北京若生智能科技有限公司
Drug Database
DE

dequalinium chloride (Naxyl / Fluomizin / Donaxyl)

✓ Approved

Medinova · 小分子 · 小分子

什么是 dequalinium chloride？

dequalinium chloride 是一种小分子，由Medinova研发。该药已获批，用于治疗相关适应症，给药途径：Intravaginal。

药物档案

商品名Naxyl, Fluomizin, Donaxyl
公司Medinova
药物类别小分子
给药途径Intravaginal
状态Approved
来源： ClinicalTrials.gov, Medinova

治疗适应症

dequalinium chloride 针对 4 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsVaginal infection✓ Approved
Infections and infestationsStreptococcal infection✓ Approved
Infections and infestationsWound infection fungal✓ Approved
Infections and infestationsTrichomoniasis intestinal✓ Approved

相关研究文献

PubMedFrontiers in neurology2026-09-11

Clinical features associated with cerebrospinal fluid Epstein-Barr virus positivity in autoimmune GFAP astrocytopathy: a multicenter retrospective cohort study.

Mao Xing X, Qu Qianqian Q, Quan Chao C, Lyu Haidong H et al.

Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) is an inflammatory disorder of the central nervous system. The clinical implications of Epstein-Barr virus (EBV) sequences detected in cerebrospinal fluid (CSF) by metagenomic next-generation sequencing (mNGS) remain uncertain. This multicenter retrospective cohort study enrolled 60 patients with GFAP-A screened from electronic medical records of two hospitals (Jan 2019-Dec 2025). Patients were stratified into CSF EBV-positive (n = 10) and CSF EBV-negative (n = 50) groups based on CSF mNGS results. Demographic characteristics, clinical manifestations, laboratory findings, MRI features, treatment, and outcomes were compared. Bonferroni correction was applied to three clinically prioritized endpoints (CSF white blood cell count, altered consciousness, CSF chloride) selected based on prior GFAP-A literature to limit multiplicity bias; the corrected two-sided significance threshold was set at α = 0.05/3 ≈ 0.0167. An exploratory Firth penalized multivariable logistic regression model fitted via R (v4.3.1, logistf package) was used to examine the adjusted associations between CSF mNGS-detectable EBV sequences and acute altered consciousness, adjusting for age and sex to mitigate small-sample bias. All other unadjusted baseline comparisons were considered exploratory and were not adjusted for multiplicity. Spearman's rank correlation was used to assess the relationships of raw EBV mNGS read counts with peak pretreatment modified Rankin Scale (mRS) score and CSF WBC count among EBV-positive patients. CSF WBC count was higher in the CSF EBV-positive group than in the CSF EBV-negative group [median, 120 (interquartile range, 105-220) vs. 33 (16-97) × 10⁶/L; raw p = 0.004; Bonferroni-adjusted p = 0.012]. Altered consciousness was more frequent in the EBV-positive group (80.0% vs. 42.0%; crude odds ratio [OR] = 5.52, 95% confidence interval [CI] 1.06-28.71; raw p = 0.039), and CSF chloride was numerically lower [111.50 (104.00-117.00) vs. 115.70 (113.00-120.00) mmol/L; raw p = 0.048]; however, neither comparison met the Bonferroni-corrected criterion (adjusted p = 0.117 and 0.144, respectively). Firth penalized multivariable logistic regression fitted in R was adjusted for age and sex. CSF EBV positivity exhibited a non-significant trend toward higher odds of acute altered consciousness (OR = 4.10, 95% CI: 0.94-24.84, p = 0.060). The extremely wide confidence interval indicated high estimation uncertainty limited by the small EBV-positive subgroup (n = 10). Female sex was associated with lower estimated odds of altered consciousness (OR = 0.17, 95% CI: 0.04-0.58, p = 0.004), while age showed no independent association (OR = 0.98, 95% CI: 0.95-1.02, p = 0.312). No statistically detectable between-group differences were observed in GFAP-IgG characteristics, MRI findings, relapse, or functional outcomes. Among the 10 EBV-positive patients, raw EBV read counts were not statistically correlated with peak pretreatment mRS score (r s = 0.118, p = 0.745) or CSF WBC count (r s = -0.073, p = 0.841). CSF WBC count was the only clinically prioritized comparison that remained statistically significant after Bonferroni correction, suggesting greater CSF pleocytosis and possibly increased intrathecal inflammatory activity in GFAP-A patients with mNGS-detectable CSF EBV. Differences in altered consciousness and CSF chloride remained inconclusive after multiplicity adjustment. Within the EBV-positive subgroup, raw EBV sequencing reads showed no correlation with inflammatory or disability measures. Current findings do not establish CSF EBV positivity as an independent pathogenic or prognostic biomarker for GFAP-A, and the biological origin of the detected EBV sequences remains uncertain.

PMID 42723798
阅读全文 →
PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-09-11

Gelatin-Based Functional Biogels With Mechanical Tunability via Pioneering Design of Co-Polymerizable Deep Eutectic Solvents.

Wu Min M, Du Yaoyi Y, Wang Xilong X, Xu Chunming C et al.

Eutectic biogels, combining deep eutectic solvents (DES) with biopolymer networks, are highly promising for advanced applications. However, the design of co-polymerizable DES (cPDES) remains largely unexplored for novel biogels. Herein, we constructed an innovative cPDES by strategically selecting 2-(acryloyloxy)ethyl trimethyl ammonium chloride as the polymerizable hydrogen bond acceptor and itaconic acid as the polymerizable hydrogen bond donor. By employing this cPDES as a functional solvent, gelatin as the matrix, and glycerol as a regulator, a multifunctional biogel (denoted as BioGel-PGG) with a unique polymeric network integrating an enhanced non-covalent network with a dual network induced by the copolymerization of DES was developed, which showed widely tunable mechanical properties (e.g., elastic modulus: 0.03-55.52 MPa, toughness: 0.05-14.03 MJ/m3). Furthermore, BioGel-PGG demonstrates multifunctionality integration, including strong skin adhesion (3.20 N/cm), good conductivity, environmental stability, recyclability, and biodegradability. Epidermal bioelectrodes based on BioGel-PGG enabled high-quality monitoring of electrophysiological signals. This work opens a new avenue for designing high-performance eutectic biogels by exploiting cPDES.

PMID 42723351
阅读全文 →
PubMedBMC pharmacology & toxicology2026-09-11

Protective role of aldehyde dehydrogenase 2 in retinal pigment epithelium cells with CoCl₂-induced hypoxic injury: an in-vitro study.

Zhang Sheng S, Chen Guanyu G, Xiao Lin L, Dong Jialing J et al.

Retinal pigment epithelial (RPE) cells are vulnerable to hypoxia-related and oxidative stress. Cobalt chloride (CoCl₂) is widely used as a chemical hypoxia mimetic; however, an appropriate concentration window for producing measurable RPE injury without the more extensive damage associated with higher concentrations remains incompletely defined. Aldehyde dehydrogenase 2 (ALDH2) contributes to reactive-aldehyde detoxification and cellular stress defense. ARPE-19 cells were exposed to 0, 10, 100, 500, 1000, or 2000 µM CoCl₂. Scratch-wound recovery and representative morphology were evaluated for up to 72 h, and relative CCK-8 metabolic activity was quantified at 24, 48, and 72 h. The 500 µM condition was selected for molecular and pharmacological experiments based on the integrated dose-response profile. Culture-supernatant 4-HNE and VEGF-A were measured by ELISA, whereas HIF-1α, ALDH2, and BAX were assessed by Western blotting. Alda-1 and Daidzin were used as an ALDH2 activator/chemical chaperone and an enzymatic inhibitory comparator, respectively. CoCl₂ caused concentration- and time-associated impairment of scratch-wound recovery. Wound closure was largely preserved at 0-100 µM, whereas 500-2000 µM produced wound-closure failure. The CCK-8 profile showed that 500 µM retained a nonmaximal metabolic signal compared with the substantially greater late reductions observed at 1000 and 2000 µM. Thus, 500 µM represented the lowest tested concentration producing significant functional injury while avoiding the more extensive injury phenotype observed at higher concentrations. Under 500 µM CoCl₂, HIF-1α increased early, ALDH2 protein abundance decreased, and culture-supernatant 4-HNE and VEGF-A increased at the later time point. Alda-1 improved wound recovery and restored ALDH2 protein abundance, whereas Daidzin aggravated the functional injury phenotype and shifted extracellular stress-marker readouts in an unfavorable direction. CoCl₂ produced a concentration-resolved, hypoxia-related and aldehyde-associated RPE injury phenotype. Alda-1 improved wound recovery and increased ALDH2 protein abundance, whereas Daidzin aggravated the functional injury phenotype. These findings support ALDH2-associated aldehyde-detoxifying defense as a modulatory component of CoCl₂-induced RPE stress.

PMID 42723120
阅读全文 →
PubMedThe journal of physical chemistry letters2026-09-10

Unraveling the Molecular Origin of the Unprecedented ortho-Chloride Effect in Cobalt-Catalyzed Asymmetric Hydrogenation of 1,1-Diarylethenes.

Mahato Akhilesh A, Mahato Anupama A, Pramanik Anup A, Sarkar Pranab P

The molecular origin of the unusual ortho-chloride effect in cobalt-catalyzed asymmetric hydrogenation of 1,1-diarylethenes has been investigated using density functional theory. The complete catalytic cycle, including alkene coordination, alkene insertion, hydrogen activation, and catalyst regeneration, was elucidated on the relevant spin surfaces. The calculations identify alkene insertion into the Co-H bond via TS1 as the enantiodetermining step, whereas catalyst regeneration is the turnover-determining step. The preferred Si-face hydride transfer is favored by 3.79 kcal/mol, corresponding to a predicted 99.6% enantiomeric excess, in excellent agreement with the experimentally observed more than 90% ee. Activation strain, AIM, NCI, and NBO analyses reveal that reduced structural distortion together with enhanced noncovalent and donor-acceptor interactions stabilizes the transition state leading to the S enantiomer. Systematic investigation of substituent effects demonstrates that only the ortho-chloro substituent provides the optimal energetic balance, whereas meta- and para-substitution or replacement by other ortho substituents substantially diminishes enantioselectivity. These findings provide the first molecular-level explanation of the ortho-chloride effect and offer guiding principles for designing highly enantioselective cobalt catalysts.

PMID 42720340
阅读全文 →
PubMedCureus2026-09-10

Late-Diagnosed Cystic Fibrosis in an Octogenarian With an Atypical Phenotype of Pancreatic Sufficiency and Preserved Pulmonary Function.

Hranec Brenda B, Hudson Luke L, Layish Daniel D

Cystic fibrosis (CF) was historically described as a severe childhood disease associated with pancreatic destruction, malnutrition, recurrent respiratory infection, and early mortality. Advances in sweat chloride testing, cystic fibrosis transmembrane conductance regulator (CFTR) gene discovery, newborn screening, multidisciplinary care, and CFTR modulator therapy have transformed the natural history of the disease. However, CF remains clinically heterogeneous, and patients with residual CFTR function may present later in life with chronic bronchiectasis, sinus disease, atypical respiratory infections, or nonspecific gastrointestinal symptoms. Diagnosis in advanced age is uncommon and may be delayed when pancreatic function is preserved and sweat chloride values are intermediate. An 87-year-old woman with late-diagnosed cystic fibrosis was followed longitudinally for chronic sinopulmonary disease. She had a history of recurrent sinus infections and was evaluated at a tertiary institution, where CF was diagnosed at approximately age 62. Her family history was notable for a maternal aunt who died from an unspecified respiratory illness. Diagnostic evaluation demonstrated an intermediate sweat chloride value of 41 mmol/L and CFTR testing showing one copy of F508del, M470V polymorphism, and a rare C76W variant. Her phenotype included chronic bronchiectasis, chronic sinusitis with nasal polyps, two prior sinus surgeries, and prior Mycobacterium avium complex infection treated in 1995. She had pancreatic sufficiency, with normal fecal elastase and no clinical response to pancreatic enzyme replacement therapy. Pulmonary function testing showed preserved lung function with stage I obstruction, including FEV1 1.33 L, 89% predicted; FVC 1.95 L, 85% predicted; and FEV1/FVC ratio of 68%, stable compared with the prior year. Her course was also notable for osteoporosis with prior vertebral compression fractures, which limited tolerance of vest-based airway clearance. Management included airway clearance with an oscillatory positive expiratory pressure device, individualized bronchodilator therapy due to tachycardia with albuterol, surveillance respiratory cultures, nutritional and weight monitoring, otolaryngology follow-up for chronic sinusitis and nasal polyps, osteoporosis management, and treatment with vanzacaftor/tezacaftor/deutivacaftor, to which she reported symptomatic improvement. This case highlights an uncommon late-diagnosed CF phenotype in an octogenarian with pancreatic sufficiency, intermediate sweat chloride, chronic sinopulmonary disease, preserved lung function, and new isolation of Pseudomonas aeruginosa. The case emphasizes that preserved pancreatic function and advanced age do not exclude CF and that adult patients with chronic bronchiectasis, sinus disease, and atypical respiratory infections should be evaluated for CFTR dysfunction when clinically appropriate.

PMID 42719490
阅读全文 →
PubMedChemical science2026-09-10

Multi-wavelength photo-activation of transmembrane chloride transport in distinct vesicle populations using photocaged indolocarbazole anionophores.

Britton Kelly R KR, Langton Matthew J MJ

Synthetic ionophores enable the study of transmembrane ion transport and show promise as therapeutics or for engineering responsive synthetic cells. Incorporation of photolabile protecting groups (photocages) allows for OFF-ON control over transport to spatiotemporally regulate activity; however, systems incorporating two different photocages such that two wavelengths of irradiation are required for activation are unknown. Here, we report a family of photocaged indolocarbazole-based anionophores that enable multi-wavelength photo-activation of chloride transport in lipid bilayer vesicles. Mono- and di-ortho-nitrobenzyl photocaged derivatives fully inhibit anion binding and transport until irradiation cleaves the protecting group to restore activity. Introduction of a BODIPY photocage afforded a unique dual-photocaged transporter, in which sequential irradiation at 530 nm and 365 nm triggers stepwise photocage cleavage to regenerate the active anionophore. This strategy also allows for selective activation of anion transport in different vesicles in a mixed population containing different mono-photocaged transporters. These results establish photocaged indolocarbazoles as a versatile platform for photo-responsive ionophores and enable unprecedented multi-wavelength sequential control of transmembrane transport in separate vesicle populations. Beyond fundamental insights into the design of stimuli-responsive transporters, this approach provides new opportunities for spatiotemporal regulation of ion transport in artificial and living cellular systems.

PMID 42719347
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多dequalinium chloride