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blood substitute (Volplex / Volplex)

✓ Approved

Sinclair · 细胞治疗 · 细胞治疗

什么是 blood substitute？

blood substitute 是一种细胞治疗，由Sinclair研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Volplex, Volplex
公司Sinclair
药物类别细胞治疗
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Sinclair

治疗适应症

blood substitute 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresAdjuvant therapy✓ Approved

相关研究文献

PubMedANZ journal of surgery2026-09-11

Surgical Strategy for En Bloc Iliacoinguinal Resection and Reconstruction Using Myopectineal Orifice Repair Principles for Anterior and Lateral Pelvic Tumors: A Case Series.

Yang Song S, Lu Yao Y, Peng Huan H, Luo Shenying S et al.

Anterior and lateral pelvic tumors may extend into the iliacoinguinal region and require wide en bloc resection. When resection includes the inguinal ligament, lower abdominal wall, and-in selected cases-the external iliac vessels, reconstruction must restore a mechanically demanding abdomen-groin junction while protecting major neurovascular structures. We describe an MPO-based reconstructive strategy and report early outcomes. We retrospectively reviewed six consecutive patients who underwent en bloc iliacoinguinal resection and reconstruction between January and December 2024. Reconstruction followed preperitoneal MPO repair principles, including a mesh-based inguinal ligament substitute, peritoneal envelope ("visceral sac") reconstruction when required, abdominal wall reinforcement, and femoral canal/oval fossa dead-space management. Prosthetic graft reconstruction was performed when the external iliac vessels were resected. All patients completed the planned procedure. Inguinal ligament substitute reconstruction was performed in 6/6 patients, peritoneal envelope reconstruction in 5/6, and external iliac vessel resection with reconstruction in 4/6. Mean operative time was (375.83 ± 129.63) min and estimated blood loss was (433 ± 245.95) mL. Mean time to first flatus was (4 ± 0.89) days and length of stay was (8.67 ± 4.37) days. Pathology confirmed R0 resection in all cases. One patient developed an oval fossa seroma that resolved with repeated aspiration; two had transient mild lower-limb edema. No limb ischemia/necrosis, enteric fistula, bowel obstruction/ileus, or early abdominal wall hernia occurred during early follow-up. MPO-based reconstruction after en bloc iliacoinguinal resection is feasible and appears safe in the short term. A stepwise approach that restores a groin anchor, re-establishes compartment separation, reinforces the abdominal wall, and manages femoral dead space may improve early junctional stability.

PMID 42723202
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PubMedFrontiers in bioengineering and biotechnology2026-09-11

A preliminary feasibility study of a tough hydrogel as a nucleus pulposus substitute for degenerative disc disease.

Kang Young-Mi YM, Moon Seong-Hwan SH, Lee Byung Ho BH, Kwon Ji-Won JW et al.

Degenerative disc disease is characterized by low back pain caused by degeneration of the intervertebral discs. Hydrogels, with favorable biocompatibility and characteristics resembling the nucleus pulposus, have received attention as potential replacement materials. In this study, we developed a tough hydrogel with enhanced mechanical performance and conducted an initial assessment of its feasibility as a nucleus pulposus substitute. The hydrogel was fabricated by incorporating 2-hydroxyethyl methacrylate-treated silk fibers into the core of a polyvinyl alcohol hydrogel. In vitro experiments, including cytotoxicity, cell adhesion and short-term proliferation tests, and mechanical assessments such as swelling, static compression, tensile testing, and dynamic mechanical analysis, were performed. Pilot in vivo studies involved implanting the hydrogel into porcine intervertebral discs, with a 21-day observation period. The in vitro results demonstrated no acute cytotoxicity and showed that the hydrogel supports cell adhesion and short-term proliferation, while mechanical testing indicated favorable elastic and viscoelastic properties comparable to those of the native nucleus pulposus. Histological analyses at 21 days indicated that the hydrogel remained within the nucleus pulposus space. These findings suggest that the developed hydrogel exhibits promising biocompatibility and mechanical characteristics; however, further studies are required to fully establish its suitability as a nucleus pulposus replacement for degenerative disc disease.

PMID 42724059
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PubMedFrontiers in cardiovascular medicine2026-09-11

IL-18 in atherosclerosis: context-dependent biology, human evidence, and translational challenges.

Zhang Dongshuai D, Wang Shuai S, Li Yang Y, Zhang Huijie H et al.

Atherosclerosis is a chronic inflammatory disease shaped by interactions among vascular cells, innate immunity, adaptive immunity, and metabolic stress. Interleukin-18 (IL-18), an IL-1 superfamily cytokine activated predominantly downstream of inflammasomes, links vascular injury to type 1 immune responses. This structured narrative review integrates mechanistic, plaque-tissue, epidemiological, genetic, and therapeutic evidence for IL-18 in atherosclerosis. Experimental studies generally support pro-atherogenic actions, but these effects vary by plaque stage, cellular context, and genetic background. Human studies consistently show enrichment of IL-18 in inflamed plaques, whereas circulating IL-18 has limited independent diagnostic or prognostic performance after multivariable adjustment in several large cohorts. Drug-target Mendelian randomization supports associations with selected cardiovascular outcomes, but does not substitute for randomized clinical evidence and remains vulnerable to pleiotropy, instrument strength, ancestry, and lifelong-exposure assumptions. Direct IL-18 inhibitors have entered clinical development in inflammatory diseases, yet cardiovascular outcome efficacy has not been established. We therefore position IL-18 as a biologically plausible but unvalidated cardiovascular target and outline a stage-gated translational agenda centered on free IL-18 assays, plaque-context biomarkers, pharmacology, patient selection, and long-term safety.

PMID 42724344
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PubMedTranslational lung cancer research2026-09-11

Predictive modeling of peripheral blood EGFR positivity in patients with advanced primary non-small cell lung cancer.

Xie Ying-Bo YB, Wang Yi-Ke YK, Yao Xuan X, Ke Kelan K et al.

Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) accounting for approximately 85% of cases. Epidermal growth factor receptor (EGFR) mutations are the most prevalent driver alterations in NSCLC, and tyrosine kinase inhibitors (TKIs) have markedly improved survival outcomes. Accurate molecular testing is essential for guiding targeted therapy. However, tissue biopsy, the current gold standard, is often limited by insufficient samples, invasive procedure risks, or tumor heterogeneity, some patients experiencing sampling failure. Liquid biopsy based on circulating tumor DNA (ctDNA) offers a minimally invasive alternative and can shorten the detection cycle by 2 to 3 weeks, but its sensitivity depends on ctDNA shedding, and patient selection for blood-based testing remains challenging in clinical practice. This study aimed to develop a peripheral blood EGFR positivity prediction model and a simple scoring system to identify high probability candidates for liquid biopsy and prioritize blood-based EGFR testing when tissue samples are inadequate. A retrospective case-control study design was employed. Data were collected from 384 patients with NSCLC who were hospitalized at The First Affiliated Hospital of Guangzhou Medical University between June 2018 and September 2024 and met the study's inclusion criteria. The patients were categorized into two groups: the peripheral blood EGFR-positive group (191 cases) and peripheral blood EGFR-negative group (193 cases). Univariate and binary logistic regression analyses were conducted to establish a predictive model for EGFR in peripheral blood, which was subsequently converted into a scoring system. The results of multi-factor analysis showed that gender, smoking status, pulmonary lymphangitic carcinomatosis, non-vertebral bone metastasis, brain metastasis, and liver metastasis were independent factors for the prediction of EGFR positivity in peripheral blood (P<0.05). The receiver operating characteristic (ROC) curve analysis of predicted peripheral blood EGFR positivity showed that the area under the curve (AUC) was 0.884. A score of ≥3 was considered a high-probability population with positive EGFR in peripheral blood. The sensitivity for diagnosing positive EGFR in peripheral blood was 84.8%, and the specificity was 73.1%. Taking the next-generation sequencing (NGS) detection results as the reference standard, the sensitivity of amplification refractory mutation system polymerase chain reaction (ARMS-PCR) detection was 94.96%, the specificity was 100%, and the overall compliance rate was 96.2% [Kappa (Cohen's kappa coefficient) =0.903, P<0.001]. The Gspnbl score demonstrates good predictive performance in identifying patients with a high probability of peripheral blood EGFR positivity. This easy‑to‑apply tool helps clinicians rapidly select appropriate candidates for liquid‑biopsy EGFR testing. ARMS‑PCR and NGS have high consistency in detecting common EGFR‑sensitive mutations. ARMS‑PCR can be adopted for rapid initial screening in critically‑ill patients with high suspicion of EGFR mutations.

PMID 42723745
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PubMedPsychophysiology2026-09-11

Body Posture-Related Differences in Pain Perception and Their Mediation by Cardiovascular Factors.

Reyes Del Paso Gustavo A GA, Santiago Dolores D, Moreno Belén B, Montoro Casandra I CI et al.

Pain modulation arising from the cardiovascular system has repeatedly been described. It is mediated by the baroreceptor system, where the activity of baroreceptor afferents inhibits nociception. Body posture changes cause blood volume redistribution that might modulate baroreceptor activity and antinociceptive effects. This study investigated posture-related differences in pain perception and their causation by cardiovascular factors. Pressure pain threshold and tolerance and pain intensity ratings were obtained in 83 healthy individuals (61 women and 22 men) while they were sitting, lying down and standing. Electrocardiography, impedance cardiography and continuous blood pressure were recorded in each posture. Pain threshold was higher while lying down than standing, and pain tolerance was higher while lying down than standing and sitting. Pain intensity ratings for suprathreshold stimulation (4 kg/cm2) were higher while standing than sitting and lying down. Blood pressure, stroke volume, cardiac output, total peripheral resistance and baroreflex sensitivity decreased while standing and increased while lying down. Blood pressure was positively associated with pain threshold in men, but not in women. Total peripheral resistance was positively associated with pain threshold and tolerance and blood pressure was negatively related to pain intensity ratings in the total sample. Lying down is associated with increased venous return, central blood volume and higher baroreceptor load, which may result in stronger antinociceptive effects. The opposite changes along with baroreceptor unloading occur while standing. Assuming a supine position is a functional human response to alleviate acute pain. However, in terms of negative reinforcement, pain reduction while lying down may contribute to passive coping behaviors in chronic pain.

PMID 42723142
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PubMedTranslational pediatrics2026-09-11

Is blood benign?-current evidence on perioperative pediatric transfusion.

Wiggins Whitman B WB, Liebe Heather H, Do Ana R AR, Taylor Janice A JA et al.

PMID 42724358
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