北京若生智能科技有限公司
Drug Database
AC

aciclovir + hydrocortisone (Xerese / Xerclear / Lipsovir)

✓ Approved

Lapidot Medical · NR3C1 · 小分子

什么是 aciclovir + hydrocortisone？

aciclovir + hydrocortisone 是一种小分子，由Lapidot Medical研发。该药已获批，用于治疗相关适应症，给药途径：Topical。

药物档案

商品名Xerese, Xerclear, Lipsovir
公司Lapidot Medical
药物类别小分子
分子靶点NR3C1, ,
给药途径Topical
状态Approved
来源： ClinicalTrials.gov, Lapidot Medical

作用机制

分子靶点

aciclovir + hydrocortisone 作用于 3 个分子靶点：

NR3C1nuclear receptor subfamily 3 group C member 1 (GR, GCCR)
(UL30)
(UL30)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

aciclovir + hydrocortisone 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Congenital, familial and genetic disordersCongenital herpes simplex infection✓ Approved

相关研究文献

PubMedNephrologie & therapeutique2026-10-27

Aciclovir and neurotoxicity in hemodialysis: A 30-year-old story

Jamez Coline C, Leflot Sophie S, Haufroid Vincent V, Fernandes Guillaume G et al.

Aciclovir is the standard treatment for herpes infections. Its almost exclusive renal elimination puts patients with end-stage renal disease at increased risk of accumulation and toxicity, warranting dosage adjustment. We report the cases of two chronic hemodialysis patients treated with aciclovir for herpes zoster who developed severe neurotoxicity despite dosages that were in line with or below current recommendations. The first patient received the recommended dose (800 mg twice daily), while the second was treated with a deliberately reduced dose (400 mg twice daily). Both patients developed acute encephalopathy associated with a cerebellar syndrome and behavioral disorders. Plasma levels were measured in one case and revealed supratherapeutic trough concentrations. Discontinuation of aciclovir, combined with intensified hemodialysis, led to rapid regression of symptoms and complete recovery. Our observations show that the dosage regimens currently recommended for hemodialysis patients can lead to significant overexposure and severe neurotoxicity. This neurotoxicity can also mimic herpes encephalitis, leading to inappropriate dose escalation and delayed diagnosis. There is a need to re-evaluate aciclovir dosage regimens in hemodialysis patients, favoring even lower doses, particularly in older patients, in order to prevent avoidable toxicity. In hemodialysis patients treated with aciclovir, the onset of neurological symptoms, after exclusion of herpes encephalitis, should raise suspicion of drug toxicity and lead to immediate discontinuation of treatment and intensification of dialysis.

PMID 42937231
阅读全文 →
PubMedMedicine2026-10-27

Delayed serum sickness-like reaction mimicking septic shock after antivenom therapy: A case report.

Wang Xiaobin X, Bin Wenkai W

Antivenom is the key specific treatment for clinically significant snakebite envenoming. Delayed serum sickness-like reactions after antivenom therapy may be overlooked after discharge and can resemble infection or septic shock. A woman in her early 60s returned approximately 7 days after antivenom therapy with generalized urticarial and purpuric maculopapular rash, pruritus, fever, vomiting, fatigue, dizziness, hypotension, and thrombocytopenia. The patient was initially managed for suspected sepsis and septic shock because of circulatory instability, elevated high-sensitivity C-reactive protein, elevated serum amyloid A, elevated procalcitonin, and inflammatory changes on chest computed tomography. The timing after antivenom exposure, rash pattern, decreased complement C3 and C4, proteinuria, and subsequent clinical course supported a severe delayed serum sickness-like reaction as an important contributor. Infection could not be completely excluded because systematic pathogen testing was not completed during the acute phase. The patient received empirical anti-infective therapy, vasopressor support, fluid resuscitation, hydrocortisone, ebastine, albumin supplementation, and other supportive care. After 7 days of treatment, blood pressure stabilized, rash and pruritus largely resolved, platelet count and inflammatory markers improved, and follow-up laboratory findings showed substantial recovery. Delayed antivenom-related serum sickness-like reactions may mimic septic shock and may be accompanied by elevated procalcitonin. In patients who develop rash and hypotension within days after antivenom therapy, clinicians should treat possible sepsis promptly while reassessing antivenom exposure, skin findings, complement levels, urinalysis, microbiological evidence, and treatment response.

PMID 42937709
阅读全文 →
PubMedThe American surgeon2026-10-26

When Source Control Is Not Enough: Bilateral Adrenal Hemorrhage After Group A Streptococcal Necrotizing Soft Tissue Infection.

Perko Allison M AM, Forestiere Matthew J MJ, Taylor Michael R MR

Refractory septic shock following adequate surgical source control presents a major clinical challenge. While persistent vasopressor dependence in necrotizing soft tissue infections (NSTI) is frequently attributed to ongoing tissue necrosis or overwhelming cytokine release, acute primary adrenal failure due to Waterhouse-Friderichsen Syndrome (WFS) represents an underrecognized, reversible etiology. We report a 41-year-old male who developed fulminant right upper extremity Group A Streptococcus (GAS) necrotizing fasciitis requiring emergent forequarter amputation. Despite definitive source control, targeted antitoxin antimicrobial therapy, and guideline-directed resuscitation, he experienced persistent vasopressor-dependent shock. On postoperative day 5, CT imaging revealed new-onset bilateral adrenal hemorrhage. The initiation of stress-dose hydrocortisone led to rapid hemodynamic stabilization and successful recovery. Surgeons must maintain a high index of suspicion for acute adrenal crisis in postoperative ICU patients with refractory shock despite source control, rather than solely driven by ongoing sepsis.

PMID 42933021
阅读全文 →
PubMedJournal of medical case reports2026-10-26

High-dose regular insulin as a potential rescue therapy in severe aluminum phosphide poisoning: a case report.

Sedaghattalab Moslem M, Akbari Ghaidafeh G

Aluminum phosphide (rice tablet) can cause cardiocirculatory collapse and has negative cardiac inotropic effect. Positive inotropic effect of insulin on the cardiac myocytes is through calcium flux. Insulin increases the intramyocytes calcium concentration by increasing conductance of calcium through the L-type calcium channels and by increasing intramyocytes concentration of cyclic adenosine monophosphate. In addition to increasing the intramyocytes calcium level, insulin also enhances the responsiveness of the cardiac cells to calcium. High-dose insulin is a potential therapy for hypodynamic and hypotensive septic shock due to its positive inotropic qualities. In this paper, a critical aluminum phosphide poisoning patient (a 25-year-old Iranian young woman), presented with mixed severe metabolic acidosis and respiratory alkalosis, tachypnea, tachycardia, and hypotension. In contrast to our previous experiences that ingestion of aluminum phosphide tablets associated with multiple organ failure and severe shock in approximately all critical poisoning patients, early initiation of high-dose intravenous regular insulin for this patient prevented multiorgan dysfunction and death. Treatment with high-dose intravenous insulin associated with IV fluids, sodium bicarbonate, hydrocortisone, potassium, dextrose therapy and supportive care resolved completely signs and symptoms of patient after 3 days in ICU. High-dose intravenous regular insulin may be act as a rescue therapy for aluminum phosphide poisoning patients. While this single case suggests a potential benefit, further studies are required to confirm these findings.

PMID 42928247
阅读全文 →
PubMedJCEM case reports2026-10-25

Multiple acute vertebral fractures during recovery from myxedema coma.

Chipier Louise L, Nachef Clément C, Richette Pascal P, Vanjak Arnaud A

Severe hypothyroidism may progress to myxedema coma, a life-threatening condition requiring urgent hormonal replacement. Although thyroid hormones and glucocorticoids are known to influence bone remodeling, no clear association between appropriate treatment of hypothyroidism and incident fracture risk has been demonstrated. We report the case of a 60-year-old postmenopausal woman with untreated primary hypothyroidism who presented with myxedema coma, precipitated by bacterial pneumonia. She was treated with hydrocortisone followed by levothyroxine replacement therapy. Two weeks after treatment initiation, she developed acute thoracolumbar pain, and follow-up computed tomography demonstrated multiple vertebral fractures extending from T8 to L5. Comparative imaging confirmed that only a T12 fracture had been present at baseline. Secondary causes of osteoporosis were excluded. Thyroid function testing at the time of evaluation showed no biochemical evidence of overtreatment. This case documents the occurrence of multiple vertebral fractures during early recovery from myxedema coma in a patient with evidence suggesting preexisting bone fragility. Although causality cannot be established, clinicians should be aware of this possibility during the early recovery phase of severe hypothyroidism.

PMID 42923588
阅读全文 →
PubMedVeterinary medicine and science2026-10-22

Proactive Treatment of Canine Allergic Otitis Externa With Hydrocortisone Aceponate: A Retrospective Observational Study.

Maina Elisa E, Rigert Jasmine Chantale JC, Filippini Carlotta C, Cao Regula R et al.

Allergic otitis externa is common in dogs and recurrence may lead to repeated consultations and antimicrobial use. Long-term data on proactive topical corticosteroid maintenance are limited. To describe 12-month relapse frequency in dogs with allergic otitis externa receiving proactive hydrocortisone aceponate maintenance therapy and compare consecutive-day and non-consecutive-day schedules. Medical records of client-owned dogs prescribed hydrocortisone aceponate ear spray were retrospectively reviewed. Maintenance started after clinical and cytological remission. Only dogs with confirmed continuation, stable concomitant allergy management and complete 12-month outcome data were included. Relapse was defined as recurrent otitis externa requiring veterinary examination, cytology and additional otic treatment. Dogs were grouped by schedule: Protocol 1, two consecutive days; and Protocol 2, two non-consecutive days weekly. Outcomes were compared using Fisher exact and Mann-Whitney U tests. Seventy-one dogs were included; 36 in Protocol 1 and 35 received Protocol 2. During 12 months, 50/71 dogs (70.4%) had no relapse, 12/71 (16.9%) had one relapse and 9/71 (12.7%) had multiple relapses. At least one relapse occurred in 9/36 dogs (25.0%) in Protocol 1 and 12/35 (34.3%) receiving Protocol 2 (p = 0.443). Multiple relapses occurred in 2/36 (5.6%) and 7/35 (20.0%) dogs, respectively (p = 0.085). Relapse counts did not differ significantly between protocols (p = 0.290). Most dogs had no relapse or only one relapse during proactive hydrocortisone aceponate maintenance. No statistically significant difference was detected between schedules, but equivalence or non-inferiority cannot be concluded.

PMID 42904785
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多aciclovir + hydrocortisone