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ibuprofen (ibuprofen, OSAT / OSAT ibuprofen)

✓ Approved

Paion · PTGS1 · 小分子

什么是 ibuprofen？

ibuprofen 是一种小分子，由Paion研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名ibuprofen, OSAT, OSAT ibuprofen
公司Paion
药物类别小分子
分子靶点PTGS1, PTGS2
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Paion

作用机制

分子靶点

ibuprofen 作用于 2 个分子靶点：

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

ibuprofen 针对 3 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Musculoskeletal and connective tissue disordersMusculoskeletal pain✓ Approved
Musculoskeletal and connective tissue disordersMyositis✓ Approved
Musculoskeletal and connective tissue disordersRheumatoid arthritis✓ Approved

相关研究文献

PubMedMarine drugs2026-07-27

Microparticles Based on Chitosan/Xanthan Gum Polyelectrolyte Complex Modulate the Anti-Inflammatory and Antinociceptive Effects of Ibuprofen and Escin.

Ćirić Ana A, Martić Nikola N, Bosanac Milana M, Andrejić Višnjić Bojana B et al.

Polyelectrolyte complex (PEC)-based carriers offer a promising strategy to improve the oral delivery of anti-inflammatory agents with limited bioavailability or variable pharmacodynamic profiles. This study evaluated the anti-inflammatory and antinociceptive effects of previously optimized formulations of chitosan/xanthan gum PEC microparticles loaded with either ibuprofen or escin, using the carrageenan-induced paw edema model, histopathological and cyclooxygenase-2 (COX-2) immunohistochemical analyses, and the hot plate test. Ibuprofen-loaded microparticles significantly reduced paw swelling during the peak inflammatory phase (5-6 h after treatment administration), although no significant differences in overall edema response or antinociceptive activity were observed compared with free ibuprofen. In contrast, escin-loaded microparticles at 10 mg/kg produced the most pronounced anti-inflammatory effect, significantly reducing paw swelling, edema area under the curve (AUC), histopathological lesion scores, and COX-2 expression compared with both the negative control and the corresponding free escin formulation. Escin-loaded microparticles also showed stronger and more sustained antinociceptive activity than free escin. However, the 20 mg/kg formulation did not provide additional anti-inflammatory or antinociceptive benefits. These findings demonstrate that chitosan/xanthan gum PEC microparticles can enhance the pharmacodynamic performance of orally administered anti-inflammatory agents. The magnitude of this effect depended on the incorporated drug and was particularly notable for escin, for which microencapsulation improved both anti-inflammatory and antinociceptive efficacy.

PMID 42505965
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PubMedGels (Basel, Switzerland)2026-07-27

Solubility, Release Behavior and Membrane Permeability of a Ibuprofen Hydrogel Co-Assembled with N-Methyl-D-Glucosamine.

Li Guoxun G, Lu Xinru X, Hu Caijuan C, Ji Jiaxuan J et al.

Small-molecule hydrogels have gradually become a research hotspot compared with polymeric hydrogels, but their practical advantages have not been fully realized in the development of pharmaceutical formulations. This study aimed to explore whether the N-methyl-D-glucosamine (GLU) could be introduced to form a ibuprofen (IBU) hydrogel for overcoming its water solubility defect and optimizing its pharmaceutical properties. Such an IBU-GLU hydrogel was prepared by simply mixing IBU with GLU in small-volume deionized water. The formed IBU-GLU hydrogel was characterized by SEM, rheology, DSC, PXRD and FTIR analyses. In addition, the solubility, in vitro release and permeability were also investigated to evaluate the solubilization and permeability-promoting effects. The resulting IBU-GLU hydrogel exhibited a typical 3D structure with excellent viscoelasticity, which relied on the equilibrium of aggregation and dissolution, as well as a good miscibility between IBU and GLU, and self-assembly driven by intermolecular interactions in an aqueous environment. Compared to pure IBU, the IBU solubility of the IBU-GLU hydrogel was significantly improved by 38.4-fold. Furthermore, IBU-GLU hydrogel demonstrated superior release rates and supersaturation ability, which was attributed to its high-energy state and internal molecular complexation. Additionally, compared with the commercially available IBU hydrogel, the prepared IBU-GLU hydrogel significantly accelerated IBU membrane permeation. Thus, this study highlighted that the designed IBU-GLU hydrogel could serve as a feasible approach to enhance the release and permeability of IBU for its druggability optimization.

PMID 42505261
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PubMedJournal of shoulder and elbow arthroplasty2026-07-26

Utility of extended reality in shoulder arthroplasty: a meta-analysis of training efficiency and glenoid guidewire accuracy.

Ruiz Max L ML, Abrams Geoffrey D GD, Freehill Michael T MT, Cheung Emilie V EV

Extended reality (XR) has seen increased usage in shoulder arthroplasty for both intraoperative guidance and surgical training, but its impact on technical accuracy and performance has not been quantified across studies. The objective of this analysis was to determine the impact of XR on educational efficiency and glenoid guidewire placement error. Two separate meta-analyses of randomized or quasi-experimental studies were performed. Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses search guidelines, 24 studies were identified in XR-based shoulder surgery education. After applying inclusion, 3 studies involving 55 participants were meta-analyzed. Using the same Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, 35 studies were identified in XR-guided shoulder arthroplasty. After applying inclusion criteria, 7 studies involving 349 guidewire placements were meta-analyzed. In the surgical education studies, XR-trained participants completed procedures faster than controls, but OSAT (Objective Structured Assessment of Technical Skills) scores did not significantly differ. Across the glenoid guidewire studies, XR guidance reduced version error and inclination error versus freehand, but entry point error was not significantly different between XR-guided procedures and freehand. XR-based tools appear to offer meaningful benefits for shoulder arthroplasty, but their impact may be domain-specific. XR education may substantially improve operative efficiency, while XR guidance may enhance the angular accuracy of glenoid guidewire placement without clearly changing entry point error.

PMID 42502475
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PubMedReports (MDPI)2026-07-24

Plasma Exchange in the Setting of Acute Ibuprofen Poisoning: A Case and Review of the Literature.

Glover Raeshun T RT, Maitta Robert W RW, Zhou Yi-Yuan YY

Background and Clinical Significance: Extracorporeal therapies such as hemodialysis, continuous renal replacement therapy (CRRT) or therapeutic plasma exchange (TPE) are mainstay treatments for acute toxins, venoms and poisonings. Ibuprofen is a common drug implicated in acute toxicity, with a major complication being acute kidney injury (AKI). As such, these patients often receive hemodialysis or CRRT, which do not remove substances with high protein binding (>80%) and low volumes of distribution (Vd) (<0.2 L/kg). The pharmacokinetics of ibuprofen have these characteristics. While hemodialysis or CRRT can clear the accumulated toxic metabolites, they do not remove the ibuprofen that causes renal injury. In contrast, TPE can remove protein-bound drugs such as ibuprofen. Case Presentation: We describe the case of a previously healthy young male who presented with AKI due to ibuprofen toxicity requiring concurrent continuous renal replacement therapy and plasma exchange. Conclusions: TPE in conjunction with hemodialysis or CRRT is an effective treatment modality for ibuprofen toxicity.

PMID 42496525
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PubMedCarbohydrate polymers2026-07-24

Chitosan-ibuprofen conjugate-based short-fiber reinforced scaffold with sustained immunomodulation for meniscus regeneration.

Ding Yangfan Y, Li Chunchun C, Cai Pengfei P, Sun Binbin B et al.

Meniscus regeneration remains challenging due to insufficient mechanical support and complex inflammatory microenvironment. We developed a mechanically stable, immunomodulatory composite short-fiber scaffold, CSI-PE, for functional meniscus repair. The scaffold was engineered by incorporating homogenized poly-L-lactic acid (PLLA)/decellularized meniscus extracellular matrix (dmECM) short fibers (designated as PE fibers for PLLA/dmECM) into a chitosan-ibuprofen (CS-IBU) conjugate matrix, followed by glutaraldehyde cross-linking and lysine modification. CSI-PE exhibited an interconnected porous structure with a porosity greater than 80%, providing excellent fatigue resistance and withstanding 100 compression cycles, providing essential mechanical stability for early-stage tissue integration. It enabled sustained IBU release for up to 56 days (67 ± 5 μg/mg), effectively modulating the immune microenvironment by reducing reactive oxygen species (ROS) production and promoting macrophage polarization. This immunomodulatory microenvironment synergistically enhanced the proliferation, migration, and fibrocartilaginous differentiation of bone marrow mesenchymal stem cells (BMSCs) under adverse conditions. In vivo, CSI-PE significantly alleviated intra-articular inflammation and facilitated high-quality tissue regeneration with well-organized collagen deposition while preventing cartilage degeneration after 8 weeks. Transcriptomic analysis further associated this regeneration with immune regulation and extracellular matrix remodeling pathways. This strategy effectively harmonizes mechanical stability with immune homeostasis, positioning CSI-PE as a promising candidate for meniscus tissue engineering.

PMID 42493143
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PubMedFrontiers in pediatrics2026-07-24

Pharmacologic treatment strategies and association with major neonatal outcomes for patent ductus arteriosus in preterm infants.

Tutak Ercan E, Cındık Nimet N, Doğan Eser E, Ayhan Yunus Emre YE et al.

Patent ductus arteriosus (PDA) is common in preterm infants. Although pharmacologic treatment promotes ductal closure, its impact on clinically meaningful outcomes remains uncertain. This study aimed to evaluate the association between different pharmacologic PDA treatment strategies and major neonatal outcomes. This retrospective cohort study included preterm infants born at <32 weeks' gestation who received pharmacologic treatment for clinically significant PDA following an integrated echocardiographic and clinical assessment in a tertiary-level neonatal intensive care unit between 2018 and 2024. Infants were categorized by treatment strategy (ibuprofen only, paracetamol only, or sequential therapy), treatment timing, and number of treatment courses. The primary outcome was a composite of bronchopulmonary dysplasia (BPD) and/or mortality. Secondary outcomes included intraventricular hemorrhage, necrotizing enterocolitis, retinopathy of prematurity, and sepsis. A total of 76 preterm infants were included, with a median gestational age of 28 weeks (IQR 26-30) and mean birth weight of 1,076 ± 343 g. Infants were treated with ibuprofen only (n = 31, 40.8%), paracetamol only (n = 27, 35.5%), or sequential therapy (n = 18, 23.7%). The composite outcome occurred in 39 infants (51.3%) and did not differ significantly across treatment groups. In multivariate analysis, gestational age emerged as the strongest independent predictor of BPD and/or mortality (adjusted OR 0.54, 95% CI 0.38-0.77; p = 0.001), while treatment category was not independently associated with outcomes. Pharmacologic PDA treatment strategies were not independently associated with BPD and/or mortality in this retrospective cohort. Gestational age showed the strongest association with the primary outcome; however, residual confounding and limited statistical power preclude causal or equivalence conclusions.

PMID 42495252
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