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lansoprazole + amoxicillin + clarithromycin (Lansap)

✓ Approved

Takeda · ATP4A · 小分子

什么是 lansoprazole + amoxicillin + clarithromycin？

lansoprazole + amoxicillin + clarithromycin 是一种小分子，由Takeda研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Lansap
公司Takeda
药物类别小分子
分子靶点ATP4A
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Takeda

作用机制

分子靶点

lansoprazole + amoxicillin + clarithromycin 作用于 1 个分子靶点：

ATP4AATPase H+/K+ transporting subunit alpha (ATP6A)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

lansoprazole + amoxicillin + clarithromycin 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersGastric ulcer✓ Approved
Infections and infestationsHelicobacter infection✓ Approved

相关研究文献

PubMedFrontiers in global women's health2026-09-11

Expanding treatment options for syphilis during pregnancy: a review of alternatives to penicillin.

Townsend Claire L CL, Mofenson Lynne L, Gottlieb Sami S, Peters Remco P H RPH et al.

Syphilis infection during pregnancy leads to around 390,000 adverse birth outcomes each year and is an important cause of preventable stillbirth. Although benzathine penicillin G is safe and effective during pregnancy for treating maternal and fetal infection, there are frequent global shortages and limited options for people with penicillin allergy. We conducted a review of potential alternatives to penicillin for treating syphilis during pregnancy when penicillin is not available or cannot be used, including ceftriaxone, amoxicillin, doxycycline, cefixime, and linezolid. Despite some efficacy data on their use in non-pregnant adults with syphilis, limited data were available on placental transfer, pharmacokinetics and dosing, efficacy or effectiveness, and safety in pregnancy. Given its favourable preclinical reproductive toxicity data, efficacy data in non-pregnant adults with syphilis, and safety during pregnancy when used for other indications, ceftriaxone could potentially be considered as an alternative treatment for pregnant women with syphilis in cases where penicillin cannot be used, as currently recommended by the World Health Organization. However, evidence about optimal dosing, feasibility, and efficacy/effectiveness for treating syphilis during pregnancy is needed. Several planned and ongoing clinical trials will provide additional data to inform the use of cefixime, amoxicillin, and linezolid in pregnant women with syphilis. Going forward, evaluation of new and existing medications for treating syphilis and preventing congenital syphilis should include a pregnancy investigation plan. Where possible, efforts should be made to ensure that high-quality pregnancy safety and efficacy or effectiveness data on drug candidates are generated in carefully designed studies to ensure that pregnant women and their infants are able to benefit from the full range of treatment options.

PMID 42724234
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PubMedCureus2026-09-10

Real-Life Application of the Penicillin Allergy Decision Rule (PEN-FAST) Score in De-Labeling Penicillin Allergy: A Case Series.

Begum Fahmida F, Dhlandhlara Takudzwa J TJ, Qazi Nadia N, Ugurlu Aylin A et al.

Penicillin allergies are common but frequently inaccurate, resulting in unnecessary use of broad-spectrum antibiotics and contributing to antibiotic resistance. Tools such as the Penicillin Allergy Decision Rule (PEN-FAST) support the assessment of penicillin allergy risk and can help identify low-risk individuals who may be appropriate candidates for a direct oral penicillin challenge. We report four cases of patients hospitalized with respiratory infections, including infective exacerbation of bronchiectasis, bronchopneumonia, and empyema thoracis, all with documented penicillin allergy labels. In each case, a more detailed review of the allergy history revealed reactions inconsistent with IgE-mediated hypersensitivity reactions, including isolated diarrhea, leg swelling, and delayed rashes. All patients had a PEN-FAST score of 0, which indicated a low risk of a true penicillin allergy. These patients underwent supervised direct oral challenges with amoxicillin or co-amoxiclav, which revealed no adverse reactions. Following a successful oral challenge, penicillin allergies were de-labeled, and the patients were started on optimal antibiotic treatment. All cases revealed favorable outcomes, such as improvements in inflammatory markers and symptoms.

PMID 42719563
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PubMedFrontiers in veterinary science2026-09-10

Case Report: Distal tibial physeal fracture secondary to septic physitis and osteomyelitis in a Boxer puppy.

Sidhu Nisha N, Cao Jennifer W JW, Frederick Steven W SW, Chambers Aidan A

Salter-Harris fracture secondary to septic physitis has been reported in foals but not puppies. In this case, a 19-week-old, 13.4 kg male intact Boxer puppy was presented with a 2-day history of acute non-weight-bearing lameness of the left pelvic limb, accompanied by distal limb swelling and lethargy. Orthogonal tibial radiographs were performed, and irregular widening of the distal tibial physis with severe edema of the surrounding soft tissues consistent with septic physitis were identified. Fifteen hours later, distal tibial radiographs were repeated, and a Salter-Harris type I fracture of the distal tibial physis, presumed to be pathologic in origin, was diagnosed. Surgical exploration revealed a subperiosteal abscess, which was drained and cultured. The physeal fracture was stabilized with cross-pin fixation, which was reinforced with a splint and bandage for the duration of recovery. Pasteurella spp. was isolated, and amoxicillin-clavulanate was prescribed for 72 days. Resolution of swelling, radiographic fracture healing, and return to normal limb function were achieved after 14 weeks postoperative, at which time the pins were removed and submitted for aerobic and anaerobic culture and susceptibility. No bacterial isolates were identified. This is the first documented case of an appendicular physeal fracture secondary to suspected septic physitis in a dog, and septic physitis should be considered a differential for puppies with spontaneous Salter-Harris fracture.

PMID 42718565
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PubMedJournal of infection and public health2026-09-10

Molecular epidemiology of multidrug-resistant uropathogenic Escherichia coli: Virulence, biofilm formation, phylogenetic distribution, and genetic diversity.

Ahmmed Md Tanjir MT, Prapti Bushra Benta Rahman BBR, Islam Tasnim T, Arnop Kazi Mohimen Alam KMA et al.

Multidrug-resistant (MDR) Escherichia coli mediated urinary tract infections (UTIs) are an increasing public health concern, especially in low- and middle-income nations. This study aimed to determine the prevalence, antimicrobial resistance and virulence profile, biofilm forming ability with phylogenetic distribution and genetic diversity of uropathogenic E. coli (UPEC) isolated from UTI patients. A total of 718 urine samples were collected from the diagnostic outpatient department of Mymensingh Medical College, Mymensingh, Bangladesh. Samples were analyzed using standard culture technique, and E. coli was identified by MALDI-TOF MS and PCR. Phenotypic antibiotic resistance was detected by the disc diffusion method. Both CRA and CVMP techniques were used to identify the biofilm forming ability. Virulence and resistance genes were identified by PCR. Genetic diversity was studied through phylogrouping, ERIC-PCR, and sequencing of 16 s rRNA gene. 125 (17.41%) samples showed significant bacteriuria and were confirmed as UTI cases. E. coli was identified in 38 (30.4%) of these cases and most of the isolates were recovered from females (63.2%) and individuals aged 15-35 years (47.4%). High resistance was observed against meropenem (100%) and amoxicillin (100%), while nitrofurantoin (7.9%) and imipenem (23.7%) had the lowest resistance rate. All of the study isolates were either MDR (66%) or XDR (34%). blaOXA (81.6%), blaCTX-M (55.3%), and qnrA (89.5%) were most prevalent resistance genes. A strong positive correlation (rₛ = 0.719, p < 0.001) was found between resistance gene load and the multiple antibiotic resistance (MAR) index. crl (100%), uidA (100%), and csgA (94.7%) were highly prevalent virulence genes. Approximately 85% of isolates were biofilm producer. Phylogenetic group B2 (36.82%) was predominant and significantly associated with virulence gene carriage and biofilm formation. Furthermore, ERIC PCR revealed a considerable genetic variability among the study isolates. These findings highlight the alarming spread of MDR and XDR E. coli strains with high virulence potential, emphasizing the need for continuous monitoring and judicious antibiotic use.

PMID 42721801
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PubMedFrontiers in chemistry2026-09-09

Repurposing of lansoprazole and nitazoxanide as NR2F2 inhibitors in the gastric cancer cell line GCIY: computational insights and siRNA-mediated in vitro tests.

Culletta Giulia G, Roomi Muhammad Sohaib MS, Caricasulo Maria Azzurra MA, Zanetti Adriana A et al.

Nuclear receptors (NRs) are a superfamily of ligand-activated transcription factors that mediate the cellular response to hormones, vitamins, and dietary lipids, thus orchestrating numerous physiological processes and influencing multiple disease states. Within this superfamily, NR2Fs, also known as Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF), are a family of nuclear orphan receptors, due to the lack of known endogenous ligands. Among them, NR2F2 transcription factor activities involve regulation of cell differentiation during organogenesis, maintenance of adult tissue homeostasis, and tumorigenesis. To date, only the CIA compounds have been identified as inhibitors of NR2F2 driven transcriptional activity in prostate cancer cell lines, with the IC50 of CIA1 falling in the lower μM range. A comprehensive computational analysis has been conducted in order to gain insight into the inhibitory activity of the prototype CIA1 against NR2F2 at a molecular level. We leveraged the outputs of computational analysis to perform a virtual screening campaign to FDA compounds capable of binding to NR2F2. Luciferase reporter assay was used to functionally validate the interaction. RNA interference approaches were used to validate the specificity of NR2F2 activity on cell proliferation. We identified lapatinib, glyburide, nitazoxanide, and lansoprazole as modulators of NR2F2-dependent reporter activity. In the gastric cancer cell line GCIY, lansoprazole and nitazoxanide exert antiproliferative effects that are mitigated by NR2F2 silencing. The convergence between in silico predictions and LBD-dependent reporter modulation supports the interpretation that lapatinib, glyburide, nitazoxanide, and lansoprazole represent bona fide functional interactors of NR2F2. Taken together, our data extend current evidence that NR2F2 is a ligandable orphan receptor whose transcriptional output can be pharmacologically tuned. Moreover, our findings provide new chemical tools for probing NR2F2 biology and nominate clinically used molecules as starting points for therapeutic or repurposing strategies targeting NR2F2-dependent programs.

PMID 42712908
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PubMedMicrobiology (Reading, England)2026-09-09

Detection of opportunistic bacterial pathogens with intrinsic amoxicillin- and cephalosporin-resistance in wild koala faecal microbiomes.

McDougall Fiona K FK, Paranagama Kalani K, Boardman Wayne S J WSJ, Wyres Kelly K et al.

Opportunistic bacterial pathogens frequently associated with human clinical infections, including antimicrobial-resistant strains, are infiltrating the microbiomes of wild animals, where they have the potential to negatively impact wildlife health. Bacterial genes conferring resistance to amoxicillin have previously been reported in koala (Phascolarctos cinereus) faecal DNA. Koalas are facing several key threats, including wildfires, and affected individuals may receive amoxicillin therapy to treat burn wounds. This study aimed to identify the species of amoxicillin-resistant bacteria in koala gut microbiomes and determine if they are opportunistic pathogens. Faecal samples collected from 98 wild-caught koalas were cultured using amoxicillin-supplemented media to isolate amoxicillin-resistant Gram-negative enteric bacteria. Isolates were screened using 16S rRNA PCR and Sanger sequencing to identify opportunistic pathogenic species, which then underwent whole-genome sequencing and antimicrobial susceptibility testing. Intrinsically amoxicillin-resistant opportunistic pathogens were obtained from 9.2% (9/98) of koala faecal samples and comprised Klebsiella oxytoca (6/98, 6.1%), Klebsiella pneumoniae (1/98, 1.0%) and Citrobacter spp. (2/98, 2.0%). Seven of nine amoxicillin-resistant opportunistic pathogens also exhibited cephalosporin resistance. Four K. oxytoca isolates belonged to lineages associated with human clinical infections, which also have the potential to cause disease in koalas, including fatal systemic infections in pouch young. The presence of amoxicillin- and cephalosporin-resistant strains may also increase the risk of gut dysbiosis and opportunistic infections when penicillins or cephalosporins are required to treat bacterial infections in koalas, highlighting the importance of good antimicrobial stewardship. The study findings demonstrate the One Health perspective of microbial pathogens and the intertwined microbial ecology between humans and wildlife.

PMID 42714937
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