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rhIFN-alpha (ReliFeron)

✓ Approved

Reliance Life Sciences Private Limited · IFNAR2 · 重组蛋白

什么是 rhIFN-alpha？

rhIFN-alpha 是一种重组蛋白，由Reliance Life Sciences Private Limited研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection、Intravenous (IV)、Subcutaneous Injection。

药物档案

商品名ReliFeron
公司Reliance Life Sciences Private Limited
药物类别重组蛋白
分子靶点IFNAR2
给药途径Injectable (Others), Intramuscular (IM) Injection, Intravenous (IV), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Reliance Life Sciences Private Limited

作用机制

分子靶点

rhIFN-alpha 作用于 1 个分子靶点：

IFNAR2interferon alpha and beta receptor subunit 2 (IFNARB, IFN-alpha-REC)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

rhIFN-alpha 针对 8 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Hairy cell leukaemia✓ Approved
Infections and infestationsHepatitis B✓ Approved
Infections and infestationsHepatitis C✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Kaposi's sarcoma✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Non-Hodgkin's lymphoma✓ Approved

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相关研究文献

PubMedBrain communications2026-09-11

A meta-analysis of periodic and aperiodic electrophysiological features in Parkinson's disease.

Norouzi Hamzeh H, Ietswaart Magdalena M, Adair Jason J, Learmonth Gemma G

Parkinson's disease is characterized by a range of motor and non-motor changes that can negatively impact quality of life. Many studies have identified potential clinical electrophysiological correlates of Parkinson's disease with an aim of developing new methods of identifying at-risk patients and forming the basis of therapeutic interventions. However, these studies do not present consistent results, and a formal meta-analysis is warranted to identify reliable EEG or magnetoencephalography (M/EEG) characteristics across datasets. In this meta-analysis of open-access M/EEG datasets (n = 6; 4 EEG and 2 MEG), we compared periodic and aperiodic characteristics of resting-state recordings in 368 patients with Parkinson's disease and 570 age-matched healthy controls. Specifically, we compared the power and peak frequency of unadjusted and aperiodic-adjusted alpha- and beta-band oscillations, and the exponent and offset, across the two groups. Parkinson's patients had a consistently elevated aperiodic exponent and offset. Patients also had higher unadjusted beta-band power, but this was no longer present when the aperiodic features were removed, suggesting that previous findings of elevated beta activity in Parkinson's disease could be confounded by aperiodic activity rather than reflecting true oscillatory differences. Patients also had higher adjusted and unadjusted alpha-band power and a slower alpha peak frequency compared with controls, whereas no group difference in beta peak frequency was identified. In conclusion, this large cohort meta-analysis points to a broadly consistent pattern of both periodic and aperiodic changes in Parkinson's patients in M/EEG signals that may be used to develop diagnostics and targeted interventions in the future.

PMID 42724388
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PubMedTranslational lung cancer research2026-09-11

PSMA6 drives non-small cell lung cancer progression by stabilizing NEDD8 and activating NF-κB signaling.

Deng Shiyang S, Li Zixuan Z, Liu Nan N, Wang Yue Y et al.

Non‑small cell lung cancer (NSCLC) is a major cause of cancer‑associated death globally. Elucidating novel molecular drivers is essential for targeted therapy development. This study sought to investigate the function and regulatory mechanism of proteasome 20S subunit alpha 6 (PSMA6) in NSCLC. Proteasome 20S subunit alpha 6 (PSMA6) expression in NSCLC tissues and cells was analyzed using The Cancer Genome Atlas (TCGA) datasets, immunohistochemistry, and Western blotting. Gain- and loss-of-function assays were performed to evaluate its biological functions. Protein interaction assays and functional rescue experiments were conducted to investigate the underlying mechanisms. We found that PSMA6 was significantly upregulated in NSCLC tissues and cell lines and was associated with poor patient prognosis. Functional experiments demonstrated that PSMA6 promoted NSCLC cell proliferation and migration. Mechanistically, PSMA6 activated nuclear factor kappa B (NF-κB) signaling by enhancing p65 nuclear translocation and IκBα phosphorylation. Further investigation revealed that PSMA6 directly interacted with neural precursor cell expressed, developmentally down-regulated 8 (NEDD8) and increased its protein stability without affecting its mRNA level. Importantly, NEDD8 knockdown abolished PSMA6-induced NF-κB activation and malignant phenotypes, confirming that PSMA6 exerts its oncogenic effects through the NEDD8/NF-κB axis. Our findings identify a novel PSMA6/NEDD8/NF-κB regulatory axis that promotes NSCLC progression and suggest PSMA6 as a potential therapeutic target.

PMID 42723894
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PubMedAnnals of neurosciences2026-09-11

Heartfulness Meditation-induced State and Trait Effects on Long-term, Short-term and Non-meditators Using Connectivity Analysis: An EEG Study on Prefrontal Cortex.

Shrivastava Anurag A, Singh Bikesh Kumar BK, Singh Deepeshwar D

Heartfulness meditation (HM) is a heart-based meditation practice that features a unique yogic transmission that involves transfer of subtle energy from a certified, experienced meditator to an aspirant. This study was conducted on HM practice to assess the state (momentary changes during meditation result in temporary physiological and neurological shifts) and trait (long-term personality changes developed with experience) effects on the brain using electroencephalogram (EEG) signal analysis. Thirty-four participants were recruited into three groups (long-term meditators [LTM], short-term meditators [STM] and non-meditators). EEG signals from the prefrontal cortex were recorded across four states: baseline, meditation, transmission and post-transmission. Functional connectivity and graph theory measures were calculated for each frequency band (delta, theta, alpha and beta). Within-group and between-group analyses were performed to quantify HM-induced state and trait effects. Significance level was tested through statistical analysis. The results show improved coordination among brain networks, increased global and local efficiency, representing a positive state effect. While performing between-group analysis, significant trait changes were observed in the LTM group over frequency bands (delta, theta and alpha) of the EEG signal. These findings suggest that the altered EEG resulting from meditation reflects neurophysiological changes and functional integration of the brain network. The positive state and trait effects were observed for HM practice in the prefrontal cortex of the brain. Furthermore, the enhanced connectivity in EEG frequency bands may lead to significant neuroplastic changes. This finding provides insights into employing functional connectivity parameters as measures for quantifying meditation quality.

PMID 42724159
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PubMedFrontiers in psychology2026-09-11

Turkish adaptation and psychometric validation of the Normative Male Alexithymia Scale-Brief Form (NMAS-BF) among male university students.

Özel İrem İ

Normative male alexithymia reflects masculinity-related difficulties in identifying and expressing emotions and is theoretically linked to restrictive emotionality within masculine socialization. Existing measures predominantly assess clinical levels of alexithymia and may fail to capture subclinical, culturally embedded patterns of emotional restriction associated with masculine socialization. This study aimed to adapt the Normative Male Alexithymia Scale-Brief Form (NMAS-BF) to Turkish language and culture and to evaluate its psychometric properties. A methodological study was conducted with Turkish male university students. Linguistic equivalence was examined in a bilingual sample (n = 46), followed by a pilot study (n = 30). Separate non-overlapping samples were used for exploratory factor analysis (n = 376) and confirmatory factor analysis (n = 376) to assess structural validity. Exploratory factor analysis was conducted using principal axis factoring. Internal consistency was evaluated using Cronbach's alpha, corrected item-total correlations, and alpha-if-item-deleted values. The Turkish version of the NMAS-BF demonstrated high internal consistency (α = 0.890), with corrected item-total correlations ranging from 0.617 to 0.770. Exploratory factor analysis using principal axis factoring supported a single-factor structure explaining approximately 58.09% of the common variance. Confirmatory factor analysis indicated good model fit for the one-factor model, χ2(9) = 20.66, χ2/df = 2.30, RMSEA = 0.059, CFI = 0.99, TLI/NNFI = 0.99, SRMR = 0.025, and GFI = 0.98. The findings provide initial evidence for the internal consistency and structural validity of the Turkish NMAS-BF among Turkish male university students. Beyond its psychometric properties, the scale provides a culturally adapted tool for examining masculinity-related emotional restriction within the context of Turkish masculine socialization. Future studies may use the Turkish NMAS-BF to investigate associations between emotional restriction, emotional awareness, emotional expression, and psychological functioning among more diverse samples of Turkish men.

PMID 42724141
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PubMedFrontiers in veterinary science2026-09-11

Acaricide resistance in Amblyomma cajennense s.l. and implications for integrated tick control in Ecuadorian cattle systems.

Pérez-Otáñez Ximena X, Vanwambeke Sophie O SO, Paucar-Quishpe Valeria V, Pérez Cecilia C et al.

Amblyomma cajennense sensu lato represents a significant challenge for sustainable tick control in tropical cattle systems due to its ecological adaptability, wide host range, and frequent co-occurrence with Rhipicephalus microplus. This study evaluated the occurrence of acaricide resistance in A. cajennense s.l. populations collected from cattle farms in coastal Ecuador. A cross-sectional field assessment was conducted on seven farms (Esmeraldas, n = 2; Manabí, n = 5) that met the minimum requirement of 30 engorged A. cajennense s.l. females per farm for resistance testing. Tick larvae were subjected to larval packet tests to determine susceptibility to three commonly used acaricides: amitraz, ivermectin, and alpha-cypermethrin. Phenotypic resistance to at least one acaricide was detected on all evaluated farms. Resistance prevalence was 43% for amitraz, 86% for ivermectin, and 100% for alpha-cypermethrin. Multi-resistance occurred on 86% of farms. Estimated lethal dose values revealed extremely high LD₉₀ and LD₉₉ levels, frequently exceeding recommended commercial concentrations by several orders of magnitude. Exploratory screening suggested that extensive cattle production systems and the presence of alternative hosts, particularly horses and other equids, may contribute to resistance emergence and persistence. The results are particularly relevant because A. cajennense s.l. frequently co-occurs with R. microplus on cattle farms, although the two species differ substantially in ecology, host use, and life cycle. Control strategies primarily designed for R. microplus, such as whole-animal acaricide treatments, may have limited impact on Amblyomma populations maintained through wildlife hosts and environmental stages. This study provides the first evidence of acaricide resistance in A. cajennense s.l. in Ecuador and highlights the need for species-specific management strategies, improved resistance monitoring, and integrated tick control programs adapted to multi-species infestations in tropical livestock systems.

PMID 42723911
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PubMedTranslational pediatrics2026-09-11

Gut microbiota alterations in Neonatal Intensive Care Unit extremely preterm infants: a Chinese tertiary center study.

Han Weijuan W, Fu Peipei P, Cui Hong H

Early‑life gut microbiota shapes neonatal health. Extremely preterm infants frequently experience gut dysbiosis, while relevant Chinese longitudinal data remain scarce. This study aimed to explore early gut microbiota dynamics and identify potential microbial markers in Neonatal Intensive Care Unit (NICU) extremely preterm infants. Infants with gestational age ≤32 weeks admitted to the NICU of Beijing Friendship Hospital, Capital Medical University from June 2019 to December 2021 were enrolled, with full-term breastfed infants as controls. Clinical data and stool samples at postnatal <3 days, 2 weeks and 4 weeks were collected for 16S ribosomal ribonucleic acid (16S rRNA) sequencing to analyze gut microbiota composition and temporal variations. A total of 34 extremely preterm and 17 term infants were included. Baseline characteristics including gender, delivery mode and prolonged rupture of membranes (PROM) (>18 h) were comparable between groups. Alpha diversity remained stable over time in term infants, while it was markedly higher within 3 days after birth than at 2 and 4 weeks in extremely preterm infants. Extremely preterm infants had higher early alpha diversity than term infants, with no intergroup differences thereafter. Principal coordinate analysis (PCoA) revealed obvious beta diversity temporal disparities in both groups. Compared with term infants, extremely preterm infants showed enriched colonization of Enterococcus, Streptococcus and Sphingomonas, along with delayed colonization of Enterobacter, Bifidobacterium and Bacteroides. Random forest analysis screened Sphingomonas as a candidate characteristic microbial genus of NICU extremely preterm infants. NICU extremely preterm infants presented distinct gut microbiota structure at multiple taxonomic levels relative to term infants. Their microbial profiles tended to converge within 4 weeks but remained unique. Sphingomonas was identified as an unvalidated candidate marker needing further verification.

PMID 42724230
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