cefalexin (Panixine DisperDose / Panixine DisperDose)

Oral Manifestations of Juvenile Behçet Syndrome: A Case Report and Mini-Review of the Literature.

El Omari Safaa S, Barhoud Oumaima O, Elarabi Samira S, Bensouda Sana S

Behçet's disease is a chronic, relapsing, multisystem inflammatory vasculitis characterized by a broad spectrum of mucocutaneous and systemic manifestations. Oral ulcerations are often the earliest and most frequent clinical feature, playing a central role in diagnosis, particularly in pediatric patients, in whom the disease remains uncommon and its diagnosis is frequently delayed. We report the case of a boy aged 11 years and 6 months with juvenile Behçet syndrome who presented with recurrent oral aphthous ulcerations, including an 8-mm ulcer on the left lateral border of the tongue and a 5-mm ulcer on the external surface of the upper lip, along with poor oral hygiene and generalized gingival inflammation. The patient had a history of arthralgia and was receiving colchicine (1 mg/day). Oral management consisted of reinforcement of oral hygiene and dietary measures, full-mouth scaling, and topical treatment with corticosteroids and propolis-based therapy. At the 10-day follow-up, complete healing of the initial oral lesions and marked improvement in gingival inflammation were observed, although new aphthous ulcers developed at different intraoral sites, consistent with the relapsing nature of the disease. This case highlights the importance of early recognition of oral manifestations in Pediatric Behçet's Disease (PEDBD) and emphasizes the key role of pediatric dentists in facilitating diagnosis, multidisciplinary management, and long-term follow-up. Appropriate oral care may contribute to improved symptom control, enhanced quality of life, and the prevention of oral complications.

Methylene Blue Oral Rinse for Cancer-Related Oral Mucositis Pain #540.

S Carlson Erik E, Arnold Robert R

Restoration of Functional Oral Intake After Proximal Gastrectomy Using an Individualized Risk-Adapted Multidisciplinary Approach: A Case Report.

Ito Shogo S, Takada Hirokazu H, Shibata Kazuhiro K, Yamamoto Hidekazu H

Dental rehabilitation restored functional oral intake after gastrectomy, followed by long-term improvement in BMI and stabilization of hematologic, iron-status, and metabolic parameters. A risk-adapted multidisciplinary approach combining medical optimization and oral rehabilitation may benefit selected patients with post-gastrectomy malnutrition.

Oral dysbiosis in children with renal failure: a systematic review.

Ruiz-Roca Juan Antonio JA, Pecci-Lloret María Pilar MP, Romano Antonio A, Carinci Francesco F et al.

The oral microbiome plays an important role in maintaining host homeostasis and may interact with systemic diseases through the oral-systemic axis. Chronic kidney disease (CKD) in childhood is associated with chronic inflammation, metabolic alterations, and immune dysfunction, which may influence microbial ecosystems. While intestinal dysbiosis has been widely studied in paediatric CKD, alterations in the oral microbiome remain less well understood. The aim of this study was to qualitatively synthesize evidence on oral microbiome alterations in children and adolescents with CKD compared with systemically healthy controls. A systematic review was conducted according to PRISMA 2020 and registered in PROSPERO (CRD420261334000). PubMed, Scopus, Web of Science, Cochrane, and SciELO were searched (February 24, 2026). Eligible studies included participants aged 0-18 years with CKD (any stage), dialysis, or kidney transplantation and a healthy control group. Risk of bias was assessed using JBI and ROBINS-I v2 tools. From 109 records, 7 studies were included. Most used saliva, tongue/oral swabs, or dental plaque, and 16S rRNA sequencing was the most frequent method. Five studies reported oral dysbiosis in CKD, including severe dysbiosis grades in adolescents with end-stage disease, while two studies reported no significant differences versus controls. Findings on individual taxa were inconsistent across studies, likely due to heterogeneity in renal phenotype, oral niche sampled, and analytical methods. Evidence suggests that salivary biochemical alterations (notably urea and pH) and inflammatory burden may influence microbial composition, whereas the tongue microbiome may show relative ecological stability in some paediatric cohorts. Children and adolescents with CKD may present oral microbiome alterations, but current evidence is limited by methodological heterogeneity and moderate-to-high risk of bias. Standardized sampling and longitudinal multicentre studies are needed to determine robust microbial signatures and their value as non-invasive biomarkers in paediatric nephrology. https://www.crd.york.ac.uk/PROSPERO/view/CRD420261334000.