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varicella zoster immunoglobulin (VariQuin)

✓ Approved

Prothya Biosolutions · 多克隆抗体 · 多克隆抗体

什么是 varicella zoster immunoglobulin？

varicella zoster immunoglobulin 是一种多克隆抗体，由Prothya Biosolutions研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection。

药物档案

商品名VariQuin
公司Prothya Biosolutions
药物类别多克隆抗体, 细胞治疗, 抗体
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved
来源： ClinicalTrials.gov, Prothya Biosolutions

治疗适应症

varicella zoster immunoglobulin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsVaricella zoster virus infection✓ Approved

相关研究文献

PubMedBMC neurology2026-09-11

Rashless varicella-zoster virus encephalitis diagnosed by metagenomic next-generation sequencing: two case reports.

Guo Wei-Meng WM, Zhang Xue-Hao XH, Yang Xin X, Chen Fang F et al.

Varicella-zoster virus (VZV) can cause a range of central nervous system (CNS) infections, but early diagnosis is difficult when typical skin rash is absent. Rashless VZV encephalitis may present with nonspecific clinical, cerebrospinal fluid (CSF), and neuroimaging findings and can mimic autoimmune encephalitis, primary central nervous system lymphoma, or other disorders. We report two cases of rashless VZV encephalitis diagnosed by CSF metagenomic next-generation sequencing (mNGS), with subsequent neurological complications. Case 1 was a 68-year-old man admitted with fever, seizures, and impaired consciousness. Brain magnetic resonance imaging (MRI) showed multifocal abnormal signals. CSF analysis revealed marked pleocytosis and elevated protein levels, and CSF cytology showed suspected atypical lymphocytes, leading to early consideration of autoimmune encephalitis and primary central nervous system lymphoma. CSF mNGS detected VZV, and rashless VZV encephalitis was diagnosed. The patient improved after intravenous acyclovir combined with a short course of dexamethasone. On day 45 after disease onset, follow-up MRI showed a new acute cerebral infarction adjacent to the posterior horn of the left lateral ventricle. Recurrent CSF pleocytosis and persistent protein elevation suggested possible VZV-associated vasculopathy. After repeated antiviral treatment, he improved again, and no recurrence was observed during more than 3 years of follow-up. Case 2 was a 74-year-old man admitted with fever, low back pain, vomiting, and impaired consciousness. Brain MRI showed multifocal abnormal signals, and CSF analysis revealed marked inflammatory changes. CSF mNGS detected VZV, supporting the etiological diagnosis of rashless VZV encephalitis. The patient improved after intravenous acyclovir combined with a short course of dexamethasone. On day 14 after disease onset, he developed urinary retention, impaired defecation sensation, and bilateral lower-limb weakness, suggesting possible lumbosacral nerve root or cauda equina involvement. Suspected VZV-related Elsberg syndrome was considered. His urinary and bowel dysfunction recovered at 2 months after disease onset. Rashless VZV encephalitis may be diagnostically challenging because early clinical, CSF, and neuroimaging findings are nonspecific. CSF mNGS can support etiological diagnosis, and careful follow-up is needed to detect delayed vascular and lumbosacral nerve root complications.

PMID 42723024
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PubMedFrontiers in neurology2026-09-11

CT-guided pulsed radiofrequency of sacral and pudendal nerves for herpes zoster-related neurogenic lower urinary tract dysfunction in male patients: a retrospective study.

Li Haojia H, Liu Jingyu J, Liao Hongsen H, Wang Dianjun D et al.

To evaluate the efficacy of CT-guided pulsed radiofrequency (PRF) neuromodulation targeting the sacral nerves (S2-S4) and the pudendal nerve in male patients with herpes zoster-related neurogenic lower urinary tract dysfunction (NLUTD), a condition lacking effective treatment and significantly impairing quality of life. A retrospective analysis was conducted on 15 male patients with herpes zoster-related NLUTD who underwent CT-guided PRF treatment between 2024 and 2025. PRF was applied to the sacral nerve roots (S2-S4) and the pudendal nerve. Clinical outcomes were assessed using residual urine volume and Visual Analog Scale (VAS) scores for pain. Most patients received two to three treatment sessions. A 12-week follow-up was conducted, and quality of life was evaluated using the 36-Item Short Form Health Survey (SF-36). PRF treatment resulted in significant and sustained improvements in both urinary function and pain. Residual urine volume decreased markedly from 174.7 ± 43.1 mL at baseline to 29.3 ± 42.2 mL at 12 weeks, while VAS scores declined from 5.8 ± 1.0 to 0.9 ± 1.1. Health-related quality of life also improved significantly, as reflected by reductions in KHQ (73.47 ± 7.17 to 27.27 ± 12.79) and IIQ-7 scores (17.40 ± 1.72 to 5.07 ± 3.01; p < 0.05). Clinical benefits were evident after the first session and further enhanced with repeated treatments, with most patients achieving near-complete symptom resolution at 12 weeks and no recurrence of urinary retention. CT-guided PRF neuromodulation of the sacral and pudendal nerves demonstrates significant therapeutic value for male NLUTD secondary to herpes zoster, providing durable improvements in pain relief, urinary function, and quality of life (SF-36) over a 12-week observation period. The dual neuromodulatory approach is safe and warrants further prospective validation.

PMID 42723792
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PubMedAnnals of medicine and surgery (2012)2026-09-11

Post-traumatic Blaschko-linear dermatitis following prostatectomy: a rare case report.

Katanji Salah Aldin SA, Kaurie Meri Abdul Masih MAM, Rayya Mohammad Zuhair MZ, Rayya Ali Zuhair AZ et al.

Blaschko-linear acquired inflammatory skin eruption includes lichen striatus and blaschkitis, which can be triggered by factors such as pregnancy and autoimmune diseases; a rare case in an elderly man post-prostatectomy illustrates the need for accurate diagnosis to prevent unnecessary treatment. A 69-year-old man developed a pruritic vesicular eruption along Blaschko's lines after undergoing prostatectomy. All laboratory tests for viruses were negative, and the biopsy result indicated post-traumatic Blaschkoid dermatitis. The patient was treated with topical corticosteroids and antihistamines, and he experienced remarkable improvement with no relapse three months later. Surgery-induced blaschkitis mimicking herpes zoster highlights the nonviral Koebner phenomenon, thereby preventing unnecessary antiviral use. Diagnosis of Blaschko-linear inflammatory eruptions should be made promptly to avoid misdiagnosis and prevent unnecessary use of antivirals. Further studies are needed on surgical trauma and cutaneous mosaicism.

PMID 42724915
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PubMedTranslational pediatrics2026-09-11

Traditional Chinese medicine combined with conventional Western medicine for chronic cough following respiratory infection in children: a systematic review and meta-analysis.

Cui Shengtao S, Xie Xiaofei X, Yang Jingjing J, Xiao Yao Y et al.

Chronic cough following respiratory infection in children is often refractory to conventional therapies. However, the current clinical evidence regarding the efficacy of traditional Chinese medicine (TCM) remains inconclusive and lacks systematic synthesis, leaving clinicians without clear guidance. This study systematically evaluated the efficacy and safety of TCM for chronic cough following respiratory infection in children to support clinical decision-making. A systematic search was conducted in the Cochrane Library, PubMed, Embase, Web of Science, Wiley Online Library, China National Knowledge Infrastructure (CNKI), and Wanfang databases. Randomized controlled trials (RCTs) of TCM for chronic cough following respiratory infection in children were included. Meta-analyses were performed using RevMan 5.4 and Stata 16.0. A total of 23 RCTs involving 2,126 children were included. Meta-analysis demonstrated that, compared with conventional Western medical treatment alone, TCM combined with conventional treatment significantly improved the overall clinical effectiveness rate [risk ratio (RR) =1.19, 95% confidence interval (CI) (1.15, 1.24), P<0.001], shortened the time to cough resolution [mean difference (MD) =-3.19, 95% CI (-4.42, -1.97), P<0.001] and the time to disappearance of pulmonary rales [MD =-2.00, 95% CI (-2.47, -1.54), P<0.001], and significantly reduced cough symptom scores [MD =-1.32, 95% CI (-1.69, -0.95), P<0.001]. For secondary outcomes, combined TCM therapy significantly reduced TCM syndrome scores, improved immune function indicators [immunoglobulin A (IgA), immunoglobulin M (IgM), and immunoglobulin G (IgG)], and decreased levels of inflammatory biomarkers [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and monocyte chemoattractant protein-4 (MCP-4)]. No statistically significant difference was observed between groups in the incidence of adverse events. TCM used as an adjunct to conventional Western medical treatment may provide additional benefits in improving clinical outcomes and alleviating symptoms in children with post-infectious chronic cough. However, due to limitations in study quality and heterogeneity, further high-quality, well-designed studies are warranted to strengthen the evidence base.

PMID 42724356
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PubMedTranslational cancer research2026-09-11

STC1 is associated with tumor progression and suppressive niches in laryngeal squamous cell carcinoma.

Chen Xiaoxue X, Li Wenjing W, Liu Yiyao Y, Zhang Lei L et al.

Laryngeal squamous cell carcinoma (LSCC) exhibits high recurrence and therapy resistance. We aimed to investigate the undefined role of Stanniocalcin-1 (STC1) in LSCC pathogenesis. The single-cell RNA sequencing (RNA-seq) data and the clinical information of LSCC patients were acquired from the public database. Prognostic differences and diagnostic efficiency of STC1 were assessed. The gene correlation was investigated by Spearman method. Enrichment analysis was performed using clusterProfiler, and immune infiltration was assessed with CIBERSORT. Finally, we analyzed the distribution of specific STC1 expression in cell types using single-cell RNA sequencing (scRNA-seq) analysis, and cell communication for ligand-receptor interactions between STC1+ cells and T cell subsets. The upregulated STC1 was linked to tumor metastasis and disease stage in LSCC. It correlated with genes involved in extracellular matrix (ECM) remodeling, epithelial-mesenchymal transition (EMT), phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt), and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) resistance. High STC1 expression was linked to an immunosuppressive microenvironment, with increased M0 macrophages and reduced CD8+ T cells, and was positively correlated with the immune checkpoints [programmed death-ligand 1 (PD-L1), cytotoxic T-lymphocyte-associated protein 4 (CTLA4), T cell immunoglobulin and ITIM domain (TIGIT), T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3)]. Single-cell analysis localized STC1 to epithelial cells, with STC1+ epithelial cells showing enriched endoplasmic reticulum (ER) stress, inflammatory signaling, and EMT during carcinogenesis. Cell-cell communication analysis revealed that STC1+ epithelial cells engage T cell subsets through more ligand-receptor pairs in the transforming growth factor-beta (TGF-β) and B- and T-lymphocyte attenuator (BTLA) pathways compared to STC1- epithelial cells. These findings indicate STC1 is strongly correlated with signatures of immune evasion and malignant progression in LSCC, suggesting that targeting STC1 may reprogram the immunosuppressive microenvironment and improve therapeutic outcomes.

PMID 42724726
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PubMedTranslational pediatrics2026-09-11

Predictive value of neutrophil-to-lymphocyte ratio and fibrinogen degradation products for renal involvement in pediatric immunoglobulin A vasculitis.

Li Guangbo G, Liao Jianying J, Zhan Zhuqin Z, Zeng Jinhua J et al.

Immunoglobulin A vasculitis nephritis (IgAVN) is the most severe complication of IgA vasculitis (IgAV) in children, yet early predictors of renal involvement remain limited. The aim of this study is to analyse the risk factors for the development of IgAVN in children with IgAV, with a view to improving early diagnosis and treatment, reducing complications and enhancing patient prognosis. This was a retrospective analysis. A total of 100 pediatric patients with IgAV hospitalized at Children's Hospital of Fudan University Xiamen Branch (Xiamen Children's Hospital) between January 2023 and June 2025 were included in the study. Patients were divided into two groups based on the presence or absence of IgAVN. Clinical characteristics and laboratory parameters were collected. Risk factors were identified using univariate and multivariate analyses, and a risk prediction model was established using logistic regression. Model performance was evaluated using the area under the receiver operating characteristic (ROC) curve (AUC). A total of 100 children with IgAV were ultimately included in this study, comprising 56 males and 44 females. They were divided into an IgAVN group (n=32) and a non-IgAVN group (n=68). Univariate analysis revealed that three laboratory parameters [C‑reactive protein (CRP), neutrophil‑to‑lymphocyte ratio (NLR), fibrinogen degradation products (FDP)] showed statistically significant differences between the IgAVN and non-IgAVN groups (P<0.05). We included the three laboratory parameters (CRP, NLR, and FDP) that showed statistically significant differences in the univariate analysis into the multivariate analysis and found that elevated NLR [odds ratio: odds ratio (OR) =1.446, 95% confidence interval (CI): 1.080-1.934, P=0.01] and elevated FDP (OR =1.854, 95% CI: 1.133-3.034, P=0.01) were independent risk factors for the development of IgAVN in children with IgAV. ROC curve analysis results showed that the AUCs for NLR >5.23 and FDP >12.35 µg/mL were 0.634 and 0.830, respectively, while the AUC for the combined NLR and FDP model was 0.882. Compared with individual indicators, the combined model demonstrated superior predictive value for IgAVN, with a sensitivity of 86.95% and a specificity of 87.40%. Elevated NLR and FDP are independent risk factors for the development of IgAVN in patients with IgAV. The combination of NLR >5.23 and FDP >12.35 µg/mL demonstrates good clinical predictive value for IgAVN and warrants attention from clinicians.

PMID 42724374
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