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leuprolide

✓ Approved

AimPharma · GNRHR · 小分子

什么是 leuprolide？

leuprolide 是一种小分子，由AimPharma研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection。

药物档案

公司AimPharma
药物类别小分子, 多肽类
分子靶点GNRHR
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved
来源： ClinicalTrials.gov, AimPharma

作用机制

分子靶点

leuprolide 作用于 1 个分子靶点：

GNRHRgonadotropin releasing hormone receptor (HH7, GRHR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

leuprolide 针对 4 个适应症，涉及 3 个治疗领域。

治疗领域疾病/病症分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Prostate cancer✓ Approved
Reproductive system and breast disordersEndometriosis✓ Approved
Endocrine disordersPrecocious puberty✓ Approved
Reproductive system and breast disordersUterine fibrosis✓ Approved

相关研究文献

PubMedGels (Basel, Switzerland)2026-07-27

A Dual-Functional Zr-Ion Crosslinked PVA-Alginate Hydrogel with Embedded ZrMgFe-LDH for Enhanced Phosphate Recovery.

Tang Fengqin F, Xiong Runwen R, Zou Shiqi S, Ma Xiaomei X et al.

Excess phosphate in aquatic environments can trigger eutrophication and pose risks to ecosystem integrity and public health, even though phosphate is indispensable for plant growth. Herein, we report the fabrication of Zr-LDHs-PS hydrogel microspheres by in situ cross-linking zirconium-magnesium-iron layered double hydroxides (ZrMgFe-LDHs) with Polyvinyl alcohol (PVA) and sodium alginate (SA). The resulting bead-type adsorbent was designed to enable efficient phosphate capture from water while facilitating subsequent, controlled phosphate release. Benefiting from the cross-linking granulation strategy, the microspheres mitigate typical limitations of powdered adsorbents, including compaction, aggregation, and poor separability. General characterization (SEM, FT-IR, XPS, XRD, BET, TG, and zeta potential) elucidated the microstructure and surface chemical composition. The Zr-LDHs-PS microspheres exhibited a maximum experimental adsorption capacity of 51.313 mg/g. Kinetics data were best fitted by the pseudo-second-order model, and adsorption isotherms were subjected to the Freundlich model, pointing to heterogeneous, multilayer adsorption. Importantly, high phosphate selectivity was preserved despite the coexistence of competing anions (Cl-, NO3-, and CO32-). After adsorption, the spent beads released phosphate gradually in water, highlighting their potential for dual functionality. Collectively, these results demonstrate that Zr-LDHs-PS hydrogel microspheres are promising candidates for extraction-based phosphate removal and resource recovery, with prospects for repurposing slow-release phosphate fertilizers to support sustainable plant nutrition.

PMID 42505254
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-07-27

A Wearable Extracorporeal Device for Imaging-Guided Therapy of Sepsis Through Rapid Removal of Bacteria.

Li Yingping Y, Mo Zhongzhu Z, Yang Qingping Q, Chen Yuxin Y et al.

Sepsis is a severe infectious disease triggered by pathogenic bacteria invading the bloodstream, with mortality risk increasing by 7%-9% for each hour of delayed treatment. Real-time pathogen monitoring and rapid intervention are crucial for the timely and effective management of sepsis. Here, we show that a wearable extracorporeal blood purification device, filled with bioorthogonal polydimethylsiloxane (PDMS) microspheres, can effectively remove bacteria while allowing for visual monitoring of bacteria clearance. The PDMS microspheres exhibit excellent stability in the bloodstream and enable efficient bacterial removal by coupling with metabolic engineering. Moreover, the extracorporeal device serves as a visual window, enabling real-time monitoring of the removal process via NIR II fluorescence imaging of captured bacteria with Ag2Se quantum dot-based nanoprobes. In both rabbit and porcine sepsis models, over 99.5% of bacteria are removed from the bloodstream within 3.5 h, while in situ quantification of removal efficacy is achieved simultaneously, promoting immune homeostasis restoration and rapid resolution of sepsis. The device offers a promising theranostic platform for real-time management of sepsis.

PMID 42504393
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PubMedJournal of immunological methods2026-07-27

A method for preparing monodisperse superparamagnetic carboxylated magnetic beads for immunoassay.

Wang Zigui Z, Li Guilin G, Liu Jiazhen J, Zhao Qiaohui Q et al.

The seed swelling/templating method remains a gold standard for producing monodisperse immunomagnetic beads, but it has several drawbacks. It cannot yield beads with high magnetic content, affecting their detection rates in immunodiagnostics. Conventional methods are inefficient and costly, often using nitro or amino groups for iron ion adsorption, which also raises safety and environmental concerns. Additionally, many commercially available beads have poor corrosion resistance, risking iron ion leakage during use. To address these issues, we improved the seed swelling method to achieve higher batch production and the following advantages: 1. The resulting immunomagnetic beads have uniform particle sizes and magnetic contents up to 40%; 2. Carboxylated porous microspheres were introduced for iron ion adsorption, improving experimental ease and environmental impact; 3. Enhancements in the encapsulation process significantly boosted corrosion resistance, allowing the beads to maintain stable magnetism for 16 h in a 5% EDTA solution.

PMID 42503391
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PubMedLangmuir : the ACS journal of surfaces and colloids2026-07-27

The Role of Extracted Free Chains in Adhesion on Soft Gel Surfaces.

Qian Wenjie W, Zhang Keli K, Xu Qin Q

Adhesion on soft polymeric materials is crucial for many engineering applications. However, the substantial surface deformations of compliant substrates present challenges for classical contact theory in describing the adhesion behavior. Furthermore, surface contact can drive the migration of free solvent within polymer networks, further complicating the governing physics of soft adhesion. In this work, we used dual-wavelength confocal microscopy to characterize how contact-induced extraction of free chains affects the adhesion profiles of microspheres on soft silicone gels with varying cross-linking densities. Locally, a phase separation region emerged near the contact points while the balance of surface stresses was preserved. Globally, the indentation depth and contact radius of the spheres were described by incorporating the competition between adhesion energy and surface stress into classical contact models. Over extended measurement periods, we imaged in situ a slow increase in the indentation depth of attached spheres in all experiments. This finding indicates a gradual rise in adhesion energy, occurring on a time scale consistent with poroelastic diffusion in soft silicone gels.

PMID 42504404
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PubMedNanomaterials (Basel, Switzerland)2026-07-27

Ni Supported on Hollow CeO2 Microspheres with Controllable Shell Thickness for Catalytic Dry Reforming of Methane.

Liu Junyi J, Cui Hongyu H, Cao Tianqi T, Zhang Chuanhui C

CeO2 hollow nanospheres were fabricated through a hard template-assisted route, with the shell thickness precisely tuned by varying the usage amount of Ce(NO3)3·6H2O. Ni was subsequently deposited onto the xCeO2-H (x = 6, 8, 10) supports via an incipient wetness impregnation method, affording Ni/6CeO2-H, Ni/8CeO2-H, and Ni/10CeO2-H catalysts, which were evaluated for catalytic dry reforming of methane (DRM). Notably, the Ni/6CeO2-H catalyst delivered stable CH4 and CO2 conversions of 70% and 76%, respectively, with an H2/CO molar ratio of 0.81 over a reaction period of 50 h at 750 °C, demonstrating exceptional catalytic stability. Comprehensive characterization revealed that the Ni/6CeO2-H catalyst featured stronger metal-support interaction (MSI) and abundant basic sites, which synergistically enhanced CO2 adsorption and activation, thereby endowing the catalyst with superior coke resistance. In situ infrared spectroscopy further elucidated the DRM reaction mechanism, revealing that surface -OH groups played a pivotal role in suppressing coke formation and sustaining high reaction efficiency by reacting with carbon precursor species (CHx*).

PMID 42506502
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PubMedACS applied materials & interfaces2026-07-27

Flexible Radioactive Patch: Reshaping the Paradigm for Scar and Cutaneous Tumor Treatment.

Huang Qian Q, Wang Jie J, Wang Dong D, Qin Yu Y et al.

The treatment of skin diseases, including hypertrophic scars and cutaneous melanoma, remains clinically challenging. Conventional radionuclide (e.g., 90Sr, 32P) patches for beta-ray external beam radiotherapy suffer from rigid structures, leading to off-target irradiation, uneven radionuclide distribution, inconsistent dosing, and potential leakage risks. To address these limitations, we developed an innovative, flexible radioactive patch (32P-RU) by integrating 32P-loaded resin microspheres with boric acid-modified flexible polydimethylsiloxane (PBDMS) gel (P4U), enabling robust adsorption of H32PO42-, homogeneous distribution, and precise, repeated reshaping to conform to irregular lesions. As a pure beta emitter, 32P (Emax = 1.71 MeV, T1/2 = 14.28 d, tissue penetration depth = 4 mm) minimizes damage to adjacent normal tissues. In preclinical models, 32P-RU demonstrated significant therapeutic efficacy: in rabbit ear hypertrophic scar models, five 4 Gy fractions reduced scar volume and improved collagen organization; in murine subcutaneous melanoma models, five 8 Gy fractions effectively suppressed tumor growth. Notably, combining 32P-RU with the immune checkpoint inhibitor (anti-PD-L1) synergistically enhanced anti-tumor effect, promoting dendritic cell maturation, increasing CD8+ T cell infiltration, and suppressing both primary and distant tumors. This conformal, safe, and effective 32P-RU patch offers a strategy for the precise treatment of superficial skin diseases, including refractory cutaneous malignancies.

PMID 42504417
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