北京若生智能科技有限公司
Drug Database
ID

idoxuridine (idoxuridine, APR / Apridin C / Apridin)

✓ Approved

Pierre Fabre S.A. · · 小分子

什么是 idoxuridine？

idoxuridine 是一种小分子，由Pierre Fabre S.A.研发。该药已获批，用于治疗相关适应症，给药途径：Topical。

药物档案

商品名idoxuridine, APR, Apridin C, Apridin
公司Pierre Fabre S.A.
药物类别小分子
分子靶点,
给药途径Topical
状态Approved
来源： ClinicalTrials.gov, Pierre Fabre S.A.

作用机制

分子靶点

idoxuridine 作用于 2 个分子靶点：

(UL30)
(UL30)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

idoxuridine 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsHerpes simplex✓ Approved
Congenital, familial and genetic disordersCongenital herpes simplex infection✓ Approved

相关研究文献

PubMedMicroorganisms2026-10-27

Serial Surveillance of Viable Bacterial Contamination in a German Hotel Across Pre-COVID and Pandemic Recovery Periods: Persistent Hotspots and Functional-Area Heterogeneity.

Martens Alexander A, Schauer Markus M, Motevalli Mohamad M, Mair Susanne S et al.

Hotels contain diverse functional environments, yet longitudinal evidence on viable bacterial contamination and its response to COVID-associated hygiene changes remains limited. This retrospective serial cross-sectional study analyzed 544 environmental samples from five audits of a German hotel conducted in 2016, 2018, 2019, 2022, and 2023. Pre-pandemic audits (2016, 2018-2019) were compared with 2022-2023 audits across four functional environments: guest rooms, child-oriented areas, wellness/water facilities, and food-service operations. Outcomes included culture positivity, contamination severity, polymicrobial and priority-microorganism detection, persistent hotspots, and organism distributions. Modified Poisson models adjusted for functional environment and used cluster-robust inference. All statistical analyses were performed in R (version 4.5.1). High contamination declined from 54.2% pre-COVID to 19.3% in 2022-2023 (aPR, 0.36; 95% CI, 0.25-0.54; p < 0.001), an adjusted reduction of 34.1 percentage points (95% CI, 21.5-46.6). Culture positivity remained unchanged (63.4% vs. 60.1%; aPR, 0.96; 95% CI, 0.83-1.12; p = 0.634), whereas polymicrobial contamination decreased (aPR, 0.61; 95% CI, 0.39-0.96; p = 0.032; adjusted reduction, 8.3 percentage points; 95% CI, 1.0-15.7). Priority-microorganism detection was unchanged (aPR, 1.06; 95% CI, 0.67-1.67; p = 0.804), despite a shift toward S. aureus and P. aeruginosa. Culture positivity remained approximately 90% in child-oriented and food-service areas. Eight of 15 recurring surface categories remained persistent hotspots, including wet-room floors, frequently touched controls, paddling-pool features, and food-service machinery. The Bacillus cereus group decreased from 12.6% to 2.5%, whereas Staphylococcus aureus and Pseudomonas aeruginosa were each detected in 0% versus 5.8% of samples (q < 0.001). Audits in 2022-2023 showed lower contamination intensity without corresponding reductions in overall culture positivity or priority-microorganism prevalence. Complementary burden-, complexity-, and organism-based indicators are needed for environmental-hygiene evaluation.

PMID 42943422
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PubMedChildren (Basel, Switzerland)2026-10-27

Gaps in Healthcare Seeking for Childhood Diarrhea Among Peruvian Children Under Five Years of Age: Socioeconomic and Clinical Patterns in a National Survey.

Vera-Ponce Víctor Juan VJ, Ballena-Caicedo Jhosmer J, Vasquez Namibia Jherly Cervera NJC, García-Rodríguez Marcos M et al.

Childhood diarrhea remains a preventable public health problem, but gaps persist in contact with external care and receipt of effective treatment. We estimated the prevalence of non-use of external care for recent diarrhea among Peruvian children aged 0-59 months during 2019-2024 and examined associated clinical, maternal, socioeconomic, and territorial factors. We analyzed repeated cross-sectional ENDES microdata using survey-weighted modified Poisson regression with Taylor-linearized variance, year-specific primary sampling units, and strata. Among 11,942 child-level survey observations with classifiable care-seeking information, non-use of external care was 43.5% (95% CI: 42.2-44.8); restrictive formal care seeking was 33.1%, and 23.4% (95% CI: 22.3-24.5) used only non-formal external sources. Among observations with valid treatment-specific information, 34.3% received oral rehydration salts, 1.0% zinc, and 0.5% both. Blood in stool was associated with lower non-use (aPR = 0.52; 95% CI: 0.42-0.63), whereas age 48-59 months was associated with higher non-use than age 0-11 months (aPR = 1.20; 95% CI: 1.08-1.33). The poorest quintile had modestly higher non-use than the richest quintile (aPR = 1.20; 95% CI: 1.03-1.41). Non-use was not associated with diarrhea still active at interview in the prespecified secondary model (PR = 0.99; 95% CI: 0.87-1.12). More than two in five recent episodes had no external care contact, and therapeutic coverage remained limited, particularly for zinc.

PMID 42940619
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PubMedInternational journal of molecular sciences2026-10-27

Mapping and Evaluation of Quantitative Trait Loci for Adult-Plant Stripe Rust Resistance in the Sichuan Wheat Cultivar Chuanmai 62.

Yao Fangjie F, Yang Ennian E, Li Jun J, Yang Wuyun W et al.

Stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), poses a persistent threat to wheat production in China. The Sichuan cultivar Chuanmai 62 (CM62) has exhibited stable adult-plant resistance (APR) for over a decade. To elucidate its genetic basis, we evaluated a recombinant inbred line population (CM62 × Avocet S) across 13 environments and genotyped it using the 55K SNP array. QTL mapping identified six QTL distributed on chromosomes 1BL, 2AS, 2BL, 5AL (two loci), and 5BL. Among these, three major QTL (QYr.CM62-1BL, QYr.CM62-2AS, and QYr.CM62-2BL) were detected. Notably, QYr.CM62-2BL was the preeminent locus, explaining 8.97-50.59% of phenotypic variance and exhibiting high stability across 11 of the 13 environments; this locus is closely linked to the previously reported QYR1 region, although whether it is allelic to QYR1 remains unclear. QYr.CM62-2AS corresponded to Yr17/YrM1225, while QYr.CM62-1BL aligned with Yr29. A significant finding was the identification of QYr.CM62-5BL, a novel minor-effect QTL mapped to the rearranged 5BL·7BL segment resulting from a 5B/7B reciprocal translocation present in both parents. Furthermore, two Kompetitive Allele-Specific PCR (KASP) markers (KASP-AX-109507945 and KASP-AX-109844182) were developed for QYr.CM62-2BL. Polymorphism screening of 328 cultivars confirmed their utility for marker-assisted selection. Collectively, our results demonstrate that the durable APR in CM62 is governed by multiple additive QTL. The newly developed KASP markers, together with the novel QYr.CM62-5BL locus and prioritized candidate genes from in silico annotation of the QYr.CM62-2BL interval, provide valuable genetic resources for pyramiding resistance alleles and future map-based cloning in wheat breeding programs.

PMID 42941966
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PubMedChildren (Basel, Switzerland)2026-10-27

Developmental Disparities and Associated Factors Among Children Aged 36-59 Months in Four Pakistani Provinces.

Shah Syed Sikandar SS, Bukhari Ashfaq Ahmad Shah AAS, Ahmad Jamil J, Alam Aftab A et al.

Early childhood developmental attainment varies across Pakistan, but provincial averages may obscure differences across developmental domains and socioeconomic groups. We examined developmental attainment and associated factors among children aged 36-59 months in four Pakistani provinces. We analyzed four provincially representative UNICEF-supported Multiple Indicator Cluster Surveys (MICS) conducted between 2017 and 2020. Development was assessed using the original Early Childhood Development Index (ECDI). Survey-design-based analyses estimated overall and domain-specific prevalence, adjusted prevalence ratios (aPRs), and wealth-related inequalities. Province-specific associations were summarized using random-effects meta-analysis. Among 46,067 children, 59.4% met the overall ECDI criteria in Punjab, 54.6% in Khyber Pakhtunkhwa, 47.5% in Sindh, and 39.1% in Balochistan. This ordering persisted after age-sex standardization. Literacy-numeracy was the least frequently attained domain, ranging from 14.6% to 27.2%, whereas physical-domain attainment exceeded 90% in all four provinces. Early childhood education (ECE) attendance was associated with higher overall ECDI attainment (pooled aPR 1.29, 95% CI 1.22-1.37). Stunting and functional difficulty were associated with lower overall attainment, while associations with adult stimulation varied across provinces. Richest-poorest differences in overall ECDI prevalence ranged from 18.8 to 35.6 percentage points. Among children aged 36-59 months in four Pakistani provinces, developmental attainment differed substantially between provinces and across developmental domains, and these differences persisted after age-sex standardization. Socioeconomic inequalities were evident in every province. ECE attendance was associated with higher developmental attainment, but this association should be interpreted cautiously because the surveys were cross-sectional and may be affected by residual confounding and selection into ECE.

PMID 42940633
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PubMedVaccines2026-10-26

Factors Associated with Adolescents' Intention to Participate in School-Based HPV Prevention Campaigns in Colombia: Implications for School-Based HPV Prevention Strategies.

Gomez-Suarez Marcela M, Monsalve-Cordoba Maria Lorcy ML, Sierra-Torres Lizeth-Yamile LY, Hernandez-Zambrano Sandra Milena SM et al.

Despite the availability of safe and highly effective human papillomavirus (HPV) vaccines, vaccination coverage remains below global targets in many low- and middle-income countries. School-based HPV prevention campaigns represent a promising strategy to promote adolescent engagement in preventive health behaviors; however, little is known about the factors of adolescents' intention to participate in these initiatives, particularly in Latin America. This study aimed to identify factors of adolescents' intention to participate in a school-based HPV prevention campaign in Bogotá, Colombia. A cross-sectional study was conducted among 125 adolescents aged 11-17 years. Sociodemographic characteristics, HPV-related knowledge, exposure to HPV-related information on social media, and intention to receive HPV vaccination were assessed as potential factors of participation. Associations with intention to participate were estimated using Poisson regression with robust variance, and adjusted prevalence ratios (aPRs) with 95% confidence intervals (CIs) were calculated. Overall, 52.8% of adolescents reported an intention to participate in a school-based HPV prevention campaign. Exposure to HPV-related information on social media showed the strongest positive association with participation (aPR = 1.80; 95% CI: 1.25-2.58), followed by accurate knowledge of the recommended age for HPV vaccination (aPR = 1.68; 95% CI: 1.10-2.57), religious practice (aPR = 1.67; 95% CI: 1.23-2.27), and intention to receive HPV vaccination (aPR = 1.49; 95% CI: 1.01-2.21). These findings identify factors associated with adolescents' intention to participate in school-based HPV prevention campaigns. Integrating evidence-based digital communication with practical HPV education may inform strategies to promote adolescent engagement. Future studies should determine whether these factors predict actual participation and implementation outcomes.

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PubMedInternational journal of women's health2026-10-26

Knowledge of Hypertensive Disorders of Pregnancy and Associated Factors Among Antenatal-Care Attendees in Mbarara City, Southwestern Uganda: A Cross-Sectional Study.

Lugobe Henry Mark HM, Migisha Richard R, Wilkinson Ian B IB, Bajunirwe Francis F et al.

Hypertensive disorders of pregnancy (HDP) are important contributors to maternal and perinatal morbidity and mortality in sub-Saharan Africa. Women's knowledge of warning signs, risk factors, diagnosis, and prevention may support earlier care-seeking and timely diagnosis, yet data from primary-level antenatal-care settings in Uganda remain limited. We assessed knowledge of HDP and associated factors among antenatal-care attendees in Mbarara City, southwestern Uganda. We conducted a cross-sectional study among pregnant women attending their third or later antenatal-care visit at six public health facilities in Mbarara City between January and March 2025. Participants were recruited by consecutive sampling. Knowledge was assessed using 41 scored knowledge items covering awareness, disease manifestations, risk factors, diagnosis, management, prevention, complications, and blood-pressure monitoring. Scores were expressed as percentages of correct responses; adequate knowledge was defined as ≥60%. Multivariable modified Poisson regression was used to estimate adjusted prevalence ratios. Among 426 antenatal-care attendees, 271 had adequate knowledge, giving a prevalence of 63.6% (95% CI: 58.8-68.2). Knowledge was highest for timing or frequency of blood-pressure checks (86.2%) and complications (76.1%), but lower for diagnosis (51.4%), timing of occurrence (53.3%), treatment and management (53.4%), and risk factors (56.8%). Adequate knowledge was more prevalent among women with secondary education (aPR=1.34; 95% CI: 1.10-1.64) or tertiary education (aPR=1.36; 95% CI: 1.04-1.78), compared with primary education or less; women with five or more pregnancies compared with primigravidas (aPR=1.77; 95% CI: 1.27-2.48); and women with family history of preeclampsia compared with those without (aPR=1.26; 95% CI: 1.06-1.50). Approximately two-thirds of antenatal-care attendees had adequate knowledge of HDP, but important gaps remained in diagnosis, timing of occurrence, treatment and management, and risk-factor recognition. Health education during antenatal care should prioritize practical messages for women with lower educational attainment, primigravidas or limited pregnancy experience, and women without a family history of preeclampsia.

PMID 42928912
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