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articaine hydrochloride + epinephrine (Septocaine)

✓ Approved

GC corporation · 小分子 · 小分子

什么是 articaine hydrochloride + epinephrine？

articaine hydrochloride + epinephrine 是一种小分子，由GC corporation研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)。

药物档案

商品名Septocaine
公司GC corporation
药物类别小分子
给药途径Injectable (Others)
状态Approved
来源： ClinicalTrials.gov, GC corporation

治疗适应症

articaine hydrochloride + epinephrine 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersAnaesthesia✓ Approved
Nervous system disordersSensory loss✓ Approved

相关研究文献

PubMedJournal of conservative dentistry and endodontics2026-10-27

Clinical evaluation of anesthetic efficacy of 2% lignocaine versus 4% articaine intraligamentary injection using StarPen after an ineffective inferior alveolar nerve block in mandibular molars with acute irreversible pulpitis: A randomized clinical trial.

Pande Shashikala Mangal SM, Kolhe Swapnil J SJ, Gulve Meenal N MN, Pradeep G L GL et al.

Inferior alveolar nerve block (IANB) frequently fails in teeth with acute irreversible pulpitis. Supplementary anesthetic technique is required in such cases to achieve profound anesthesia. This randomized single-blind controlled trial evaluated and compared the anesthetic efficacy of 2% lignocaine versus 4% articaine as intraligamentary (IL) injections using StarPen after ineffective IANB in mandibular molars with acute irreversible pulpitis. This is a randomized clinical trial. Fifty subjects having irreversible pulpitis in mandibular molars with failed IANB were selected. Before IL injection, intraoperative pain was recorded on the Visual Analog Scale (VAS). Patients were divided into two groups (n = 25). Group I received 2% lignocaine and Group II received 4% articaine as IL injections using StarPen. Further access cavity was prepared, and canals were located, following working length determination. Then intraoperative pain was assessed on VAS. Kolmogorov-Smirnov and Shapiro-Wilk tests were done to check for normal distribution of the data. An unpaired t-test was applied to compare the groups. Statistical significance was calculated at P < 0.05, and P < 0.001 was considered statistically highly significant. Both the drugs, Group I (lignocaine IL, 1.67 ± 0.89) and Group II (articaine IL, 1.25 ± 0.87), were significantly effective in reducing pain levels in failed IANB cases, but the difference was not statistically significant. Both the drugs are almost equally effective as IL injection in achieving profound pulpal anesthesia. StarPen can be used for painless IL injections with better compliance and easy handling.

PMID 42936395
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PubMedInternational journal of molecular sciences2026-10-27

Influence of UV Irradiation Source and of Carboxylic Acid Additives on the Kinetics of Photodegradation of Five Tricyclic Antidepressant Drugs in Aqueous Medium.

Ciuca Maria D MD, Racovita Radu C RC

Use of antidepressant medication has increased substantially nowadays. Investigations of their photostability in aqueous environment are therefore needed both for shelf life assessment of liquid pharmaceutical formulations and for development of wastewater remediation technologies. In this work, the comparative kinetics of photodegradation of five tricyclic antidepressants (TCAs) in aqueous solution was studied under direct photolysis using UVA, UVB, and UVC sources, respectively. A gas chromatography-mass spectrometry (GC-MS) method was developed and validated intra-laboratory for accurate quantification of the five TCAs (amitriptyline hydrochloride AMI, doxepin hydrochloride DOX, imipramine hydrochloride IMI, clomipramine hydrochloride CLO, trimipramine maleate TRI) in the course of photodegradation. UVC photolysis yielded the highest rates of photodegradation, followed by UVB and then UVA. The molecular structure and UV absorption characteristics of individual TCAs were shown to influence photodegradation rates as well. Specifically, heteroatoms (N, O, Cl) present in the molecule and redshifted UV absorption bands increased photosensitivity typically in the order: AMI < IMI < TRI < CLO < DOX. The effect that some mono- and polycarboxylic acids dissolved in the aqueous solutions had on TCA photodegradation kinetics under UVC was also investigated and, for most TCAs, rates were faster and durations required for their complete photodegradation decreased generally in the order: citric > oxalic > maleic > benzoic acid. Furthermore, citric acid was reused for a second round of TCA photodegradation and showed rate enhancement effects very close to those exhibited in the first round.

PMID 42941717
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PubMedPharmaceutics2026-10-27

Impact of Process Parameters on the Quality Attributes of High-Dose Metformin Hydrochloride Film-Coated Tablets.

Duc Nguyen Tan NT, Nguyen Dang-Khoa DK, Liet Huynh Thanh HT, Thiet Nguyen Huynh NH et al.

Background/Objectives: Formulating high-dose metformin hydrochloride film-coated tablets is challenging due to the poor flowability and compressibility inherent to high drug loading. To ensure process robustness and consistent product quality, understanding the impact of manufacturing variables is crucial. This study evaluated the effects of key process parameters on the quality attributes of 1000 mg metformin hydrochloride tablets to establish optimal processing conditions for reliable production. Methods: The manufacturing process, comprising wet granulation, compression, and film coating, was investigated to evaluate the influence of key process parameters on tablet quality attributes. Granules were characterized for bulk density, tapped density, and compressibility index. Core tablets were evaluated for physical appearance, weight variation, hardness, and dissolution at a 45 min sampling point across various compression forces and tableting speeds. Film-coating efficiency was assessed based on coating quality, dissolution behavior, and stability. Favorable manufacturing conditions were empirically identified through single-variable optimization and statistical analysis. Results: Wet granulation conducted at a chopper speed of 1400 rpm for 7 min yielded granules with the lowest compressibility index (11.88%), demonstrating significantly improved flowability. Compression at a force of 10 kN and a speed of 40 rpm produced core tablets with acceptable appearance, robust hardness (7.06-7.37 kP), and complete drug release (100%). Tablet hardness was governed by a strong interaction between compression force and tableting speed (partial η2 = 0.929, p < 0.001) rather than by either factor alone: at 20 kN, hardness collapsed sharply once tableting speed reached 30 rpm, coincident with mild capping, identifying this force-speed combination as a process-failure condition. For the coating process, maintaining a tablet bed surface temperature of 40 °C ensured optimal coating uniformity without compromising product quality. Dissolution profile comparison against a coated reference product in the primary dissolution medium (pH 6.8) yielded f2 similarity values above 50 for all eight core tablet conditions, and stability testing under accelerated/thermal-stress conditions (up to 65 °C) confirmed maintained dissolution, assay, and related-substance (1-cyanoguanidine) compliance for both the test and reference products. The optimized manufacturing conditions successfully produced film-coated tablets that conformed to all predetermined quality specifications. Conclusions: Manufacturing process parameters significantly influenced the quality attributes of high-dose metformin hydrochloride film-coated tablets. Proper selection and control of these processing conditions ensured consistent granule properties, optimal tablet quality, and enhanced manufacturing robustness.

PMID 42942796
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PubMedPharmaceuticals (Basel, Switzerland)2026-10-27

Propolis vs. Chlorhexidine Gluconate and Benzydamine Hydrochloride on Sequelae After Third Molar Surgery: A Randomized Controlled Trial.

Bayramoğlu Zeynep Z, Halıcı Zekai Z, Özakar Emrah E, Sevinç Özakar Rukiye R

Background. Impacted lower third molar surgery is characterized by postoperative sequelae such as pain, edema, and trismus. While chlorhexidine (CHX) is the gold-standard antiseptic, its side effects prompt the search for natural alternatives. The aim of this study is to examine the effects of propolis gargle on wound healing following third molar surgery and to compare it with chlorhexidine gluconate and benzydamine hydrochloride (CHX+BENZ). Methods. In this prospective, randomized, double-blind, active-controlled trial, 52 patients were assigned to 3% Propolis (n = 24) or 0.12% CHX+BENZ (n = 28) groups. Mouthwashes were applied twice daily from postoperative days 2 to 7, and pain (VAS), edema, and trismus were evaluated preoperatively and on days 2 and 7. Statistical significance was set at p < 0.05. Results. No significant differences were found in pain and trismus (p > 0.05). However, the Propolis group exhibited significantly lower edema on day 2 compared to the CHX+BENZ group (p = 0.004), and complication rates were also notably lower in the Propolis group. Conclusions. The novel, non-alcoholic 3% propolis mouthwash demonstrated no statistically significant differences in short-term pain and trismus outcomes compared to CHX+BENZ, alongside a statistically smaller day-2 facial edema measurement. While these findings support its potential as a supportive oral rinse following third molar surgery, adequately powered prospective trials are warranted to validate these preliminary observations before routine clinical adoption.

PMID 42943312
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PubMedViruses2026-10-27

Inhibition of Adrenergic Receptors Reduces Genital HSV-1 Clinical Recurrences in Guinea Pigs.

Green Jillian C JC, Moore Greyson A GA, Irwin Matthew D MD, Joyce Jonathan D JD et al.

Herpes simplex virus 1 (HSV-1) establishes latency in both sensory and sympathetic neurons. Stress is strongly correlated with HSV-1 reactivation. The acute stress hormone epinephrine initiates HSV-1 reactivation in vitro upon activating at least two adrenergic receptors (ARs), including α2, β1, and/or β2-AR. To determine if blocking these receptors could reduce HSV-1 recurrences, we infected guinea pigs vaginally with HSV-1 (17+) and, after latency was established, treated them daily with atipamezole (specific α2-AR inhibitor), propranolol (nonspecific β-AR inhibitor), or atipamezole/propranolol combined. Clinical recurrences decreased in the treatment groups compared to untreated: atipamezole (29.3%, p = 0.123), propranolol (43.6%, p = 0.021), and atipamezole/propranolol (39.1%, p = 0.021). No significant differences were observed between groups in HSV-1 viral load in pelvic ganglia, or in transcription of the latency-associated transcript (LAT) in guinea pigs that were asymptomatic when euthanized, suggesting AR inhibitors did not affect latency. In guinea pigs euthanized during recurrences, viral DNA was similar between groups in sensory ganglia but reduced in sympathetic ganglia in treatment groups compared to untreated, suggesting that reactivation still occurred in sensory but was limited in sympathetic neurons in AR inhibitor-treated animals. The use of adrenergic beta blockers may be a useful therapeutic to reduce HSV-1 clinical recurrences.

PMID 42944001
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PubMedPeerJ2026-10-27

Pulsed electric field-mediated elimination of yeast [PSI +] prion is variant dependent and affects cell growth dynamics.

Jonutyte-Trembo Neda N, Versockienė Justina J, Katauskas Gvidas G, Novickij Vitalij V et al.

Yeast Saccharomyces cerevisiae is a widespread model system in which mechanisms of prion induction and elimination have been identified. New and safe substances and methods are being sought to eliminate prions from cells. In this research, we applied guanidinium hydrochloride (GuHCl) alone and in combination with pulsed electric field treatment against [PSI +] prion. The analysis of cell culture optical density and doubling time showed that the method of [PSI +] prion elimination increases cell doubling time, with combined treatment having a more severe impact on cell growth than GuHCl treatment alone. Additionally, we found that both elimination methods can impact the optical culture density achieved by [psi -] cells. However, the cells in which the [PSI +] prion has been eliminated by GuHCl alone are able to reach the same optical density as unaffected [psi -] cells and a higher optical density than the affected [psi -] cells by GuHCl alone. These findings suggest that the presence and subsequent removal of the [PSI +] prion influence early exponential growth, revealing lasting effects on cell growth dynamics that are distinct from previously reported effects on stationary phase survival. This work highlights how prion elimination strategies, including chemical and electric field treatments, can impact post-curing growth behavior in yeast cells.

PMID 42936698
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