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Rho(D) Immune Globulin

✓ Approved

CSL Limited · 多克隆抗体 · 多克隆抗体

什么是 Rho(D) Immune Globulin？

Rho(D) Immune Globulin 是一种多克隆抗体，由CSL Limited研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

公司CSL Limited
药物类别多克隆抗体, 抗体
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, CSL Limited

治疗适应症

Rho(D) Immune Globulin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Congenital, familial and genetic disordersRhesus haemolytic disease of newborn✓ Approved

相关研究文献

PubMedSports (Basel, Switzerland)2026-07-27

Relationship Between Emotional States, Emotion Regulation and Executive Functions in Professional Female Football Players.

Gómez-Rosales Alan de Jesús AJ, Ortiz-Jiménez Xóchitl Angélica XA, Sanchez-Lopez Javier J

Football performance depends on multiple interacting factors, including physical, technical, tactical, and psychological components. Among the psychological factors associated with optimal performance are athletes' emotional states, their regulation, and executive functions. Although executive functions and emotional states have been widely studied in sport settings, research examining the relationship between these variables in athletes is limited, particularly in female football players. The aim of this study was to explore the relationship between emotional states, emotional regulation, and performance on cognitive tasks in female players from the Mexican football league. Twenty-eight players participated in two individual assessment sessions in which anxiety and depression levels, emotional regulation, and executive functions-planning, inhibitory control, working memory, and cognitive flexibility-were evaluated using psychological and neuropsychological tests. Results indicated a positive correlation between decision-making and emotional attention (rho = 0.36; p < 0.05), as well as between depression levels and onset latency in a working memory task (rho = 0.38; p < 0.04). Finally, a negative correlation was identified between the percentage of risk cards and the TMMS attention score (rho = -0.47; p < 0.01). These findings suggest associations between emotional processes and cognitive functioning in professional female football players and warrant further investigation in sport-performance settings.

PMID 42506811
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PubMedActa physiologica (Oxford, England)2026-07-27

From the Perspective of the Peripheral Sensory Nervous System: The Role of Vitamin D in Neurogenic Inflammatory Skin Disorders.

Commaroto Sarah A SA, Granstein Richard D RD

Vitamin D (VD) is a secosteroid hormone with critical physiologic roles in calcium homeostasis and bone mineralization. Recently, studies have uncovered VD's broader effects on immune system and nervous system function. VD receptors (VDRs) and enzymes responsible for the metabolism of VD have been discovered in dorsal root ganglion (DRG) neurons and nociceptive sensory neurons, implicating VD as a potential regulator of neurogenic inflammation. Neurogenic inflammation is a phenomenon in which sensory nerve fibers in the peripheral nervous system (PNS) are activated and release neuropeptides such as substance P (SP) and calcitonin gene-related peptide (CGRP), resulting in vasodilation, cytokine production, and immune cell infiltration. This process has been shown to drive chronic inflammatory skin disorders, including atopic dermatitis (AD) and psoriasis. VD has been recognized as a key factor in the pathogenesis and management of both conditions; however, the mechanism underlying its clinical benefits remains unclear. Emerging evidence has shown VD to influence CGRP signaling, interleukin-6 (IL-6) production, and TRPV1 channel activity-pathways that are integral to nociception and pruritus, as well as the Th17- and Th2-driven inflammation seen in psoriasis and AD, respectively. Thus, this review provides an overview of VD's possible mechanistic role in neurogenic skin inflammation and the implications of these pathways for identifying new therapeutic targets for psoriasis and AD.

PMID 42503299
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PubMedMedical sciences (Basel, Switzerland)2026-07-27

Serum Catestatin Level as a Novel Biomarker of Oral Lichen Planus.

Karan Mia Roglic MR, Martinovic Dinko D, Puizina Ema E, Martinovic Lovre L et al.

Background/Objectives: Oral lichen planus (OLP) is a chronic immune-mediated disease of the oral mucosa in which T-cell infiltration, epithelial injury, and stress-related neuroendocrine signaling appear to intersect. Catestatin (CST), a peptide generated from chromogranin A (CgA), modulates catecholamine release and inflammatory cell responses; however, its association with localized mucosal inflammation in OLP has not been clarified. This study aimed to compare serum CST levels between OLP patients and healthy controls and to examine their association with clinical subtype, disease severity, and vitamin D status. Methods: In this cross-sectional study, 51 patients with clinically and histopathologically confirmed OLP and 60 healthy controls were enrolled at the University Hospital of Split. Serum CST was quantified using ELISA. OLP severity was assessed with the REU score by a single experienced oral medicine examiner who was blinded to laboratory results, and pain and burning were recorded separately using 0-10 VASs. Results: Serum CST levels were significantly higher in OLP patients compared to healthy controls (p < 0.001). CST levels showed a strong positive correlation with the REU total score (r = 0.781, p < 0.001), as well as with VAS pain (r = 0.708, p < 0.001) and VAS burning (r = 0.729, p < 0.001). Erosive OLP exhibited significantly higher CST levels compared to the non-erosive subtype (p < 0.001). Furthermore, serum vitamin D levels were significantly lower in OLP patients (p < 0.001), with no significant correlation observed between CST and vitamin D levels. Conclusions: Serum CST levels were higher in OLP patients and showed close associations with REU scores and symptoms, with the strongest signal observed in erosive disease. CST may therefore contribute to the neuroendocrine-immune profile of OLP and may be useful as an adjunctive marker of clinically active or erosive disease. Larger prospective studies including salivary and tissue-based CST measurements are needed before CST can be used for routine monitoring.

PMID 42506385
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PubMedOral health & preventive dentistry2026-07-27

Association between Albumin-to-Globulin Ratio and Periodontitis: A Cross-Sectional and Mendelian Randomisation Analysis.

Wang Jiakui J, Xie Pengxian P, Kang Zhengqiang Z

Periodontitis has been linked to systemic inflammation and nutrition. The albumin-to-globulin ratio (AGR) is a readily available inflammatory and nutritional index, but its relationship with periodontitis remains to be fully clarified. This study examined the association between AGR and periodontitis using the National Health and Nutrition Examination Survey (NHANES) data and Mendelian randomisation (MR). The cross-sectional analysis included 10,094 participants from NHANES 2009-2014. Weighted multivariable logistic regression, restricted cubic splines (RCS), subgroup analyses, and threshold effect analysis were performed. Furthermore, MR analysis was conducted using genetic data for AGR (98,626 individuals) and periodontitis (9,560 cases and 169,166 controls) to further evaluate the relationship. After fully adjusting for confounders, logistic regression shows elevated AGR was associated with lower odds of periodontitis (OR = 0.52, 95% CI: 0.40-0.67). The top quartile group had 44% fewer cases of periodontitis than the lowest quartile group (OR = 0.56, 95% CI: 0.46-0.68). The RCS revealed an L-shaped nonlinear association between AGR and periodontitis. Threshold effect analysis showed that when AGR 1.79, higher AGR was significantly associated with lower odds of periodontitis (OR = 0.37, 95% CI: 0.28-0.50). Stratified analyses suggested a stronger association among participants aged 60 years. MR did not substantiate a genetic correlation between AGR and periodontitis (p = 0.304). Higher AGR was associated with a lower prevalence of periodontitis, particularly among adults aged 60 years. However, MR analysis did not provide genetic evidence supporting this link. Prospective studies are needed to clarify this relationship.

PMID 42506964
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PubMedNeurogastroenterology and motility2026-07-27

EndoFLIP Guided Assessment of Pyloric Distensibility Identifies Associations With Delayed Gastric Emptying and Symptoms of Gastroparesis.

Chakraborty Subhankar S, Spandorfer Adam A, Bonilla Flavio F, Gofar Kebire K et al.

Pyloric dysfunction assessed by EndoFLIP has been implicated in the pathogenesis of gastroparesis. However, the relationship between pyloric dysfunction, gastric emptying, and severity of gastroparesis symptoms remains unclear. Investigate the association of pyloric distensibility index (DI) and area under the curve (AUC) for a DI to volume curve with percent of gastric retention and severity of gastroparesis symptoms. We retrospectively reviewed the electronic charts of 321 adult patients who underwent graded pyloric sphincter distension over a range of 30-70 mL balloon volume using an EF-322 EndoFLIP catheter during a sedated upper endoscopy. To be included in the analysis, participants should have also completed questionnaires about severity of gastroparesis symptoms before EndoFLIP (n = 229). Gastric emptying study (GES) test results completed within the last 10 years were abstracted from chart review (n = 132). AUC for adjacent balloon volumes (40-50, 50-60 and 60-70 mL) were calculated using the trapezoid formula. Associations between DI, AUC, gastric emptying and GI symptoms were assessed using non-parametric independent sample tests, and Spearman's correlation. Receiver operating characteristic (ROC) curve was used to calculate the ability of DI and AUC to distinguish between those with normal and abnormal gastric emptying. Median age of the study population was 50 years (IQR 20.0). Majority of patients were female (79.9%), and White (89.1%). More than half of those with prior GES had gastroparesis (N = 68, 51.5%). Pyloric DIs at 60 and 70 mL and AUCs at 50-60 and 60-70 mL were smaller in those with delayed gastric emptying compared to those with normal gastric emptying. Pyloric DI at 50 mL (rho = -0.16, p = 0.014) and AUCs at 40-50 mL (rho -0.16, p = -0.018) and 50-60 mL (rho = -0.16, p = 0.019) showed significant associations with severity of stomach fullness, decreasing as severity of the symptom worsened. Pyloric DI of 8.9 mm2/mmHg at 60 mL (94.7% sensitive, 26.2% specific, AUC 0.61, p = 0.029) and 6.25 mm2/mmHg at 70 mL (92.5% sensitive, 31% specific, AUC 0.62, p = 0.038) distinguished between normal and delayed gastric emptying. In linear mixed-effects modeling, anesthesia type demonstrated a volume-dependent effect on pyloric DI, with monitored anesthesia care (MAC) associated with higher DI than general anesthesia (GA) at increasing balloon volumes (anesthesia × volume p < 0.001). Further, female sex was independently associated with lower DI (β -3.55, p = 0.002), but this was offset by a significant anesthesia × gender interaction, whereby females exhibited relatively higher DI under monitored anesthesia care compared to general anesthesia (β +3.49, p = 0.005). Pyloric sphincter DI and AUC at higher balloon volumes differentiated those with normal from those with delayed gastric emptying. The relationship with severity of gastroparesis symptoms was limited to stomach fullness. The effect of type of anesthesia on pyloric distensibility depends on balloon volume and sex of the patient. Pyloric DI and AUC at 60 and 70 mL could be helpful to phenotype the pyloric sphincter in patients with gastroparesis symptoms.

PMID 42504491
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PubMedJournal of personalized medicine2026-07-27

The Immune System and the Plural Autisms: A Narrative Review.

Whiteley Paul P, Carr Kevin K, Shattock Paul P, Hooper Malcolm M et al.

Plural autisms offer one important way of organising the massive heterogeneity that is currently included under the singular diagnostic label of autism spectrum disorder (ASD). Characterised exclusively by behavioural criteria related to social communication skills and restricted or repetitive patterns of symptoms, the observable diversity in presentations and developmental trajectories partially explains the lack of universally applicable biomarkers and answers about underlying biology. One particularly important area potentially pertinent to several manifestations of the plural autisms is a connection to the immune system, whether noted across differing patterns of immune functions or following immune challenge in the context of inflammatory processes exerting an effect on developmental processes and behaviour. Utilising a narrative review, we highlight various research analysing a role for immune functions in the context of the heterogeneous autisms stretching across under-, over- and autoimmune processes. Current evidence for immune system involvement in various autisms carries considerable limitations, and studies are often based on small sample sizes, focusing on selective clinical subgroups, and using case-based observations. Notwithstanding the available evidence, substantial and more detailed further studies are required in relation to immune-related screening, building also on the currently limited evidence on the potential usefulness of personalised immune-affecting interventions following appropriate screening and identification of pertinent immune-related issues.

PMID 42506105
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