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interleukin-2 (Interking)

✓ Approved

Shenzhen Neptunus · IL2RA · 重组蛋白

什么是 interleukin-2？

interleukin-2 是一种重组蛋白，由Shenzhen Neptunus研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)、Subcutaneous Injection。

药物档案

商品名Interking
公司Shenzhen Neptunus
药物类别重组蛋白
分子靶点IL2RA
给药途径Injectable (Others), Intravenous (IV), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Shenzhen Neptunus

作用机制

分子靶点

interleukin-2 作用于 1 个分子靶点：

IL2RAinterleukin 2 receptor subunit alpha (IL2R, TCGFR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

interleukin-2 针对 15 个适应症，涉及 4 个治疗领域。

治疗领域疾病/病症分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Adenosquamous cell lung cancer✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Bladder cancer✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Breast cancer✓ Approved
Infections and infestationsHepatitis B✓ Approved
Infections and infestationsLeprosy✓ Approved

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相关研究文献

PubMedDiabetes/metabolism research and reviews2026-10-26

Exercise Modulates the Osteoimmune Axis: Myokine-Mediated Mechanisms in Diabetic Bone Disease.

Wu Chao C, Zou Jun J, Yuan Yu Y

Patients with type 2 diabetes mellitus (T2DM) often present with normal or even elevated bone mineral density (BMD), yet exhibit a significantly increased fracture risk-a phenomenon referred to as the 'diabetic bone paradox'. This discrepancy underscores the inadequacy of conventional BMD-centred assessment systems in fully elucidating the mechanisms underlying bone fragility in T2DM. Current evidence suggests that T2DM-related skeletal fragility is multifactorial, involving alterations in bone quality, advanced glycation end-product (AGE) accumulation, low bone turnover, microarchitectural deterioration, diabetic complications, increased fall risk and chronic inflammation. Recent advances in osteoimmunology have revealed that immune cell polarization driven by chronic low-grade inflammation, along with an imbalanced receptor activator of nuclear factor-κB ligand/osteoprotegerin (RANKL/OPG) axis, may contribute to the dysregulation of bone remodelling in T2DM. As a cornerstone intervention in T2DM management, exercise not only acts directly on bone tissue via mechanical loading but also may exert systemic immunomodulatory effects through myokines secreted by skeletal muscle. Exercise-induced myokines, such as interleukin-6 (IL-6), irisin, β-aminoisobutyric acid (BAIBA) and interleukin-15 (IL-15), may modulate the osteoimmune microenvironment and restore the dynamic equilibrium between bone resorption and formation by modulating macrophage polarization, restoring the Th17/Treg balance, bone marrow adipose tissue metabolism, and chronic inflammatory signalling pathways. Moreover, exercise may further promote bone metabolic homoeostasis by suppressing negative regulatory signals, such as myostatin. Therefore, this narrative review summarises the aberrant features of the osteoimmune axis in T2DM, with a focus on the potential mechanisms by which exercise and its induced myokines may modulate the osteoimmune microenvironment to ameliorate diabetic bone disease, thereby providing a framework for understanding exercise as a potential non-pharmacological intervention and identifying areas requiring further translational investigation.

PMID 42929066
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PubMedIndian dermatology online journal2026-10-26

Gasdermin B and Interleukin-17 Gene Expression in Psoriasis Vulgaris: A Case-Control Study.

Ghanem Mai M M MMM, Hammam Mostafa A MA, El Derbaly Sara A SA, Rashad Asmaa S AS et al.

Psoriasis vulgaris is a chronic immune-mediated skin disorder characterized by keratinocyte hyperproliferation and T-cell-driven inflammation. Recent evidence suggests a potential role of gasdermin family proteins, particularly Gasdermin B (GSDMB), and the proinflammatory cytokine Interleukin-17A (IL-17A) in its pathogenesis. To assess the gene expression levels of GSDMB and Interleukin-17A in patients with psoriasis vulgaris and explore their relationship with disease severity. This case-control study included 150 subjects: 75 patients with plaque psoriasis and 75 age- and sex-matched healthy controls. Disease severity was assessed using the psoriasis area and severity index (PASI). Quantitative real-time polymerase chain reaction was performed on peripheral blood samples to measure GSDMB and IL-17A mRNA expression. The expression levels of both GSDMB and IL-17A were significantly elevated in psoriasis patients compared with controls ( P = 0.005 and P = 0.001, respectively). Higher gene expression levels were observed in cases with severe psoriasis, with significant correlations between GSDMB and PASI (r = 0.336, P = 0.003), and IL-17A and PASI (r = 0.260, P = 0.024). A strong positive association was also noted between GSDMB and IL-17A expression (r = 0.327, P = 0.004). Small sample size and estimation of gene expression in blood, not in skin lesions. Psoriasis vulgaris is associated with significant upregulation of GSDMB and IL-17A gene expression. These markers may serve as reliable indicators of disease presence and severity, supporting their potential role as diagnostic and prognostic biomarkers in psoriasis.

PMID 42929801
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PubMedShock (Augusta, Ga.)2026-10-26

Preliminary Exploration of the Hepatoprotective Effect of Nanocrystalline Curcumin Against Traumatic Hemorrhagic Shock-Induced Liver Injury in a Desert Dry-Heat Environment: A Network Pharmacology-Based Study.

Chen Changxu C, Shen Caifu C, Shi Chuankai C, Zhou Enning E et al.

Traumatic hemorrhagic shock (THS) under desert dry-heat conditions can exacerbate secondary liver injury, highlighting the need for effective therapeutic interventions. This study investigated the protective effects of nanocrystalline curcumin (NC-Cur) against THS-induced liver injury in a desert dry-heat environment and explored its potential molecular mechanisms. Network pharmacology, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses, and protein-protein interaction network analysis were used to identify candidate targets. Molecular docking and molecular dynamics simulations examined curcumin-protein interactions. Forty male Sprague-Dawley rats were randomly assigned to control, model, solvent, or NC-Cur treatment groups (n = 10 each). The model, solvent, and treatment groups underwent traumatic hemorrhagic shock under desert dry-heat conditions. Hepatic injury was assessed by histopathology, serum aminotransferases, inflammatory cytokines, oxidative stress markers, and Western blotting. Network analysis identified 116 overlapping targets, with heat shock protein 90 alpha A1 (HSP90AA1), AKT serine/threonine kinase 1 (AKT1), and B-cell lymphoma 2 (BCL-2) prioritized as the core targets. Docking predicted favorable interactions with all three proteins, while molecular dynamics simulations supported stable binding between curcumin and HSP90AA1. Compared with untreated model rats, NC-Cur-treated rats showed attenuated hepatic histopathological injury, reduced alanine and aspartate aminotransferases, tumor necrosis factor-α, interleukin-1β, and malondialdehyde, and increased superoxide dismutase. Western blotting indicated reduced HSP90AA1 and increased phosphorylated AKT1 expression after NC-Cur treatment, with changes also observed in BCL-2 expression. These findings suggest that NC-Cur may alleviate liver injury associated with THS under desert dry-heat conditions in male rats, potentially involving HSP90AA1-AKT1-BCL-2-related signaling.

PMID 42929369
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PubMedGels (Basel, Switzerland)2026-10-26

Copper Peroxide-Loaded Dual-Responsive Hydrogel for Enhanced Diabetic Wound Healing Through Oxygen Release and Promotion of Angiogenesis.

Yu Lanqin L, Jia Xiang X, Xu Lejia L, Li Xiaojun X et al.

Diabetic foot ulcers (DFUs) present a major clinical challenge because of persistent hyperglycemia, hypoxia, impaired angiogenesis, and chronic inflammation. Conventional dressings have limited capacity to modulate these pathological processes. Here, we report a glucose/pH dual-responsive hydrogel, denoted CBOD, constructed through a dynamic covalent network comprising Schiff base and boronate ester bonds between phenylboronic acid-grafted chitosan (CS-BA) and dopamine-modified oxidized sodium alginate (OSA-DA). Copper peroxide (CuO2) nanoparticles are encapsulated within this network to form CuO2/CBOD. Under acidic (pH 5.5) and high-glucose conditions, competitive binding and bond hydrolysis promote network relaxation, facilitating the stimuli-dependent release of oxygen and copper ions. In vitro assessments demonstrate good cytocompatibility and enhanced migration and tube formation of human umbilical vein endothelial cells (HUVECs). In a diabetic rat model of full-thickness excisional wounds, the hydrogel accelerates wound closure, with closure approaching 100% by day 14. Treatment is associated with reduced expression of the M1-associated markers interleukin-1β (IL-1β) and cluster of differentiation 80 (CD80), increased expression of the M2-associated markers interleukin-10 (IL-10) and cluster of differentiation 163 (CD163), and enhanced expression of the vascular markers cluster of differentiation 31 (CD31) and alpha-smooth muscle actin (α-SMA). These findings support the potential of CuO2/CBOD as a multifunctional dressing for diabetic wound management.

PMID 42929899
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PubMedDiseases (Basel, Switzerland)2026-10-26

Role of Interleukin 17 in Severe Acute Pancreatitis: Human Retrospective Pilot Study.

Iosif Diana D, Gherghina Viorel V, Suceveanu Andra Iulia AI, Orasanu Cristian Ionut CI et al.

Background/Objectives: Severe acute pancreatitis accounts for 20% of acute pancreatitis episodes and carries a substantial mortality risk. The systematic severity of the disease is driven by a massive cytokine release, with Interleukin-17 (IL-17) acting as a crucial modulator of the pro-inflammatory cascade. This study aimed to evaluate the prognostic value of serum IL-17 at admission and correlate it with multi-organ dysfunctions and clinical-biological outcomes in patients with severe acute pancreatitis. Methods: A retrospective analysis was conducted on a cohort of 35 patients with severe acute pancreatitis. Demographic, etiological, and clinical-biological baseline characteristics were extracted. Serum IL-17 levels were determined at admission using the ELISA method, and data were statistically analyzed. Results: Significantly higher levels of IL-17 were observed in patients who developed multi-organ failure. Prognostic thresholds were identified via ROC analysis to predict organ dysfunctions: ≥19.77 pg/mL for neurological dysfunction (AUC = 0.814, p = 0.003) and acute respiratory distress syndrome (AUC = 0.756, p = 0.024); ≥18.45 pg/mL for respiratory (p = 0.004) and cardiovascular dysfunctions (AUC = 0.820, p = 0.002); and ≥19.81 pg/mL for renal dysfunction (AUC = 0.735, p = 0.020). Furthermore, univariate binary logistic regression identified elevated serum IL-17 as a significant prognostic factor for mortality among patients admitted to the intensive care unit (OR = 1.062, p = 0.048). Conclusions: Serum IL-17 at admission functions as a significant prognostic biomarker that reflects the severe systemic pro-inflammatory status in severe acute pancreatitis and mirrors the risk of subsequent organ dysfunctions and mortality. Incorporating IL-17 into initial risk stratification protocols may assist clinicians in timely therapeutic escalation.

PMID 42929978
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PubMedDentistry journal2026-10-26

Effects of E-Cigarette Aerosol Extracts on Human Neutrophil Viability and Inflammatory Responses to Streptococcus mutans.

Tabnjh Abedelmalek Kalefh AK, Lingström Peter P, Campus Guglielmo G, Christenson Karin K et al.

Background/Objective: The increasing use of electronic cigarettes (e-cigarettes) has raised concerns about their possible effects on oral immune responses. Neutrophils are essential for host defense against cariogenic bacteria such as Streptococcus mutans (S. mutans), and impaired neutrophil function may facilitate the progression of oral diseases. This study aims to investigate whether exposure to vaping aerosols alters neutrophil viability, oxidative responses, and proinflammatory cytokine production in response to the cariogenic bacterium S. mutans. Methods: Human neutrophils isolated from healthy donors were exposed to e-cigarette aerosol extracts produced from flavored and unflavored e-liquids, with and without nicotine. Cytotoxicity was determined by measuring lactate dehydrogenase (LDH) release. Intracellular reactive oxygen species (ROS) generation following S. mutans exposure was used as an indirect measure of neutrophil phagocytic activity. Pro-inflammatory cytokines (interleukin-1 beta (IL-1β) and interleukin-8 (IL-8)) were measured using an enzyme-linked immunosorbent assay (ELISA). Results: Under the tested conditions, e-cigarette aerosol extracts did not cause significant cytotoxicity. However, in neutrophils stimulated with S. mutans, certain flavorings (particularly tobacco and dessert-related flavors) significantly reduced ROS generation, suggesting impaired antimicrobial responses. In contrast, fruit and mint flavors had little impact. Minor flavor-dependent differences were observed for IL-1β and IL-8. The presence of nicotine did not significantly affect the levels of these cytokines. Conclusions: Aerosol extracts from e-cigarettes altered neutrophil oxidative responses in a flavor-dependent manner but did not cause significant cytotoxicity. These findings suggest mild immunological modulation rather than a direct inflammation effect and indicate that e-cigarette aerosols may alter antimicrobial responses despite having minimal effects on IL-1β and IL-8.

PMID 42930411
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