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erythromycin (erythromycin, KV)

✓ Approved

Lumara Health · 治疗药物

什么是 erythromycin？

erythromycin 是一种治疗药物，由Lumara Health研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名erythromycin, KV
公司Lumara Health
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Lumara Health

治疗适应症

erythromycin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsSalmonellosis✓ Approved

相关研究文献

PubMedThe Journal of physiology2026-10-26

KV channels contribute to thermal hyperaemia in skeletal muscle of humans.

Ruiz-Pick Ysabella I YI, Wagle-Babb Sophia G SG, Kichloo Asim A, Olivencia-Yurvati Albert H AH et al.

Localized application of heat is used therapeutically to reduce skeletal muscle pain and improve mobility and recovery in various populations. The efficacy of this thermal therapy is considered to be partly a result of increased blood flow in the skeletal muscle directly exposed to heat (i.e. thermal hyperaemia). However, the mechanisms mediating thermal hyperaemia in skeletal muscle of humans remain poorly understood. Voltage-dependent potassium (KV) channels play a pivotal role linking upstream vasodilatory signals to electro-mechanical mechanisms that mediate vascular smooth muscle relaxation. Therefore, the present study aimed to test the hypothesis that KV channel antagonism would attenuate thermal hyperaemia in skeletal muscle of humans. We used microdialysis to directly measure local blood flow via the ethanol washout technique at two sites in the vastus lateralis muscle of 10 healthy adults (seven women). One probe was perfused with 0.9% saline, whereas the other was perfused with the KV channel antagonist 4-aminopyridine (26.6 mm). Pulsed short-wave diathermy was used to induce deep heating of the vastus lateralis for 90 min. Muscle temperature was measured midway between the microdialysis probes via a thermocouple. Baseline blood flow did not differ between probes (P = 0.684). Pulsed short-wave diathermy increased skeletal muscle temperature through 90 min of heating (P < 0.001). However, the accompanying increase in blood flow at 90 min was attenuated when perfused with 4-aminopyridine (P = 0.0222). These data suggest that KV channels substantially contribute to thermal hyperaemia in skeletal muscle of humans. KEY POINTS: The efficacy of thermal therapy is considered to be partly a result of increased blood flow in the skeletal muscle directly exposed to heat (i.e. thermal hyperaemia). However, the mechanisms mediating thermal hyperaemia in skeletal muscle remain poorly understood. Voltage-dependent potassium (KV) channels play a pivotal role as downstream effectors that mediate vascular smooth muscle relaxation. Therefore, we tested the hypothesis that KV channel antagonism would attenuate thermal hyperaemia in skeletal muscle of humans. Using microdialysis, we found that KV channel antagonism with 4-aminopyridine attenuated thermal hyperaemia at 90 min of localized heating, when this vasodilatory response was the greatest. We identified a critical role for KV channels in human skeletal muscle thermal hyperaemia, establishing these channels as important downstream effectors of this vasodilatory response.

PMID 42928976
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PubMedCurrent oncology (Toronto, Ont.)2026-10-26

Diagnostic CT-Based Palliative Radiotherapy Using kV Image Verification: A Prospective Feasibility Study.

Wei Kelly K, Hui Jason J, Gill Bradford B, Grahame Sheri S et al.

Patients receiving palliative radiotherapy (PRT) often experience substantial symptom burden and may face challenges attending multiple hospital visits. Planning treatment using an existing diagnostic computed tomography (dCT) scan instead of a dedicated computed tomography (CT) simulation may improve access to timely care. This prospective feasibility study evaluated a dCT-based planning workflow using kilovoltage (kV) image verification for patients with bone metastases, with potential applicability to resource-limited settings. Ten patients receiving conventional PRT (8 Gy in 1 fraction or 20 Gy in 5 fractions) with an eligible dCT acquired within 28 days were enrolled. As part of this feasibility study, all patients also underwent standard CT simulation, which served as the dosimetric comparator and fallback treatment pathway. Radiotherapy plans generated on dCT and CT simulation scans were compared for dosimetric quality, while treatment deliverability, patient satisfaction, and estimated carbon emissions were assessed. Seven of ten patients were successfully treated using the dCT workflow. The three remaining patients were transitioned to standard CT simulation treatments due to an uncorrectable dCT image rotation in the planning software (n = 1), scheduling constraints (n = 1), and a larger-than-anticipated difference in patient separation on the treatment unit (n = 1). Target coverage and organ-at-risk doses were comparable between dCT and CT simulation plans, satisfaction among dCT-treated patients was high, and potential avoidance of CT simulation was estimated to reduce carbon emissions by approximately 10 kg carbon dioxide equivalent (CO2e) per patient. These findings demonstrate that dCT-based planning with kV image verification is feasible, provides dosimetry comparable to conventional CT simulation, and warrants further evaluation as a strategy to improve access to timely PRT while reducing healthcare resource use and environmental impact.

PMID 42930144
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PubMedMedical physics2026-10-25

Real-time intrafraction 3D spine tracking using gantry-mounted kV imaging for single fraction high dose functional radiosurgery.

Xing Shu S, Meyer Sebastian S, Zhang Lei L, Zhu Liangjia L et al.

Spinal nerve root ablation of 70-90 Gy with single fraction stereotactic radiosurgery (SRS) delivered in short partial arcs (30-60 degrees) is an emerging treatment for managing chronic thoracoabdominal wall pain. The proximity of the target to spinal cord and the high per fraction dose demand intrafraction motion monitoring with sub-millimeter accuracy. Pre-treatment cone-beam CT (CBCT) and intermittent room-mounted triggered kV imaging do not provide continuous internal anatomical verification during beam delivery. Gantry-mounted real-time tracking solutions have been mostly validated for full arc stereotactic body radiation therapy (SBRT) at substantially lower doses. We report comprehensive evaluations of a gantry-mounted, real-time 3D kV spine tracking system based on template matching of continuously acquired fluoroscopic images. Tracking performance was assessed under the demanding conditions of short-arc, high-dose functional SRS. We also present its first clinical use during spinal nerve root ablation for chronic thoracoabdominal wall pain. We first performed pre-clinical evaluation with an anthropomorphic spine phantom placed on a programmable motion platform. Tracking performance was evaluated at incremental phantom offsets from -4 to 4 mm and varying arc lengths. The detected shifts were compared to the known offset, as well as estimated shifts from CBCT and room-mounted triggered kV imaging system. Moreover, the tracking accuracy was validated clinically in 12 spine SBRT patients using CBCT projections acquired as part of the routine care. The detected shifts were benchmarked against the CBCT-derived shifts, with offline re-analyses at reduced arc lengths. Finally, under an IRB-approved protocol, the real-time tracking system was deployed as a secondary monitor in two patients (three disease sites) receiving 70 Gy frameless single-fraction SRS to the spinal nerve dorsal roots. We evaluated overall tracking performance and compared the detected shifts in vertebral position to CBCT and room-mounted triggered kV system detected shifts. The phantom study demonstrated an average accuracy of 0.2 ± 0.1 mm (maximum: 0.6 mm) in the detected spine position for offsets up to 4 mm. No substantial impact of the arc length was observed, and the agreement with CBCT and room-mounted triggered kV system was within 0.2 mm. The clinical validation with CBCT data showed an average agreement within 0.4 mm in all directions, with maximum deviations of 0.8 mm. During clinical nerve root ablation treatments, the vertebral body was successfully tracked throughout treatment. Intrafraction motion exceeding 1 mm was detected in 2 of 3 sites by our real-time tracking system, prompting corrective CBCTs and couch shifts. The median (interquartile range) difference in the detected vertebra position compared to room-mounted triggered kV system was -0.2(0.6) mm, 0.1(0.4) mm, and -0.1(0.4) mm in vertical, lateral, and longitudinal directions. Our preliminary study demonstrated the feasibility of vertebral body tracking using a real-time 3D kV tracking system during nerve root ablation treatments. Real-time monitoring detected actionable intrafraction motion that prompted couch corrections in 2 of 3 sites, which room-mounted triggered imaging would not have identified until the subsequent arc. This capability might be particularly valuable for short-arc, high-dose treatments, where the window for intrafraction verification is narrow, and the consequence of undetected motion is high.

PMID 42922088
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PubMedJournal of microscopy2026-10-25

A neural network-based Monte Carlo X-ray (MC X-ray) approach for quantitative analysis of homogeneous multi-element bulk samples at 20 kV.

Gao Dawei D, Brodusch Nicolas N, Piché Nicolas N, Gauvin Raynald R

Accurate quantitative analysis of homogeneous bulk samples is critical in materials science and mineral industry applications, yet conventional standards-based Energy Dispersive Spectroscopy (EDS) quantitative analysis remains reliable and widely used. However, for some laboratories or sample types, obtaining, maintaining, or matching appropriate physical standards may be inconvenient or impractical. In this study, we introduce a dynamic framework for elemental quantification of homogeneous multi-element bulk samples investigated in an SEM at an accelerating voltage of 20 kV by integrating Monte Carlo X-ray (MC X-ray), a Monte Carlo simulation program, with artificial neural networks (ANNs). Synthetic spectra and corresponding weight fraction pairs were generated using MC X-ray under the same 20 kV measurement condition, and a multilayer perceptron (MLP) was trained to map spectral features to elemental weight fractions. Validation across 11 certified standard samples yielded root mean square error (RMSE) values from 0.0056 to 0.0179 in weight fraction and coefficients of determination (R2) from 0.9873 to 0.9981, even in cases with overlapping peaks. For elements with certified weight fractions of at least 0.05, the mean absolute percentage error was 4.41%. The model, tailored to specific sample and measurement conditions, enables quantitative analysis in under 15 min on consumer-grade hardware. By reducing the dependence on physical standards and calibration procedures, this approach provides a complementary simulation-based method for quantitative microanalysis when suitable measured standards or stored standard libraries are not readily available for the analysis of homogeneous bulk materials.

PMID 42921765
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PubMedBioorganic chemistry2026-10-25

Development of cinnamyl derivatives as antibiotic-potentiating agents.

Hympanova Michaela M, Kufa Martin M, Muckova Lubica L, Prchal Lukas L et al.

Here, we report the discovery and optimization of 1-cinnamylpiperazine derivatives as antibiotic-potentiating agents inspired by the known RND efflux pump inhibitor 1-(1-naphthylmethyl)piperazine (NMP). A structurally diverse series of analogues was synthesized and evaluated for intrinsic antibacterial activity, cytotoxicity, and ability to potentiate antibiotic activity against Escherichia coli. Most derivatives showed low intrinsic antibacterial activity, consistent with an adjuvant mode of action. In combination assays, several compounds enhanced the antibiotic activity of erythromycin and linezolid, with halogenated derivatives showing the strongest potentiating effects. Compound 27 displayed the broadest potentiation profile, showing synergistic interactions with five of the seven tested antibiotics, namely linezolid, novobiocin, fusidic acid, pyridomycin, and clindamycin. Notably, it showed a superior potency to the structurally related reference inhibitor NMP. Experiments with AcrAB-TolC-deficient E. coli mutants, together with dye accumulation (Hoechst 33342) and membrane-permeabilization assays, suggested that 1-cinnamylpiperazine derivatives modulate efflux-associated resistance in a manner distinct from NMP, with increased membrane permeability likely contributing to their overall potentiating effect. Beyond planktonic cultures, compound 27 also potentiated erythromycin and linezolid against mature E. coli biofilms. These findings identify 1-cinnamylpiperazines as promising antibiotic adjuvant scaffolds for further optimization against drug-resistant Gram-negative infections.

PMID 42927674
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PubMedACS omega2026-10-25

Magnetic Electrospun Polycaprolactone (PCL) Fibers Modified with Oleic Acid-Coated Iron Oxide Nanoparticles.

Morales Angie N AN, Jaime Danay M DM, Barra Guilherme M O GMO

Magnetic polycaprolactone (PCL) fibers containing oleic acid-coated iron oxide nanoparticles (IONPs/OA) were produced by electrospinning. First, a systematic study was carried out to determine the optimal processing parameters, establishing a 20% (w/v) PCL concentration, an applied voltage of 20 kV, a needle-to-collector distance of 22 cm, and a flow rate of 2 mL/h as the most suitable parameters. Homogeneous neat PCL fibers with an average diameter of 543 ± 88 nm were obtained under these conditions. Subsequently, different IONPs/OA concentrations (5, 10, and 20 wt %) were incorporated, leading to a progressive increase in fiber diameter, with a maximum of 961 ± 201 nm for the 20 wt % formulation. Magnetic measurements confirmed superparamagnetic behavior at room temperature for all composite fiber samples, with a maximum saturation magnetization (M s) of 6.1 ± 0.1 emu/g for the 20 wt % formulation. Thermogravimetric analysis revealed that the incorporation of IONPs/OA into the fibers decreased the degradation temperature by approximately 63 °C compared to neat PCL. Finally, water contact angle (WCA) measurements revealed a progressive increase in fiber hydrophobicity, reaching a maximum WCA of 135°. These results indicate that the produced fibers exhibited promising morphological, compositional, thermal and magnetic properties for potential future biomedical applications, such as drug delivery and magnetic hyperthermia.

PMID 42923517
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