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selpercatinib

✓ Approved

Loxo Oncology · NTRK1 · 辅助诊断

什么是 selpercatinib？

selpercatinib 是一种辅助诊断，由Loxo Oncology研发。该药已获批，用于治疗相关适应症，给药途径：Others。

药物档案

公司Loxo Oncology
药物类别辅助诊断
分子靶点NTRK1
给药途径Others
状态Approved
来源： ClinicalTrials.gov, Loxo Oncology

作用机制

分子靶点

selpercatinib 作用于 1 个分子靶点：

NTRK1neurotrophic receptor tyrosine kinase 1 (TRK1, TRK)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

selpercatinib 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Uterine cancer✓ Approved

相关研究文献

PubMedInternational journal of emergency medicine2026-09-11

Virtual reality versus companion-delivered therapeutic touch for reducing pain and anxiety during suturing: a randomized controlled trial.

Khajehhasani-Rabori Tooba T, Haji-Maghsoudi Saiedeh S, Mehdipour-Rabori Roghayeh R

Wound suturing is a common procedure in emergency departments and can cause considerable pain and anxiety. Non-pharmacological approaches, such as virtual reality (VR) and therapeutic touch, may help improve patients' comfort during the procedure. This randomized controlled trial compared the effects of VR and companion-delivered therapeutic touch on pain and anxiety during emergency suturing. The trial was conducted in the emergency department of Shahid Bahonar Hospital in Kerman, Iran, between 2025 and 2026. In total, 87 patients were allocated to three groups: VR (n = 30), therapeutic touch (n = 27), and standard care (n = 30). Pain was assessed using the Visual Analog Scale (VAS), and state anxiety was measured using the State-Trait Anxiety Inventory-State scale (STAI-State) immediately before and after suturing. The data were analyzed using statistical methods that adjusted for baseline differences between the groups. The groups differed significantly in age and baseline anxiety. After adjustment for baseline values and age, both the VR and therapeutic touch groups had significantly lower post-procedure pain scores than the standard-care group (P < 0.001), whereas the difference between the VR and therapeutic touch groups was not statistically significant. For state anxiety, both intervention groups had significantly lower adjusted post-procedure scores than the standard-care group, and the VR group had significantly lower anxiety scores than the therapeutic touch group (P < 0.001). Both VR and therapeutic touch were associated with lower pain and anxiety during emergency suturing than standard care. VR appeared to provide an additional advantage over therapeutic touch for reducing anxiety, but not pain. These non-pharmacological interventions may offer practical options for improving patients' comfort during stressful emergency procedures. The trial was prospectively registered with the Iranian Registry of Clinical Trials (IRCT20260627069963N1) on July 3, 2026.

PMID 42723022
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PubMedOpen research Europe2026-09-11

From principles to practice: A code of conduct for the human-centered and ethical development of immersive technologies.

XR4HUMAN (The Equitable, Inclusive, and Human-Centered XR), De La Cruz Bernabe Rosemarie R, Baraas Rigmor C RC, Cox Shereen S et al.

The XR4Human Code of Conduct was developed over a 12-month period using a participatory co-design approach that combined multi-disciplinary expert workshops with members of the consortium followed by stakeholder and public consultations. The process was intentionally iterative. Drafting, review, and revision were guided by reflective equilibrium to reconcile empirical inputs from the project deliverables, normative principles, and practical constraints. The final Code is organised into nine domains that consolidate core principles relevant to the responsible design, development, and deployment of XR systems. These principles are made more concrete through seven articles that specify actionable obligations. To support real-world adoption, the Code is operationalised via an Ethical Impact Assessment and a companion Compliance Checklist aligned to the core principles and articles.

PMID 42723640
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PubMedData in brief2026-09-11

A Felis catus proteomic dataset and PeptideAtlas resource to explore the proteome of the domestic cat.

Kusebauch Ulrike U, Sun Zhi Z, Reddy Panga J PJ, Watson Phillip P et al.

Domestic cats (Felis catus) are one of the most common companion animals, and the health status and well-being of cats is becoming increasingly important. Several aspects of feline biology are vastly understudied relative to the importance of cats in society. These include robust methods to identify and measure proteins, which are critical for fundamental understanding and disease diagnosis. A searchable proteome map for cats is not available yet and here we measured immortalized feline cells, various tissues and serum using data-dependent acquisition (DDA) mass spectrometry to provide a foundational map of the cat proteome. Data were analyzed using the Trans-Proteomic Pipeline with stringent criteria and low false-discovery rate (FDR). The dataset consisting of 157 acquired files is presented as a first Felis catus PeptideAtlas build, a high-quality, publicly available resource of the proteome of the domestic cat that reports the identification of 242,844 unique peptides representing 8972 feline proteins or 45.6% of the annotated reference proteome. This resource can be mined for other studies and expanded as new data become available. The Felis catus PeptideAtlas and related data are publicly available via https://peptideatlas.org/builds/feline and ProteomeXchange (PXD075481).

PMID 42724733
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PubMedFrontiers in psychology2026-09-11

Beyond retrofitting: validating a purpose-built reading diagnostic assessment through a cognitive diagnostic approach.

Sun Hang H, Yin Shengkai S

Diagnostic assessment, which aims to identify the strengths and weaknesses of learners' cognitive abilities for targeted remediation, has gained momentum in recent years. This study applied a cognitive diagnostic approach to validate the UDig Reading Test, designed to diagnose the reading skills of tertiary-level English as a foreign language (EFL) learners in China. Using a mixed-methods design, test-takers' think-aloud protocols, expert judgments, and cognitive diagnostic modeling were integrated to examine the accuracy of the predefined item-subskill associations. Large-scale performance data from 642 test-takers were analyzed to estimate their reading subskill mastery patterns. Results showed that the predefined item-subskill associations were generally supported by empirical evidence. In particular, search reading was empirically confirmed as a targeted subskill in the expeditious reading section, despite its absence from the initial test specifications. Subskill prevalence analysis identified the subskill of understanding the structure and cohesion of a passage as the most challenging one, providing evidence that may inform targeted instructional support. This study responds to persistent calls for research into truly diagnostic assessments rather than retrofitting existing tests and demonstrates the value of the cognitive diagnostic approach in enhancing the diagnostic precision of reading assessment. It also outlines a research agenda for developing cognitive diagnostic assessment from inception so as to fully realize its diagnostic potential.

PMID 42723962
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PubMedApplied psychological measurement2026-09-11

ICC-Based Projection of IRT/MIRT Response Functions Into DINA-Style Diagnostic Summaries.

Hsieh Tien-Yu TY

Assessments calibrated under item response theory are often expected to support diagnostic reporting, though their parameters differ from diagnostic classification models. This study introduces a projection procedure that summarizes continuous response functions into diagnostic metrics based on explicit reference distributions and mastery thresholds. These metrics-the projected nonmaster success summary, projected master success summary, and projected separation index-are conditional averages over defined mastery regions rather than portable parameters. Simulations and an empirical application show strong item-level agreement with recalibrated diagnostic models, while downstream classification showed varying sensitivity across calibration contrasts. Under a fixed reference distribution and threshold system, the projected separation index provided a conditional item-screening criterion and supported targeted warning-flag review.

PMID 42724259
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PubMedTranslational lung cancer research2026-09-11

Comparison of diagnostic yield between electromagnetic navigation bronchoscopy-guided forceps biopsy and target-fixing technique-assisted RP-EBUS-guided transbronchial cryobiopsy with a guide sheath for peripheral lung lesions.

Kim Taehun T, Song Jae Woon JW, Hong Jung Hee JH, Youn Seong Hwan SH et al.

Accurate diagnosis of peripheral lung lesions remains challenging, particularly for small nodules. Electromagnetic navigation bronchoscopy (ENB) improves access to peripheral airways but shows variable diagnostic yield. Radial probe endobronchial ultrasound-guided transbronchial cryobiopsy with a guide sheath (RP-EBUS-guided TBC with GS) allows semi-real-time lesion confirmation and acquisition of larger tissue samples. This study compared the diagnostic yield and safety of ENB-guided biopsy and RP-EBUS-guided TBC. This retrospective observational study included patients who underwent ENB-guided transbronchial biopsy or RP-EBUS-guided TBC with a GS for lung lesions suspected to be malignant on computed tomography between May 2021 and December 2025 in South Korea. Propensity score matching was applied using logistic regression with a caliper width of 0.2 standard deviation (SD) of the logit of the propensity score, adjusting for lesion size, axial distribution, lobe location, nodule characteristics, and bronchus sign. Matching resulted in 201 pairs, although some baseline imbalances remained. The overall diagnostic yield was significantly higher for RP-EBUS-guided TBC than for ENB (91.1% vs. 73.4%, P<0.001). Sensitivity for malignancy was also higher with RP-EBUS-guided TBC (88.4% vs. 73.3%, P<0.001). In the matched cohort, RP-EBUS-guided TBC was significantly associated with higher diagnostic yield [odds ratio (OR) 2.715, P<0.001] and sensitivity (OR 3.897, P<0.001). Pneumothorax occurred more frequently in the RP-EBUS-guided TBC group; however, the difference was not statistically significant (OR 2.054, P=0.20). RP-EBUS-guided TBC with a GS was associated with a higher diagnostic yield than ENB-guided forceps biopsy, without a statistically significant increase in major complications in patients with peripheral lung lesions.

PMID 42723793
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