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lansoprazole + amoxicillin + clarithromycin (Lansap)

✓ Approved

Takeda · ATP4A · 小分子

什么是 lansoprazole + amoxicillin + clarithromycin？

lansoprazole + amoxicillin + clarithromycin 是一种小分子，由Takeda研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Lansap
公司Takeda
药物类别小分子
分子靶点ATP4A
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Takeda

作用机制

分子靶点

lansoprazole + amoxicillin + clarithromycin 作用于 1 个分子靶点：

ATP4AATPase H+/K+ transporting subunit alpha (ATP6A)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

lansoprazole + amoxicillin + clarithromycin 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersGastric ulcer✓ Approved
Infections and infestationsHelicobacter infection✓ Approved

相关研究文献

PubMedGastroenterology research and practice2026-10-27

Advances in Research on the Genotype-Phenotype Correspondence of Antibiotic Resistance in Helicobacter pylori and Its Molecular Mechanisms: A Narrative Review.

Gong Hui H, Huang Yan Chun YC, Yang Bo B, Song Zhen Yu ZY et al.

Helicobacter pylori (H. pylori), recognized as the primary pathogen responsible for chronic gastric infections, has exhibited an increasing prevalence of antibiotic resistance, which significantly impairs the efficacy of clinical treatments. In recent years, the extensive utilization of antibiotics alongside the rising prevalence of resistant strains has elevated the investigation of the resistance mechanisms of H. pylori to a prominent area of research. This article systematically examines the phenotypic characteristics associated with the antibiotic resistance of H. pylori, establishing a correspondence with resistance genotypes. Particular emphasis is placed on analyzing the resistance mechanisms linked to commonly prescribed antibiotics such as clarithromycin, metronidazole, and amoxicillin, in addition to the molecular characteristics of the relevant resistance genes (such as mutations in "gyrA," "gyrB," "23S rRNA," "frxA," "pbp1," and "rdxA"). By merging advancements in molecular biology with findings from epidemiological studies, this review explores the potential application of resistance genotype detection in facilitating tailored clinical treatment approaches. The objective of this review is to enhance the understanding of the resistance mechanisms of H. pylori, fostering the development of precise diagnostic and therapeutic strategies and offering theoretical insights and future research pathways for the treatment of anti-H. pylori infections.

PMID 42935758
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PubMedPharmaceuticals (Basel, Switzerland)2026-10-27

Old Drugs, New Targets: Molecular Docking Insights into Repurposing Proton Pump Inhibitors for the TLR4/MD-2, NLRP3, and C5aR1 Axes in Autoimmune Liver Diseases.

Yıldız Mehmet M, Şeker Erdi E, Altınkaya Engin E, Poustforoosh Alireza A et al.

Background/Objectives: Autoimmune liver diseases (AILDs), including autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis, may include treatment-resistant cases and therefore require new therapeutic strategies. This in silico study evaluated proton pump inhibitors (PPIs) across three pathophysiologically complementary inflammatory targets relevant to hepatic immune injury: TLR4/MD-2, representing upstream innate immune sensing; NLRP3, representing inflammasome-mediated inflammatory amplification; and C5aR1, representing complement-dependent leukocyte recruitment. Methods: The binding profiles of four PPIs (rabeprazole, lansoprazole, omeprazole, and pantoprazole) were analyzed by molecular docking against TLR4/MD-2 (3FXI), NLRP3 (7VTP and 7PZC), and C5aR1 (6C1R and 5O9H). TAK-242, MCC950, and avacopan were included as target-associated reference ligands solely to provide structural and protocol-specific context. Their docking scores were not used as benchmarks of relative binding affinity, inhibitory potency, or pharmacological efficacy. MM-GBSA binding free energy calculations for the best score in all proteins were performed. Molecular docking and molecular dynamics analyses indicated stable interactions for the best docking score. Results: PPIs showed variable but potentially meaningful docking affinities across the evaluated targets. Rabeprazole produced favorable docking scores within the investigated TLR4/MD-2 (-7.85 kcal/mol) and inactive NLRP3 (-9.10 kcal/mol) binding sites under the present docking protocol. The reference ligands TAK-242 and MCC950 were included only to provide structural and protocol-specific context, and their docking scores were not interpreted as measures of relative pharmacological potency. Among the PPIs, lansoprazole showed the most favorable docking score for the C5aR1 allosteric site (-6.93 kcal/mol). Interaction analyses suggested favorable hydrophobic contacts and substantial spatial occupancy within the investigated binding pockets; however, cross-target docking compatibility may partly reflect nonspecific hydrophobic accommodation rather than genuine polypharmacology, and whether these predicted interactions produce target-specific functional effects requires experimental validation. MM-GBSA analysis supported the predicted stability of the rabeprazole-NLRP3 (7PZC) complex (ΔGbind = -56.97 kcal/mol). Conclusions: These findings prioritize rabeprazole and lansoprazole as PPI scaffolds showing favorable predicted interactions across several inflammation-related target structures within the applied computational framework. These results are hypothesis-generating and do not establish target inhibition, target engagement, or therapeutic efficacy. The results are hypothesis-generating and warrant experimental studies to determine whether these predicted interactions translate into target engagement or modulation of inflammatory signaling in AILDs.

PMID 42943278
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PubMedAntibiotics (Basel, Switzerland)2026-10-27

Network Analysis of Antimicrobial MIC Profiles Reveals Extensive Covariation in Chicken-Associated Escherichia coli from Large-Scale Breeding Flocks in Central Hungary.

Kerek Ádám Á, Tornyos Gergely Álmos GÁ, Szarka Edit E, Husz Levente Hunor LH et al.

Background: The surveillance of non-clinical bacteria from food-producing animals can reveal antimicrobial selection patterns without conditioning sampling on clinical disease, but categorical resistance estimates are difficult to compare when organism-specific breakpoints are incomplete. We aimed to characterize antimicrobial MIC distributions in chicken-associated Staphylococcus spp., Enterococcus spp., and Escherichia coli from Central Hungary and to determine whether E. coli MIC profiles formed structured covariance networks. Methods: The dataset comprised 133 isolates collected in 2022-2023 (28 Staphylococcus spp., 59 Enterococcus spp., and 46 E. coli). MIC distributions were summarized using MIC50/MIC90, and E. coli MICs were analyzed by Spearman correlation with Benjamini-Hochberg correction. Historical threshold classification was retained only as a sensitivity analysis, and nine E. coli genomes provided contextual genomic information. Results:Staphylococcus spp. showed lower amoxicillin MIC50/MIC90 values (0.25/1 µg/mL) than Enterococcus spp. (1/256 µg/mL), illustrating marked cross-genus differences. In E. coli, MIC50/MIC90 values included 16/512 µg/mL for ceftriaxone, 128/256 µg/mL for neomycin, 32/128 µg/mL for enrofloxacin, and 32/>512 µg/mL for trimethoprim-sulfamethoxazole. Ten associations met |ρ| ≥ 0.40 and adjusted q < 0.05, forming two connected components that persisted after sensitivity analyses for upper-bound accumulation and the amoxicillin-amoxicillin/clavulanic acid relationship. The nine genomes showed heterogeneous resistance-associated gene calls. Conclusions: Continuous MIC analysis revealed phenotypic covariance not captured by categorical summaries alone and identified region-specific targets for stewardship-oriented follow-up. Inference remains isolate-level rather than farm-adjusted, and the genomic panel is not representative of the phenotypic cohort; longitudinal sampling linked to antimicrobial-use data and larger matched phenotype-genotype datasets are therefore warranted.

PMID 42938740
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PubMedAntibiotics (Basel, Switzerland)2026-10-27

Evolution and Detection of β-Lactamases in Helicobacter pylori Isolates from High- and Low-Risk Southwestern Colombian Areas for Gastric Cancer.

Guzman Kevin Andres KA, Miño Jose Dario Portillo JDP, Cifuentes Sandra S, Riquelme Arnoldo A et al.

Gastric cancer (GC) is one of the leading causes of cancer-related mortality worldwide, with Helicobacter pylori infection recognized as its main risk factor. Eradication therapy is the cornerstone of GC prevention; however, increasing antimicrobial resistance (AMR) threatens the effectiveness of amoxicillin-based regimens. This study investigated the occurrence and evolutionary distribution of β-lactamase genes in Colombian H. pylori isolates. A total of 67 H. pylori isolates from Colombian regions with high and low GC risk were analyzed. The presence of blaTEM and blaSHV genes was assessed using PCR, following in silico primer validation against complete H. pylori genomes. Phylogenomic relationships were reconstructed using the Neighbor-Joining method in MEGA XI, with the best-fitting evolutionary model selected according to (AIC). The GTR + G + I model was identified as the optimal model and was subsequently used for phylogenetic reconstruction. The resulting tree was visualized using iTOL. This study reports, for the first time in Colombia, that the presence of β-lactamase genes in H. pylori. blaTEM and blaSHV were detected in 9 of 48 Andean isolates (18.75%), whereas no β-lactamase genes were identified in isolates from the low-risk Pacific region. These genes were associated with genetic potential for amoxicillin resistance. Phylogenomic analysis identified a distinct Andean lineage in which all β-lactamase-positive isolates clustered. β-Lactamase genes in Colombian H. pylori are geographically restricted to high-risk Andean populations and associated with a defined phylogenetic lineage. These findings provide new insights into the evolution of amoxicillin resistance and support the implementation of genomic surveillance to optimize eradication strategies and improve precision management of H. pylori infection.

PMID 42938684
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PubMedAntibiotics (Basel, Switzerland)2026-10-27

From Outpatient Consumption to Receiving Waters: A Retrospective Screening Assessment of Antibiotic Loads, Resistance Indicators, and Implications for the Recast Urban Wastewater Treatment Directive.

Łuczkiewicz Aneta A, Artichowicz Wojciech W, Szopińska Małgorzata M, Jankowska Katarzyna K et al.

Background/Objectives: Wastewater treatment plants (WWTPs) are recognized point sources of pharmaceutical residues and antimicrobial-resistant bacteria. This challenge is explicitly addressed in the 2024 recast of the Urban Wastewater Treatment Directive (UWWTD), which introduces risk-based obligations for micropollutant removal. Methods: Here, five antibiotics (azithromycin, clarithromycin, erythromycin, ciprofloxacin and sulfamethoxazole) were retrospectively (2017-2018) assessed in influent and effluent of four WWTPs and in their receiving waters (riverine and marine outfalls), including the Vistula Estuary. Measured incoming load (MIL) was compared with predicted incoming load (PIL), a cost-efficient proxy derived from outpatient consumption data. Results: The screening-level PIL-MIL consistency check showed closer agreement in catchments without major hospital inputs. In WWTPs, ciprofloxacin showed consistently high apparent aqueous-phase removal in both campaigns (>95%), sulfamethoxazole showed moderate removal (64-85%), while macrolides exhibited highly variable and sometimes apparent negative removal, yielding effluent concentrations up to 3989 ng L-1 (azithromycin) and 2866 ng L-1 (clarithromycin). Receiving waters generally contained < 10 ng L-1 of the investigated antibiotics, but a low-dilution-capacity river showed a clear WWTP influence. Presumptive cefotaxime-resistant Escherichia coli, used as proxies for emerging ESBL/AmpC-associated resistance, reached ~5% and 20% of CFU downstream of WWTP discharges. Environmental (ERA) and AMR-related (AMR-RA) risk quotients (RQs) were mostly <0.1. However, RQs for azithromycin approached or exceeded unity in Gdańsk and Puck Bay. Coastal recipients are more vulnerable despite high dilution, since marine predicted no-effect concentrations (PNECs) for antimicrobials are lower than those for freshwater. Conclusions: The study supports the value of retrospective baseline data and site-specific screening frameworks for risk-based prioritization under the recast UWWTD.

PMID 42938704
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PubMedVeterinary sciences2026-10-27

An Effective Diagnostic Approach for Successful Recovery from Mycobacterium avium Systemic Infection in a Basset Hound Dog.

Zoppi Simona S, D'Errico Valeria V, Di Blasio Alessia A, Acutis Pier Luigi PL et al.

We describe the diagnostic pathway, clinical follow-up and resolution of generalized avian tuberculosis in a Basset Hound dog. Lethargy, anorexia, weight loss and shifting lameness were observed. Cytological examination of specimens collected from prescapular, retromandibular and popliteal lymph nodes revealed the presence of acid-fast bacilli, subsequently identified as Mycobacterium avium subsp. hominissuis by microbiological and molecular tests. MIC determination was performed to guide therapy, which was subsequently based on clarithromycin (5 mg/kg orally every 12 h) and moxifloxacin (10 mg/kg orally every 24 h). Early and rapid diagnosis, combined with prompt initiation of appropriate antibiotic treatment, resulted in complete recovery of the affected dog.

PMID 42944141
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