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erythromycin (erythromycin, KV)

✓ Approved

Lumara Health · 治疗药物

什么是 erythromycin?

erythromycin 是一种治疗药物,由Lumara Health研发。该药已获批,用于治疗相关适应症,给药途径:Oral (PO)。

药物档案

商品名erythromycin, KV
公司Lumara Health
给药途径Oral (PO)
状态Approved

治疗适应症

erythromycin 针对 1 个适应症,涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsSalmonellosis✓ Approved

相关研究文献

PubMedGels (Basel, Switzerland)2026-07-27

Polydopamine-Modified Boron Nitride Reinforced Silicone Gel Composites with Enhanced Thermal Conductivity and Electrical Insulation Performance.

Feng Mengjia M, Zhao Chaoyue C, Li Wenbo W, Lv Xinfeng X et al.

Silicone gel (SG) is widely used as a soft encapsulation material for high-voltage power devices because of its excellent flexibility, thermal stability, and electrical insulation. However, its intrinsically low thermal conductivity and susceptibility to partial discharge (PD) at triple-junction interfaces restrict long-term operational reliability. In this study, polydopamine-modified hexagonal boron nitride (P-BN) was introduced into silicone gel to construct thermally conductive and electrically insulating composites. The SG/P-BN composites exhibited reduced filler agglomeration and a more continuous filler-matrix morphology than the corresponding SG/BN composites, while the model-extrapolated trap analysis suggested composition-dependent changes in the higher energy charge trapping states of the P-BN-containing composites. As a result, the SG/P-BN composites exhibited enhanced thermal stability, reduced coefficient of thermal expansion, and improved heat-transfer capability, with thermal conductivity increasing from 0.183 W/m·K for pristine SG to 0.25 W/m·K. The composite containing 2 wt% P-BN showed the best insulation performance, with breakdown strength increasing from 24.05 to 28.45 kV/mm at 25 °C and from 19.59 to 24.71 kV/mm at 150 °C. Under a simplified triple-junction laboratory configuration, the PD inception voltage increased from approximately 3.1 kV for pristine SG to 4.1 kV for SG/P-BN2, accompanied by fewer high-amplitude discharges. This work demonstrates improved material-level thermal conductivity and electrical insulation performance of P-BN-containing silicone gel composites under the investigated laboratory conditions.

PMID 42505326
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PubMedGels (Basel, Switzerland)2026-07-27

Pulsed Electric Field-Modified Hot-Pressed Peanut Meal Protein for Gel-like High Internal Phase Emulsions.

Liao Yutong Y, Song Jiayi J, Huang Jiaxin J, Liang Kexin K et al.

Hot-pressed peanut protein isolate (HPPI), severely denatured during oil extraction, exhibits limited interfacial functionality, restricting its application in structured emulsions. In this study, high-voltage pulsed electric field (PEF) was employed to modulate the structural and interfacial properties of HPPI, a sustainable food biopolymer. PEF treatment induced conformational rearrangement, including a shift in secondary structure from α-helix to β-sheet and increased exposure of hydrophobic residues. These structural changes reduced particle size and increased surface charge, with optimal modification at 2.5 kV/cm. Consequently, interfacial activity was significantly improved, as evidenced by decreased interfacial tension and increased dilatational modulus, indicating a more elastic interfacial film was formed. The modified protein (2.5 kV/cm) effectively stabilized high internal phase emulsions (HIPEs) with typical gel-like viscoelastic features, achieving optimal stability at 2.0 wt% protein concentration, 75% oil phase fraction, and NaCl concentrations below 100 mM. Overall, PEF treatment enhances the interfacial functionality of HPPI by modulating its structure and interfacial film properties, thereby facilitating the fabrication of biopolymer-based food-grade HIPEs for practical food applications.

PMID 42505255
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PubMedMolecular biology reports2026-07-27

Antibiotic resistance patterns and resistance-associated genes in Streptococcus pneumoniae: insights from healthy children.

Masroor Azin A, Attarzadeh Maryam Sadat MS, Mojtahedi Ali A, Moghadam Majid Taati MT et al.

The emergence of resistance to β-lactam and macrolide antibiotics, the main therapeutic agents for Streptococcus pneumoniae infections, poses a major public health challenge. This study aimed to investigate antibiotic resistance patterns and characterize the resistance-associated genes in pneumococcal isolates. Nasopharyngeal swab specimens were collected from 318 healthy children younger than 16 years of age. S. pneumoniae isolates were identified using conventional culture, Gram staining, and biochemical tests. Antimicrobial susceptibility was determined by the disk diffusion method, and the minimum inhibitory concentration (MIC) of erythromycin was measured using the E-test. Molecular PCR assays were performed to confirm pneumococcal identification and detect antibiotic resistance genes. Nasopharyngeal carriage of S. pneumoniae was detected in 25 of 318 children (7.86%). Penicillin showed the highest resistance rate (92%), whereas vancomycin exhibited the lowest (8%). Based on the E-test results, seven isolates (28%) were non-susceptible to erythromycin, including four (16%) resistant and three (12%) intermediate isolates. Therefore, 13 isolates (52%) were classified as multidrug-resistant (MDR). Among the 25 isolates, the pbp2b and ermA genes were each detected in one isolate (4%), whereas ermB, mef(A/E), and tetM were identified in 8 (32%), 16 (64%), and 23 (92%) isolates, respectively. The tet(O) gene was not detected in any isolate. These findings highlight the importance of continuous surveillance of pneumococcal carriage and antimicrobial resistance in pediatric populations to support evidence-based treatment strategies and public health interventions.

PMID 42507236
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PubMedAntibiotics (Basel, Switzerland)2026-07-27

Antimicrobial Resistance Profiles of Bacterial Pathogens Associated with Acute Diarrheal Disease: A Three-Year Retrospective Study in a Romanian Tertiary-Care Hospital.

Borcan Alina Maria AM, Caravia Laura Georgiana LG, Secuiu Bianca B, Borcan Calin Andrei CA et al.

Despite its typically self-limiting course, acute diarrheal disease continues to be clinically relevant from an antimicrobial resistance surveillance perspective. In-depth analyses at a national level remain limited, with available Romanian studies from the last decade focusing on individual pathogens, often relying on a restricted isolate collection. In this context, we aimed to evaluate antimicrobial resistance profiles and distribution of Salmonella spp., Campylobacter spp., Escherichia coli, Yersinia spp. and Shigella spp. Data was obtained from records from the Microbiology Laboratory of a tertiary-care hospital serving the south region of Romania, over a 3-year period. Campylobacter spp. had high resistance rates to ciprofloxacin (81.65% for C. jejuni; 85.15% for C. coli) and tetracycline (44.65% for C. jejuni; 56.07% for C. coli). Erythromycin resistance remained low and stable over the study period, with no statistically significant temporal variation; however, C. coli isolates demonstrated significantly higher erythromycin (p = 0.001) and tetracycline (p = 0.008) resistance rates compared to C. jejuni. Overall Salmonella spp. resistance rate to ciprofloxacin was 46.00%, with higher resistance observed in serogroups C (63.64%) and D (52.53%) (p < 0.01). Ampicillin (AMP) resistance varied significantly across years and serogroups, with serogroup B consistently demonstrating higher resistance rates (40.48%) (p < 0.001). E. coli isolates reacting with pathotype-associated O antisera revealed high resistance levels to ampicillin (41.57%), amoxicillin-clavulanic acid (AMC) (38.73%) and sulfamethoxazole-trimethoprim (SXT) (19.25%), with low resistance levels to ciprofloxacin (9.04%) and ceftriaxone (CRO) (9.71%); no significant variation in resistance patterns was identified across years or serological pools, suggesting a relatively stable resistance profile over the study period. Yersinia spp. isolates showed no notable antimicrobial resistance levels. Shigella spp. isolates exhibited high resistance for ampicillin (78.57%), sulfamethoxazole-trimethoprim (68.75%), amoxicillin-clavulanic acid (50.00%) and ceftriaxone (35.41%). This study addressed a recognized gap in Romanian and Eastern European surveillance data and aims to contribute to a stronger evidence base for future epidemiological investigations and antimicrobial stewardship efforts. Resistance rates identified in our study may provide valuable information for comparison with data generated from veterinary, food and environmental surveillance programs, thereby supporting a more comprehensive understanding of antimicrobial resistance (AMR) epidemiology. These findings may additionally contribute to the development of coordinated strategies aimed at mitigating the emergence and spread of AMR.

PMID 42505595
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PubMedBiomimetics (Basel, Switzerland)2026-07-27

SE-Attention Augmented Hybrid CNN-BiLSTM Model for Leakage Current-Based Detection of Cracked and Broken High-Voltage Porcelain Insulators.

Alçin Ömer Faruk ÖF, Özküçük Muhammed Buğracan MB, Gençoğlu Muhsin Tunay MT

Extreme and sudden temperature fluctuations observed as a result of global climate change increase the environmental pressure on energy transmission infrastructure. These meteorological changes significantly increase the risk of failure for porcelain insulators, which exhibit low thermal resistance and are susceptible to sudden arcing and surface deformations. In this study, a hybrid CNN-BiLSTM-SE architecture augmented with the Squeeze-and-Excitation attention mechanism is proposed using surface leakage current signals to diagnose healthy, cracked, and broken structural conditions in three-unit porcelain insulators. The SE block in the architecture dynamically rescales feature maps from CNN layers on a channel-by-channel basis. Thus, it highlights the signal characteristic that is dominant for fault diagnosis just before the BiLSTM units learn temporal dependencies. Leakage current data were obtained under an experimental setup at 60 kV for 15 different conditions covering all possible combinations of healthy, cracked, and broken insulator units. The raw signals were preprocessed with the Savitzky-Golay filter to suppress noise while preserving the diagnostic waveform morphology. 24 features covering time-domain statistics, frequency-domain spectral characteristics, and wavelet-domain energy components were extracted and used as model inputs. The CNN-BiLSTM-SE architecture achieved a classification accuracy of 93.83%, surpassing the standalone CNN (88.89%), BiLSTM (87.65%), and CNN-BiLSTM (91.36%) models, as well as classical machine-learning baselines (SVM: 87.65%, Random Forest: 90.12%, Boosted Trees: 87.65%).

PMID 42505490
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PubMedAntibiotics (Basel, Switzerland)2026-07-27

Natural Deep Eutectic Solvent-Based Dispersive Liquid-Liquid Microextraction Coupled with UHPLC-MS/MS for the Determination of Antibiotic Residues in Food Products.

Mostafa Ahmed A, Shaaban Heba H, Alqarni Abdulmalik M AM, Alturki Mansour S MS et al.

The application of green analytical chemistry (GAC) principles is increasingly important in developing sustainable analytical practices for food safety monitoring. Natural deep eutectic solvents (NADESs) have emerged as green alternatives to conventional organic solvents. This study aimed to develop a sustainable analytical method for determining antibiotic residues in processed meat and frozen poultry products. A dispersive liquid-liquid microextraction (DLLME) procedure based on a NADES composed of anisaldehyde and decanoic acid (3:1, molar ratio) was coupled with UHPLC-MS/MS for the simultaneous determination of macrolides (clarithromycin, erythromycin), sulfonamides (sulfamethoxazole, sulfadimethoxine), and a fluoroquinolone (enrofloxacin) in food samples. Key extraction parameters, including NADES volume, vortex time, centrifugation time, sample amount, and pH, were optimized. The method was validated for linearity, accuracy, precision, and recovery and applied to real samples from the Saudi market. The method showed excellent analytical performance, with good linearity (R2 ≥ 0.9982), recoveries of 84.1-99.4%, and RSDs ≤ 5.75%. The target antibiotics were successfully quantified in processed meat and frozen poultry samples, confirming applicability. In addition, a comprehensive evaluation using eight assessment tools confirmed the method's environmental sustainability, practicality and innovation. The proposed NADES-based DLLME-UHPLC-MS/MS method is a rapid, sensitive, and eco-friendly alternative to conventional techniques for monitoring antibiotic residues in processed meat and poultry, supporting both food safety and GAC principles.

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