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idoxuridine (idoxuridine, APR / Apridin C / Apridin)

✓ Approved

Pierre Fabre S.A. · · 小分子

什么是 idoxuridine？

idoxuridine 是一种小分子，由Pierre Fabre S.A.研发。该药已获批，用于治疗相关适应症，给药途径：Topical。

药物档案

商品名idoxuridine, APR, Apridin C, Apridin
公司Pierre Fabre S.A.
药物类别小分子
分子靶点,
给药途径Topical
状态Approved
来源： ClinicalTrials.gov, Pierre Fabre S.A.

作用机制

分子靶点

idoxuridine 作用于 2 个分子靶点：

(UL30)
(UL30)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

idoxuridine 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsHerpes simplex✓ Approved
Congenital, familial and genetic disordersCongenital herpes simplex infection✓ Approved

相关研究文献

PubMedTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2026-07-27

Identification of stripe rust resistance loci in Gansu wheat landraces using genome-wide association analysis.

Zhang Zhe Z, Zhang Yu Y, Guo Ying Y, Ye Xinyi X et al.

Stripe rust severely threatens global wheat production. Identifying and using favorable resistance loci from landraces can increase the genetic diversity and durability of resistance in modern wheat cultivars. In this study, we phenotyped 376 wheat landraces from Gansu for stripe rust resistance through seedling inoculation with race CYR34 and multiyear field trials across six environments. Genotyping was performed using a 16 K SNP array and known gene markers. In total, seven significant quantitative trait loci located on chromosomes 2A, 2D, 3B, 3D, 4B, and 7A were detected at the seedling stage. Four significant and stable QTLs, including the known pleiotropic adult plant resistance gene Yr18, were identified at the adult plant stage. Among them, Yr.hzau.4B was stably detected at both ASR and APR, explaining 9.46% and 11.58% of the phenotypic variation, respectively. Haplotype analysis revealed that, compared with materials carrying the unfavorable haplotype, wheat landraces harboring the favorable Yr.hzau.4B haplotype presented a reduction of 0.6 grading units in the average infection type for ASR and a 32.4% decrease in DS for APR. Additive interaction analysis further indicated a decreasing trend in both IT and DS with an increasing number of favorable haplotypes. Additionally, a KASP molecular marker for Yr.hzau.4B was developed and validated in an independent population. Integrated candidate gene analysis revealed 29 putative resistance-related genes, encompassing gene families such as kinases and transporters. This study identified new resistance gene loci and developed breeder-friendly molecular markers. These compounds can be used to improve stripe rust resistance in wheat and provide useful resources for the breeding of wheat resistance.

PMID 42506996
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PubMedDrug and alcohol dependence2026-07-26

Urban-rural and racial/ethnic disparities in modes of preconception cannabis use among insured patients receiving prenatal care at an integrated healthcare system in Northern California from 2020 to 2023.

Brown Qiana L QL, Cortez Catherine A CA, Nugent Joshua R JR, Adams Sara R SR et al.

To examine joint associations between race/ethnicity and urbanicity in any cannabis use and modes of cannabis use during preconception. In this cross-sectional study, insured pregnant patients (N = 146,166) were screened for cannabis use at prenatal care entry between February, 2020 and September, 2023 at a large integrated healthcare system in Northern California and answered questions about preconception cannabis use (any cannabis use and modes of use [smoking, blunts, edibles, vaping, dabs and topicals]). Multivariable Poisson regression models examined associations between race/ethnicity and urbanicity in preconception cannabis use. The prevalence of any cannabis use was 17%, smoking was the most common mode (67%). Preconception cannabis use was often highest in cities and lowest in town/rural areas. The magnitude of place-based differences was often greatest among non-Hispanic (NH) Black patients and patients from NH multi-racial/other/unknown racial/ethnic groups. For example, while the prevalence of any cannabis use and smoking was highest in cities and lowest in town/rural areas among each racial/ethnic group, the adjusted prevalence ratio (aPR) (1.55; 95% confidence interval [CI]=1.27-1.90) for any cannabis use comparing cities to town/rural areas was higher among NH Black patients; and the aPR for smoking (1.55; 95% CI=1.07-2.24) was highest for patients from NH multi-racial/other/unknown racial/ethnic groups. Living in cities is often associated with increased preconception cannabis use. The greater magnitude of place-based differences in use among NH Black patients and patients from NH multi-racial/other/unknown racial/ethnic groups indicates that where these patients live potentially matters more in preconception cannabis use.

PMID 42501517
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PubMedClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis2026-07-25

Diagnostic Management of Asymptomatic Pulmonary Embolism: A Predictive Model Integrating Inflammatory Markers and Clinical Characteristics in Patients With Deep Vein Thrombosis.

Mu Xiaomin X, An Qi Q, Wan Guangxu G, Sun Ziqiang Z

BackgroundPulmonary embolism (PE) may be asymptomatic due to the compensatory function of the lungs themselves, which easily leads to missed diagnosis and increased risks. Although computed tomography pulmonary angiography (CTPA) can improve the detection rate, routine CTPA screening for patients with concurrent lower extremity deep vein thrombosis (DVT) still faces challenges. These include limited medical resources, restricted use of contrast agents (e.g., allergies, renal function issues), and low specificity of D-dimer. Therefore, there is a need to develop optimized diagnostic strategies based on inpatient DVT populations to accurately identify high-risk patients requiring CTPA, while acknowledging that these findings cannot be directly generalized to all DVT outpatients and reduce unnecessary contrast agent exposure.MethodsThis retrospective study analyzed patients admitted with lower extremity DVT (Jan 2022-Apr 2024). After excluding those with acute PE symptoms or other key confounders (e.g., recent anticoagulation), 401 patients were included. All underwent CTPA and were classified into asymptomatic PE (n=198) or isolated DVT (n=203) groups. Predictors of asymptomatic PE were identified using binary logistic regression.ResultsAfter screening based on inclusion and exclusion criteria, 401 patients were finally included in the analysis, with 198 cases in the asymptomatic PE group and 203 cases in the DVT group. Multivariate regression analysis showed that hypertension, neutrophil-to-lymphocyte ratio (NLR), smoking duration, right distal DVT, right proximal DVT, and lower extremity swelling and pain were independent risk factors for asymptomatic PE (OR = 3.461, 1.303, 1.103, 2.878, 4.495, 7.176,). The area under the curve (AUC) of the model was 0.874, with a sensitivity of 73.74% and a specificity of 82.27%.ConclusionThe combined detection of these independent risk factors-hypertension, NLR, smoking duration, right distal DVT, right proximal DVT, and lower extremity swelling and pain-is expected to facilitate early screening for asymptomatic PE in hospitalized DVT populations, with further external verification required to extend its applicability to broader DVT cohorts.

PMID 42501018
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PubMedFrontiers in oncology2026-07-25

Analysis of clinicopathological features and prognosis of mesenteric versus anti-mesenteric rectal cancer: a single-center retrospective cohort study.

Hao Dalei D, Dong Longzhan L, Xi Xiangpeng X, Liu Yulin Y et al.

The mesorectal and anti-mesorectal sides of the rectum differ considerably in embryonic origin, blood supply, lymphatic distribution, and anatomical relations. Tumor location (mesenteric vs. anti-mesenteric) may therefore influence tumor biology and clinical outcomes. This study aimed to evaluate the impact of axial tumor location on clinicopathological features and prognosis in rectal cancer using preoperative high-resolution pelvic MRI. We retrospectively reviewed 380 rectal cancer patients who underwent radical resection between January 2017 and July 2023. Based on preoperative MRI axial images, tumors were classified by their deepest point of invasion relative to the rectal lumen: the mesenteric side group (3-9 o'clock, posterior/posterolateral walls, n=213) and the anti-mesenteric side group (9-3 o'clock, anterior/anterolateral walls, n=167). Demographic, clinicopathological, surgical, and survival data were compared between groups. Among the 380 patients, 213 were assigned to the mesenteric side tumor group and 167 to the anti-mesenteric side tumor group. Baseline characteristics, including age, gender, BMI, TNM stage, MRF status, EMVI, and vascular/nerve invasion, did not differ significantly between two groups (all P > 0.05). With a median follow-up of 56 months, the 3-year local recurrence-free survival (LRFS) rate was significantly lower in the anti-mesenteric group than in the mesenteric group (91.6% vs. 97.1%, P = 0.029). No significant differences were observed in 3-year disease-free survival (83.2% vs. 82.1%, P = 0.832) or overall survival (85.6% vs. 81.7%, P = 0.501) between the two groups. Multivariable Cox regression analysis identified age (HR = 1.043, P = 0.002), surgical procedure (APR vs. LAR, HR = 1.967, P = 0.022), pathological T stage (HR = 2.800, P = 0.023), and pathological N stage (HR = 3.683, P < 0.001) as independent prognostic factors for overall survival. Pathological N stage was the sole independent predictor for disease-free survival (HR = 3.088, P < 0.001). Although axial location was not an independent predictor of overall or disease-free survival (P > 0.05), it was significantly associated with LRFS (anti-mesenteric vs. mesenteric: HR = 2.684, 95% CI: 1.126-6.398, P = 0.026) along with pathological N stage (HR = 3.960, 95% CI: 1.316-11.919, P = 0.014).These findings suggest that anti-mesenteric tumor location is an independent predictor of increased local recurrence risk, providing valuable information for surgical planning and postoperative surveillance beyond conventional staging. Anti-mesenteric rectal tumors are associated with a higher risk of local recurrence, likely due to complex local anatomy and surgical challenges. While pathological N stage, pathological T stage, age, and surgical procedure remain primary independent prognostic factors for survival outcomes, preoperative MRI assessment of axial location provides valuable supplemental information that may help stratify local recurrence risk, refine surgical planning, and optimize postoperative monitoring.

PMID 42500279
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PubMedSports medicine (Auckland, N.Z.)2026-07-24

The Legacy of Olympic Sport: A Cross-Sectional Comparison of the Musculoskeletal and General Health of 1488 Retired Female Summer and Winter Olympians and 998 Female General Population Controls.

Guilfoyle Lauren L, MacPherson Alan A, Cooper Dale D, Crossley Kay M KM et al.

Little is known about the long-term health outcomes associated with sustained elite performance once female Olympians retire from their Olympic careers. The aim of this study was to determine and compare (1) musculoskeletal health, (2) general health and (3) current physical activity (PA) behaviours between a global sample of female retired Olympians and general population controls. A cross-sectional survey comprised four sections: (1) background information, (2) injury history, (3) current musculoskeletal health and (4) general health. A total of 1488 retired female Olympians and 998 female controls completed the survey. Poisson regression analysis was used to determine prevalence ratios (aPR) with 95% confidence intervals (CI) adjusted for age, body mass index (BMI) and/or previous significant injury or current persistent pain. Adjusting for age, BMI and previous significant injury, more retired female Olympians reported stiffness, pain and/or osteoarthritis (OA) (aPR [95% CI]) in the cervical spine (stiffness 1.42 [1.08-1.86]; OA 1.85 [1.01-3.39]), lumbar spine (stiffness 1.41 [1.18-1.67], pain 1.41 [1.15-1.73]) and hip (OA 1.82 [1.08-3.06]) compared with controls. Stiffness, pain and OA at the knee were also higher for Olympians, but not when adjusting for prior injury. No differences were observed between groups for self-reported disease states, however the prevalence of most health conditions increased among Olympians following retirement, except for depression which decreased. Both groups rated their health-related quality of life (retired female Olympians: 88/100; Controls: 89/100) and mental health similarly, while the prevalence of participation in weekly sport (aPR: 0.75 [0.66-0.85]) and physical activity (aPR: 0.91 [0.87-0.95]) was slightly lower in retired Olympians when adjusted for age, BMI and current persistent musculoskeletal pain. Retired female Olympians report poorer musculoskeletal health than the general population, a difference only partly attributable to previous significant injury, which suggests elements of elite athletic exposure may underlie some of these outcomes. Primary and secondary prevention of shoulder, hip and knee injuries remains a priority with consideration to long-term outcomes. Future research should broaden our understanding of retired female athlete health by exploring the largely under-researched domains of cognitive, reproductive, breast and pelvic floor health.

PMID 42493755
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PubMedFrontiers in oncology2026-07-24

Sphincter-saving surgery versus abdominoperineal resection in low rectal cancer: the role of indocyanine green fluorescence angiography in surgical decision-making.

Misca Mihaela C MC, Petrea Sorin V SV, Boanta Roxana D RD, Aldoescu Sorin S et al.

The choice between sphincter-saving surgery and abdominoperineal resection (APR) for low rectal cancer balances oncological radicality against functional preservation. Indocyanine green fluorescence angiography (ICG-FA) provides objective intraoperative assessment of bowel perfusion at the colonic stump, where ischemia is a leading cause of anastomotic failure. In this prospective, single-center, descriptive cohort study (January 2021-December 2025) of more than 400 patients operated for colorectal cancer, 70 had low rectal cancer (≤6 cm from the anal verge) and 27 underwent sphincter-saving surgery - 7 intersphincteric resections, 4 immediate low colorectal or coloanal anastomoses, and 16 two-staged Turnbull-Cutait pull-through procedures. ICG-FA of the colonic stump was performed in 22 patients (81.5%), with proximal repositioning of the resection line whenever fluorescence was inadequate. ICG-FA prompted modification of the resection line in 9 of 22 patients (40%), almost always proximally, but never altered the decision between sphincter preservation and APR. A radical (R0) resection was achieved in 19 of 21 patients with margin status recorded; two had an involved circumferential margin (R1), both in locally advanced node-positive tumors. Postoperative complications occurred in 15 of 27 patients (56%), mostly Clavien-Dindo grade I-II. There was no 30-day mortality; one late in-hospital death from an independent myocardial infarction occurred beyond 30 days. Sphincter-saving surgery for low rectal cancer is feasible but carries substantial morbidity. ICG-FA is a reproducible, low-risk adjunct that informs intraoperative decision-making; whether it reduces anastomotic complications requires confirmation in randomized studies.

PMID 42494610
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