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calcium carbonate + vitamin D3 (Ideos)

✓ Approved

Innothera · VDR · 小分子

什么是 calcium carbonate + vitamin D3？

calcium carbonate + vitamin D3 是一种小分子，由Innothera研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Ideos
公司Innothera
药物类别小分子
分子靶点VDR
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Innothera

作用机制

分子靶点

calcium carbonate + vitamin D3 作用于 1 个分子靶点：

VDRvitamin D receptor (NR1I1, PPP1R163)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

calcium carbonate + vitamin D3 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

相关研究文献

PubMedFrontiers in microbiology2026-09-11

Microbially induced calcite precipitation (MICP): mechanisms, engineering applications, and pathway to field-scale deployment - a comprehensive review.

He Tao T, Chen Jiaxing J, Lou Xiyan X

Over the last twenty years, there has been a great amount of multidisciplinary interest in Microbially Induced Calcite Precipitation (MICP) as a truly sustainable solution to ground treatment using Portland cement. The process utilizes the urease activity of ureolytic bacteria, most commonly Sporosarcina pasteurii to convert soluble urea and calcium to solid calcite in the pore space of granular media, providing cementation, impermeability reduction and contaminant sequestration without excavation or heat. This review compiles over sixty publications covering all aspects of MICP research, ranging from the enzymological chemistry of urease to the documented field trials of over 100 m3 of treated volume, to the thermodynamics of calcium carbonate polymorphism. Unconfined compressive strengths of over 10 MPa have been reached in laboratory columns and wind erosion reduction of 95% has been observed in field tests, while the efficiency of heavy metal removal can reach up to 99% for lead in aqueous laboratory systems, though removal efficiencies in soil matrices are typically lower and highly dependent on metal concentration, soil type, and treatment conditions. The self healing concrete application is the most advanced toward commercial maturity, and there are products available from Basilisk, Evonik and BioMason. Ground improvement, liquefaction mitigation, and coastal erosion control are other geotechnical applications at Technology Readiness Levels 5 to 7, with the challenges of uniformity of treatment in heterogeneous soils, management of the by-product of ammonium, bacterial transport at depth, and competitiveness with conventional grouting. New developments such as non-ureolytic microbial pathways, fiber and biochar reinforced hybrid biocementation, 3D bio-printing of living mineral structures, and process optimization via machine learning with R2 > 0,95, are also being explored. The review closes with a candid critique of the gaps in the research, especially long-term durability information, scale-specific cost analyses, and standardized monitoring protocols, which will decide whether or not MICP becomes a successful laboratory-based concept that moves into a common engineering tool.

PMID 42724962
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PubMedInternational journal of dentistry2026-09-11

Evaluation of the Effect of Adding Various Polymeric Rheological Agents on the Physical and Mechanical Properties of Calcium Silicate Cement.

Zadsirjan Saeede S, Feli Mojgan M, Zargar Nazanin N, Tayebi Golnaz G et al.

The effect of polymer addition on the properties of calcium silicate cement (CSC) was evaluated. The powder component was based on calcium silicate. The liquid component contained distilled water (control group) and distilled water with polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), and polycarboxylate ether (PCE) polymers separately or in combination (PVA + PCE, PVP + PCE) at concentrations of 1 and 3 wt%. In addition to the evaluation of handling properties, some analyses were performed, including setting time, compressive strength, flowability, and injectability. The best-performing groups were selected as the final groups. The specimens were immersed in distilled water and simulated body fluid (SBF) for 1 and 7 days to evaluate the amount of calcium ion release, weight changes, and hydroxyapatite formation. One-way ANOVA, repeated measures ANOVA, and Tukey tests were used for statistical analysis (α = 0.05). Based on the handling evaluation and the results of the setting time, compressive strength, flowability, and injectability analyses, the PVA 3% and PVP 3% groups were selected as the optimal groups and subjected to further analysis. The PVA 3% group showed the highest calcium ion release after 1 day of immersion, while no significant difference was observed among the groups on the seventh day. All three groups (PVA 3 wt%, PVP 3 wt%, and control) showed the formation of calcium phosphate deposits after immersion in SBF. The use of PVA 3% and PVP 3% polymers separately in the liquid component of CSC improved the properties of this cement.

PMID 42724287
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PubMedJournal of medicinal food2026-09-11

Effects of Lactiplantibacillus plantarum HY7715 Supplementation on Lower Limb Muscle Strength and Power in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.

Hong Dong-Ki DK, Jeon Soomin S, Woo Seonwook S, Shin Sangyeon S et al.

Age-associated reductions in muscle strength and physical function have become an important public health concern among older adults, and gut microbiome-targeted interventions have emerged as a potential strategy to mitigate these declines. We evaluated the effects of Lactiplantibacillus plantarum HY7715 (L. plantarum HY7715) on lower-limb muscle function, serum vitamin B2, and gut microbiome profiles in older adults exhibiting reduced muscle strength. In this 12-week, randomized, double-blind, placebo-controlled trial, 100 adults aged 50-85 years were assigned to receive HY7715 (5.0 × 109 CFU/day) or placebo. Compared with placebo, HY7715 supplementation was associated with greater increases in multiple measures of quadriceps strength, with the left and bilateral mean measures remaining significant after baseline adjustment. Selected hamstring strength and quadriceps muscle power outcomes also showed significant improvements in the unadjusted analyses. Overall, the most consistent findings were observed for quadriceps strength, whereas the hamstring strength and quadriceps muscle power findings were less consistent after baseline adjustment. Serum vitamin B2 concentration increased significantly following HY7715 supplementation, and the between-group difference remained significant after adjustment for baseline dietary riboflavin intake. Microbiome analyses demonstrated increased Chao1 alpha diversity, significant within-group shifts in beta diversity, and increased relative abundances of Lactiplantibacillus and L. plantarum. HY7715 supplementation was associated with greater increases in selected quadriceps strength measures and serum vitamin B2 concentrations in adults with reduced muscle strength.

PMID 42723314
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PubMedPlastic and reconstructive surgery. Global open2026-09-11

Limb Salvage Using Local Antibiotic Beads for Calcaneal Osteomyelitis With Multidrug-resistant Infection and Chronic Limb-threatening Ischemia.

Alhunayan Danah D, Alsaleh Ahmed A, Makhdoomi Mahmood M, Khuraibet Salma S et al.

Calcaneal osteomyelitis in diabetic patients with chronic limb-threatening ischemia (CLTI) and multidrug-resistant (MDR) infection poses a significant reconstructive challenge. Limited perfusion, high plantar loading, and constrained antimicrobial delivery often narrow salvage options and increase the risk of major amputation. We report a case of recurrent calcaneal osteomyelitis in a 53-year-old man with type 2 diabetes, chronic kidney disease, peripheral vascular disease, CLTI, and polymicrobial MDR infection. Management included revascularization, serial debridement, culture-directed systemic therapy, negative-pressure wound therapy, hyperbaric oxygen therapy, structured offloading, and adjunctive local antibiotic delivery using calcium sulfate beads. Following recurrence, repeat calcaneal debridement and saucerization were performed, and vancomycin- and gentamicin-loaded calcium sulfate beads were placed individually into the calcaneal defect. The wound progressed with no recurrent infection or exposed bone. Complete epithelialization was achieved at 14 months, and the patient remained pain-free and independently ambulatory in offloading footwear. In recurrent calcaneal osteomyelitis complicated by CLTI and MDR infection, calcium sulfate antibiotic carriers may serve as a useful adjunct to staged multimodal limb salvage. By combining dead-space management with high local antibiotic delivery after repeat debridement, this approach may be considered in selected ischemic, infection-resistant presentations.

PMID 42724855
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PubMedJournal of thoracic disease2026-09-11

Factors associated with postoperative respiratory failure in hospitalized patients with thoracolumbar fractures: a retrospective cross-sectional study based on the MIMIC-IV database.

Zhou Jingjing J, Weng Lili L, Ni Yan Y, Jin Ling L

Postoperative respiratory failure is a serious complication following thoracolumbar fracture surgery, yet research in this specific population remains scarce. This retrospective cross-sectional study used the Medical Information Mart for Intensive Care IV (MIMIC-IV) database to identify factors associated with postoperative respiratory failure in hospitalized patients with thoracolumbar fractures. Postoperative respiratory failure was identified using diagnosis codes recorded during hospitalization. The variance inflation factor (VIF) test was used to assess collinearity among the collected variables. Least absolute shrinkage and selection operator (LASSO), random forest, and Adaptive Boosting (AdaBoost) regression analyses were used to rank variable importance. A Venn chart was used to determine the common variables identified by the three screening methods. Univariate and multivariate logistic regression were used to determine the factors associated with postoperative respiratory failure. The receiver operating characteristic (ROC) curve and nomogram analysis were used to evaluate discriminative performance. All statistical tests were two-sided. A total of 726 patients were included in this study, and 110 patients experienced respiratory failure. Among 25 candidate variables, 10 were identified as key candidates for respiratory failure according to their importance. On univariate analysis, pneumonia [odds ratio (OR) =11.489, 95% confidence interval (CI): 7.173-18.401; P<0.001], white blood cell (WBC) count (OR =1.086, 95% CI: 1.050-1.123; P<0.001), bicarbonate (OR =0.899, 95% CI: 0.854-0.946; P<0.001), calcium (OR =0.602, 95% CI: 0.463-0.782; P<0.001), potassium (OR =1.501, 95% CI: 1.164-1.935; P=0.002), and age (OR =1.013, 95% CI: 1.002-1.023; P=0.01) were associated with respiratory failure. In multivariate analyses, pneumonia and calcium remained independently associated with respiratory failure in all three models [for model 3, OR =7.532, 95% CI: 4.447-12.758, P<0.001; and OR =0.610, 95% CI: 0.443-0.841, P=0.003, respectively], whereas WBC count and potassium remained associated in most models. The area under the ROC curve (AUC) of the comprehensive model combining pneumonia, calcium, WBC count, and potassium was 0.798 (95% CI: 0.746-0.845). Pneumonia, calcium, WBC count, and potassium were factors associated with postoperative respiratory failure in patients with thoracolumbar fractures. The combined model based on these factors showed acceptable discrimination.

PMID 42724579
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PubMedFrontiers in surgery2026-09-11

Association of preoperative serum 25-hydroxyvitamin D levels with deep vein thrombosis after total knee arthroplasty: a hypothesis-generating analysis of coagulation function mechanisms.

Shang He H, Li Jun J, Ma Tao T, Wei Yuan Y et al.

This hypothesis-generating study aimed to explore the association of preoperative serum 25-hydroxyvitamin D [25(OH)D] levels with deep vein thrombosis (DVT) risk after total knee arthroplasty (TKA) and clarify the potential coagulation-related mechanisms. A total of 193 patients undergoing primary unilateral TKA in a single center were stratified into 25(OH)D deficiency (<20 ng/mL, n = 106), insufficiency (20-29 ng/mL, n = 47), and sufficiency (≥30 ng/mL, n = 40) groups. Postoperative DVT (detected via day 5-7 venous ultrasonography) and coagulation indices [D-dimer, prothrombin time (PT)] were compared across groups. Univariate and multivariate logistic regression were used to screen DVT-related factors, and Firth's penalized logistic regression was applied for a sparse-data sensitivity analysis. The overall postoperative DVT incidence was 13.5% (26/193). A bivariate analysis revealed a markedly higher DVT rate in the deficiency group (18.9%) than in the sufficiency group (2.5%), with a crude 2 × 2 odds ratio (OR) of 9.070 [95% confidence interval (CI): 1.198-68.542, P = 0.015]; this estimate was unstable due to only one DVT case in the sufficiency group. To provide a more stable estimate, a secondary binary logistic regression model (deficiency vs. non-deficiency) was performed, which identified preoperative 25(OH)D deficiency as significantly correlated with postoperative DVT (OR = 3.140, 95% CI: 1.200-8.212, P = 0.020). After analysis of covariance adjustment for baseline levels, the deficiency group maintained significantly higher postoperative D-dimer and shorter PT than the sufficiency group (both P < 0.001). A univariate analysis identified 25(OH)D deficiency and elevated postoperative D-dimer as DVT-related risk factors. In the secondary exploratory model adjusting for postoperative D-dimer (a potential mediator), the association between vitamin D deficiency and DVT was attenuated (OR = 2.576, 95% CI: 0.941-7.049, P = 0.065), indicating a possible mediating effect rather than confounding bias. Firth's sensitivity analysis on the binary model further verified the robustness of this finding (OR = 2.918, 95% CI: 1.142-7.456, P = 0.025). Preoperative 25(OH)D deficiency is associated with elevated postoperative DVT risk after TKA in univariate analyses. Abnormal postoperative D-dimer and PT levels suggest that vitamin D status may modulate coagulation-fibrinolysis balance. The attenuated association after D-dimer adjustment supports a potential mediating mechanism. As a hypothesis-generating analysis, these preliminary findings require further validation in large-scale prospective studies to confirm the independent predictive value of preoperative vitamin D deficiency for post-TKA DVT.

PMID 42723925
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