北京若生智能科技有限公司
Drug Database
DE

dequalinium chloride (Naxyl / Fluomizin / Donaxyl)

✓ Approved

Medinova · 小分子 · 小分子

什么是 dequalinium chloride？

dequalinium chloride 是一种小分子，由Medinova研发。该药已获批，用于治疗相关适应症，给药途径：Intravaginal。

药物档案

商品名Naxyl, Fluomizin, Donaxyl
公司Medinova
药物类别小分子
给药途径Intravaginal
状态Approved
来源： ClinicalTrials.gov, Medinova

治疗适应症

dequalinium chloride 针对 4 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsVaginal infection✓ Approved
Infections and infestationsStreptococcal infection✓ Approved
Infections and infestationsWound infection fungal✓ Approved
Infections and infestationsTrichomoniasis intestinal✓ Approved

相关研究文献

PubMedMaterials (Basel, Switzerland)2026-10-27

Influence of CO2-Mineralised Alkaline Waste Materials on the Chloride Ingress Resistance of Sustainable Cementitious Materials.

Paredes María Victoria MV, Guerrero Ana A, Moreno de Los Reyes Ana María AM, Sánchez Javier J et al.

Using CO2-mineralised alkaline waste as a supplementary cementitious material has the potential to advance sustainable construction practices. This paper evaluates the effect of carbonating three fine industrial waste materials-construction and demolition waste, ladle furnace slag, and biomass ash-on the durability performance of blended cements in which they replace 7% and 20% of ordinary Portland cement. The performance of carbonated waste was compared with that of their non-carbonated counterparts through chloride ingress resistance, a key parameter governing reinforcement corrosion. The results show that prior carbonation can significantly influence chloride transport properties, although the magnitude and direction of the effect depend strongly on the waste type and replacement level. Mortars with carbonated construction and demolition waste or ladle furnace slag generally reduced the chloride diffusion coefficient compared with the corresponding non-carbonated materials. This behaviour was associated with greater portlandite consumption and enhanced chloride-binding capacity. Nevertheless, none of the blended systems outperformed the ordinary Portland cement (OPC ) in terms of chloride diffusion resistance. Conversely, biomass ash at 20% replacement led to markedly reduced performance, with the estimated time to steel depassivation decreasing to 1-2 years under the exposure conditions considered. These findings indicate that prior carbonation may improve the suitability of some wastes for cementitious applications relative to their non-carbonated counterparts, although the resulting chloride resistance remains lower than that of OPC. The benefits are of waste carbonation are therefore material-dependent and should be assessed on a case-by-case basis.

PMID 42941094
阅读全文 →
PubMedCancers2026-10-27

Chloride Channels as Determinants of Anti-Cancer Drug Response: Why the Therapeutic Direction Reverses Between Channels and Between Tissues.

Seo Yohan Y

Background/Objectives: Resistance to cytotoxic chemotherapy and radiotherapy is usually attributed to DNA repair, drug efflux and apoptotic threshold. Chloride channels intersect these processes but are rarely considered as a group. This review asks whether chloride flux forms a coherent, targetable axis of treatment response and, if not, how the therapeutic direction differs by channel and tissue. Methods: PubMed was searched to 23 August 2026; all free-text searches were re-executed on 22 September 2026 and supplemented by controlled-vocabulary searches. Cited records were checked against NCBI E-utilities and screened for retractions. Claims were graded by whether pharmacological phenotypes were reproduced by genetic perturbation and by the available target-engagement and replication evidence. Results: The therapeutic direction is not uniform. In experimental models, LRRC8A- and LRRC8D-containing channels mediate substantial platinum uptake, and dose-stratified associations between their expression and outcome have been reported in head and neck cancer, supporting prospective evaluation as predictive biomarkers; contrary reports in ovarian, colon and breast models indicate that this direction is established for platinum uptake rather than for cytotoxic resistance in general. CFTR is an intestinal tumour suppressor and the only channel reviewed with an approved potentiator, yet its direction reverses in glioma, with a prostate report of CFTR-dependent cisplatin resistance pointing in the same direction. Conversely, ClC-3, ANO1 and CLIC1 are associated with resistance when gained, although CLIC1 is better supported as a determinant of drug response than of tumorigenesis. Sixteen modulators are compared by potency, assay format, selectivity/counter-screening and clinical status; widely used blockers are often poorly selective. Conclusions: Chloride transport is not a single therapeutic target class. Candidate chloride-channel blockers should be counter-screened against LRRC8/VRAC before combination with platinum therapy, and CFTR potentiation should not be generalised across tumour types. Conflicting evidence is reported alongside the directions it qualifies rather than set aside.

PMID 42938901
阅读全文 →
PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-10-27

Structural and Electronic Origins Enabling Chlorine Anion Redox in Halide Cathodes.

Chang Yun-Ping YP, Huang Jheng-Yi JY, Chu Po-Jui PJ, Chiang Ching-Yu CY et al.

Anion redox has been shown to increase specific capacity in oxide and sulfide cathodes; however, its existence in chloride-based systems remains an open question. Using Li2FeCl4 as the role model, this work investigates potential chlorine anion redox by meticulous structural analysis combined with computational electronic evidence. pDOS and COHP reveal filled nonbonding orbital localization on anion. Electron extraction leads to [FeCl6]n- octahedra distortions as evidenced by pre-edge analysis and theoretical structural optimizations. The observed reductive coupling between iron and chlorine reflects their electronic interaction and charge compensation mechanism. Extending beyond current studies focused on chalcogens, these findings have broadened the scope for the future of anion redox into the chloride family.

PMID 42934958
阅读全文 →
PubMedERJ open research2026-10-27

Long-term safety and efficacy of lumacaftor/ivacaftor in children aged ≥12 months of age with cystic fibrosis: a 96-week open-label study.

Zemanick Edith T ET, McColley Susanna A SA, Linnemann Rachel W RW, Rayment Jonathan H JH et al.

We evaluated long-term safety and efficacy of lumacaftor (LUM)/ivacaftor (IVA) in children aged 12 to <24 months with cystic fibrosis (CF) homozygous for F508del. This international, 96-week, phase 3, open-label study enrolled children who completed parent study 809-122 (after 2-week washout) or were LUM/IVA-naïve. The primary end-point was safety and tolerability. The secondary efficacy end-point was change from baseline in sweat chloride concentration. 52 children (39 from 809-122; 13 LUM/IVA-naïve) participated. Mean±sd exposure to LUM/IVA was 597±162 days. All children had at least one adverse event, which were mostly mild (32.7%) or moderate (55.8%) in severity and consistent with common manifestations of CF or early childhood illnesses. One child (1.9%) discontinued study drug due to a treatment-emergent adverse event of increased alanine/aspartate aminotransferases that resolved after discontinuation. 12 (23.1%) children had serious adverse events, none of which was considered related to LUM/IVA. At week 96, mean absolute change from pre-treatment baseline in sweat chloride concentration was -21.0 (95% CI -27.6 to -14.3) mmol·L-1. Growth parameters, which did not change significantly, were in the normal range throughout the 96-week treatment period. Improvements from baseline were observed in mean fecal elastase-1, fecal calprotectin, and serum immunoreactive trypsinogen. LUM/IVA remained generally safe and well-tolerated over 96 weeks. Improvements in sweat chloride concentration and markers of pancreatic function and intestinal inflammation were consistent with the parent study. These results demonstrate the long-term safety and efficacy of LUM/IVA in the 12 to 24-month-old population.

PMID 42935985
阅读全文 →
PubMedMicroorganisms2026-10-27

Biodegradation of Polyvinyl Chloride by Acinetobacter sp. Isolated from Soil.

Chai Shumao S, Wang Jiahao J, Zhang Yiru Y, Zhang Zihan Z et al.

The excessive use of plastics has seriously damaged the environment. Biodegradation of plastics, especially polyvinyl chloride (PVC), by microorganisms has become a promising strategy for the remediation of environmental pollution. Plastic-contaminated soil is an important source for isolating microorganisms with plastic-degrading ability. In this study, a PVC-degrading strain, designated PVC-3-16, was isolated from farmland soil and identified as Acinetobacter calcoaceticus. After 60 days of incubation, a new characteristic functional group was detected on the surface of PVC powder by attenuated total reflection Fourier transform infrared spectroscopy. A putative catalase-peroxidase enzyme derived from the genome of PVC-3-16 was successfully expressed and purified. After treatment with the catalase-peroxidase, hydroxyl groups and cracks were detected on the surface of PVC films by attenuated total reflection Fourier transform infrared spectroscopy and scanning electron microscopy, respectively. The Mn, Mw, and Mz values of the PVC films decreased by 10.7%, 9.4%, and 5.7%, respectively, after treatment. The degradation product catalyzed by the catalase-peroxidase was identified as C21H44O. These findings indicate that PVC-3-16 is a promising strain that can be used for PVC biodegradation.

PMID 42943572
阅读全文 →
PubMedBiomolecules2026-10-27

Structure Basis for Chloride Recognition and Transport by Human Kidney Brain Anion Transporter (KBAT).

Wang Yurou Y, Xie Tengyu T, Wu Songyue S, Wang Anxin A et al.

SLC26A11, also known as the kidney and brain anion transporter (KBAT), mediates the transport of multiple anionic substrates across the plasma membrane. It is highly enriched in cerebellar Purkinje cells, where loss of KBAT results in hyperpolarized membrane potentials and increased intrinsic firing frequency, correlating with locomotor dysfunction. Despite its physiological significance, the molecular basis of substrate recognition and transport by KBAT remains elusive. Here, we present the structure of full-length human KBAT in an inward-facing conformation with chloride ions (Cl-) bound. Sequence analysis of the substrate-binding pockets uncovers the important residue E320 in KBAT. Protonation of E320 abolishes its interaction with S363 and correlates with Cl- binding in the canonical substrate pocket, as substantiated by molecular dynamics (MD) simulations. Quantitative MD contact analysis delineates the rearrangements of residue interactions underlying the alternative access transport, consistent with an elevator-like transport mechanism. The cross-arranged transmembrane helices of the Gate and Core domains require minimal conformational rearrangement to achieve alternating access to the membrane. Collectively, our study provides a critical foundation for comprehensively understanding the recognition and transport mechanisms of human KBAT, with potential implications for developing therapies for neuronal swelling.

PMID 42939639
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多dequalinium chloride