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blood substitute (Volplex / Volplex)

✓ Approved

Sinclair · 细胞治疗 · 细胞治疗

什么是 blood substitute？

blood substitute 是一种细胞治疗，由Sinclair研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Volplex, Volplex
公司Sinclair
药物类别细胞治疗
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Sinclair

治疗适应症

blood substitute 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresAdjuvant therapy✓ Approved

相关研究文献

PubMedNutrients2026-10-27

Sepiapterin Enables Liberalisation of Natural Protein Intake While Improving Metabolic Control in Adolescents with Phenylketonuria.

Pinto Alex A, Daly Anne A, Vijay Suresh S, Evans Sharon S et al.

Background: Sepiapterin is a synthetic precursor of tetrahydrobiopterin (BH4) that increases intracellular BH4 availability and has demonstrated greater phenylalanine-lowering efficacy than sapropterin. We evaluated its effect on dietary liberalisation and metabolic control in adolescents with phenylketonuria (PKU). Methods: Seven adolescents with PKU (median age of commencing sepiapterin: 13 years, range 12-17 years), including five previously responsive to sapropterin, were studied. Median natural protein intake, protein equivalent from protein substitute, and total protein intake were compared during diet-only treatment, sapropterin treatment (where applicable), and after 12 months of sepiapterin. Blood phenylalanine (Phe) and tyrosine (Tyr) concentrations were assessed over 12 months for each treatment period. Results: Median natural protein intake increased from 6.5 g/day (range 4.5-15) during diet-only treatment (n = 7) to 20 g/day (10-25) with sapropterin (n = 5) and 70 g/day (34-90) after 12 months of sepiapterin (n = 7). This represented a median increase of 218% (70-471%) compared with sapropterin and 600% (200-1900%) compared with diet alone. Median total protein intake on sepiapterin was 90 g/day (70-114), equivalent to 1.4 g/kg/day, and four participants discontinued protein substitute completely. Mean (±SD) blood Phe concentrations were lower with reduced variability on sepiapterin (303 ± 157 µmol/L during diet-only treatment; 321 ± 136 µmol/L with sapropterin; 260 ± 116 µmol/L with sepiapterin), while Tyr concentrations remained stable. The percentage of blood Phe concentrations within target improved with sepiapterin (≤360 µmol/L: 83%, range 77-100) compared with diet alone (68%, range 17-100) and sapropterin (66%, range 40-91). Most participants incorporated high-protein foods into their diets, including meat (7/7), fish (6/7), cheese (6/7), and milk or yoghurt (5/7). Conclusions: Twelve months of sepiapterin enabled marked dietary liberalisation while improving metabolic control in adolescents with PKU. These findings suggest that sepiapterin may substantially reduce treatment burden and represent an important advance in the management of this challenging age group.

PMID 42942947
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PubMedActa pharmaceutica (Zagreb, Croatia)2026-10-27

Integrating network pharmacology and experimental validation reveals PI3K/AKT as a critical pathway in pachymic acid-induced inhibition of hepatocellular carcinoma.

Liang Jun J, Zhang Hongyu H, Pan Shixin S, Si Tao T et al.

Pachymic acid (PA), a natural lanost-8-ene-type triterpenoid isolated from Poria cocos, exhibits diverse pharma cological activities, including anti-oxidant, anti-inflammatory, antiaging, and hypnotic effects. Emerging evi dence has highlighted its potential anticancer properties, particularly its ability to suppress the proliferation of various cancer cell lines, though the underlying mechanisms remain largely undefined. In this study, we employed a network pharmacology approach to explore the anti-hepatocellular carcinoma (anti-HCC) effects of PA. GO and KEGG enrichment analyses identified the PI3K/AKT signalling pathway as a key candidate mediating PA's activity in liver cancer cells. This prediction was subsequently validated by Western blotting, which confirmed that PA markedly inhibited the growth of HepG2 HCC cells through suppression of the PI3K/AKT pathway, as evidenced by reduced AKT phosphorylation. Collectively, our findings provide new insights into the anticancer mechanisms of PA and support its potential as a promising candidate for novel anti-HCC therapies.

PMID 42937263
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PubMedMaterials (Basel, Switzerland)2026-10-27

Development of New Materials with Different Types of By-Products to Manufacture Construction Elements for Thermal Insulation.

Musa Ali A, Ahmed Leena L, Rosales Manuel M, Agrela Francisco F et al.

This study evaluates mortars that incorporate mixed recycled aggregates, biomass bottom ash, chamotte, wood waste, and expanded clay as partial substitutes for cement and natural aggregates. Three series of mortars were investigated: with 25% cement replacement, partial sand replacement, and simultaneous replacement of cement and sand. Mechanical, physical, durability, and thermal properties were evaluated, along with their relationships through a correlation analysis. Cement substitution did not result in a drastic reduction in compressive strength and produced limited thermal improvements, whereas sand substitution led to substantially greater reductions in thermal conductivity, ranging from approximately 10.3% for MRA to 59.1% for wood waste compared to the control. Expanded clay reduced thermal conductivity by 24.7%, while BBA-L showed greater insulating potential than BBA-PG but resulted in a reduction in compressive strength. The combination of chamotte, limestone filler as a cement substitute, MRA, and expanded clay as an aggregate substitute provided the best balance between thermal and mechanical performance, achieving a compressive strength of approximately 39 MPa at 90 days and reducing thermal conductivity by nearly 22% compared to the reference mortar. The results demonstrate that thermal performance depends largely on density and porosity, although the optimal selection of materials requires simultaneously considering both mechanical and physical properties.

PMID 42941150
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PubMedMedicine2026-10-27

Advance care planning communication training workshop for professional care workers in Japan: A mixed-method approach.

Ohashi Hiroko H, Hirakawa Yoshihisa Y, Abe Keiko K, Andoh Hideaki H et al.

Advance care planning (ACP) is a process of communication between individuals and care teams. ACP enables individuals to make informed decisions regarding their future healthcare and support when their capacity to express or discuss personal choices becomes restricted. In this study, we aimed to develop and implement an ACP educational program for Japanese professional care workers and describe changes in their attitudes and practices post-implementation. We developed an ACP educational program. Eighty-two professional care workers from 5 prefectures participated from January to September 2019. We conducted pre- and post-tests, post-program interviews, and written interviews 3 months post-program. Changes in knowledge and attitudes were statistically analyzed, and interviews were analyzed using qualitative content analysis. The program helped participants improve their knowledge of substitute decision-making by families, withdrawal of tube feeding, and living wills. Participants experienced reduced difficulty in caring for dying patients. The qualitative analysis of post-program interviews identified the following 7 themes: foundational knowledge of ACP, attentive interviewing, inferring clients' preferences from informal conversation, rapport-building, consensus-building among stakeholders, merits of initiating ACP discussions by professional care workers, and skill in explaining the concept of a living will. The written interviews conducted after 3 months identified the following 4 themes: discussion opportunities, discussion skills, self-determination and substitute decision-making, and thinking about death as a personal matter. These qualitative analyses reinforced and explained the quantitative survey results. The ACP educational program presented herein helps improve the education of professional care workers and disseminates ACP.

PMID 42937768
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PubMedFrontiers in public health2026-10-27

From shared reading to self-narration: a developmental pathway for reading-based psychological support.

Zhao Mengjing M, Zhang Yishu Y

Reading-based psychological support is usually studied as clinical bibliotherapy, shared reading, or literacy-related intervention, and these strands are rarely followed across childhood, adolescence, and emerging adulthood. This perspective asks whether shared reading can become a source of self-narration. In childhood, reading with a responsive adult may support emotional language and meaning-making. During adolescence, some narrative resources may be selectively taken up and revised. In emerging adulthood, they may be used to organize transitions, commitments, and possible futures into an evolving life story. The account presents this as a developmental hypothesis rather than as evidence that childhood reading causes later narrative identity. Reading is treated as a complement to mental-health treatment, not as a substitute. The result is a set of empirical questions about mediation, developmental timing, relational quality, and contextual confounding.

PMID 42935503
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PubMedGenes2026-10-27

Improving the Usability of Donor Data from Registries Using an Extreme Learning Machine Approach to Upgrade Low-/Mid- to High-Resolution HLA Data.

Kepentzis Stavros S, Chatzistamatiou Theofanis T, Digalakis Jason J, Petropoulou Ourania O et al.

High-resolution Human Leukocyte Antigen (HLA) typing is required for unrelated donor selection, yet many registry records remain low- or intermediate-resolution. Haplotype frequency imputation is the standard remedy, but its accuracy decreases for rare haplotypes. A locus-specific Extreme Learning Machine (ELM) framework, trained on the Greek national donor registry (n = 117,345), upgrades low-/intermediate-resolution genotypes and imputes untyped loci; output weights are solved analytically. It was validated on two independent Greek cohorts (n = 20,100; 4353) against GRIMM and two expectation maximization baselines, on the same donors. Accuracy depended on the high-resolution context available (94% for HLA-A with four anchor loci; 19-22% with none) and on the posterior probability threshold (78-91% ORAM, 70-84% GRPT), while call rate fell from 98.1% to ~41%; the two cannot be maximized together. GRIMM called fewer donors (1.8-47.9%) at comparable or higher accuracy. Allele-vocabulary abridgment excluded 14-47% of external-cohort allele calls; stratified by vocabulary membership, ORAM accuracy was 94.2% for in-vocabulary donors and 73.7% for the rest. The training procedure has no convergence guarantee. ELM upgrading converts legacy registry data into probabilistic high-resolution calls, with registry-scale training completing in minutes. These calls can narrow donor searches but cannot substitute for confirmatory typing.

PMID 42938355
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