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DTPa-Hib vaccine (Infanrix DTPa/Hib)

✓ Approved

GSK · 细胞治疗 · 细胞治疗

什么是 DTPa-Hib vaccine？

DTPa-Hib vaccine 是一种细胞治疗，由GSK研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection。

药物档案

商品名Infanrix DTPa/Hib
公司GSK
药物类别细胞治疗, 疫苗
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved
来源： ClinicalTrials.gov, GSK

治疗适应症

DTPa-Hib vaccine 针对 3 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsDiphtheria✓ Approved
Infections and infestationsPertussis✓ Approved
Infections and infestationsTetanus✓ Approved

相关研究文献

PubMedSoft matter2026-10-27

Eu-DTPA-PE modulates temperature-dependent birefringence in polymer-free monoolein-based lipid particles.

Zadeh Diba Allameh DA, Fanucci Gail E GE

Lanthanide-chelating lipids offer a route to responsive soft submicron lipid-particle materials, yet how their interfacial properties encode membrane curvature and temperature-dependent optical behavior remain poorly understood. Here, polymer-free monoolein/DOPC submicron lipid particles doped with Eu-DTPA-PE, with the monoolein : (DOPC + Eu-DTPA-PE) molar ratio fixed at 17 : 3, over Eu loadings of 1-12.5 mol% are examined using temperature-dependent polarized light microscopy (PLM), dynamic light scattering (DLS), and Eu3+ fluorescence to relate interfacial structure to curvature-linked changes in mesoscopic organization. In the absence of chelating lipids, MO/DOPC submicron lipid particles display an isotropic optical response at low temperature that reproducibly develops strong birefringence upon heating, behavior consistent with but not uniquely diagnostic of a transition from a cubic-like to a more anisotropic nonlamellar state. Introducing low Eu-DTPA levels (1-2.5 mol%) retains predominantly isotropic-appearing fields over a similar or modestly expanded lower-temperature range, consistent with altered interfacial interactions without requiring polymeric stabilizers. At higher Eu-DTPA-PE contents (≥5-12.5 mol%), the PLM micrographs exhibit increasingly extensive birefringent textures across the temperature series, although fixed-threshold image analysis identifies formulation-specific abrupt, broad, or nonpersistent changes rather than a single monotonic loading-dependent birefringence-onset sequence. DLS showed that the formulations remained submicron, colloidally stable lipid-particle dispersions across the full Eu-DTPA-PE loading series. Steady-state Eu3+ fluorescence revealed substantially enhanced emission for Eu-DTPA-PE lipid-particle formulations relative to aqueous EuCl3, indicating a formulation-dependent Eu3+ emission response. The increased luminescence is consistent with a changed local Eu3+ environment and altered nonradiative quenching within the lipid assemblies; however, steady-state emission alone does not independently establish local hydration or coordination geometry. For the 10 and 12.5 mol% Eu-DTPA-PE (18 : 0) formulations, integrated Eu3+ emission normalized to ICP-MS-determined Eu concentration was similar, indicating that the greater raw emission at 12.5 mol% was largely explained by its greater Eu content. Together with earlier Gd-DTPA monoolein submicron lipid particles, these results establish lanthanide-chelating lipids as a modular platform in which chelator-lipid composition can modulate temperature-dependent birefringence and Eu3+ photophysical behavior in polymer-free monoolein-based submicron lipid particles.

PMID 42937441
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PubMedJournal of imaging informatics in medicine2026-10-27

Deep Learning Radiomics to Predict Vessels Encapsulating Tumor Clusters and Prognosis in Hepatocellular Carcinoma Based on Gd-EOB-DTPA-Enhanced MRI.

Wang Miaomiao M, Wang Yinzhong Y, Cao Liang L, Shen Ya Y et al.

Vessels encapsulating tumor clusters (VETC) are significantly associated with poor prognosis in hepatocellular carcinoma (HCC), with implications for patient survival and clinical management. This study aimed to evaluate a deep learning (DL) radiomics model based on Gd-EOB-DTPA-enhanced MRI for preoperative prediction of the VETC pattern in HCC. Patients with pathologically confirmed HCC who underwent Gd-EOB-DTPA-enhanced MRI between January 2016 and August 2024 were retrospectively enrolled. Visually assessed radiological features were collected to construct a clinical-radiological (CR) model. Deep learning and handcrafted radiomics features were extracted from arterial, portal venous, and hepatobiliary phases. Feature selection and DL radiomics model construction were performed using the least absolute shrinkage and selection operator (LASSO). Multivariable logistic regression was applied to develop a hybrid model and corresponding nomogram. Model discrimination was quantified using the area under the receiver operating characteristic curve (AUC). Cox regression analysis was performed to identify predictors of recurrence-free survival (RFS). In the training cohort, the hybrid DL-radiomics nomogram yielded the highest AUC (0.92), compared with 0.87 for the DL model, 0.80 for the radiomics model, and 0.74 for the CR model. However, standalone DL model showed better discriminative performance in the internal validation cohort, with an AUC of 0.87, sensitivity of 0.80, and specificity of 0.87. VETC status, AST level, and intratumoral necrosis were identified as independent predictors of RFS and incorporated into the VAI prognostic model. The VAI model achieved an AUC of 0.75 (95% CI, 0.68-0.80), which was significantly higher than those of three conventional prognostic systems (range, 0.52 [95% CI, 0.46-0.59] to 0.58 [95% CI, 0.51-0.64]). The hybrid DL-radiomics model based on Gd-EOB-DTPA-enhanced MRI showed favorable discriminative performance for VETC prediction in the training cohort, while the standalone DL model demonstrated better performance in the internal validation cohort. The VAI model enables individualized prediction of postoperative RFS for patients undergoing hepatectomy.

PMID 42934383
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PubMedPharmaceuticals (Basel, Switzerland)2026-10-27

Adjunctive Corticosteroids in Pediatric Meningitis: Current Evidence, Clinical Controversies, and Future Directions.

Zambelli Giulia G, Masetti Marco M, Diona Sonia S, Bonacorsi Lorenzo L et al.

Background: Pediatric bacterial meningitis remains an important cause of death and long-term neurological disability despite advances in vaccination, antimicrobial therapy, and supportive care. Because host inflammation contributes substantially to secondary neuronal injury, adjunctive corticosteroids have been investigated as a strategy to reduce inflammation-mediated complications. This narrative review aims to critically evaluate the current evidence on corticosteroid therapy in pediatric meningitis, with particular emphasis on acute bacterial meningitis, major clinical and neurological outcomes, treatment timing, pathogen-specific effects, and the impact of changing post-vaccination epidemiology. Methods: A structured search of PubMed/MEDLINE, Scopus, and Web of Science was conducted for relevant publications available up to June 2026. Randomized controlled trials, observational studies, systematic reviews, meta-analyses, and international guidelines involving patients aged 0-18 years were considered. Evidence was synthesized narratively, focusing on mortality, hearing loss, neurological sequelae, long-term outcomes, safety, causative pathogen, and timing of corticosteroid administration. Results: Adjunctive dexamethasone has not demonstrated a consistent mortality benefit, while evidence concerning hospital stay, intensive care utilization, and healthcare costs remains limited. Its most reproducible benefit is a reduction in sensorineural hearing loss, particularly in Haemophilus influenzae type b (Hib) meningitis. Benefits in pneumococcal meningitis are less consistent, and evidence supporting routine use in meningococcal disease remains limited. Efficacy appears greatest when dexamethasone is administered before or with the first antibiotic dose and may be less pronounced in the post-vaccination era. In tuberculous meningitis, corticosteroids improve survival, whereas routine use is not supported in uncomplicated viral meningitis or cryptococcal meningitis. Conclusions: Adjunctive dexamethasone should be used selectively in pediatric meningitis, with its clearest benefit being hearing preservation in early-treated Hib meningitis. Treatment decisions should account for pathogen, timing, and epidemiological context.

PMID 42943260
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PubMedAnimals : an open access journal from MDPI2026-10-27

An mRNA-LNP Vaccine Encoding the Erns-E1-E2 Polyprotein Confers Complete Protection Against Bovine Viral Diarrhea Virus in Mice.

Yue Zongzhe Z, Li Yanmin Y, Yang Hongjun H, Bian Shiao S et al.

Bovine viral diarrhea virus (BVDV) remains a major barrier to sustainable livestock development. Conventional BVDV vaccines are limited by inherent drawbacks such as potential virulence reversion and insufficient protective efficacy, which severely hamper global BVDV eradication efforts. mRNA vaccine technology, characterized by high expression efficiency, a favorable safety profile, and scalable manufacturing, offers a promising platform for next-generation BVDV vaccine development. In this study, we developed an mRNA-LNP vaccine candidate (Erns/E1/E2 vaccine) encoding the full-length structural glycoproteins Erns, E1 and E2, and systematically evaluated its immunogenicity and protective efficacy in BALB/c mice. The E2 extracellular domain-human IgG1 Fc fusion mRNA vaccine (E2/IgG1 vaccine) and a commercial inactivated BVDV vaccine served as controls. Our results demonstrated that the Erns/E1/E2 vaccine elicited significantly higher neutralizing antibody titers (log10NT50 = 2.50 ± 0.082) and lymphocyte proliferation responses (stimulation index = 6.927 ± 0.145) than both control vaccines at 28 days post-primary vaccination (two weeks post-booster). Notably, no viral RNA was detected in any tissue or blood samples from Erns/E1/E2-immunized mice at any time point following BVDV challenge, indicating complete immune protection against viral infection, whereas viral loads were consistently detected in multiple tissues of both control groups. These findings establish the Erns/E1/E2 vaccine as a highly promising BVDV vaccine candidate and provide critical experimental support for advancing mRNA-based BVDV vaccine development.

PMID 42939244
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PubMedAvian diseases2026-10-27

Spike Binding and Replication of Kidney-Cell-Adapted Infectious Bronchitis Virus in Chickens.

Saiada Farjana F, Zegpi Ramon A RA, Joiner Kellye S KS, Toro Haroldo H et al.

Viral subpopulations in Arkansas Delmarva Poultry Industry (ArkDPI)-derived IBV vaccines are rapidly selected in inoculated chickens, resulting in tracheal damage and virus persistence. These subpopulations with distinct spike (S) amino acid sequences were previously eliminated from an ArkDPI-derived vaccine strain during serial passage in chicken embryonic kidney (CEK) cells, and a new viral population with an S protein harboring three amino acid differences relative to the original vaccine major population became predominant. Recombinant S protein representing the CEK-adapted vaccine strain showed severely reduced or no detectable binding to CEK cells. The two amino acid substitutions in the S1 subunit and the single amino acid substitution in the S2 subunit independently reduced binding. Structural models predicted that each of the amino acid substitutions involved an amino acid located at the interface between monomers in the trimer, suggesting that the conformation and/or stability of alternative conformations of the trimer might be affected. Recombinant S protein representing the CEK-adapted virus also exhibited reduced or nondetectable binding to most relevant chicken tissues in vitro. We compared replication after ocular inoculation in 1-day-old chickens between our CEK-adapted ArkDPI virus and a commercial ArkDPI-derived vaccine. Viral replication in individual chickens was monitored by relative levels of viral RNA in tears 3, 5, and 8 days postvaccination (DPV) and in choanal and tracheal swabs 5 and 8 DPV, determined by reverse transcription quantitative polymerase chain reaction. At 3 DPV, tears of chickens inoculated with 105 50% embryo infectious doses (EID50) of CEK-adapted vaccine and 104 EID50 commercial ArkDPI vaccine had similar viral loads, while those of chickens given 104 EID50 CEK-adapted vaccine were two orders of magnitude lower. Viral loads in tears of both chicken groups given the CEK-adapted vaccine remained at levels similar to 3 DPV through days 5 and 8 DPV, while those in chickens given the commercial vaccine increased three orders of magnitude during the same period. Statistically significant differences among groups were also observed in viral loads in choanal and tracheal swabs at both 5 and 8 DPV, though less pronounced. The sharp increase in viral load in tears of chickens given the commercial vaccine was likely due to efficient replication of vaccine subpopulations selected in chickens, which are lacking in the CEK-adapted vaccine. Selection of vaccine subpopulations in chickens given the commercial vaccine, but not in chickens given the CEK-adapted vaccine, was verified by S1 gene sequencing of the IBV genomes in samples from individual chickens in all vaccinated groups. Protection following ocular challenge at 19 DPV with virulent Ark IBV, as assessed by reductions in viral loads in tears, correlated with vaccine viral loads at 5 and 8 DPV, with the greatest correlation (r = 0.52) with vaccine viral load in choanal swabs at 8 DPV.

PMID 42937671
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PubMedJournal of clinical medicine2026-10-27

Assessment of Liver Fibrosis Using the Coefficient of Variation on Gadoxetic Acid-Enhanced Hepatobiliary Phase MR Imaging: A Prospective Multicenter Study.

Kim Youe Ree YR, Kim Tae-Hoon TH, Jeong Chang-Won CW, Lee Young Hwan YH et al.

Background: Accurate non-invasive assessment of liver fibrosis is needed in patients with chronic liver disease. Gadoxetic acid (Gd-EOB-DTPA)-enhanced hepatobiliary phase (HBP) magnetic resonance (MR) imaging reflects hepatocyte function and parenchymal heterogeneity, and the coefficient of variation (CV), which quantifies pixel-level signal inhomogeneity, has been proposed as a quantitative imaging biomarker of liver fibrosis. However, previous studies were retrospective, single-center, and lacked direct pathological validation. Objectives: To investigate the factors associated with CV on HBP images, evaluate the correlation between CV and pathologically confirmed liver fibrosis stage, and compare the diagnostic performance of CV with serum biomarkers, including the aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 (FIB-4), in a prospective multicenter setting. Methods: This prospective multicenter study was conducted between April 2017 and August 2020 at three medical centers. Ninety-nine participants who underwent Gd-EOB-DTPA-enhanced HBP T1-weighted MRI and liver biopsy or surgery were enrolled. CV was measured on HBP images, and the METAVIR fibrosis stage was used as the reference standard. Univariate and multivariable linear regression analyses, including an additional model adjusted for institution and pathology confirmation method, Welch's analysis of variance with the Games-Howell post hoc test, Spearman's rank correlation analysis, receiver operating characteristic (ROC) curve analysis with DeLong's method for AUROC comparison, and intraclass correlation coefficient (ICC) analyses were performed. Results: Ninety-nine participants (64 men and 35 women; mean age, 55.5 ± 15.1 years) were enrolled. In multivariable linear regression analysis adjusted for institution and pathology confirmation method, pathologic fibrosis stage (B = 0.468; 95% CI, 0.358-0.578; p < 0.001) and serum albumin level (B = -0.341; p = 0.015) were independently associated with CV. Spearman's correlation coefficient between CV and fibrosis stage was 0.74 (p < 0.001). The AUROCs of CV for significant fibrosis (≥F2), advanced fibrosis (≥F3), and cirrhosis (F4) were 0.92, 0.88, and 0.86, respectively (all p < 0.001). CV outperformed APRI and FIB-4 across most fibrosis thresholds (p < 0.001 to p = 0.045), except for FIB-4 in the diagnosis of ≥F2 fibrosis (p = 0.09). The intra- and inter-observer ICC values were 0.94 and 0.84, respectively. Conclusions: In this prospective multicenter study with pathologically confirmed fibrosis stages, CV derived from Gd-EOB-DTPA-enhanced HBP MR images showed a strong correlation with liver fibrosis stage and higher diagnostic performance than APRI and FIB-4 across most fibrosis thresholds. Because CV can be calculated from routine clinical MRI acquisitions without additional hardware or blood tests, it may serve as a practical biomarker for non-invasive liver fibrosis assessment. However, because this study was conducted in a Korean cohort with predominantly hepatitis B virus-related liver disease, further validation in other ethnic groups and etiologies is needed.

PMID 42941510
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