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grass pollen vaccine (DepiQuick)

✓ Approved

Laboratorios LETI · 治疗药物

什么是 grass pollen vaccine？

grass pollen vaccine 是一种治疗药物，由Laboratorios LETI研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Oral (PO)、Subcutaneous Injection、Sublingual (SL)/Oral Transmucosal。

药物档案

商品名DepiQuick
公司Laboratorios LETI
给药途径Injectable (Others), Oral (PO), Subcutaneous Injection, Sublingual (SL)/Oral Transmucosal
状态Approved
来源： ClinicalTrials.gov, Laboratorios LETI

治疗适应症

grass pollen vaccine 针对 3 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Respiratory, thoracic and mediastinal disordersAsthma✓ Approved
Immune system disordersHypersensitivity✓ Approved
Immune system disordersSeasonal allergy✓ Approved

相关研究文献

PubMedAoB PLANTS2026-10-27

Interspecific variation in nectar and pollen reward among plant species commonly planted to support pollinators.

Gregor Madeline M, Lei Wendy W, Ergastolo Adelaide A, Suni Sevan S

Pollinators facilitate the reproduction of most wild plants. Declines in pollinator populations have led to interest in establishing floral enhancements to support them. However, knowledge about how food rewards vary across plant species planted to support pollinators remains scant. Using a greenhouse common garden, we quantified nectar volume, nectar sucrose, and pollen protein quantity for 11 species commonly planted to support pollinators in Mediterranean climates. We evaluated if variation was explained by life history and the potential for tradeoffs between nectar and pollen quality. There was high variation in nectar and moderate variation in pollen protein across species. The probability of producing nectar was higher for perennial plants. For flowers that contained nectar, there were no differences between annual and perennial plants in nectar traits. The species that produced the highest quality nectar (Scrophularia californica) produced pollen with the lowest protein amounts, and the species that produced the lowest quality nectar (Madia elegans) produced pollen with the highest protein amounts. There was no statistical association between pollen protein amounts and nectar traits across species. The nutrition pollinators obtain from foraging on most species studied here may come primarily in the form of carbohydrates or protein, but not both. However, one species (Epilobium canum) produced both high-quality nectar and pollen, so identifying others that produce similarly broad, high-quality rewards would be worthwhile. Our results also suggest that including perennial plants in pollinator gardens will facilitate pollinator acquisition of carbohydrates.

PMID 42936625
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PubMedAntioxidants (Basel, Switzerland)2026-10-27

Replacing Soybean Meal with Ultrafine Pulverized Mulberry Leaf (Combined with Multi-Enzyme Preparations) Reduces Fat Deposition and Alleviates Oxidative Stress in Grass Carp via Gut-Liver Axis Regulation.

Yuan Haotian H, Long Ling L, Zeng Yelin Y, Huang Long L et al.

Grass carp are prone to excessive fat deposition in intensive aquaculture, which impairs their health and reduces economic returns. Here, we investigated the effects of replacing soybean meal with ultrafine pulverized mulberry leaves combined with multi-enzyme preparations on lipid metabolism in grass carp using phenotypic and multi-omics approaches. A total of 480 grass carp (8.45 ± 0.17 g) were fed a basal diet and two experimental diets (6% and 12%) containing mulberry leaf for 60 d. Replacing soybean meal with ultrafine pulverized mulberry leaf with multi-enzyme preparations reduced serum triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and dorsal muscle ether extract levels, downregulated hepatic glycolysis (gk, pfk, pk) and lipogenesis (fas and acc) genes and increased intestinal lipase activity. Intestinal omics identified the lysine degradation pathway as a key pathway that regulates lipid metabolism. Reduced levels of multiple differential metabolites and enhanced microbial metabolic functions are closely associated with inhibition of lipid metabolism in grass carp. The reduction in fat deposition, particularly polyunsaturated fatty acids, the downregulation of antioxidant capacity, as indicated by decreased glutathione peroxidase and superoxide dismutase activities and reduced total antioxidant capacity, along with a decrease in malondialdehyde levels, suggests that the lipid-lowering effects could alleviate oxidative stress. Replacing soybean meal with ultrafine pulverized mulberry leaves combined with multi-enzyme preparations reduced lipid deposition and alleviated oxidative stress in grass carp by regulating the gut-liver axis. When replacing soybean meal, a 12% proportion of ultrafine pulverized mulberry leaves combined with multi-enzyme preparations in the diet is recommended.

PMID 42939924
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PubMedInsects2026-10-27

Comparative Analysis of Thrips Prey and Pollen Usage by Three Predatory Mites, Amblyseius largoensis, Neoseiulus californicus and Neoseiulus barkeri.

Munawar Asim A, Kaiyu Li L, Xuan Chen C, Abou El-Ela Amr S AS et al.

Phytoseiid mites (PDMs) utilize both herbivorous prey and an alternative food source in agroecosystems. However, biocontrol screening of PDMs has largely focused on their predation function against prey, with their use of alternative food often ignored. Therefore, in the present study, we compared the performance of three PDM species (Amblyseius largoensis (Muma), Neoseiulus californicus (McGregor) and Neoseiulus barkeri Hughes), fed on two food sources: onion thrips (Thrips tabaci) and pollen (an alternative food) on potato plants. All three PDMs concentrated their attacks on the vulnerable prey stages, with early larval instars attacked at the highest rate, while N. californicus proved the most effective egg predator and N. barkeri the least. A. largoensis located and attacked prey the fastest both in leaf arenas and on intact plants, despite the longest per-prey handling time and attacked the fewest prey across a density gradient while leaving the least thrips-induced leaf damage. Prey rather than pollen was the primary driver of survival in every PDM, and A. largoensis persisted longest under food limitation and was the only species to gain further benefit from pollen when prey was already available. This ranking inverted in mixed-species arenas, where N. californicus consistently outsurvived the other two species under prey-present and pollen-only conditions. Foraging efficiency, food resource use and intraguild dominance were dissociated for PDM performance. Thus, a multiple-trait screening can be considered in PDM selection for thrips management in crops.

PMID 42940983
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PubMedThe New phytologist2026-10-27

Reconstructing Cenozoic grasslands in North America and western Eurasia: evidence for cold-season grasses from 3D phytolith morphology.

Hermans Rosalie M RM, Gallaher Timothy J TJ, Brightly William H WH, Zender Callie C et al.

Pooideae, the largest grass subfamily, radiated in the Northern Hemisphere from the Paleocene onward and today dominates cold-season and high-altitude grasslands. Fossil phytolith assemblages suggest pooid-rich ecosystems during the Oligocene-Miocene, but the lack of quantitative phytolith identification has limited reconstruction of early grassland composition and ecology. We combined 3D geometric morphometrics of grass silica short-cell phytoliths (GSSCPs) with machine-learning classification and phylogenetically informed climate modelling. A dataset of modern GSSCPs was used to classify Eocene-Miocene phytoliths from Türkiye and the US Great Plains and reconstruct paleoclimate. 3D GSSCP morphology distinguished modern grass subfamilies and tribes. Fossil assemblages contained mainly phytoliths assigned to Bambusoideae and Pooideae (including Poeae I and II). In modern grasses, Crenate and Polylobate phytolith dimensions correlated with temperature and precipitation. Fossil Crenates and Polylobates yielded climate estimates warmer and wetter than today. Ancestral state reconstructions indicated milder winter conditions at early Pooideae nodes, with cold tolerance arising early. Major temperate grass lineages (Poeae I and II) were established earlier than previously recognized, and Pooideae-rich grasslands were present by the Oligo-Miocene under warmer, wetter climates than today. These findings demonstrate the value of 3D phytolith morphometrics for interpreting early grassland evolution.

PMID 42934156
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PubMedPlants (Basel, Switzerland)2026-10-27

Species Combinations Shape Vegetation and Soil Nutrient Responses to Grass-Legume Reseeding in a Degraded Semi-Arid Grassland.

Xu You Y, Liu Guang G, Fu Tian-Sheng TS, Fu Gui-Hong GH et al.

Reseeding is widely used to restore degraded grasslands, but the extent to which restoration outcomes depend on grass-legume species combinations remains unclear. We conducted a two-year field experiment in a degraded semi-arid grassland in Inner Mongolia, China, using two grasses (Elytrigia elongata and Bromus inermis) and two legumes (Caragana microphylla and Lespedeza davurica) reseeded as monocultures or grass-legume mixtures. Reseeding resulted in higher vegetation cover than the unseeded control across all treatments, whereas biomass responses depended on species combination, with B. inermis + L. davurica showing the highest mean biomass and cover in both years. Most reseeding treatments reduced Shannon-Wiener and Simpson diversity, whereas E. elongata + C. microphylla maintained both indices at levels comparable to the unseeded control. Legume-containing treatments consistently increased soil total N, ammonium nitrogen, nitrate N, and microbial biomass N, while available P and microbial biomass C increased across all reseeding treatments. Vegetation productivity was positively associated with soil nutrient availability and microbial biomass but negatively associated with plant diversity. Overall, reseeding promoted early vegetation and soil recovery, but grass-legume mixtures were not universally superior to monocultures. These findings suggest that B. inermis + L. davurica may be preferred for rapid vegetation recovery, whereas E. elongata + C. microphylla may be considered when maintaining plant diversity is a priority.

PMID 42943179
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PubMedChildren (Basel, Switzerland)2026-10-27

Outdoor Environmental Risk Factors for Paediatric Ragweed Sensitisation: A Formal Model Comparison.

Lovrić Mario M, Banić Ivana I, Časni Kristina K, Šunić Iva I et al.

Background/Objectives: Ragweed (Ambrosia artemisiifolia) is a major aeroallergen in Central and Eastern Europe. Croatian children in regions with twofold difference in pollen exposure show near-identical sensitisation prevalence (the "Zagreb paradox"), and an earlier analysis found regional pollen and rural residence to be the only associated environmental factors. We re-examined whether air pollution, surrounding landscape and indoor environment contribute to it. Methods: This cross-sectional analysis used 3520 of the 4016 children recruited to the EU FP7 ATOPICA study, who had their complete data re-analysed within the EU Horizon Europe EDIAQI project. Sensitisation was defined as a skin prick test wheal of at least 2 mm. Environmental predictors (particulate matter, PM10; nitrogen dioxide, NO2; regional pollen; CORINE land cover within 5 km; rural residence; and indoor exposures) were compared using the Akaike Information Criterion (AIC) in logistic regression models, which were adjusted for age and parental atopy. Results: Sensitisation prevalence was 10.8%. PM10 and categorical pollen area fitted the data equally well (ΔAIC 1.7): both describe the same inland-coastal contrast and cannot be distinguished with area-level data. NO2 added nothing to either. Of the 16 landscape variables, only transitional woodland-shrub remained associated with sensitisation after Bonferroni correction (adjusted odds ratio, aOR 0.93 [95% confidence interval, CI 0.90-0.97]); total green area was nominally associated (aOR 0.92 [95% CI 0.87-0.98]; p = 0.009). Children in rural locations were less often sensitised (aOR 0.69 [95% CI 0.50-0.96]; p = 0.026), as previously reported; a mediation analysis could not determine whether broadleaved forest cover explains this association. Indoor exposures added little to model fit. Conclusions: Area-level data cannot separate particulate air pollution from pollen exposure, so a contribution of air pollution can be neither confirmed nor excluded. Rural residence and, with less certainty, surrounding green space were associated with less sensitisation, and the indoor environment added little to it.

PMID 42940685
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