北京若生智能科技有限公司
Drug Database
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astromicin sulfate (astromicin sulfate / Astromicin)

✓ Approved

Kyowa Kirin Co., Ltd. · 治疗药物

什么是 astromicin sulfate？

astromicin sulfate 是一种治疗药物，由Kyowa Kirin Co., Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名astromicin sulfate, Astromicin
公司Kyowa Kirin Co., Ltd.
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Kyowa Kirin Co., Ltd.

治疗适应症

astromicin sulfate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsSalmonellosis✓ Approved

相关研究文献

PubMedPlastic and reconstructive surgery. Global open2026-09-11

Limb Salvage Using Local Antibiotic Beads for Calcaneal Osteomyelitis With Multidrug-resistant Infection and Chronic Limb-threatening Ischemia.

Alhunayan Danah D, Alsaleh Ahmed A, Makhdoomi Mahmood M, Khuraibet Salma S et al.

Calcaneal osteomyelitis in diabetic patients with chronic limb-threatening ischemia (CLTI) and multidrug-resistant (MDR) infection poses a significant reconstructive challenge. Limited perfusion, high plantar loading, and constrained antimicrobial delivery often narrow salvage options and increase the risk of major amputation. We report a case of recurrent calcaneal osteomyelitis in a 53-year-old man with type 2 diabetes, chronic kidney disease, peripheral vascular disease, CLTI, and polymicrobial MDR infection. Management included revascularization, serial debridement, culture-directed systemic therapy, negative-pressure wound therapy, hyperbaric oxygen therapy, structured offloading, and adjunctive local antibiotic delivery using calcium sulfate beads. Following recurrence, repeat calcaneal debridement and saucerization were performed, and vancomycin- and gentamicin-loaded calcium sulfate beads were placed individually into the calcaneal defect. The wound progressed with no recurrent infection or exposed bone. Complete epithelialization was achieved at 14 months, and the patient remained pain-free and independently ambulatory in offloading footwear. In recurrent calcaneal osteomyelitis complicated by CLTI and MDR infection, calcium sulfate antibiotic carriers may serve as a useful adjunct to staged multimodal limb salvage. By combining dead-space management with high local antibiotic delivery after repeat debridement, this approach may be considered in selected ischemic, infection-resistant presentations.

PMID 42724855
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PubMedFrontiers in microbiology2026-09-11

Microbiota-associated metabolic networks in gut-kidney communication and renal immune regulation: mechanisms and therapeutic potential.

Zhang Hongkun H, Zhang Tao T, Pan Zhengchao Z, Zhang Yue Y et al.

Kidney disease development and progression involve not only local inflammation, immune dysregulation, and fibrosis but also alterations in gut microbiota composition and metabolic function. Microbiota-associated metabolic signals connect the intestinal ecosystem, host metabolism, and the renal immune microenvironment through their associations with intestinal barrier integrity, renal tubular epithelial homeostasis, immune cell function, and inflammatory-fibrotic responses. Depending on their biological origin, receptor engagement, target-cell specificity, and disease context, these signals may either support immune homeostasis and tissue repair or contribute to persistent inflammation and tissue remodeling. Representative mediators include short-chain fatty acids, tryptophan-derived metabolites, bile acid-related signaling molecules, indoxyl sulfate, p-cresyl sulfate, trimethylamine N-oxide, succinate, and other host-microbiota-associated metabolites. Their biological effects, however, cannot be interpreted independently of renal function because circulating metabolite levels are also influenced by impaired renal clearance, systemic inflammation, dietary factors, and host metabolism. Conversely, kidney dysfunction reshapes intestinal barrier integrity, microbial ecology, and metabolic output, establishing a dynamic gut-kidney metabolic-immune feedback network. In this Review, we summarize current evidence linking microbiota-associated metabolic networks to renal immune remodeling across different kidney diseases, highlighting metabolite origin, shared target-cell responses, disease-specific and context-dependent mechanisms, and current evidence limitations. We further discuss therapeutic strategies targeting this axis and emphasize key translational challenges, including distinguishing causal metabolic drivers from secondary metabolic alterations and developing precision interventions based on metabolic and immune phenotypes.

PMID 42724485
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PubMedJournal of perinatology : official journal of the California Perinatal Association2026-09-11

Magnesium therapy in persistent pulmonary hypertension of the newborn: a scoping review.

Dadon Yuval Y, Mimouni Francis B FB, Arad Iris I, Mendlovic Joseph J

To map evidence on magnesium sulfate (MgSO₄) therapy for PPHN, focusing on efficacy, safety, mechanisms, and knowledge gaps. Scoping review following JBI methodology and PRISMA-ScR. MEDLINE, Embase, Cochrane Reviews, and CENTRAL were searched without date restrictions. Thirteen publications were included: 11 primary clinical reports, including three randomized trials, and two evidence syntheses. The primary reports included 253 neonates but differed in populations, severity, comparators, and outcomes. Intravenous MgSO₄ usually comprised a 200 mg/kg loading dose followed by continuous infusion. Small, mostly uncontrolled studies reported improved oxygenation but could not establish efficacy. Comparative studies showed slower or less consistent responses than inhaled nitric oxide or sildenafil. Adverse effects included hypotension, bradycardia, and increased inotropic requirements; long-term safety data were limited. Evidence remains insufficient to support routine MgSO₄ use for PPHN.

PMID 42722769
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PubMedBiophotonics discovery2026-09-11

Impact of skin pigmentation on photoacoustic tomography: a phantom study.

Bulthuis Rianne F G RFG, Lubbers Nan S NS, Lucka Felix F, Steenbergen Wiendelt W et al.

Skin pigmentation is a known source of bias in optical and photoacoustic imaging. Although these effects are well investigated for two-dimensional photoacoustic imaging systems, their impact on three-dimensional (3D) photoacoustic tomography remains largely unexplored. We aim to generate insights into the impact of skin pigmentation on the performance of 3D breast photoacoustic tomography using phantoms. We developed hemispherical breast phantoms compatible with a multi-wavelength photoacoustic-ultrasound tomography system. The phantoms incorporate a thin skin-mimicking layer over an adipose-mimicking bulk material. Four phantoms with identical geometry and increasing pigmentation levels were fabricated. Embedded wall-less channels filled with sulfate solutions of varying concentrations enabled depth- and spectral-dependent analysis. Increasing pigmentation led to stronger skin photoacoustic signals, reduced signal-to-background ratios at depth, and increased reflection-related background artifacts. Spectral measurements revealed pigmentation-dependent attenuation and reduced chromophore contrast in the wavelength range relevant for oxygen saturation estimation. Three-dimensional photoacoustic tomography is susceptible to pigmentation-induced bias affecting imaging depth and spectral analysis. The presented phantom provides a validated platform for developing strategies to improve the reliability and inclusivity of photoacoustic tomography imaging across skin tones.

PMID 42724443
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-09-11

Synergistic Regulation of Deep-Cycling-Induced Zn Pulverization and Resting Galvanic Corrosion in Practical Lean Zinc Anodes.

Xu Jing J, Li Haolin H, Jing Qiyin Q, Zhao Lingfei L et al.

Scaling up aqueous zinc (Zn)-ion batteries with long cycling stability and calendar life (i.e., long rest periods at open-circuit potential) remains challenging, particularly with the use of a thick Zn foil anode. A more practical and scalable approach involves adopting a lean-Zn configuration with a current collector. Due to the limited Zn availability, lean Zn anodes experience different failure mechanisms, manifested as Zn pulverization in cycle life and galvanic corrosion during calendar life. Unfortunately, these issues have long been overlooked. Herein, we introduce benzotriazole (BTA), a well-known corrosion inhibitor, as an electrolyte additive in aqueous zinc sulfate (ZnSO4) electrolytes. BTA modifies the electric double layer (EDL) structure on the Zn anode, alleviating the mismatch between Zn2 + mass transport and reduction kinetics. This leads to the formation of dense, flat zinc deposits rather than the Zn pulverized structures, significantly reducing contact loss during stripping. On the other hand, the strong chemisorption of BTA on the Cu substrate effectively blocks electron transfer pathways responsible for galvanic corrosion, reducing capacity fade during calendar aging. When paired with a MnO2 cathode, the lean-Zn anode enables the full cell to retain 90.3% of its capacity over 600 cycles at a negative: positive (N:P) ratio of 3:1.

PMID 42723211
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PubMedGeobiology2026-09-11

Adaptation of Microbialite-Associated Prokaryotic Communities to Natural and Experimental Anoxic Conditions.

Caumartin Jeanne J, Benzerara Karim K, Gutiérrez-Preciado Ana A, Iniesto Miguel M et al.

Microbialites are rocks formed by microbial communities that influence, promote, and/or control the precipitation of mineral phases. The oldest microbialites date back to the Archean and formed under globally anoxic conditions. Accordingly, modern microbialites developing under oxic conditions are limited analogs of their earliest predecessors. We discovered microbialites in the deep, seasonally anoxic water column of crater lakes Alchichica and Atexcac (Mexico). We studied the prokaryotic communities of plankton and microbialites from oxic and anoxic layers, alongside the temporal dynamics of microbialite communities incubated under strict continuous anoxia. 16S rRNA gene amplicon sequencing showed shifts in the relative abundance of taxa under anoxia, rather than changes in overall diversity. Regardless of their original depth, microbialite-associated communities from oxic and anoxic zones converged after ~25 weeks of laboratory exposure to a N2-H2-CO2 (85:10:5) atmosphere. Sequences assigned to likely anoxygenic photosynthetic taxa, notably within the Alpha- and Gammaproteobacteria, together with phyla associated with sulfate-reduction and other sulfur-cycling bacteria, increased in relative abundance. We isolated seven bacterial strains under anoxia, some of them biomineralizing. Several of these strains were cyanobacteria affiliated with the Leptolyngbyales, suggesting that they either continue to perform oxygenic photosynthesis or, hypothetically, switch to H2S-dependent anoxygenic photosynthesis. Our results indicate that these microbialite communities adapt to long-term anoxia (more than 70 weeks) under laboratory conditions, likely sustaining photosynthetic alkalinization and carbonate precipitation under such conditions.

PMID 42723166
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