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varicella zoster immunoglobulin (VariQuin)

✓ Approved

Prothya Biosolutions · 多克隆抗体 · 多克隆抗体

什么是 varicella zoster immunoglobulin？

varicella zoster immunoglobulin 是一种多克隆抗体，由Prothya Biosolutions研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection。

药物档案

商品名VariQuin
公司Prothya Biosolutions
药物类别多克隆抗体, 细胞治疗, 抗体
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved
来源： ClinicalTrials.gov, Prothya Biosolutions

治疗适应症

varicella zoster immunoglobulin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsVaricella zoster virus infection✓ Approved

相关研究文献

PubMedIJID regions2026-10-27

Concurrent varicella and dengue infection in an adolescent female: diagnostic and clinical challenges in an endemic setting.

Gabot John Kelvin S JKS, Sengson Ruth Faye R RFR, Smith Chris C, Han Su Myat SM

Varicella-zoster virus (VZV) infection and dengue virus infection are common viral illnesses in tropical regions. However, concurrent infections are rarely reported and may present significant diagnostic challenges because of overlapping clinical manifestations, including fever, rash, and hematologic abnormalities. We report a laboratory-confirmed co-infection with VZV and dengue virus in a previously healthy 17-year-old female patient from Quezon City, Philippines. She initially presented with a 3-day history of fever and a generalized pruritic vesicular rash and was treated for varicella with oral acyclovir. Despite antiviral therapy, persistent high-grade fever, epigastric abdominal pain, leukopenia (2.8 × 10⁹/l), and thrombocytopenia (85 × 10⁹/l) prompted further investigation on the fourth day of illness. Diagnostic testing confirmed acute dengue infection by positive nonstructural protein 1 antigen and dengue immunoglobulin M test results, while VZV polymerase chain reaction testing of vesicular fluid confirmed varicella. The patient received supportive dengue management alongside continued acyclovir therapy. Clinical symptoms improved, with resolution of fever by the sixth day of illness, normalization of hematologic parameters, and progressive crusting of lesions. She was discharged without complications. This case highlights the importance of considering dengue co-infection in patients with apparent varicella who develop persistent fever, abdominal pain, leukopenia, or thrombocytopenia in dengue-endemic settings. Early laboratory confirmation is essential to distinguish overlapping clinical features, guide appropriate management, and prevent missed or delayed diagnoses.

PMID 42936464
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PubMedMicroorganisms2026-10-27

Lack of Evidence for Seasonal Variation in Herpes Zoster: A Nine-Year Retrospective Cross-Sectional Study.

Erçin Zuhal Z, Toprak Mehtap M

Herpes zoster results from the reactivation of latent varicella-zoster virus and may cause serious complications. Although traditionally considered nonseasonal, recent studies have reported summer peaks in herpes zoster occurrence. Given these inconsistencies, monthly and seasonal variations in herpes zoster case rates and their implications for prevention were evaluated in this study. In this retrospective cross-sectional study, the medical records of patients diagnosed with herpes zoster at a dermatology outpatient clinic between January 2017 and December 2025 were reviewed. Data on age, sex, and the year, month, and season of diagnosis were collected and analyzed using IBM SPSS Statistics for Windows, version 30.0. The highest proportion of herpes zoster cases occurred in patients aged 60-69 years. Visit-adjusted case rates did not differ significantly across months or seasons. A significant increasing trend in herpes zoster case rates was observed from 2020 to 2025. Herpes zoster is a vaccine-preventable disease that may cause serious complications and shows an increasing trend in occurrence. No statistically significant seasonal variation in herpes zoster occurrence was detected in this cohort, supporting the importance of maintaining year-round preventive strategies, including vaccination.

PMID 42943630
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PubMedJournal of clinical medicine2026-10-27

Cutaneous Events After Recombinant Zoster Vaccination and Shoulder Injury Related to Zoster Vaccine Administration: A Narrative Review.

Ciccullo Carlo C, Ciccullo Arturo A, Farah Sonia S, Bevilacqua Claudia C et al.

Background: Herpes zoster results from the reactivation of varicella-zoster virus (VZV), with incidence increasing with age and immunosuppression. The recombinant zoster vaccine (RZV, Shingrix®, GlaxoSmithKline Biologicals SA, Rixensart, Belgium) has demonstrated high efficacy in preventing herpes zoster and its complications. Methods: We conducted a narrative review of English-language publications addressing cutaneous events, musculoskeletal events, and shoulder injury related to vaccine administration following recombinant zoster vaccination. Original studies, pharmacovigilance analyses, case reports, case series, and relevant reviews published up to 31 January 2026, were considered. Results: Available evidence on cutaneous and musculoskeletal events following recombinant zoster vaccination was limited and heterogeneous. Reported cutaneous events included inflammatory and hypersensitivity-type reactions, vesicular or bullous eruptions, and episodes of VZV reactivation occurring in temporal proximity to vaccination. In virologically confirmed cases, the detected VZV strains were wild-type, consistent with reactivation of latent wild-type virus. Musculoskeletal symptoms, including arthralgia and myalgia, were more commonly reported but were generally mild and self-limiting. Evidence concerning SIRVA was limited and restricted to a single case report following intramuscular zoster vaccine administration. Conclusions: Current evidence supports a favorable safety profile for Shingrix®. Cutaneous events are uncommon and heterogeneous, while evidence concerning SIRVA is limited to a single case report following zoster vaccination, precluding estimates of incidence or a product-specific association. Proper injection technique and continued pharmacovigilance remain essential.

PMID 42941477
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PubMedJournal of medical virology2026-10-27

Molecular Epidemiology of Varicella-Zoster Virus Among Patients From Two French Tertiary Care Hospitals: Differential Distribution of Clades According to Demographic Criteria.

Fernandez José J, Cheminet Melinda M, Mazarguil Lucie L, Gay Mathilde M et al.

Varicella-zoster virus (VZV) nomenclature currently recognizes seven established clades (designated 1-6 and 9). A geographical segregation of VZV clades has been shown, with Clades 1, 3, and 6 predominating in Europe, Americas, and Australia, Clade 2 in Japan and East-Asia, and Clades 4 and 5 in Asia and Africa. This distribution of VZV clades is dependent on the importation of viral strains, because of immigration and travels, and the implementation of varicella vaccine. The surveillance of VZV epidemiology is therefore necessary. VZV genotyping strategies rely on evaluating a panel of single nucleotide polymorphisms (SNPs) across the different open reading frames (ORFs) of the viral genome. We described retrospectively the VZV clade distribution among 339 patients in Pitié-Salpêtrière (Paris) and Bordeaux University hospitals from 2018 to 2023. Clade 1 was detected in 27.1%, Clade 3 in 37.2%, Clade 5 in 31.9%, and other clades in 3.8% of the patients. The distribution of clades did not differ according to sex, immune status of the patients, and clinical presentation of VZV infection. However, patients infected with Clade 5 were statistically younger than those infected with other clades, especially European-born patients. This epidemiological characteristic of VZV Clade 5 may have multifactorial etiology, including the combination of viral, host, and environmental factors.

PMID 42937133
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PubMedViruses2026-10-27

Can Herpesvirus Infections Influence When and How We Age?

Kaistha Shilpa Deshpande SD, Rouse Barry T BT, Rodrigues Junior L C LC

Aging is accompanied by numerous interlinked cellular, genetic, and molecular changes, one of the most consequential being inflammaging: a chronic, low-grade systemic inflammatory state linked to metabolic dysregulation and pleiotropic effects on immune function. Although diverse intrinsic and extrinsic factors are known to drive inflammaging, the contribution of persistent viral infection remains incompletely understood. Here, we evaluate evidence that human herpesviruses, including cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex viruses (HSV-1/2), and varicella zoster virus (VZV), may act as chronic antigenic and inflammatory stimuli capable of amplifying inflammaging and shaping the trajectory of aging. We review the molecular, cellular, and systems-level mechanisms by which herpesvirus latency and periodic reactivation sustain innate and adaptive immune activation, promote cellular senescence, and contribute to immune dysregulation and exhaustion. We further examine epidemiological evidence linking herpesvirus infection to dementia and other age-associated outcomes and highlight emerging data suggesting that antiviral treatment and vaccination, such as against VZV, may mitigate these effects. We conclude that herpesviruses are best understood as adjuvant contributors, rather than primary drivers, of inflammaging, and propose that persistent herpesvirus infection be considered an addressable risk factor in strategies aimed at promoting healthy aging.

PMID 42943982
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PubMedTropical medicine and health2026-10-27

Acute measles encephalitis in adults: a case series in Vietnam.

Nguyen Huy Quang HQ, Cao Hung Duy HD, Van Do Thanh T, Doan Tra Thu TT et al.

Acute measles encephalitis is a rare but severe complication of measles, particularly in adults, and carries high mortality and a substantial risk of neurological sequelae. Two mechanisms are recognized: direct viral invasion of the brain, termed primary measles encephalitis, and an immune-mediated postinfectious process, termed acute postinfectious measles encephalitis. Most descriptions come from children, and the presentation, pathogenesis, and management of adult disease remain poorly defined. We describe four adults (aged 34-45 years) admitted with fever, rash, and altered mental status. Acute measles infection was confirmed by serum measles-specific IgM or measles virus RNA on real-time reverse-transcription PCR. Measles virus RNA was detected in cerebrospinal fluid in Case 1, indicating primary measles encephalitis. Case 2 was initially mistaken for varicella because of an atypical vesicular rash. Case 3 developed quadriparesis and sphincter dysfunction with electromyographic evidence of bilateral S1 radiculopathy; spinal imaging was not performed. Case 4 showed progressive thalamic and temporal lesions on magnetic resonance imaging. Cerebrospinal fluid pleocytosis ranged from 57 to 1046 cells/µL, and improved in most patients within 3 days of intravenous immunoglobulin. Two patients recovered without neurological sequelae, one survived with residual deficits, and one died from persistent cerebral injury complicated by multidrug-resistant septic shock. In adults, acute measles encephalitis may reflect a biphasic process that combines direct viral neuroinvasion with immune-mediated inflammation, rather than a purely postinfectious phenomenon. Intravenous immunoglobulin was temporally associated with clinical and biochemical improvement, but its therapeutic role cannot be established from a case series and requires controlled study.

PMID 42934780
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