.

PMID 42943260
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PubMedThe Pediatric infectious disease journal2026-10-27

Antimicrobial Resistance and Molecular Epidemiology of Haemophilus influenzae Causing Pediatric Acute Otitis Media in Japan.

Kitaya Shiori S, Kakuta Risako R, Sakata Ryuji R, Ogawa Miho M et al.

Antimicrobial-resistant strains of Haemophilus influenzae are associated with treatment failure and recurrence in acute otitis media (AOM). We aimed to characterize the current antimicrobial susceptibility of H. influenzae isolates from children with AOM, elucidate β-lactam and quinolone resistance mechanisms, and determine the molecular epidemiology of resistant strains. We analyzed 182 H. influenzae isolates from the middle ear fluid of children aged ≤3 years with AOM from multiple regions in Japan (February 2022-May 2023). Antimicrobial susceptibility was tested, and β-lactamase genes (blaTEM-1 and blaROB-1) were detected. Sequence analyses of ftsI, encoding PBP3 and quinolone resistance-determining regions were performed to elucidate the resistance mechanisms. Multilocus sequence typing (MLST) was conducted for the ampicillin- and quinolone-low-susceptible strains. Of 182 isolates, 14 (7.7%), 10 (5.5%), 36 (19.8%) and 122 (67.0%) were β-lactamase-producing, β-lactamase-nonproducing ampicillin-resistant (BLNAR), low-BLNAR and β-lactamase-nonproducing ampicillin-susceptible strains, respectively. All 10 BLNAR and 4 β-lactamase-producing isolates exhibited group III PBP3 amino acid substitutions associated with high-level resistance. MLST revealed genetic diversity among BLNAR isolates, whereas 7 (50.0%) β-lactamase-producing isolates belonged to ST103, indicating clonal dissemination. Amino acid substitutions in the quinolone resistance-determining region were detected in six quinolone-low-susceptible strains; these isolates exhibited diverse STs. The β-lactam susceptibility of H. influenzae isolates causing pediatric AOM exhibited an overall improvement. However, an increasing trend in quinolone-low-susceptible strains was observed. Specific clones represented by ST103 were detected among some of the β-lactamase-producing strains, warranting careful monitoring.

PMID 42937372
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PubMedJournal of clinical microbiology2026-10-27

Diagnosing pediatric skeletal system infections: you are as good as your lab.

Yagupsky Pablo P

Pediatric skeletal system infections are medical emergencies that may cause severe acute complications and long-term orthopedic disabilities. Because the clinical presentation of septic arthritis and osteomyelitis may mimic non-infectious conditions, early identification of the causative agent and determination of its antibiotic susceptibility profile are cornerstones of patient management. The etiology of childhood skeletal system infections has changed over time, reflecting the implementation of conjugate vaccines against Haemophilus influenzae type b and Streptococcus pneumoniae, as well as the development of sensitive molecular detection tests. These novel laboratory methods, coupled with rapid pathogen identification by MALDI-TOF technology, have reduced the fraction of "culture-negative" infections and shortened the turnaround time for pathogen identification from days to hours. However, even today, a substantial fraction of bone and joint infections remains microbiologically unconfirmed. Metagenomic next-generation sequencing holds great promise, but its high cost, the need for technical expertise, and the detection of commensal organisms of dubious significance severely limit its routine use. On the other hand, metagenomic next-generation sequencing has not expanded the list of known pediatric skeletal system pathogens, suggesting that underutilization of current diagnostic methodologies, rather than reduced sensitivity, drives suboptimal diagnosis.

PMID 42937321
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PubMedFrontiers in public health2026-10-27

Global epidemiology of the factor H binding protein in meningococcal serogroup B invasive isolates: a targeted literature review.

Iantomasi Raffaella R, Lopez Lacey L, Forns Joan J, Slate Sarah Rose SR et al.

Invasive meningococcal disease (IMD) is a relatively rare but clinically serious infection caused by the bacterium Neisseria meningitidis, with meningococcal serogroup B (MenB) being one of the most common causes. Both of the currently available MenB vaccines contain factor H binding protein (fHbp), which has high antigenic variability; thus, it is important to monitor MenB-fHbp epidemiology. This targeted literature review aimed to assess the global prevalence and diversity of fHbp in MenB isolates over time. A search of PubMed was conducted in June 2025 to identify studies reporting on MenB-fHbp characterization, without any search limits. Data were extracted and confirmed through independent review. Nomenclature was unified using PubMLST, and results were summarized descriptively. Of 1,354 identified studies, 52 were selected for inclusion, published between 2009 and 2025, representing 34 countries across Africa, Asia, Australia, Europe, North America, and South America. MenB-fHbp subfamily A variants were typically dominant in Africa, Asia, and South America, while MenB-fHbp subfamily B variants were typically dominant in Australia, Europe, and North America. Prevalent fHbp peptides in MenB isolates varied widely across countries and regions and within countries over time, including a multitude of less common peptides. The studies included in this review demonstrate the global diversity of fHbp in MenB isolates, highlighting the importance of continued surveillance and the need for vaccines that provide broad fHbp coverage.

PMID 42936222
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PubMedMicrobial cell factories2026-10-27

High-density fermentation of Haemophilus parasuis serovar 12 using a hybrid optimization strategy and its associated metabolic rewiring.

Ma Yongkang Y, Gao Jiazeng J, Han Sie S, Liu Lixia L et al.

High-cell-density fermentation of Haemophilus parasuis, particularly the prevalent and virulent serovar 12, is critical for cost-effective vaccine production but remains constrained by low cell yields in conventional media. In this study, we demonstrate a high-efficiency fermentation strategy enabled by a hybrid Artificial Neural Network-Genetic Algorithm (ANN-GA) optimization to overcome these nutritional limitations. Notably, the Response Surface Methodology (RSM) + ANN-GA-optimized (ZP) medium supported a viable cell density of 1.1 × 1010 CFU·mL- 1 in a 14-L bioreactor scale-up, significantly outperforming traditional TSB medium while reducing production costs by approximately 64%. A comparative transcriptomic analysis between ZP and TSB conditions was employed to elucidate the biological mechanism underlying this enhanced growth efficiency. Within the optimized environment, H. parasuis serovar 12 exhibited a distinct metabolic rewiring: the bacterium significantly downregulated energy-expensive amino acid transport systems and aminoacyl-tRNA biosynthesis while concurrently upregulating central carbon metabolism (glycolysis and TCA cycle) and nucleotide sugar metabolism. This transcriptional shift suggests that the optimized nutrient balance allows H. parasuis serovar 12 to transition from a "scavenging" mode to a more efficient biosynthetic state, thereby maximizing biomass accumulation without compromising vaccine efficacy (90% survival rate in a mouse challenge model). This finding paves the way for the rational design of industrial media for H. parasuis and facilitates cost-effective vaccine manufacturing.

PMID 42934658
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PubMedMicroorganisms2026-10-27

Virulence Mechanisms of Streptococcus pneumoniae During Co-Infection.

Briggs Nicholas S NS, Camaione Stefano S, Goodall Jack J, Bruce Kevin E KE et al.

Streptococcus pneumoniae (pneumococcus) represents a key clinical challenge, being a major global cause of morbidity and mortality. Typically existing as a nasopharyngeal commensal, pneumococcus undergoes significant metabolic changes during its switch to a virulent pathogen, when it can cause severe pneumoniae, bacteriemia and meningitis. This switch is poorly understood but is thought to be influenced by environmental signals arising from co-infections between pneumococcus and other bacteria as well as viruses in the nasopharynx. This review provides a comprehensive overview of the multi-stage progression of pneumococcal invasive disease, from initial colonisation to host barrier migration. We examine environmental triggers that drive the lifestyle switch from commensal to virulent, highlighting the role of other organisms in this stimulation. In particular, we focus on influenza A and respiratory syncytial virus, as well as other bacteria including Staphylococcus aureus, Moraxella catarrhalis and Haemophilus influenzae. Overall, we bring the current understanding of the field into the context of the growing antimicrobial resistance global threat, demonstrating that understanding these complex cross-species interactions is vital for developing clinical interventions against secondary pneumococcal infections.

PMID 42943593
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