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(S)-amlodipine + (S)-atenolol

✓ Approved

Emcure Pharmaceuticals · ADRB1 · 小分子

什么是 (S)-amlodipine + (S)-atenolol？

(S)-amlodipine + (S)-atenolol 是一种小分子，由Emcure Pharmaceuticals研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

公司Emcure Pharmaceuticals
药物类别小分子
分子靶点ADRB1, CACNA1C
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Emcure Pharmaceuticals

作用机制

分子靶点

(S)-amlodipine + (S)-atenolol 作用于 2 个分子靶点：

ADRB1adrenoceptor beta 1 (B1AR, RHR)
CACNA1Ccalcium voltage-gated channel subunit alpha1 C (CaV1.2, CACNL1A1)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

(S)-amlodipine + (S)-atenolol 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Cardiac disordersAngina pectoris✓ Approved
Vascular disordersHypertension✓ Approved

相关研究文献

PubMedFrontiers in medicine2026-10-27

Effects of isobaric spinal anesthesia combined with different nerve block techniques on postoperative pain and complications in elderly patients undergoing proximal femoral nail antirotation: a retrospective observational study.

Li Jingjing J, Ma Ning N, Zhao Yuan Y, Liang Na N et al.

To explore the impacts of isobaric spinal anesthesia combined with different nerve blocks on postoperative pain, complications, satisfaction and perioperative comfort in elderly patients undergoing proximal femoral nail antirotation(PFNA). A retrospective analysis was conducted on elderly PFNA patients enrolled from 2019 to 2021 in the Department of Traumatic Orthopedics at the People's Hospital of Ningxia Hui Autonomous Region. Patients were divided into four groups: group S(simple isobaric spinal anesthesia), group S + FNB(spinal anesthesia plus femoral nerve block), group S + LFCN(spinal anesthesia plus lateral femoral cutaneous nerve block), group S + FICB(spinal anesthesia plus fascia iliaca compartment block). Primary outcomes were dynamic VAS scores at different postoperative time points, while secondary outcomes comprised postoperative complications and pain management indicators. All data were collected and statistically compared. A total of 191 elderly patients who underwent PFNA met the inclusion criteria. In group S, VAS scores on postoperative days 2 and 3 were lower than those at 1 day preoperatively, whereas in groups S + FNB, S + LFCN, and S + FICB, VAS scores on postoperative days 1, 2, and 3 were lower than preoperative values. In all four groups, VAS scores on postoperative days 2 and 3 were lower than those on postoperative day 1 (P < 0.05). On postoperative day 1, VAS scores in groups S + FNB and S + LFCN were lower than those in group S, while VAS scores in group S + FICB were significantly lower than those in groups S + FNB, S + LFCN, and S on postoperative days 1, 2, and 3 (P < 0.05). The incidence of postoperative nausea, vomiting, and pruritus was lower in group S + FICB than in group S (P < 0.05). The dose of sufentanil required for rescue analgesia was lower in groups S + LFCN and S + FICB than in group S, and lower in group S + FICB than in groups S + FNB and S + LFCN (P < 0.05). The number of patients requiring postoperative rescue analgesia was lower in group S + FICB than in groups S + FNB, S + LFCN, and S (P < 0.05). Postoperative satisfaction was higher in group S + FICB than in group S (P < 0.05). Preoperative isobaric spinal anesthesia combined with fascia iliaca compartment block was associated with better postoperative pain relief, reduced adverse reactions, and improved perioperative comfort in elderly patients, and was more effective than other anesthesia strategies.

PMID 42935918
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PubMedMicroorganisms2026-10-27

Lignin Degradation Potential of Novel Streptomyces Isolates from the Juniperus turcomanica Rhizosphere via Broad-Spectrum Enzymatic Activities.

Saparmyradov Keremli K, Yergeshov Abdulla A AA, Islamov Bakhtiyar R BR, Rahmanova Altyn K AK et al.

This study provides a comprehensive characterization of Streptomyces isolates associated with the rhizosphere of the centenarian Juniperus turcomanica. Screening for ligninolytic activity revealed that isolates-ATM9, ATM14, ATM15, ATM16, ATM18, and ATM19 synthesize enzymes capable of decolorizing methylene blue and modifying lignosulfonates. Isolates ATM16 and ATM18 demonstrated the highest efficiency in lignosulfonate decomposition, with lignosulfonate becoming undetectable in their culture broth. In the straw lignin degradation process, isolates ATM15 and ATM16 showed the most significant reductions in lignin content (44.2% and 54.8%, respectively), demonstrating promising biodegradation potential. Majority of isolates demonstrated antagonistic activity against fungal strains, while ATM19 completely inhibited the growth of all phytopathogenic fungi tested. Taxonomic identification based on 16S rRNA gene sequencing confirmed that all isolates belong to the genus Streptomyces, with species including S. shaanxiensis (ATM9), S. chryseus (ATM14), S. narbonensis (ATM15), S. venezuelae (ATM16), S. spiroverticillatus (ATM18), S. longhuiensis (ATM19), and Streptomyces sp. (ATM24). Considering our data, S. venezuelae ATM16 and S. spiroverticillatus ATM18 stand out as the most promising strains for biotechnological applications due to their ligninolytic and antagonistic activity against fungal phytopathogens. Furthermore, this study provides the first report on enzymatic and antifungal activities for the recently proposed species S. longhuiensis (ATM19) and S. shaanxiensis (ATM9).

PMID 42943585
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PubMedFrontiers in microbiology2026-10-27

The multifaceted role of SsrB in S. Typhi H58 during THP-1 macrophage infection.

Fernandez Marion M, Deolankar Soham S, Singh Moirangthem Kiran MK, Zangoui Parisa P et al.

S. Typhi, the causative agent of typhoid fever, remains less well understood due to its human-restricted nature compared to S. Typhimurium, which enjoys a broad host range. Herein, we investigated the acid response of S. Typhi and the role of the SPI-2 master regulator SsrB during infection of human THP-1 macrophages. Using fluorescence lifetime imaging of the pH-sensitive probe mCherryTYG, we demonstrate that the S. Typhi cytosol acidifies during infection of THP-1 macrophages, similar to S. Typhimurium. This acidification triggers a marked up-regulation of SsrB, with S. Typhi expressing significantly more SsrB molecules than S. Typhimurium, as quantified by photoactivatable localization microscopy. Despite increased SsrB expression, activation of the SsrB-dependent reporter PsifA was reduced, indicating serovar-specific differences in SsrB activity. Unexpectedly, deletion of ssrB in S. Typhi increased net intracellular replication and host cell cytotoxicity, contrasting with its essential role in S. Typhimurium. Using phosphorylation incompetent (D56A) and acid-sensing deficient (H12Q) mutants, we demonstrate that the reduction in cytotoxicity is phosphorylation-independent, whereas restriction of net intracellular replication requires both phosphorylation and acid-dependent DNA binding. The SPI-2 effector SifB partially mediates this restriction. Our findings show that SsrB contributes to two infection phenotypes with distinct genetic requirements: it limits host cytotoxicity in a manner that requires neither phosphorylation nor acid-enhanced DNA binding, and it restricts intracellular replication in a manner that requires both activities. Whether these two phenotypes are executed by separate or by shared downstream targets was not established here. These results challenge the assumption that SsrB is dispensable for S. Typhi pathogenesis and highlight serovar-specific virulence strategies.

PMID 42935884
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PubMedAntioxidants (Basel, Switzerland)2026-10-27

Sulfur-Induced Thiol Metabolism Confers Arsenic Stress Tolerance Despite Increased Arsenic Accumulation in Rice Seedlings.

Jung Ha-Il HI, Kim Myung-Sook MS, Lee Eun-Jin EJ, Lee Tae-Gu TG et al.

Arsenic (As) contamination poses a serious threat to rice production and food safety. Although sulfur (S) nutrition is known to alleviate As toxicity through thiol-based detoxification, the mechanisms underlying the relationship between S-induced As accumulation and tolerance remain poorly understood. We investigated the effects of contrasting S levels (0, 1, and 4 mM) on As accumulation, translocation, oxidative stress responses, thiol metabolite pools, and mineral nutrient profiles in hydroponically grown rice seedlings exposed to 15 µM As for 15 days. S supplementation alleviated As-induced growth inhibition in a dose-dependent manner despite increasing total As accumulation in both roots and shoots, demonstrating that S-mediated tolerance is independent of reduced As accumulation. Elevated S supply reduced oxidative stress markers (O2•-, H2O2, and MDA), while markedly enlarged the pools of γ-glutamylcysteine (γ-EC), glutathione, and phytochelatins (PCs), particularly in roots. S supplementation also improved the uptake of major essential nutrients, including nitrogen and potassium in shoots, while selectively modulating micronutrient distributions under As stress. Correlation analysis showed that root As content was strongly and positively correlated with γ-EC and PC2-PC4, and principal component analysis separated the treatments along the S gradient in both roots and shoots. Collectively, these results suggest that S enhances As tolerance in rice seedlings through thiol-dependent detoxification, thereby decoupling As tolerance from As accumulation rather than by restricting As accumulation.

PMID 42939905
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PubMedInternational journal of molecular sciences2026-10-27

Comparative Chloroplast and Mitochondrial Genomics of Sorbus L. Sensu Lato: Genome Diversity, Structural Variation, and Phylogeny.

Wu Yuxia Y, Yang Wenhua W, Zheng Yongqi Y, Yu Xuedan X et al.

Sorbus L. sensu lato represents a taxonomically complex group within Rosaceae, but organelle genome variation remains insufficiently characterized, particularly at the intraspecific level. Here, we assembled the complete mitochondrial genome of S. discolor and 214 complete chloroplast genomes, comprising 71 S. discolor and 143 S. pohuashanensis accessions, and performed comparative and phylogenetic analyses alongside published genomes. The S. discolor mitogenome spanned 372,987 bp and contained 56 genes, representing the smallest genome yet exhibiting the highest number of annotated genes among the six mitogenomes examined; it also possessed the fewest simple and long sequence repeats. A GAA-to-TAA substitution introduced a premature stop codon in mitochondrial sdh3, resulting in pseudogenization. Across six species, sdh3 was either intact, pseudogenized, or absent, whereas putative nuclear sdh3 homologs were identified in S. discolor and S. pohuashanensis. Comparative analysis of 263 chloroplast genomes revealed that highly variable regions differed between interspecific and intraspecific datasets, whereas trnH-GUG-psbA consistently exhibited relatively high nucleotide diversity. The chloroplast phylogeny placed all sampled compound-leaved species within Sorbus s. s., whereas the sampled simple-leaved taxa were positioned closer to the base, with a similar pattern observed in the mitochondrial phylogeny based on six species. These findings reveal contrasting patterns of organelle genome variation and provide resources for genetic diversity assessment, marker development, and future studies of Sorbus genetic resources.

PMID 42942091
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PubMedInternational journal of molecular sciences2026-10-27

Metabolomic Profiling Reveals Heat-Responsive Metabolic Markers in Honey Bee Workers Under Contrasting Diets.

Jang Hyeonji H, Kim Hyunjee H, Frunze Olga O, Kwon Hyung-Wook HW et al.

Acute heat exposure challenges honey bee (Apis mellifera) workers, yet the associated small-molecule response and its relationship to nutritional status remain incompletely resolved. Workers were conditioned for 7 days on bee bread plus sucrose (B+S) or sucrose alone (S), maintained at 37 °C or exposed to 45 °C for 3 h, and thorax-abdomen metabolites were profiled by untargeted Ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS). Three independent cages were used per diet × temperature group, with 15 workers per cage pooled to generate one cage-level biological replicate (n = 3 per group). Putative metabolite annotation used accurate-mass (10 ppm) and isotope-pattern matching against METLIN and the Agilent Personal Compound Database and Library (PCDL), followed by manual curation, without tandem mass spectrometry (MS/MS) o or authentic-standard confirmation. After statistical filtering and biological curation, 149 heat-responsive metabolite annotations were retained under B+S and 123 under S. Targeted re-extraction of proteinogenic amino acids from the same raw files recovered 16 common peaks across all samples. Fifteen increased at 45 °C in both diets, whereas proline decreased; 14 of 16 showed a larger fold change under B+S. Phenylalanine-related metabolism showed the strongest convergence across targeted amino-acid analysis, untargeted phenylpyruvate detection, and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment. Lipid-class responses also differed descriptively between diets, with a bias toward decreased free fatty acyls under B+S and decreased phospholipids under S. These findings define coordinated metabolic markers of acute heat exposure in worker bees and show that, within the targeted amino-acid dataset, response magnitudes were generally larger under B+S while retaining the same overall direction.

PMID 42942007
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