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DTwP-HepB-Hib-IPV vaccine (Easysix)

✓ Approved

Panacea Biotec Limited · 重组蛋白 · 重组蛋白

什么是 DTwP-HepB-Hib-IPV vaccine?

DTwP-HepB-Hib-IPV vaccine 是一种重组蛋白,由Panacea Biotec Limited研发。该药已获批,用于治疗相关适应症,给药途径:Injectable (Others)、Intramuscular (IM) Injection。

药物档案

商品名Easysix
公司Panacea Biotec Limited
药物类别重组蛋白, 疫苗
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved

治疗适应症

DTwP-HepB-Hib-IPV vaccine 针对 5 个适应症,涉及 2 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsDiphtheria✓ Approved
Infections and infestationsHepatitis B✓ Approved
Infections and infestationsPertussis✓ Approved
Infections and infestationsTetanus✓ Approved
Surgical and medical proceduresPolio immunisation✓ Approved

相关研究文献

PubMedEuropean journal of investigation in health, psychology and education2026-10-26

Validation of the Brief Pathological Narcissism Inventory and Its Association with Cyber Intimate Partner Violence in Portuguese Emerging Adults.

Rego Mónica M, Caridade Sónia S

Cyber intimate partner violence (C-IPV) refers to abusive and controlling behaviors enacted through digital technologies toward a current or former intimate partner. Previous research suggests that pathological narcissism may be associated with C-IPV. This study examined the psychometric properties of the Brief Pathological Narcissism Inventory (B-PNI), the frequency of self-reported C-IPV perpetration and related behaviors, and the association between C-IPV perpetration and pathological narcissism among emerging adults. The sample comprised 371 participants aged 18-25 years (M = 21.52, SD = 1.97), of whom 78.7% were female. Confirmatory factor analysis provided support for the a priori two-factor model of the B-PNI (CFI = 0.982, TLI = 0.965, RMSEA = 0.076), comprising grandiose and vulnerable narcissism. The B-PNI showed satisfactory internal consistency and theoretically expected associations with psychopathological symptoms and broader personality dimensions. Overall, 79.5% of participants reported at least one C-IPV behavior, with 61.5% reporting online control, 62.0% online jealousy, and 31.5% online intrusive behaviors. C-IPV perpetration was positively and significantly associated with both grandiose and vulnerable narcissism, although the associations were small in magnitude. The findings provide preliminary support for the use of the B-PNI among Portuguese emerging adults and indicate that pathological narcissism is associated with C-IPV perpetration. Given the modest magnitude of these associations, narcissistic traits should be considered as one of multiple individual and relational factors potentially involved in C-IPV.

PMID 42930218
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PubMedTrauma, violence & abuse2026-10-26

Increasing Language Access for Intimate Partner Violence Support Services: A Scoping Review.

Richey Ann E AE, DiMascolo Lisa D LD, Bender Anna E AE, Bhattacharya Anindita A et al.

Intimate partner violence (IPV) is a significant public health concern. Survivors face numerous barriers to accessing services, particularly when services in many places are only provided in English. This scoping review aimed to identify research and practice-based articles that explore interventions to increase language accessibility to support services for IPV. Articles were identified through a systematic search of databases and selected for inclusion if they involved language accessibility for IPV support services across settings (e.g., legal services, advocacy, hotlines, social services, healthcare, law enforcement). We identified 15 research and 14 practice-based articles for inclusion. Most interventions and practices for increasing language access were in settings related to health care, advocacy and social services, or community-based organizations. Research articles described various adaptations to interventions for increasing language access, which mostly included interpretation, translation, bilingual assistance, and culturally tailored programs. All research articles had language access adaptations for their intervention, but only 60% of the research articles included specific findings related to language access and culture. Practice-based articles discussed guidance around the development, assessment, and evaluation of a language access plan, language access engagement and implementation, and different elements and settings for language access. Findings highlight the intersection between language and culture, underscoring the need to address these interconnected aspects beyond simple translation and interpretation. IPV support services should hire multilingual and multicultural staff and address fear around immigration status. Increased funding is needed to ensure higher quality language access supports are implemented. Additional implications for research, practice, and policy are discussed.

PMID 42929235
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PubMedCancer discovery2026-10-26

First mRNA Cancer Vaccine Succeeds in Phase III Trial.

Adding the mRNA-based individualized neoantigen vaccine intismeran autogene to the PD-1 inhibitor pembrolizumab following surgery for melanoma reduced the risk of disease recurrence or death by 42%, according to the results of the phase III INTerpath-0001 trial. The data were presented at the ESMO Congress 2026, held October 23-27, in Madrid, Spain.

PMID 42929716
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PubMedAnimal health research reviews2026-10-26

Innovative vaccine strategies for sustainable control and eradication of peste des petits ruminants virus.

Bello Muhammad Bashir MB, Hameed Sodiq A SA, Abdullahi Adama Musa AM, Lawal Nafi'u N et al.

PMID 42929676
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PubMedEpidemiologia (Basel, Switzerland)2026-10-26

A Carriage-Structured Model of Meningococcal Meningitis: Backward Bifurcation, Seasonal Recurrence, and the Reach of Conjugate-Vaccine Strategies in the African Meningitis Belt.

Gatyeni Siphokazi Princess SP

Epidemic meningococcal meningitis in the African meningitis belt recurs on two timescales: a sharp annual dry-season peak and irregular multi-annual epidemics five to twelve years apart, whose mechanistic origin remains unsettled. Invasive disease is a rare, dead-end outcome of asymptomatic nasopharyngeal carriage, so susceptible-infectious templates misrepresent community transmission. We ask how carriage structure shapes bifurcation, seasonal recurrence, and the reach of conjugate-vaccine strategies. We formulate a deterministic carriage-structured model in which only carriers transmit, immunity against re-acquisition is leaky, and a conjugate vaccine is imperfect and wanes. We use the Castillo-Chavez-Song centre manifold method, numerical continuation, Floquet and eigenvalue analysis, and scenario simulations of abstract rate- and pulse-type interventions parameterised from published belt ranges. The basic reproduction number R0 is a property of carriage transmission, decoupled to first order from disease incidence. Backward bifurcation at R0=1 is governed by a threshold ε∗ on carriage-blocking immunity; only the untreated fatality hazard and treatment capacity are absent from the local condition. It is impossible without vaccination and, with any positive routine coverage, persists across the plausible coverage range, giving vaccine-induced bistability. Continuation confirms a fold at R0,c≈0.946 (φ=0.12yr-1, weak carriage immunity), but not at baseline immunity. Under seasonal forcing, dynamics converge to a simple annual cycle throughout the region searched; we found no multi-annual recurrence, although damped eigenmodes of the unforced system have periods overlapping the observed interval. Within this deterministic, single-strain model, irregular recurrence likely requires additional structure, with stochastic amplification of damped cycles a natural next step. Whether sustained immunisation eliminates epidemics or merely postpones them may depend on the same carriage-efficacy threshold that governs the bistability result.

PMID 42930328
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PubMedJournal of virology2026-10-26

Early innate immune signatures correlate with Ad26.COV2.S vaccine immunogenicity and protective efficacy.

Colarusso Alessandro A, Stephenson Kathryn E KE, Collier Ai-Ris Y A-RY, Wegmann Frank F et al.

The innate immune system is rapidly activated following antigen exposure and plays a critical role in shaping the ensuing adaptive immune responses. In this study, we performed bulk RNA sequencing and proteomic profiling in a cohort of 25 rhesus macaques following Ad26.COV2.S immunization to characterize early innate correlates of vaccine immunogenicity and protection. Our results show that innate immune activation occurred as early as day 1 post-vaccination and demonstrated a systemic enrichment of antiviral interferon pathways, cytokine signaling, and activation of innate immune cell signatures. These early transcriptomic signatures correlated positively with humoral and cellular immune responses at 6 weeks following vaccination and correlated inversely with viral loads following SARS-CoV-2 challenge. Similar correlates of immunogenicity were observed in a cohort of 25 adult healthy participants vaccinated with Ad26.COV2.S. Taken together, these findings highlight the importance of early activation of the innate immune responses following Ad26.COV2.S vaccination in shaping the protective adaptive immune response.IMPORTANCEEarly innate immune responses may shape vaccine immunogenicity and protection. We evaluated responses to Ad26.COV2.S vaccination in rhesus macaques and humans and found that day 1 innate immune signatures correlated with subsequent adaptive responses. These findings suggest that early post-vaccination immune programming influences immunogenicity and protective efficacy months later.

PMID 42929544
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