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selpercatinib

✓ Approved

Loxo Oncology · NTRK1 · 辅助诊断

什么是 selpercatinib？

selpercatinib 是一种辅助诊断，由Loxo Oncology研发。该药已获批，用于治疗相关适应症，给药途径：Others。

药物档案

公司Loxo Oncology
药物类别辅助诊断
分子靶点NTRK1
给药途径Others
状态Approved
来源： ClinicalTrials.gov, Loxo Oncology

作用机制

分子靶点

selpercatinib 作用于 1 个分子靶点：

NTRK1neurotrophic receptor tyrosine kinase 1 (TRK1, TRK)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

selpercatinib 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Uterine cancer✓ Approved

相关研究文献

PubMedJournal of the Society for Cardiovascular Angiography & Interventions2026-10-27

Optimal Sheath for Single-Access Percutaneous Coronary Intervention With Impella CP Hemodynamic Support.

Thakker Ravi R, Khalif Adnan A, Xu Ying Y, Bilazarian Seth S et al.

Single-access percutaneous coronary intervention (PCI) with the Impella CP (Abiomed) has increased in prevalence. Despite this, the optimal PCI sheath remains unknown. We characterized the optimal 7F PCI sheath using the single-access technique. The outer diameter measurement of the sheaths was performed using a Keyence 2-axis laser micrometer (Keyence). The force needed to insert the sheath and the torqueability of the guide catheter were assessed using the Mark-10 M5i Advanced Digital Force/Torque Indicator (Mark-10 Corporation) on a simulated single-access setting in a simulated skin pad. The sample size was determined to be 5 sheaths for each test. The BRITE TIP 11 cm (Cordis), BRITE TIP 35 cm (Cordis), and Destination sheath (Terumo) had the largest outer diameters; the Prelude IDeal (Merit Medical) and Terumo Glidesheath (Terumo) had the smallest outer diameters. The Glidesheath was easiest for insertion/removal, followed by the Prelude IDeal and Impella Low Profile (LP) Companion sheath (Abiomed). The Impella LP Companion, Prelude Roadster (Merit Medical), and Destination sheaths allowed for the best torqueability and lowest force to remove the guide catheter. The longer Impella LP Companion sheath did not impact torqueability, but the removal force increased by 50% compared with the shorter Impella LP Companion sheath. The Impella LP Companion sheath demonstrated the best torqueability and least effort in advancing the guide catheters, while the Prelude Roadster and Destination also performed well on these metrics. The Prelude IDeal and Glidesheath were good options for single-access because of their smaller outer diameters and hydrophilic coating and were easiest for insertion/removal through the 14F LP sheath.

PMID 42936568
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PubMedMicroorganisms2026-10-27

A Review of Recombinase-Aided Amplification (RAA) in Veterinary Medicine.

Li Shaomei S, Gao Jieqi J, Miao Yongqiang Y, Chen Qianlin Q et al.

Rapid and accurate pathogen detection is crucial to mitigating the significant economic impacts of infectious animal diseases. Recombinase-aided amplification (RAA) has emerged as a highly promising isothermal diagnostic tool, characterized by its rapid turnaround time, robust amplification efficiency, and single-copy analytical sensitivity. In veterinary diagnostics, RAA has evolved from single-pathogen proof-of-concept assays to become a promising technology for point-of-care scenarios. This review critically evaluates the integration of RAA with real-time fluorescence, CRISPR-Cas systems, lateral flow dipsticks (LFDs), and suspension microarray technologies, highlighting their impact on assay sensitivity and point-of-care (POC) applicability. Despite recent advancements, including encouraging progress in multiplexing and expanded applications in companion animal medicine, inherent challenges such as matrix effects in crude clinical samples, aerosol contamination risks, and commercialization barriers remain. By benchmarking RAA against traditional molecular methods and structurally similar technologies like recombinase polymerase amplification (RPA), this review outlines future trajectories for optimizing RAA platforms, aiming to maximize their utility in routine veterinary surveillance and epidemiological control.

PMID 42943590
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PubMedBiomolecules2026-10-27

Updates on the Translational Value of Idiopathic Pulmonary Fibrosis Models Across Species: Deeper Insights Through Comparative Pathology.

Gargiulo Sara S, Gramanzini Matteo M, Bonente Denise D, Barone Virginia V

Over the past few decades, advances in comparative pathology have strengthened the potential translational value of animal models of Idiopathic Pulmonary Fibrosis (IPF). The integration of human-relevant diagnostic biomarkers into preclinical studies, such as advanced imaging techniques and standardized histopathological methods, has improved the comparability of experimental findings with human disease. Naturally occurring fibrotic lung diseases in some breeds of companion dogs and cats and induced disease models in laboratory rodents show varying degrees of similarity to human IPF. They represent valuable comparative medicine tools to better understand disease mechanisms and test new therapies, each with advantages and limitations. Critically evaluating their complementarity is essential for gaining reliable insights into disease processes through preclinical animal studies and for developing effective treatments. This comprehensive review aims to update current knowledge of these animal models of IPF, focusing on comparative pathology, imaging, and histological features and evaluating their respective strengths, limitations, and translational relevance within the conceptual framework of "One Health, One Medicine, One Pathology". By exploiting convergent pathophysiological processes across species, this interdisciplinary collaborative paradigm aims to promote the effective use of model organisms in biomedical research and foster mutual benefits for both humans and animals.

PMID 42939773
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PubMedAnimals : an open access journal from MDPI2026-10-27

Comparative Veterinary Psychopharmacology in Dogs and Cats: Neurotransmitter Targets, Translational Boundaries, and Species-Specific Pharmacokinetics.

Kim Iljin I, Yun Jang-Hyuk JH

Behavioral disorders in companion animals are increasingly being managed with pharmacotherapy. However, prescription practices often rely on extrapolation from human psychiatry without considering species-specific phenotypes, diagnostic frameworks, or pharmacokinetic variability. A structured translational approach is required to align mechanistic plausibility with clinical evidence and interspecies constraints. This review consolidates the current information on the pharmacological modulation of neurotransmitter systems in canine and feline behavioral disorders using a comparative framework. Neurotransmitter circuits are mapped to relevant phenotypes. Controlled clinical evidence supports the use of selected serotonergic agents for specific chronic behavioral indications in dogs, whereas evidence in cats remains scarce and indication-specific. Controlled veterinary evidence is also available for selected agents used in acute or situational behavioral indications and for selegiline in canine cognitive dysfunction. Contrastingly, the broader neurotransmitter-phenotype relationships and emerging pharmacological targets discussed in this review are supported by mechanistic or translational evidence and should not be interpreted as established clinical indications. Cross-species translation is most defensible at the level of conserved receptors and transporters, whereas direct transfer of human diagnostic categories and subjective symptoms is limited in veterinary patients. Species- and drug-specific pharmacokinetic differences, along with limited feline data, necessitate careful dose initiation, titration, and monitoring to mitigate adverse effects and drug interactions. This review provides a structured framework for interpreting psychopharmacological evidence in dogs and cats by integrating pharmacological mechanisms, the design and scope of available clinical studies, translational boundaries, and species- and drug-specific pharmacokinetic considerations. Future research could benefit from standardized outcome measures, expanded feline trials, and pragmatic real-world designs.

PMID 42939158
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PubMedAnimals : an open access journal from MDPI2026-10-27

Multimodal Postmortem Investigation of Fatal Thoracic Metallic Projectile Trauma in a Jindo Dog: Radiographic, Computed Tomographic, Necropsy, and Histopathological Findings.

Kim Ah-Young AY, Kim Jongho J, Joo Hansung H, Cheon Sangkyung S et al.

Metallic projectile injuries in companion animals present complex diagnostic and evidentiary challenges, especially when comprehensive crime scene data and intact projectiles are absent. This report describes the forensic postmortem investigation of an adult male Jindo dog submitted by law enforcement authorities following fatal penetrating trauma in South Korea. Digital radiography identified multiple radiopaque metallic opacities in the left thoracic region, accompanied by severe pleural effusion and subcutaneous emphysema. Postmortem computed tomography (PMCT; 16-slice MDCT, 0.75-mm slice thickness) precisely delineated clustered hyperattenuating metallic fragments embedded in the left thoracic wall, an oblique displaced fracture of the left fourth rib, marked hemopneumothorax with compression atelectasis, and pneumomediastinum, while excluding cranial or abdominal injury. At necropsy, approximately 100 mL of pleural blood was evacuated, and through-and-through pulmonary transcapsular lacerations were identified traversing the right and left cranial lung lobes. Multiple deformed metallic fragments were recovered adjacent to the fractured rib under strict forensic chain-of-custody protocols. Histopathology of pulmonary laceration margins confirmed acute hemorrhage, fibrin deposition, and early neutrophilic margination, establishing an acute antemortem vital reaction (survival interval < 1 h). Histological examination of the cutaneous entry and exit margins revealed mechanical tearing without thermal coagulation or soot residue, consistent with an intermediate-to-distant discharge. The anatomical convergence of lesions supported a right-to-left projectile trajectory, with the left axillary defect presenting features compatible with a shored exit wound. Death was attributed to fatal acute hemopneumothorax and bilateral pulmonary laceration secondary to perforating metallic projectile injury. This case demonstrates the indispensable diagnostic and prosecutorial value of integrating digital radiography, PMCT virtopsy, forensic necropsy, and histopathology in veterinary medicolegal investigations of non-accidental trauma.

PMID 42939195
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PubMedAnimals : an open access journal from MDPI2026-10-27

The mLOS Open-Source Software for Analyzing Length of Stay in Animal Shelters.

Mavrovouniotis Michael Loizos ML

Length of stay (LOS) is critical in shelter management and animal welfare. Its assessment by calendar period must account for animals whose stay overlaps with period boundaries. mLOS is an open-source R tool that uses animal-level intake and outcome records to analyze LOS distributions and competing outcomes using survival-analysis methods. A companion Python package, ShelterDataPrep, prepares raw data extracts for analysis. The factors used are calendar period, intake type, and a user-defined animal group. The counting-process formulations left-truncate stays in progress at the beginning of a period and right-censor stays ongoing at period end. Kaplan-Meier estimates the stay distribution, Aalen-Johansen gives cumulative incidence by outcome type, and Cox and Weibull regressions compute the effect of each factor adjusted for others. A run computes in-care stay curves, remaining stay curves, competing outcomes, outcome conditional on tenure, and population-load figures including census. Each is produced for the unified sample and separately by factor. Pooled and per-factor Cox regressions produce hazard ratios while corresponding Weibull regressions produce LOS ratios. Validation includes hand-derived exact tests and simulation fixtures that recover known behavior. The outputs comprise plots, companion CSVs, a JSON with complete results, a consolidated workbook, and an experimental slide deck.

PMID 42939138
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