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erythromycin (erythromycin, KV)

✓ Approved

Lumara Health · 治疗药物

什么是 erythromycin？

erythromycin 是一种治疗药物，由Lumara Health研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名erythromycin, KV
公司Lumara Health
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Lumara Health

治疗适应症

erythromycin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsSalmonellosis✓ Approved

相关研究文献

PubMedJournal of medicinal chemistry2026-09-10

Allosteric Inhibitors of Erythromycin Resistance Methyltransferase Reverse Antibiotic Resistance.

Sahu Damini D, Badgujar Leena Laxmikant LL, Yadav Dhananjay D, Dahm Greta Charlotte GC et al.

Methylation of a critical adenine residue of the 23S rRNA residing in the nascent exit tunnel of the bacterial ribosome, by Erythromycin resistant methyltransferases (Erms), reduces binding of macrolide, lincosamide, and streptogramin B (MLSB) class of antibiotics and confers high-level resistance. Using an allosteric site-directed focused virtual screening approach, nucleoside analogues were identified as the initial scaffold. 6-thioinosine, recognized as a significant initial hit molecule, was confirmed through in vitro screening to be a potent scaffold. Further, structure-based inhibitor evolution approach yielded improved analogues that demonstrated an MIC of 8 μg/mL via a combination therapy approach where Erm inhibitors were administered along with standard antibiotics in MLSB resistant clinical isolates. Our findings demonstrate that a strategy where allosteric inhibitors are developed to impede the ability of pathogenic ribosomal methyltransferases to recognize target RNA can serve as a generic approach for reversal of antibiotic resistance in a combination therapy mode.

PMID 42720463
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PubMedJournal of applied clinical medical physics2026-09-10

Towards adaptive radiotherapy: Comparing HyperSight and standard CBCT reconstructions on a C-Arm Linac.

Clarke Niamh L NL, Hughes Jeremy L JL, Wanigaratne Derrick D, Yeo Adam U AU

Cone-beam computed tomography (CBCT) is integral to image-guided radiation therapy and increasingly used for adaptive radiotherapy and CBCT-based dose calculation. Conventional kV-CBCT systems on C-arm TrueBeam linacs with Feldkamp-Davis-Kress (FDK) reconstruction have historically been limited by reduced Hounsfield Unit (HU) accuracy, scatter contamination, image noise and reconstruction artefacts. Iterative CBCT (iCBCT) reconstruction has improved image quality and HU consistency relative to the conventional FDK reconstruction. HyperSight represents a further evolution through software and hardware development with an enhanced detector design, advanced reconstruction algorithms and gantry rotation speeds up to 9°/s. This study reports commissioning and evaluation of HyperSight iterative CBCT (HS-iCBCT) acquired on a Varian TrueBeam (v4.1), to support adaptive workflows in comparison with standard (Std-FDK) and iterative CBCT (Std-iCBCT) on a TrueBeam (v2.7). CBCT images were acquired on a Varian TrueBeam using the conventional kV On-board Imager (OBI) for Std-FDK and Std-iCBCT reconstructions and the HyperSight kV-imaging system for HS-iCBCT. Commissioning included CBCT dose calculation protocol optimization, CT-to-electron density (CT-ED) calibration and validation using STEEV, Rando and the CIRS Dynamic Thorax phantoms. CBCT images of anthropomorphic Head, Thorax/Spine, Rib and Lung phantoms were rigidly registered to the planning CT (pCT) and resampled using Velocity AI (v4.2). Voxel-wise HU difference histograms were generated, with peak position used to quantify systematic HU bias. Treatment plans (20 Gy/1# for Brain SRS/Spine, 24 Gy/2# for Rib and 54 Gy/3# for Lung) were optimized on the pCT and recalculated on the CBCT datasets. Dose-volume histogram (DVH) metrics were assessed and 3D-gamma analysis (2%/1 mm to 1%/1 mm; 10%/70% dose thresholds) was performed and compared with Std-FDK and Std-iCBCT. HS-iCBCT showed improved HU accuracy compared with Std-iCBCT and Std-FDK when benchmarked against the pCT. For materials ≤ 1.08 g/cm3, the mean HU difference was lowest for HS-iCBCT at 7.7 ± 4.1 HU, compared with 23.6 ± 13.5 HU for Std-iCBCT and 38.0 ± 19.7 HU for Std-FDK (Friedman p < 0.05). For higher-density materials, HS-iCBCT demonstrated mean HU differences of 33.5 ± 22.9 HU, compared with 46.2 ± 22.2 HU for Std-iCBCT and 93.4 ± 57.6 HU for Std-FDK. HS-iCBCT improved image quality with HU difference histograms demonstrating peak values closest to zero (∆HU within 15HU). An optimized CBCT acquisition protocol (140 kV) combined with a single baseline 120 kV pCT HU-ED calibration curve proved feasible for CBCT-based dose calculation. Dose calculation agreement was strongest for HS-iCBCT (p < 0.05) with median target dose differences measuring < 0.3%, < 0.6%, 0.6% and < 0.4% for the Brain, Thorax/Spine, Rib, and Lung anatomies, respectively. Median (min-max) gamma passing rates across all anatomical sites were 98.8% (97.8-99.8), 98.7% (96.7-99.6), and 96.0% (94.5-99.5) with 2%/1 mm passing criteria for HS-iCBCT, Std-iCBCT, and Std-FDK, respectively. HyperSight reduces HU variability, improves image quality, and enhances CBCT-based dose calculation relative to conventional CBCT implementations. Use of a single optimized CBCT dose calculation protocol and baseline HU-ED calibration curve proved feasible across multiple anatomical sites, supporting implementation of HS-iCBCT for adaptive radiotherapy workflows on conventional C-arm TrueBeam linacs.

PMID 42717692
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PubMedCardiovascular diagnosis and therapy2026-09-10

Simulation of calcium blooming artifacts in coronary CT angiography from digital phantoms.

Wang Xiaoling X, Li Guanyu G, Suo Shiteng S, Kumar Sant S et al.

Calcium blooming artifacts, predominantly caused by the partial volume effect, may limit the accuracy of coronary stenosis assessment on coronary computed tomography angiography (CTA). Existing comparative tests or physical phantoms to evaluate de-blooming methods are costly, time-consuming, and limited in geometry and materials. This study developed a computational method to simulate CTA images incorporating calcified plaques from digital phantoms to help understand the characteristics of blooming artifacts. Digital vascular phantoms with different plaque geometries and stenosis severities were created and imaged by computed tomography (CT) simulation. To assess the accuracy of simulation, CT images of three-dimensional (3D)-printed physical phantoms were acquired by CT scanners. To investigate the consistency of the impacts of tube voltage and reconstruction kernel on calcium blooming artifacts, both simulated and acquired CT images were quantitatively analyzed. The average structural similarity index measure (SSIM) of simulated and acquired images was 0.94±0.04. CT number, image noise and calcified area comparison between the simulated and corresponding acquired images showed good agreement. Normalized calcified area was 1.12±0.13, 1.05±0.12, 0.99±0.11 (P<0.001), for 80, 100 and 120 kV, respectively, across the simulated and acquired images. Normalized calcified area was 0.93±0.04, 0.96±0.06, 1.02±0.05, and 1.07±0.16, for reconstruction kernels from sharp to soft (P<0.001) for simulated images; result was 0.99±0.17 (sharp) vs. 1.09±0.13 (soft) for acquired images (P<0.001). Linear regression analysis indicated that measured calcified area increased as tube voltage decreased or reconstruction kernel became softer (r2>0.98) both for simulated and acquired images. Simulated CT images from digital phantoms resembled the acquired images by CT scanners. Tube voltages and reconstruction kernels significantly affected the extent of calcium blooming artifacts both for simulated and acquired images. The proposed framework for calcium blooming artifacts may provide an in silico testbed for improving coronary CTA interpretation.

PMID 42719256
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-09-09

Machine Learning-Guided Disulfide Modulation of Polyimides for High-Performance and Self-Healable Dielectric Energy Storage.

Wu Xinzhe X, Wang Zhuo Z, Ding Liping L, Guo Yuchen Y et al.

Conventional PI films exhibit excellent thermal stability; however, their weak self-healing under electrical and mechanical stress limits operational reliability. Herein, a machine-learning-guided screening strategy is employed to predict the Eb of sulfur-modulated PI systems, enabling the rapid identification of optimal disulfide incorporation. As a result, a series of PI films with varying disulfide contents (0-30 wt.%) are fabricated. The results reveal a non-monotonic dependence of Eb on disulfide content, with an optimal composition (PI-15) achieving a high Eb of 700 kV mm-1 and a Wdis of 10.02 J cm-3 at RT, together with 670 kV mm-1 and 6.64 J cm-3 at 150°C. Notably, after self-healing, PI-15 retains high performance, with Eb recovering to 675 and 640 kV mm-1 and Wdis to 8.59 and 6.02 J cm-3 at RT and 150°C, respectively. In addition, the films exhibit excellent operational stability under temperature, frequency, and fatigue cycling at 500 kV mm-1. Mechanistically, disulfide incorporation enables a synergistic coupling of strengthened intermolecular interactions and dynamic bond exchange, suppressing charge transport and local field concentration while facilitating structural rearrangement. This work demonstrates new working mechanisms for designing high-performance PI, providing strong potential for high-temperature capacitive energy storage under harsh operating conditions.

PMID 42715092
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PubMedMicroscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada2026-09-09

Room-Temperature FIB-Based TEM Specimen Preparation for Radiation-Sensitive Solid-State Electrolytes.

Hao Ruixin R, Shi Hongsheng H, Gao Tianyi T, Hu Xiangchen X et al.

Focused ion beam (FIB) preparation of garnet-type solid-state electrolytes such as Li6.4La3Zr1.4Ta0.6O12 (LLZTO) is complicated by beam-induced charging, amorphization, and lithium exsolution. In this work, we develop a room-temperature FIB-based transmission electron microscopy (TEM) workflow that effectively mitigates these artifacts without the need for cryogenic protection. Molecular dynamics simulations show that localized electric fields driven by charge accumulation induce defect accumulation, sequential ion loss, and structural collapse, with structural amorphization already emerging at the stage where the detected elemental loss is limited to Li and O. Monte Carlo simulations quantify Ga+ implantation ranges and establish an empirical thickness-voltage relationship to prevent lamella bending. The optimized workflow integrates substrate-supported prethinning, alternating dual-side milling, and low-voltage grazing-incidence polishing, which minimizes Ga+ implantation, Li/O sputtering, and amorphization. The resulting LLZTO lamellae exhibit high crystallinity and chemical fidelity, confirmed by low-dose high-resolution TEM, selected area electron diffraction, and scanning transmission electron microscopy (STEM) imaging at 200 and 300 kV. This combined experimental and computational approach provides a reproducible route for preparing sensitive solid-state electrolyte specimens.

PMID 42713993
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-09-09

Construction of Dual 3D Networks in Boron Nitride/Aramid Nanofiber Films Enables High Thermal Conductivity and Mechanical Performance.

Liao Yun Y, Yang Zefeng Z, Guo Zitong Z, Chen Youning Y et al.

The intrinsically low thermal conductivity of meta-aramid insulation paper used within new energy vehicle drive motors leads to severe heat accumulation, posing a significant threat to operational safety. However, simultaneously achieving high thermal conductivity, superior electrical insulation, and excellent mechanical properties in meta-aramid insulation paper remains a formidable "trade-off" challenge. Herein, this study proposes a functionally decoupled "dual 3D network" strategy. By specifically confining multiscale modified boron nitride within rigid and flexible dual-conformation aramid nanofiber networks, mutually intertwined, dense thermally conductive and load-transfer dual 3D networks are successfully constructed. Benefiting from this unique architecture, the resulting composite film achieves a significant enhancement in both in-plane (18.25 W/(m·K)) and through-plane (0.94 W/(m·K)) thermal conductivities, representing remarkable increases of 4811.5% and 392.4%, respectively. Simultaneously, it endows the film with an outstanding dielectric breakdown strength of 184.1 kV/mm and a robust tensile strength of 96.41 MPa. Under a stringent 150°C oil-immersed thermal aging test, the film also demonstrates exceptional aging resistance. Molecular dynamics (MD) simulations reveal that this strategy triggers dense interfacial hydrogen bonding and intense dipole electrostatic interactions at the molecular scale, which creates robust interfacial anchoring nodes and highly efficient thermal conductive pathways.

PMID 42715001
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