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DTwP-HepB-Hib-IPV vaccine (Easysix)

✓ Approved

Panacea Biotec Limited · 重组蛋白 · 重组蛋白

什么是 DTwP-HepB-Hib-IPV vaccine?

DTwP-HepB-Hib-IPV vaccine 是一种重组蛋白,由Panacea Biotec Limited研发。该药已获批,用于治疗相关适应症,给药途径:Injectable (Others)、Intramuscular (IM) Injection。

药物档案

商品名Easysix
公司Panacea Biotec Limited
药物类别重组蛋白, 疫苗
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved

治疗适应症

DTwP-HepB-Hib-IPV vaccine 针对 5 个适应症,涉及 2 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsDiphtheria✓ Approved
Infections and infestationsHepatitis B✓ Approved
Infections and infestationsPertussis✓ Approved
Infections and infestationsTetanus✓ Approved
Surgical and medical proceduresPolio immunisation✓ Approved

相关研究文献

PubMedJournal of interpersonal violence2026-09-10

Measuring Physical and Sexual Intimate Partner Violence Experiences: Comparison of Indirect and Direct Methods in Kenya.

Williams Anaise A, Stamas Nicole N, Wood Shannon N SN, Tayel Salma S et al.

Intimate partner violence (IPV) threatens women's health; hence, accurate measurement is critical. Indirect questioning via list experiments or item-count methods offers added privacy and may minimize underreporting. However, less is known about participants' ability to answer item counts and, critically, how indirect assessment compares with direct methods. To advance these questions, our list experiment adaptation entails indirect lists (with and without the IPV question for item-count comparison) and direct questioning, for sexual and physical IPV experience separately. By not constraining item-count responses, we assess list experiment numerical comprehension. The study aims to examine (a) numerical comprehension for indirect assessment and (b) the difference in past-year IPV prevalence estimation generated via indirect versus direct measures. A 2024 cross-sectional survey with partnered women was conducted across four Kenyan counties (n = 3,323). Numerical comprehension was indicated by a non-plausible difference in the five-item and four-item lists (>1 or <0). Among comprehenders, IPV prevalence was estimated using direct and indirect methods, with the difference in prevalence estimation assessed overall and by sociodemographic sub-groups. List experiment comprehension was compromised for 12.8% and 10.1% of women, for physical and sexual IPV, respectively. The prevalence of past-year physical and/or sexual IPV was 22.2% as assessed by direct and 36.7% as assessed by indirect methods, resulting in a difference of 14.5 percentage points. Indirect methods produced higher IPV prevalence estimates across all sociodemographic sub-groups, suggesting that direct methods may risk underestimation. Results highlight numeracy as a limitation in list experiments, particularly for vulnerable sub-populations. List experiments can also be cumbersome and limited in their breadth. Ultimately, direct IPV estimation remains a best practice for population surveys, acknowledging risk for underestimation. Indirect methods can validate direct IPV estimation on a limited set of experiences and add value where privacy issues constrain direct methods.

PMID 42720064
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PubMedThe Journal of the Association of Nurses in AIDS Care : JANAC2026-09-10

Motivations of Pregnant Women Initiating HIV Preexposure Prophylaxis Within Routine Antenatal Clinics Enrolled in a Randomized Trial in Western Kenya.

Watoyi Salphine S, Larsen Anna A, Akim Eunita E, Concepcion Tessa T et al.

Vertical HIV transmission remains a public health challenge in high-burden areas. This cross-sectional study analyzed baseline data from 600 pregnant women without HIV in western Kenya who initiated preexposure prophylaxis (PrEP) between January 2022 and July 2023. We examined associations between participant characteristics, self-perceived HIV risk, and PrEP initiation motivations. Overall, 36.3% reported high HIV risk perception. High self-perceived risk was associated with having multiple sexual partners, high empiric risk scores, intimate partner violence (IPV), and anxiety. Unplanned pregnancies and IPV correlated with specific PrEP motivations. Findings highlight the need for tailored counseling, IPV screening, and integrated maternal and child health services to improve PrEP uptake and reduce vertical transmission.

PMID 42720206
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PubMedFrontiers in immunology2026-09-10

A bivalent oral yeast vaccine displaying Nocardia seriolae FHA and LMBV MCP confers protection in largemouth bass (Micropterus salmoides).

Lu Jianfei J, Gu Boge B, Yu Pengzhen P, Chen Jiong J

Largemouth bass ranavirus (LMBV) and Nocardia seriolae are major pathogens affecting largemouth bass (Micropterus salmoides), causing significant economic losses. In this study, recombinant yeasts expressing the fibronectin-binding protein A (FHA) of N. seriolae or the major capsid protein (MCP) of LMBV were constructed using the yeast surface display (YSD) system. Based on these recombinant strains, a bivalent oral yeast-based vaccine was developed and its protective efficacy was systematically evaluated. Oral administration of the vaccine induced specific antibodies against FHA and MCP in serum, as well as increased the transcription levels of adaptive immune genes (IgM, IgT, MHC-II) and innate immune genes (IL-1β, TNF-α, IFN-1, Mx2) in the hindgut, liver, and spleen. Importantly, the bivalent oral vaccine provided significant protection against both pathogens in largemouth bass, with relative percent survival (RPS) values of 56.7% against N. seriolae and 63.3% against LMBV. Meanwhile, the oral vaccine reduced pathogen loads and alleviated histopathological lesions. In summary, these findings suggest that the bivalent oral vaccine developed in this study could serve as a promising strategy for controlling N. seriolae and LMBV infections in largemouth bass aquaculture.

PMID 42718698
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PubMedMicrobiology resource announcements2026-09-10

Genomic characterization of the attenuated human cytomegalovirus strain TR-VAC developed for subviral particle vaccine production.

Schmidt Hanno H, Hewel Charlotte C, Büscher Nicole N, Linke Matthias M et al.

We report the complete genome sequence of the attenuated human cytomegalovirus strain TR-VAC, developed for subviral particle vaccine production. Oxford Nanopore duplex sequencing confirmed all engineered modifications, including UL130 repair, UL25 stop codons, ddFKBP insertion, GFP deletion, and retention of the bacterial artificial chromosome backbone, without large-scale structural rearrangements.

PMID 42720293
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PubMedTropical doctor2026-09-10

Vaccine hesitancy in peripheral communities: Combating digital malpractice.

Siddiqui Gulnaz Fatima GF, Siddiqui Shahid Akhtar SA

PMID 42720454
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PubMedCureus2026-09-10

Recurrent Mumps in a Fully Vaccinated Young Adult With a Prior Breakthrough Infection: A Case Report.

Ramadugu Rithika R, Pidikiti Chandra Varshini CV, Cordero Peña Alesha A, Almonte Angelis A et al.

Mumps is a vaccine-preventable viral disease that typically presents with parotid gland swelling and constitutional symptoms. Although widespread immunization has substantially reduced disease incidence, outbreaks continue to occur among vaccinated populations, raising concerns regarding waning immunity and vaccine failure. Recurrent mumps following both prior natural infection and complete vaccination is uncommon and remains infrequently reported. We describe a 21-year-old woman who presented with a four-day history of fever, malaise, myalgia, and progressive painful swelling of the left parotid gland associated with difficulty chewing and speaking. She had received two doses of measles-mumps-rubella (MMR) vaccine according to the national immunization schedule and had a documented history of mumps infection at nine years of age, occurring after she had already completed her two-dose MMR series (vaccine-breakthrough infection). Physical examination revealed tender unilateral parotid enlargement, cervical lymphadenopathy, and evidence of undernutrition with a body mass index of 16.7 kg/m². Laboratory evaluation demonstrated iron deficiency anemia. Further evaluation, including positive mumps RT-PCR and positive anti-mumps IgM serology, confirmed acute mumps infection, while investigations excluded alternative causes of parotid enlargement. The patient was managed conservatively with isolation, supportive care, nutritional supplementation, and symptomatic treatment, resulting in complete clinical recovery without complications. This case highlights that recurrent mumps can occur despite prior natural infection and complete MMR vaccination. Although waning immunity and host factors such as undernutrition may have contributed to susceptibility, a causal relationship cannot be established from a single case. Continued surveillance and awareness of breakthrough infections remain important, particularly in resource-limited settings.

PMID 42719503
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