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rabies antiserum

✓ Approved

Shanghai Serum Biotechnology · 多克隆抗体 · 多克隆抗体

什么是 rabies antiserum？

rabies antiserum 是一种多克隆抗体，由Shanghai Serum Biotechnology研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection。

药物档案

公司Shanghai Serum Biotechnology
药物类别多克隆抗体, 抗体
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved
来源： ClinicalTrials.gov, Shanghai Serum Biotechnology

治疗适应症

rabies antiserum 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsRabies✓ Approved

相关研究文献

PubMedOne health (Amsterdam, Netherlands)2026-10-27

Epidemiology of animal bites and post-exposure vaccination coverage in Davao City, Philippines: A five-year retrospective cohort study, 2019-2023.

Hinay Alfredo A AA, Parilla-Sarabia April Joy AJ, Reyes Jennifer Ashley H JAH, Lopez Mariel Phoebe M MPM et al.

Rabies remains a major public health threat in the Philippines, particularly in urban areas such as Davao City, where frequent animal bites from domestic reservoirs increase the transmission risk at the human-animal-environment interface. Detailed epidemiological data on animal bites and post-exposure prophylaxis (PEP) coverage are limited. This One Health-framed retrospective cohort study describes trends in bite incidents, assesses PEP coverage, and identifies gaps in rabies prevention efforts from 2019 to 2023. Surveillance data from the Davao City Animal Bite Treatment Centers captured 98,442 cases. Dogs caused 63.5% of bites, with a significant upward trend (p = 0.027; τ = 1.0, 95% CI 0.200-1.800); cat bites (36.4%) rose sharply, indicating an emerging reservoir challenge. Children ≤15 years of age showed a significant increase (p = 0.027). The 3rd congressional district had the most pronounced rise across demographics and exposure categories. Tissue culture vaccine coverage remained at 100%, equine rabies immunoglobulin rose from 18.5% to 85.9%, whereas human rabies immunoglobulin remained low post-COVID. Despite universal TCV access, immunoglobulin gaps limit its control. Rising cat bites and severe exposures demand integrated One Health strategies, enhanced surveillance, animal vaccination, and supply chain strengthening, to achieve zero human rabies deaths by 2030.

PMID 42935849
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PubMedAvian diseases2026-10-27

Multimodal Diagnosis of Erysipelas (Erysipelothrix rhusiopathiae) Outbreaks in Two New York Ring-Necked Pheasant (Phasianus colchicus) Hunting Preserves.

Rebollada-Merino Agustin A, Duhamel Gerald E GE, Demeter Elena A EA, Guarino Cassandra C et al.

Outbreaks of Erysipelothrix rhusiopathiae infection are well documented in poultry but only sporadically reported in gamebirds. We report two erysipelas outbreaks causing 7% and 9% mortality in separate flocks of ring-necked pheasants (Phasianus colchicus) in New York State in 2024. Gross examination of three pheasants from each flock (n = 6) revealed splenomegaly and renomegaly in birds from one flock and Syngamus trachea in two birds from the other flock. Bacteriological culture of samples of lungs, livers, and spleens yielded E. rhusiopathiae from birds in both flocks based on matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) of bacterial isolates. Serotyping of the E. rhusiopathiae isolates revealed serovar 5 from one flock and serovar 6 from the other flock. Histological examination revealed vasculitis and bacilli within the cytoplasm of endothelial cells and macrophages, as well as intravascular bacterial thrombi and emboli in multiple tissues. Other histologic findings included splenic necrosis, myocarditis, interstitial pneumonia, and hepatitis. Immunohistochemistry of tissue samples with a rabbit polyclonal antiserum raised against serotypes 1a, 1b, and 2 identified E. rhusiopathiae serotype 6 but not serotype 5. This report highlights multimodal diagnostic approaches to confirming erysipelas outbreaks in gamebirds using histopathology and immunohistochemistry combined with bacteriological culture and isolate identification by MALDI-TOF MS and serotyping.

PMID 42937681
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PubMedMicroorganisms2026-10-27

Sheep-Associated Malignant Catarrhal Fever in an Exotic Rusa Deer (Cervus timorensis): Implications for Wildlife Health in Southern Brazil.

Headley Selwyn Arlington SA, Rodriguez Maria Constanza MC, Pinto-Ferreira Fernanda F, Dall Agnol Alais Maria AM et al.

Sheep-associated malignant catarrhal fever (SA-MCF) is a frequently fatal, pantropic, lymphoproliferative disease caused by ovine gammaherpesvirus 2 (OvGHV2), with sheep serving as the asymptomatic reservoir host. Although the Rusa deer (Cervus timorensis) are known to be highly susceptible to OvGHV2 in other regions, cases have not been documented in this species from Brazil. This report describes the spontaneous occurrence of OvGHV2 infection in a captive Rusa deer from Southern Brazil and discusses possible impacts on wildlife. Three deer from the same property died suddenly without prior clinical signs. These animals had no known contact with sheep or goats, but were maintained in an epidemiological niche where OvGHV2 was detected in subclinically infected free-ranging wild boars (FRWBs) and cattle. One of these was submitted for routine post-mortem evaluations. Gross lesions included ulcerative and erosive lesions of the alimentary tract, pulmonary edema, and marked meningeal congestion. Histopathology revealed erosive and ulcerative esophagitis, abomasitis, omasitis, and rumenitis, with nonsuppurative meningoencephalitis, and vasculitis in several organs, consistent with SA-MCF. Molecular testing of brain tissue detected OvGHV2 DNA by qPCR. Furthermore, PCR assays amplified the partial fragments of the OvGHV2 tegument protein (ORF75) and the glycoprotein (gB) genes. Other neurological pathogens of ruminants including BoAHV5, BVDV, Listeria monocytogenes, Histophilus somni, and rabies virus were not detected. Additionally, phylogenetic analyses, based on ORF75 and gB genes, revealed that the nucleotide sequences derived from this study clustered with and had elevated sequence homology with the OvGHV2 reference strains and other strains derived from ruminants maintained in different geographical locations. The absence of contact with sheep, combined with prior evidence of subclinical OvGHV2 infection in FRWBs and cattle within the same epidemiological niche, suggests the involvement of alternative wildlife reservoirs or bridge hosts in viral transmission. Additionally, these results expand the host range of OvGHV2 in Brazil, highlight the vulnerability of exotic cervids to SA-MCF, and underscore the need for integrated wildlife-livestock surveillance strategies in regions where multiple susceptible species coexist.

PMID 42943451
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PubMedVeterinary world2026-10-26

Knowledge, attitudes, and preventive behaviors toward rabies among urban residents in Bangkok, Thailand: Implications for targeted One Health rabies elimination strategies.

Luenglertamorn Kittithat K, Borvornpadungkitti Taksaporn T, Luangyawee Rapee R, Choksuchat Siwat S et al.

Rabies remains a fatal zoonotic disease and an important public health concern despite substantial reductions in human cases in Thailand. Continued circulation of rabies among animal populations highlights the need to strengthen public awareness and preventive behaviors. This study aimed to assess knowledge, attitudes, and preventive behaviors regarding rabies among Bangkok residents, identify sociodemographic factors associated with these outcomes, and examine relationships among knowledge, attitudes, and preventive behaviors to support urban rabies prevention and control strategies. A cross-sectional online survey was conducted among Bangkok residents between December 2024 and August 2025 using a structured, content-validated questionnaire. Of 262 respondents, 258 met the eligibility criteria and were included in the analysis. Descriptive statistics summarized participant characteristics and knowledge, attitudes, and preventive behaviors. Binary logistic regression identified factors associated with these domains, while Pearson's chi-square test evaluated associations among knowledge, attitudes, and preventive behaviors. Overall, 58.9% of participants demonstrated sufficient knowledge, whereas attitudes and preventive behaviors were generally favorable. Correct responses were highest for rabies transmission (97.7%), clinical signs in dogs (98.8%), and animal vaccination (96.9%), whereas only 36.1% correctly identified the recommended observation period following a bite incident. Participation in rabies awareness activities was limited (26.7%), although 73.6% reported routine pet rabies vaccination. Multivariable logistic regression showed that private sector employees were less likely to demonstrate sufficient knowledge (adjusted odds ratio [AOR] = 0.268, 95% confidence interval [CI]: 0.148-0.483; p < 0.001) and positive attitudes (AOR = 0.337, 95% CI: 0.186-0.610; p < 0.001) than students/unemployed participants. Participants aged 26-40 years had lower odds of appropriate preventive behaviors (AOR = 0.338, 95% CI: 0.173-0.657; p = 0.001), whereas participants whose pets had received rabies vaccination were more likely to report appropriate preventive behaviors (AOR = 2.512, 95% CI: 1.413-4.465; p = 0.002). Significant positive associations were identified between knowledge and attitudes and between knowledge and preventive behaviors (both p < 0.001). Although participants generally demonstrated favorable rabies-related knowledge, attitudes, and preventive behaviors, important gaps persisted regarding post-bite animal observation and participation in rabies awareness activities. Occupation and age were important determinants of knowledge, attitudes, and preventive behaviors, while responsible pet vaccination was positively associated with preventive practices. These findings support targeted, culturally appropriate educational interventions, workplace- and community-based awareness programs, and stronger One Health collaboration to advance urban rabies prevention and support Thailand's progress toward the WHO "Zero by 30" rabies elimination goal.

PMID 42928789
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PubMedBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2026-10-26

Genetic characterization of rabies virus circulating in crab-eating fox (Cerdocyon thous) in the State of Paraiba, Northeastern Brazil.

Bezerra Camila de Sousa CS, Gomes Albério Antônio de Barros AAB, Dantas Antônio Flávio Medeiros AFM, de Azevedo Sergio Santos SS et al.

Rabies is a fatal viral zoonosis that remains endemic in more than two-thirds of all countries worldwide, causing approximately 70,000 human deaths annually-equivalent to one death every ten minutes. The rabies virus (RABV), a member of the genus Lyssavirus (family Rhabdoviridae), has bats and canids as its primary reservoirs, although infections have also been reported in other wild species, including Cerdocyon thous (crab-eating fox) and Pseudalopex vetulus (hoary fox). In this study, we performed a comprehensive genomic and biological characterization of a RABV variant circulating in wild foxes from the Northeastern region of Brazil. Using Next Generation Sequencing (NGS), phylogenetic analysis, and in vitro and in vivo assays, we identified genetic similarities between these isolates and previously described RABV strains from wild and domestic canids in Brazil. However, the presence of escape mutants indicates a heterogeneous viral population, suggesting ongoing adaptive evolution in wildlife reservoirs. These findings reinforce the importance of genomic surveillance to detect emerging variants that may compromise current vaccination or control strategies. Overall, our results provide new insights into the molecular diversity, pathogenicity, and ecological dynamics of RABV circulating among wild canids in Brazil, contributing to improved understanding and prevention of rabies in endemic regions.

PMID 42932002
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PubMedVaccines2026-10-26

SYN023, a Humanized Monoclonal Antibody Cocktail, Broadly Neutralizes Genetically Diverse Lyssaviruses and Validates Epitope Prediction Accuracy.

Qu Jiagui J, Rupprecht Charles E CE, Yu Pengcheng P, Zhu Wuyang W et al.

Background/Objectives: Lyssaviruses pose a persistent global public health threat, underscoring the need for broad-spectrum neutralizing antibodies to improve rabies post-exposure prophylaxis (PEP). The humanized monoclonal antibody cocktail SYN023 is approved for PEP in China and under active global regulatory review. This study aimed to validate pseudovirus-based neutralization assays, verify SYN023 epitope prediction accuracy, and systematically characterize its pan-lyssavirus neutralizing activity. Methods: Assay validation was performed by directly comparing neutralization titers obtained with authentic rabies virus (RABV) and pseudotyped virus. Epitope analysis was performed, followed by in vivo evaluation in a canine PEP challenge model. The pseudovirus-based neutralization assay was used to assess SYN023 broad-spectrum activity across diverse lyssaviruses. Results: Neutralization titers from authentic and pseudotyped viruses showed high concordance (R2 = 0.8341, p < 0.0001), supporting the pseudovirus system as a reliable surrogate assay. Epitope analysis confirmed that SYN023's epitope is fully conserved in the highly virulent New York City (NYC) RABV strain. In canine PEP challenge studies using the NYC strain, SYN023 conferred strong protection at 0.1-0.5 mg/kg. SYN023 exhibited potent neutralizing activity against phylogenetically diverse non-rabies lyssaviruses, including Mokola virus (MOKV; EC50 = 14.74 µg/mL), whereas three clinically validated reference antibodies failed to neutralize MOKV even at concentrations up to 1000 µg/mL. Conclusions: This study demonstrates that the pseudovirus-based neutralization assay is a reliable surrogate assay. It also confirms the functional accuracy of the epitope mapping strategy and demonstrates the broad neutralization spectrum of SYN023 against a diverse panel of lyssaviruses.

PMID 42931391
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