北京若生智能科技有限公司
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rabies vaccine

✓ Approved

China National Biotec Group · 疫苗 · 疫苗

什么是 rabies vaccine？

rabies vaccine 是一种疫苗，由China National Biotec Group研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection。

药物档案

公司China National Biotec Group
药物类别疫苗
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved
来源： ClinicalTrials.gov, China National Biotec Group

治疗适应症

rabies vaccine 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsRabies✓ Approved

相关研究文献

PubMedMicroorganisms2026-10-27

Systemic T-Cell Activation Landscapes Elicited Following Intramuscular and Intranasal Immunization with the Active NDV-Vectored Anti-COVID-19 Vaccine "Patria" in Humans.

Carranza Claudia C, Torres-Flores Alejandro A, Romero-Rodríguez Dámaris P DP, López-Macías Constantino C et al.

COVID-19 vaccines remain essential for pandemic control, but antibody responses wane, and viral variants emerge. Affordable platforms enabling local manufacturing are important for equitable vaccine access in low- and middle-income countries (LMICs). The locally developed and manufactured NDV-vectored AVX/COVID-12 "Patria" vaccine may help address this need. We conducted an exploratory analysis of antigen-specific cellular immunity in 17 healthy SARS-CoV-2-naïve volunteers from a previously reported phase I safety and immunogenicity cohort (NCT04871737). Eight participants received intramuscular (IM) and nine received intranasal (IN) vaccination. Peripheral blood collected through 90 days was stimulated in vitro with recombinant Wuhan-Spike protein and analyzed using activation-induced marker (AIM) assays, intracellular cytokine staining, and high-dimensional flow cytometry. AIM+ CD4+ T-cell frequencies peaked around day 28 at 0.45 (1.13)% after IM and 0.18 (0.6)% after IN vaccination, while AIM+ CD8+ T-cell responses remained lower, reaching 0.09 (0.22)% and 0.03 (0.33)%, respectively, median (IQR). Cytokine-producing T-cell responses showed no consistent route-related differences. High-dimensional analysis identified multiple activation-associated phenotypes in CD3+ and CD3- compartments, across both vaccination routes, with distinct temporal dynamics. These exploratory findings show systemic Spike-responsive T-cell activation in this cohort after both routes and provide a refined characterization of vaccine-induced cellular immunity, warranting further investigation of IN administration.

PMID 42943471
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PubMedOne health (Amsterdam, Netherlands)2026-10-27

Epidemiology of animal bites and post-exposure vaccination coverage in Davao City, Philippines: A five-year retrospective cohort study, 2019-2023.

Hinay Alfredo A AA, Parilla-Sarabia April Joy AJ, Reyes Jennifer Ashley H JAH, Lopez Mariel Phoebe M MPM et al.

Rabies remains a major public health threat in the Philippines, particularly in urban areas such as Davao City, where frequent animal bites from domestic reservoirs increase the transmission risk at the human-animal-environment interface. Detailed epidemiological data on animal bites and post-exposure prophylaxis (PEP) coverage are limited. This One Health-framed retrospective cohort study describes trends in bite incidents, assesses PEP coverage, and identifies gaps in rabies prevention efforts from 2019 to 2023. Surveillance data from the Davao City Animal Bite Treatment Centers captured 98,442 cases. Dogs caused 63.5% of bites, with a significant upward trend (p = 0.027; τ = 1.0, 95% CI 0.200-1.800); cat bites (36.4%) rose sharply, indicating an emerging reservoir challenge. Children ≤15 years of age showed a significant increase (p = 0.027). The 3rd congressional district had the most pronounced rise across demographics and exposure categories. Tissue culture vaccine coverage remained at 100%, equine rabies immunoglobulin rose from 18.5% to 85.9%, whereas human rabies immunoglobulin remained low post-COVID. Despite universal TCV access, immunoglobulin gaps limit its control. Rising cat bites and severe exposures demand integrated One Health strategies, enhanced surveillance, animal vaccination, and supply chain strengthening, to achieve zero human rabies deaths by 2030.

PMID 42935849
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PubMedNature microbiology2026-10-27

Lack of ancestral SARS-CoV-2 imprinting promotes Omicron sublineage BA.3.2.2 infection in children.

Niu Xiao X, Xiong Dan D, He Peizhuo P, Yu Lingling L et al.

The ongoing SARS-CoV-2 evolution is constrained by population-level immune imprinting. Recent genomic surveillance revealed an unexpected demographic shift with the Omicron sublineage BA.3.2.2 being predominant in paediatric populations globally. Here we show that this paediatric susceptibility arises from the absence of immune imprinting against ancestral SARS-CoV-2 Wuhan strain. Serological analyses reveal a failure to neutralize BA.3.2.2 in young children with no ancestral strain exposure. Single-B-cell sequencing analyses demonstrate that BA.3.2.2 evades Omicron-specific Class 1/4 neutralizing antibodies that target the ACE2-binding site, encoded by immunoglobulin heavy-chain variable (IGHV) germline genes IGHV2-5 and IGHV5-51, which dominate in weakly imprinted individuals. BA.3.2.2 remains susceptible to broadly cross-reactive Class 1 antibodies, encoded by IGHV3-53/66, typically enriched in adults with strong Wuhan-strain imprinting, such as mRNA vaccine recipients. Together, these findings show that classic immune imprinting provides superior protection against a highly divergent variant, explaining the age-biased transmission of BA.3.2.2, and informing future paediatric vaccination strategies.

PMID 42934357
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PubMedHuan jing ke xue= Huanjing kexue2026-10-27

[Impacts of Land Use Structure Evolution in the Wuhan Metropolitan Area on Terrestrial Carbon Storage].

Xing Shu-Xuan SX, Yang Sheng-Fu SF, Fu Wen-Jie WJ, Lu Zhong-Zheng ZZ et al.

As a typical example of a rapidly urbanizing region， the Wuhan Metropolitan Area is ideal for analyzing the impacts of future land-use structure under different development scenarios on terrestrial carbon stock， which is of great significance for achieving regional sustainable development. By integrating the GeoSOS-FLUS， Geodetector， and InVEST models， this study estimated the spatiotemporal characteristics of land use and terrestrial carbon stock in the Wuhan Metropolitan Area from 1990 to 2020， examined their driving factors， and established four scenarios-natural development， cultivated land protection， ecological protection， and comprehensive development-to simulate and predict carbon stock dynamics for 2030 and 2060. The results indicate the following： ① From 1990 to 2020， the information entropy of land-use structure in the Wuhan Metropolitan Area increased year by year， with significant structural differences among subregions. The expansion of construction land encroached on 1 538.29 km2 of cultivated land， increasing its proportion from 4.96% to 8.18%. Cultivated land decreased at an average annual amount of 111.73 km2， mainly in the core areas of the urban agglomeration. ② The conversion of cultivated land to forest land and construction land was the main driver of carbon stock changes， and the conversion of cultivated land to construction land resulted in a carbon stock loss of approximately 1 073×104 t. Temporal factor detection analysis indicated that DEM and NDVI were the most influential driving factors. ③ Scenario simulation results showed that by 2060， the highest carbon stock would occur under the cultivated land protection scenario （64.90×107 t）， followed by the comprehensive development scenario （63.63×107 t）. These findings provide a scientific basis for assessing terrestrial carbon stocks and their spatial driving forces in urban areas and offer a reference for policymakers in formulating "dual carbon" strategies and promoting sustainable development.

PMID 42935423
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PubMedMicroorganisms2026-10-27

SARS-CoV-2 Breakthrough Infection Reveals Platform-Associated Long-Term Immune Remodeling in a Central Asian Cohort.

Akhmaltdinova Lyudmila L, Bekbossynova Makhabbat M, Dossybayeva Kuanysh K, Tauekelova Ainur A et al.

This study aimed to evaluate platform-specific immune memory trajectories in patients with breakthrough COVID-19 over a 12-month period. This prospective longitudinal study enrolled adults hospitalized with PCR-confirmed COVID-19. Participants were stratified according to prior COVID-19 vaccination status into three groups: unvaccinated, adenoviral-vector-vaccinated, and inactivated-virus-vaccinated. Comprehensive immune profiling included quantification of humoral responses and flow cytometric analysis of T- and B-cell memory subsets. Group differences were assessed using Kruskal-Wallis tests; longitudinal naïve CD8+ T-cell dynamics were modeled using linear mixed-effects models; multivariate immune signatures were identified using random forest classification with SHAP analysis. The most distinct cellular finding was a sustained reduction in naïve CD8+ T cells in the adenoviral-vector-vaccine group, which persisted for 12 months in patients without pneumonia. Machine learning models demonstrated high discriminative performance for patients without pneumonia (AUC = 0.89-0.92), identifying a specific triad of markers in the adenoviral-vector-vaccine group: decreased naïve CD8+ T cells, decreased double-negative effector memory T cells, and increased naïve CD19+ B cells. Linear mixed-effects modeling confirmed that contraction of the naïve CD8+ T-cell compartment over time was significant exclusively in AdV recipients, whereas pneumonia was the dominant predictor in unvaccinated individuals. No significant temporal or disease-related dynamics were observed in the inactivated vaccine group, whose immune profiles largely overlapped with those of unvaccinated individuals. COVID-19 vaccine platforms induce distinct, durable immune imprints that modulate responses to subsequent breakthrough infections. The adenoviral-vector platform was associated with unique phenotypic remodeling of the T-cell compartment, specifically persistent contraction of the naïve CD8+ pool. These findings suggest that the vaccine platform itself, beyond the target antigen, shapes the trajectory of immune competence and long-term memory.

PMID 42943491
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PubMedMicroorganisms2026-10-27

In Silico Design and Evaluation of a Multi-Epitope Vaccine Candidate Against Staphylococcus haemolyticus.

Almatroudi Ahmad A

S. haemolyticus is an emerging multidrug-resistant pathogen that frequently causes nosocomial infections, yet no licensed vaccine is currently available for its prevention. In this study, conserved surface-associated proteins were screened to identify B-cell, cytotoxic T-lymphocyte, and helper T-lymphocyte epitopes for the design of a multi-epitope vaccine candidate. The selected epitopes were assembled into a 254-amino acid construct containing human β-defensin-3, the PADRE sequence, and selected linkers. The resulting construct was predicted to be antigenic, non-allergenic, and non-toxic, with favorable physicochemical properties, structural stability, and solubility. The selected CTL and HTL epitopes provided an estimated global population coverage of 97.5%, indicating broad predicted coverage across different populations. Structural analysis supported the quality of the refined three-dimensional model. Molecular docking predicted favorable interactions between the vaccine construct and TLR2 and TLR4, while 200 ns molecular dynamics simulations indicated that receptor-vaccine interactions were maintained during the simulation period. Codon optimization and in silico cloning further supported the feasibility of recombinant expression in Escherichia coli. Overall, the computational analyses support the proposed multi-epitope construct as a potential vaccine candidate against S. haemolyticus and provide a basis for its further experimental evaluation.

PMID 42943392
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