北京若生智能科技有限公司
Drug Database
ID

idoxuridine (idoxuridine, APR / Apridin C / Apridin)

✓ Approved

Pierre Fabre S.A. · · 小分子

什么是 idoxuridine？

idoxuridine 是一种小分子，由Pierre Fabre S.A.研发。该药已获批，用于治疗相关适应症，给药途径：Topical。

药物档案

商品名idoxuridine, APR, Apridin C, Apridin
公司Pierre Fabre S.A.
药物类别小分子
分子靶点,
给药途径Topical
状态Approved
来源： ClinicalTrials.gov, Pierre Fabre S.A.

作用机制

分子靶点

idoxuridine 作用于 2 个分子靶点：

(UL30)
(UL30)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

idoxuridine 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsHerpes simplex✓ Approved
Congenital, familial and genetic disordersCongenital herpes simplex infection✓ Approved

相关研究文献

PubMedJournal of thoracic disease2026-09-11

Prediction of postoperative pulmonary infection after video-assisted thoracoscopic anatomical pulmonary resection using an interpretable machine learning model.

Yang Maoqiang M, Yang Zihan Z, Li Dongxue D, Huang Guiting G et al.

Postoperative pulmonary infection (PPI) remains a significant complication after video-assisted thoracoscopic anatomical pulmonary resection (VAT-APR). This study aimed to develop and validate an interpretable machine learning (ML) model for perioperative prediction of PPI using Light Gradient Boosting Machine (LightGBM) integrated with SHapley Additive exPlanations (SHAP) for patients undergoing VAT-APR. This retrospective predictive modeling study included 512 patients who underwent VAT-APR between January 2020 and December 2024 at the Department of Thoracic Surgery, The First People's Hospital of Yunnan Province, Kunming, China. Preoperative and intraoperative features were extracted, and the dataset was randomly partitioned into training (70%) and validation (30%) sets. Five ML algorithms were evaluated, with the LightGBM model selected as optimal. The LightGBM model demonstrated strong discriminative performance, achieving an area under the curve (AUC) of 0.832 [95% confidence interval (CI): 0.795-0.869], with an accuracy of 0.781 and an F1-score of 0.710, outperforming five comparator algorithms. Feature importance analysis identified operative time, percentage of predicted forced expiratory volume in 1 second (FEV1%), age, and monocyte count as the most influential predictors. The model showed good calibration (Hosmer-Lemeshow test, P=0.32) and yielded a positive net clinical benefit across a range of threshold probabilities in decision curve analysis. The interpretable LightGBM-SHAP model provides a robust and transparent approach for perioperative risk assessment of PPI, with potential to inform individualized perioperative management and targeted preventive strategies.

PMID 42724730
阅读全文 →
PubMedCancer2026-09-10

Prevalence of breast, cervical, and colorectal cancer screening among adults according to disability type and difficulty level, United States, 2021 and 2023.

Mazzitelli Natalia N, Star Jessica J, Meggett Kinsey K, Han Xuesong X et al.

Adults with disabilities face multiple barriers to cancer screening services. Few studies have examined screening receipt across multiple disability domains via standardized measures in contemporary nationally representative samples. Data were pooled from the 2021 and 2023 National Health Interview Survey. Prevalence of United States Preventive Services Task Force recommendation concordant breast, cervical, and colorectal cancer screening was estimated according to disability domain (vision, hearing, mobility, cognition, communication, and self-care) and difficulty level ("substantial," "some," and "none"), which were defined according to the Washington Group Composite Disability Indicator. A total of 1712, 1147, and 3106 sample respondents eligible for breast, cervical, and colorectal screening had disabilities, respectively, which translates to 6.02 million, 5.10 million, and 11.17 million when population weighted. Breast and cervical screening prevalence decreased with increasing difficulty level for self-care, vision, mobility, and cognition domains, with the lowest receipt among those reporting substantial versus no self-care difficulties (breast: 52% vs. 79%; adjusted prevalence ratio [aPR], 0.69; 95% CI, 0.58-0.82; cervical: 37% vs. 78%; aPR, 0.63; 95% CI, 0.51-0.78). Communication disability was associated with lower cervical screening (35% substantial vs. 78% none; aPR, 0.65; 95% CI, 0.52-0.82) but not for other screenings. Conversely, stool testing for colorectal screening was higher among adults with substantial mobility difficulties (22% vs. 16% none; aPR, 1.24; 95% CI, 1.12-1.38) and some self-care, mobility, and vision difficulties, compared to those with none. Addressing barriers for individuals with self-care limitations could improve suboptimal screening levels across multiple cancer screenings. Self-sampling modalities, including stool testing, may mitigate accessibility issues, and warrant further evaluation.

PMID 42720530
阅读全文 →
PubMedScientific reports2026-09-10

Severity of irritable bowel syndrome and its correlates among Middle East and North African medical students: a multicentric cross sectional study.

Abdelshafi Abdelrahman A, Abdelhamid Zeinab G ZG, Osama Belal B, Mohammed Yasmine Adel YA et al.

Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder that is commonly reported among individuals experiencing high levels of stress, such as medical students. Despite its significance, data on the severity of IBS and its correlates remains scarce in the Middle East and North Africa (MENA) region. This study is a secondary analysis of a previously published multicenter study and aimed to evaluate the severity of irritable bowel syndrome (IBS) and identify the correlates of severe IBS among medical students with Rome IV-confirmed IBS. This multicentric cross-sectional study was conducted across 27 medical faculties in seven MENA countries) from March until May 2024. A bilingual (Arabic/English) online self-reported questionnaire was used to assess IBS severity via the validated IBS-Symptom Severity Scale. Data analysis was performed using SPSS, version 26. Remission, mild, moderate, and severe IBS symptoms were detected among 15.28%, 31.38%, 36.60%, and 16.73% of the participants, respectively. Students with severe IBS symptoms had a significantly higher mean age compared to other students (p = 0.019). Among students with severe IBS symptoms, the proportion of overweight/obese (18.5%) was significantly higher than that of underweight/normal weight (16.1%) (p = 0.022). Furthermore, among students with severe IBS symptoms, there were significantly higher proportions of positive depression (p < 0.001), anxiety (p < 0.001), and history of food or drug hypersensitivity (p < 0.001). In the Generalized linear model - Adjusted Poisson regression analysis for determination of the correlates of severe IBS among medical students, Anxious students [aPR = 1.87 (95% CI 1.418-2.461)] and depressed students [aPR = 1.86 (95% CI 1.512-2.284)] were significantly more likely to experience severe IBS symptoms (p < 0.001*). Similarly, students with a history of food or drug hypersensitivity were significantly more likely to have severe IBS [aPR = 1.29 (95% CI 1.079-1.546)] (p = 0.005). The present study demonstrated that more than half of students with IBS In the MENA region exhibited moderate to severe symptoms. Psychological comorbidities were predominant among students with severe IBS symptoms, highlighting the strong association between mental health conditions and IBS symptom severity in this population.

PMID 42717224
阅读全文 →
PubMedCureus2026-09-10

Outcomes of Open, Percutaneous, and Closed Treatment of Isolated Mandibular Condylar Fractures.

Tiwana Hardeep H, Sangha Harneet H, Kennedy Dean D, Salas Abigail A et al.

Objectives Mandibular condylar fractures are common facial fractures, and the optimal balance between open and less invasive treatment remains debated. Readmission provides a reproducible hospital-utilization outcome that can be examined in large administrative datasets. This study aimed to compare 30-day readmission following open, percutaneous, and closed treatment of mandibular condylar fractures (MCF) using national inpatient databases. Methods We performed a retrospective database study using the 2016 Kids' Inpatient Database (KID) and the 2019-2020 National Readmissions Database (NRD). KID was used only for supplemental pediatric inpatient characterization and was not used to calculate readmission. The 6,240-case analytic cohort and all 30-day readmission analyses, including the pediatric subgroup analyses, were derived from the 2019-2020 NRD. Isolated MCF were identified with ICD-10-CM (International Classification of Diseases, 10th Revision, Clinical Modification) diagnosis codes, and treatment was classified with ICD-10-PCS (Procedure Coding System) procedure codes as open, percutaneous, or closed. Pearson chi-square tests were used for categorical comparisons, with 95% confidence intervals and Cramer's V reported for effect size. A two-sided p < 0.05 was considered statistically significant. Results A total of 6,240 NRD index cases met the study criteria. After correction of denominator and decimal-place transcription errors in the prior version, approach-specific 30-day readmission rates ranged from 4.8% to 8.3% across All Patient Refined Diagnosis-Related Groups (APR-DRG) severity strata. No significant differences were identified among open, percutaneous, and closed approaches within severity strata (all p ≥ 0.711). Age- and fixation-stratified analyses similarly showed no consistent difference between internal and external fixation; pediatric readmission results represent the pediatric subset of the NRD and do not include KID encounters. Conclusion No treatment approach demonstrated a consistent 30-day readmission advantage across the examined subgroups. Readmission should be interpreted as a hospital-utilization outcome rather than a direct measure of functional or clinical effectiveness. Treatment selection should remain individualized according to patient and fracture characteristics.

PMID 42718931
阅读全文 →
PubMedHernia : the journal of hernias and abdominal wall surgery2026-09-09

Minimally invasive versus open abdominoperineal resection and the risk of postoperative perineal hernia: a systematic review and meta-analysis.

Yokoyama Beatriz Yukari BY, E Silva Victória Recidivi VR, de Souza Aguiar Lucas Carvalho Lemos LCL, Gonçalves Hélder Santos HS et al.

The impact of minimally invasive surgery on the risk of postoperative perineal hernia after abdominoperineal resection (APR) or extralevator abdominoperineal excision (ELAPE) remains uncertain. This study compares perineal hernia rates and perioperative outcomes between minimally invasive and open approaches. PubMed, Scopus, Web of Science, and Cochrane Library were searched through June 2026. Pooled odds ratios (ORs) and mean differences (MDs) with 95% confidence intervals (CIs) were calculated using random-effects models. A Bayesian meta-analysis was additionally performed for the primary outcome. Four comparative observational studies involving 763 patients were included; 249 underwent minimally invasive APR/ELAPE, and 514 underwent open APR/ELAPE. Postoperative perineal hernia was significantly more frequent following minimally invasive surgery (OR 4.13; 95% CI 2.24-7.61; p < 0.001). Intraoperative blood loss was significantly lower in the minimally invasive group (MD - 156.5 mL; 95% CI - 298.4 to - 14.5; p = 0.03), as was operative time (MD - 41.7 min; 95% CI - 60.8 to - 22.5; p < 0.01). No significant differences were observed in hospital stay (MD - 2.5 days; 95% CI - 5.4 to 0.4; p = 0.09) or 30-day readmission rates (OR 1.41; 95% CI 0.82-2.42; p = 0.209). Bayesian analysis yielded a posterior mean OR of 4.04 (95% CrI 1.96-8.36), corresponding to a 99.9% posterior probability that minimally invasive surgery increases the risk of postoperative perineal hernia. Minimally invasive APR/ELAPE was associated with an increased risk of postoperative perineal hernia compared with the open approach. Strategies to reduce this complication while preserving the benefits of minimally invasive surgery warrant further investigation.

PMID 42714662
阅读全文 →
PubMedBiomechanics and modeling in mechanobiology2026-09-09

An adaptive physics refinement framework to investigate red blood cells' impact on adhesive tumor cell transport.

Stoop Jorik J, Martin Aristotle A, Randles Amanda A

Red blood cells play a dominant mechanical role in blood flow and strongly influence the transport and arrest of circulating tumor cells during metastasis. Circulating tumor cells (CTCs) are subject to physical interactions with blood components and adhesive interactions with endothelial cells, both of which critically influence their margination and likelihood of arrest. However, the impact of red blood cells (RBCs), the most abundant cellular component of blood, on CTC adhesion remains understudied. Multiscale computational methods provide a unique platform for investigating RBC-CTC interactions by enabling precise parameter control and quantitative analysis. Nevertheless, traditional explicit simulations have been limited in physiological relevance due to the high computational demand of modeling sub-micron scale adhesion dynamics in millimeter-scale vasculature. Here we employ and extend an adaptive physics refinement (APR) framework that couples a high-resolution region of interest to a coarsely resolved bulk fluid domain. We incorporate both RBC interactions and adhesive dynamics in the high-resolution region, enabling simulation of adhesive CTC transport with drastically reduced computational memory. Simulation results demonstrate that RBC-CTC interactions and RBC orientation significantly impact CTC trajectory and adhesive behavior. Compared to traditional explicit fluid-structure-interaction methods, the APR approach results in an order of magnitude decrease in memory usage, enabling analysis of larger vessel domains pertinent to metastasis. By providing a computationally efficient tool for simulating RBC interactions and adhesive dynamics, the extended APR framework paves the way for systematic investigation of tumor cell transport with increased physiological relevance.

PMID 42714623
阅读全文 →

注册免费账户还可查看另外 8782 篇文献

免费注册查看全部文献 →

了解更多idoxuridine