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Ortho-ACI

✓ Approved

Orthocell Pty, Ltd. · 细胞治疗 · 细胞治疗

什么是 Ortho-ACI？

Ortho-ACI 是一种细胞治疗，由Orthocell Pty, Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Surgical Implantation。

药物档案

公司Orthocell Pty, Ltd.
药物类别细胞治疗
给药途径Surgical Implantation
状态Approved
来源： ClinicalTrials.gov, Orthocell Pty, Ltd.

治疗适应症

Ortho-ACI 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Musculoskeletal and connective tissue disordersChondropathy✓ Approved

相关研究文献

PubMedNatural product reports2026-07-27

Ortho-alkyl phenylalkenoyl natural products: structural diversity, bioactivities and biosynthesis.

Huang Qianfei Q, Chen Xuxiang X, Ma Shuhong S, Li Zilin Z et al.

Covering: up to 2026.Ortho-alkyl phenylalkenoyl-containing natural products, including cinnamoyl-containing nonribosomal peptides (CCNPs) and ortho-alkyl phenylalkenoic acids (APAs), are structurally and biologically diverse bacterial metabolites that have become a major focus of natural product research. These metabolites exhibit broad bioactivities, including antimicrobial, antiangiogenic, cytotoxic, anti-inflammatory, and nematicidal effects. Biosynthetically, CCNPs and APAs share a conserved, highly reduced (HR) type II polyketide synthase (PKS)-derived framework, featuring characteristic isoenzymes (ISOs) and specialised cyclases that assemble the ortho-alkyl phenylalkenoyl core. They diverge fundamentally in pathway architecture: CCNPs contain NRPS-synthesised peptide backbones, whereas APAs lack NRPS components and possess expanded KS/CLF pairs. Biosynthetic studies have revealed novel mechanisms (e.g., isomerization, 6π-electrocyclisation) and multifunctional enzymes, providing valuable biocatalysts for synthetic biology. Although their biological activities depend strongly on structural context, emerging evidence highlights these metabolites as a promising source of lead compounds. Continued interdisciplinary efforts integrating natural product chemistry, biosynthesis, and medicinal chemistry are expected to unlock their therapeutic potential.

PMID 42507473
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PubMedJournal of functional biomaterials2026-07-27

Static and Dynamic Mechanical Properties of 3D-Printable Aligner Resins: An In Vitro Study with FTIR Chemical Characterization.

Serafin Marco M, Boccalari Elisa E, Borgese Marina M, Caprioglio Alberto A et al.

Directly printed aligners are advancing rapidly, but the mechanical behavior of the resins behind them is still only partly understood. This in vitro study compared the static flexural behavior, short-term stress relaxation, and FTIR profiles of five Class IIa-certified 3D-printable resins for direct orthodontic aligners. The five resins, TC-85, TA-28, DCA, Clear-A V2, and Ortho Flex, were printed as standardized rectangular bars and tested at 37 °C. Three-point bending to 1 mm deflection yielded the maximum flexural stress and the flexural modulus, while a 30 min hold at fixed deflection captured stress relaxation. FTIR added a qualitative chemical characterization. Differences between resins were substantial. DCA led on every static measure, pairing the highest flexural stress and modulus with the highest final relaxation modulus and the best stiffness retention. Clear-A V2 was also statically stiff but retained force only intermediately, whereas TC-85 combined high stiffness with pronounced relaxation. Ortho Flex performed modestly under static loading yet held on to a moderate fraction of its stiffness, and TA-28 relaxed the most. Directly printed aligner resins are mechanically heterogeneous, and static bending alone did not predict short-term force stability. Relaxation metrics should therefore accompany static testing whenever a resin is selected for a specific clinical purpose.

PMID 42506566
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PubMedThe journal of physical chemistry. A2026-07-27

Engineering Fast Reverse Intersystem Crossing and Radiative Decay in [1,2,4]Triazolo[1,5-a]pyridine-Based TADF Emitters via Donor Strength and Positional Control of Dihedral Angle and Reorganization Energy: A Density Functional Theory Study.

Saini Chetan C, Chung Jin Suk JS, Kang Sung Gu SG

Achieving a balance between the radiative decay rate (kr) and the reverse intersystem-crossing (rISC) rate (krISC) persists as a fundamental hurdle in thermally activated delayed-fluorescence (TADF) emitters because the processes depend oppositely on the overlap of frontier molecular orbitals. We computationally designed and explored 30 [1,2,4]triazolo[1,5-a]pyridine (TP)-based donor-π-acceptor emitters divided into two molecular series, 2,6TP and 2,7TP, according to the site for substituting the donor-appended phenyl linker on the TP acceptor core. The relationships among the donor-acceptor dihedral angle (θDA), singlet-triplet energy gap (ΔEST), spin-orbit coupling (SOC), radiative decay rate (kr), reverse intersystem crossing rates (krISC), reorganization energy (λ), and activation energy (ΔGrISC) governing the excited-state dynamics were systematically analyzed. The ortho-substituted dimethylacridine-based emitters exhibit nearly optimal dihedral angles (∼77°-78°), resulting in low reorganization energies (λ ≈ 0.22-0.30 eV), small ΔEST values (∼0.05 eV), moderate SOC matrix elements (∼0.3-0.4 cm-1), enhanced kr values (>105 s-1), and krISC values exceeding 106 s-1, together with low activation barriers for rISC (ΔGrISC ≈ 0.08-0.10 eV). The results further demonstrate that ΔGrISC is governed strongly by λ in addition to ΔEST, indicating that minimizing ΔEST alone is insufficient to ensure efficient TADF performance. Overall, this study offers a comprehensive design framework for developing high-performance TP-based TADF emitters for potential organic light-emitting diode applications through synergistic optimization of molecular geometry, reorganization energy, and activation energy.

PMID 42506586
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PubMedJournal of cardiovascular development and disease2026-07-27

When the Heart and Hip Collide: The Interplay Between Atrial Fibrillation and Neck of Femur Fractures.

Faherty Hannah H, Hlaing Thin Ei TE, Thakkar Khushi K, Hamad Mahir M et al.

The association of atrial fibrillation (AF) and neck of femur fractures (NOF) are common in old people, creating a complex clinical scenario with significant implications for morbidity, mortality, and healthcare systems. This narrative review explores the bidirectional relationship between AF and NOF, focusing on shared risk factors, pathophysiological links, and challenges in clinical management, and also reviews the benefit of an orthogeriatric model. Advanced age, frailty, osteoporosis, polypharmacy, and cardiovascular comorbidities predispose patients to both conditions, while AF itself increases fall risk through haemodynamic instability, syncope, and adverse effects of rate- or rhythm-controlling medications. Importantly, the physiological stress of hip fracture and subsequent surgery can precipitate new-onset or worsening AF via inflammatory, neurohormonal, and metabolic mechanisms. The main challenge for ortho-geriatricians lies in anticoagulation management and preoperative and postoperative management. While anticoagulation reduces thromboembolic risk in AF, it increases perioperative bleeding risk in patients with NOF, often leading to delays in surgery that are independently associated with poorer outcomes. This review examines the current evidence regarding perioperative anticoagulation strategies, timing of surgery, and postoperative resumption of therapy. In addition, the review examines important outcome parameters such as mortality, stroke, bleeding, length of hospital stay, and functional recovery. This highlights the importance of not only improving multidisciplinary care involving orthopaedics, cardiology, geriatrics, and anaesthesia to optimise outcomes, but also enhancing risk stratification. Standardised perioperative pathways and integrated geriatric-cardiac assessment may help mitigate complications. Therefore, understanding how AF and NOF interact is key to delivering holistic, patient-centred care for an increasingly elderly population in orthogeriatric wards.

PMID 42505911
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PubMedJournal of cutaneous pathology2026-07-26

Giant Centrifugal Miliaria Profunda.

Alperovich Ruth R, Mancini Anthony J AJ, Montanari Daniela D, Guitart Joan J et al.

Miliaria profunda is due to duct obstruction and rupture below the epidermis, with dermal sweat leakage associated and a variable inflammatory reaction. A rare but distinct presentation of miliaria profunda in infants is named giant centrifugal miliaria profunda (GCMP), showing centrifugal expansion of large, annular plaques. On histology, GCMP shows hyperkeratosis with ortho- and parakeratosis, and acanthosis with foci of intercellular edema. Acrosyringia are distended with obstruction by eosinophilic plugs of ortho-parakeratotic material. Dermal ducts appear dilated and show squamous metaplasia. A periductal and peri-eccrine variable inflammatory infiltrate contains neutrophils and often granulomatous inflammation is identified. We report two cases of GCMP, one of them associated with an MAP2K1 germinal RASopathy.

PMID 42502171
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PubMedJournal of inorganic biochemistry2026-07-26

Synthesis, encapsulation, and cytotoxic effects of new Schiff-base copper complexes.

Bosquetti Lucas M LM, Sousa Vitória S VS, Gomes Kaio S KS, de Oliveira Fernando A FA et al.

Gliomas remain one of the most lethal malignancies, with limited therapeutic options and poor prognosis under current standard-of-care regimens. Copper-based metallodrugs represent an emerging therapeutic strategy, but their clinical translation is hampered by rapid speciation in biological media and poor tumor selectivity. In this work, eight novel copper(II) Schiff-base complexes were synthesized from four diamine backbones (1,3-diaminopropane, 2,2-dimethyl-1,3-propanediamine, 2,2'-(ethylenedioxy)bis(ethylamine) and 1,3-diaminopropan-2-ol) and four aldehydes (3,4-dimethoxybenzaldehyde, vanillin, ethyl vanillin, and ortho-vanillin), and characterized by IR, UV-Vis, EPR, elemental analysis, and mass spectrometry. EPR spectroscopy revealed distinct coordination geometries across the series, ranging from distorted tetrahedral to a unique square-planar N₂O₂ geometry in [Cu(OVDP)](ClO₄)₂ (compound OVDPCu, where OV = ortho-vanillin and DP = 1,3-diaminopropane). All complexes were encapsulated in liposomal nanocarriers by solvent nanoprecipitation, yielding monodisperse vesicles with incorporation efficiencies of 20-60%. Cytotoxicity was assessed by MTT assay against the glioblastoma cell line LN-18 and the non-tumorigenic hippocampal line mHippoE-2. Free ligands were low in activity, confirming that cytotoxicity is copper-dependent. OVDPCu was the most potent free complex against LN-18 cells, consistent with its square-planar geometry enhanced DNA-targeting capacity. Liposomal encapsulation of OVDPCu enhanced potency 3.8-fold over the free complex (EC₅₀ = 3.4 μM against LN-18), while maintaining a selectivity index of 5.1 over non-tumorigenic cells, attributed differential endocytic uptake by tumor cells and protection of the intact complex from premature serum protein interaction. These findings establish a clear structure-geometry-activity relationship in copper(II) Schiff-base chemistry and support encapsulated OVDPCu as a compelling candidate for further preclinical validation in glioblastoma models.

PMID 42501589
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