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calcium carbonate + vitamin D3 (Ideos)

✓ Approved

Innothera · VDR · 小分子

什么是 calcium carbonate + vitamin D3？

calcium carbonate + vitamin D3 是一种小分子，由Innothera研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Ideos
公司Innothera
药物类别小分子
分子靶点VDR
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Innothera

作用机制

分子靶点

calcium carbonate + vitamin D3 作用于 1 个分子靶点：

VDRvitamin D receptor (NR1I1, PPP1R163)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

calcium carbonate + vitamin D3 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

相关研究文献

PubMedMetabolites2026-07-27

Content of Vitamin D2 in Alternative Biological and Nutritional Sources and Its Effectiveness as Compared to Vitamin D3-A Narrative Review.

Bieg Filip F, Galanty Agnieszka A, Arancibia-Ávila Patricia P, Gorinstein Shela S et al.

Background/Objectives: Interest in alternative, non-animal sources of vitamin D has increased due to the global prevalence of its deficiency and the growing demand for plant-based dietary options. Mushrooms and algae have emerged as potential sustainable sources of vitamin D2 and, in selected cases, vitamin D3 following ultraviolet (UV) exposure. However, the comparative bioavailability and clinical effectiveness of vitamin D2 relative to vitamin D3 remain controversial. This review aims to evaluate the content of vitamin D2 in mushrooms and algae, the impact of UV irradiation on its synthesis, and the effectiveness of vitamin D2 supplementation compared with vitamin D3 in humans. Methods: PubMed, ScienceDirect, and Google Scholar were searched (1996-2026). Only human intervention studies were included when assessing clinical efficacy. Data on natural sources and pharmaceutical formulations were analyzed. Results: UV irradiation markedly increases vitamin D2 content in mushrooms, as compared to cultivated products. Algal vitamin D content varies, depending on species and UV exposure, with no robust clinical trials confirming improvement of serum 25(OH)D after algal supplementation. Across multiple randomized controlled trials, vitamin D2 consistently increased circulating 25(OH)D2 but frequently reduced 25(OH)D3 and demonstrated lower efficacy in raising total 25(OH)D compared with vitamin D3, as confirmed by a recent meta-analysis. Conclusions: Although UV-enhanced mushrooms represent a quantifiable dietary source of vitamin D2, clinical evidence consistently indicates lower efficacy of vitamin D2 compared with vitamin D3. Algae cannot currently be considered a validated source of vitamin D for improving human vitamin D status. Further mechanistic and long-term clinical studies are required.

PMID 42506436
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PubMedCureus2026-07-27

A Case of Severe Hypercalcemia in a Patient Taking Tirzepatide: Potential Risk Factors.

Iqbal Safiah S, Javed Faiza F, Oyibo Samson O SO

Hypercalcemia is commonly caused by hyperparathyroidism and malignancy. Medication-induced hypercalcemia is less common. Tirzepatide is a dual glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide receptor agonist (GLP-1/GIP RA) used to aid weight loss and glycemic control. It is associated with gastrointestinal side effects, but its effect on calcium homeostasis has not been well reported. We report the case of a 75-year-old woman with a history of type 2 diabetes, hypertension, obesity, chronic kidney disease, and post-surgical hypothyroidism and hypoparathyroidism, who presented with severe symptomatic hypercalcemia one month after starting tirzepatide while taking bendroflumethiazide, calcium carbonate, and alfacalcidol. Her serum calcium levels had been in the normal treatment range before the initiation of tirzepatide. All other possible causes of hypercalcemia were ruled out. Her calcium levels returned to normal after intravenous fluid therapy and withholding tirzepatide, bendroflumethiazide, and calcium carbonate. This case highlights the potential occurrence of severe hypercalcemia during the concurrent use of tirzepatide with bendroflumethiazide, a calcium supplement, and vitamin D in the context of chronic kidney disease. With the increasing use of tirzepatide, healthcare workers need to be mindful of the interaction between tirzepatide and these potential risk factors. While further research is required, we suggest serum calcium monitoring during similar clinical scenarios.

PMID 42504310
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PubMedNanomaterials (Basel, Switzerland)2026-07-27

A Unified Gas-Liquid Carbonation Platform for Habit-Controlled Calcite Nanostructures.

Lee Seungyeol S, Woo Juhwan J, Rhee Chul Woo CW

Calcite habit engineering offers a route to transform CO2 mineralization from bulk sequestration into value-added nanomaterial production. Here, we demonstrate that additive chemistry and seeding strategy can serve as separable, recipe-level levers for directing calcite habit formation within a unified CaO/Ca(OH)2 gas-liquid carbonation platform. This strategy highlights how solution-mediated habit control can bridge fundamental calcite crystallization mechanisms with scalable CO2 utilization and value-added carbonate nanomaterial production. Sodium glutamate yielded ~100 nm rhombohedral nanoparticles, staged MgSO4/ZnSO4 dosing produced whisker-like crystalline nanorods with aspect ratios of 4-7, and two-step seeded carbonation with NH4Cl generated fusiform spindle subunits that assembled into hierarchical rosette architectures. X-ray diffraction confirmed calcite as the only crystalline calcium carbonate phase detected under the present measurement conditions, with no detectable aragonite or vaterite reflections. SEM/TEM revealed distinct primary-subunit architectures, including internal striations in spindle particles indicative of oriented attachment. Thermogravimetry, N2 physisorption, and EDS further distinguished the products and showed that Mg/Zn/S modifiers in the whisker route are retained predominantly at crystal surfaces rather than incorporated into the calcite lattice. These results define calcite habit control through two independent levers: additive-driven facet selectivity and kinetic decoupling of nucleation from growth/assembly. The platform links scalable synthesis, CO2 utilization, and functional carbonate design.

PMID 42506486
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PubMedFaraday discussions2026-07-27

Understanding the stability of the solid electrolyte interphase formed by vinylene carbonate and fluoroethylene carbonate in sodium-ion batteries.

Schuster Jan Felix JF, Hu Qihan Q, King Laura L, Lapidus Alexandre Linas AL et al.

The formation of a stable solid electrolyte interphase (SEI) in sodium-ion batteries is a challenge which is usually solved by introducing film-forming electrolyte additives. The functions and decomposition of common additives like vinylene carbonate (VC) and fluoroethylene carbonate (FEC) are not fully understood and yield different results in full- and half-cells. This study reveals that the electrochemical reduction of an electrolyte solution based on 1 M NaPF6 dissolved in ethylene carbonate and diethyl carbonate (EC : DEC) with no additive yields a lower charge loss, while electrolytes containing 2 wt% VC or FEC additives suffer from higher charge consumption for the formation and reformation of SEI due to higher solubility. To solely investigate stability and dissolution of the SEI in the absence of other ageing mechanisms, a model cell consisting of a carbon-coated aluminium foil working electrode and Prussian white counter and reference electrodes was used. Additionally, the experiments show a detrimental effect from using sodium metal counter electrodes. This work sheds light on the insufficiency of VC and FEC electrolyte additives in forming a perfect SEI. However, further investigations are required to account for additional ageing mechanisms to provide a comprehensive understanding of the role of VC and FEC in practical sodium-ion batteries.

PMID 42504679
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PubMedInorganic chemistry2026-07-27

Structure and Compressional Behavior of Sillén-Type (BiO)2(CO3) Bismutite Carbonate.

Chuliá-Jordán Raquel R, Santamaría-Pérez David D, Botan-Neto Benedito Donizeti BD, Bera Ganesh G et al.

In this joint experimental/computational work, we study the ambient-conditions structure of bismutite (BiO)2(CO3) and its evolution under high pressure by means of a combination of in situ synchrotron X-ray diffraction (XRD) measurements, Raman spectroscopy, and density-functional theory (DFT) calculations. Using single-crystal XRD, (BiO)2(CO3) is determined to be an orthorhombic Cmcm phase with disorder arising from carbonate rotations at ambient-conditions and DFT confirms the stability of the structure. In situ high-pressure synchrotron powder XRD measurements showed that the Cmcm ambient-pressure structure adequately accounts for the observed diffraction patterns up to 17.7 GPa. The compressibility was determined, obtaining an experimental bulk modulus of 67.2(11) GPa and significant anisotropy in the axial compressibilities: the a and c axes, parallel to the (BiO)22+ layers, are less compressible than the b direction perpendicular to those layers, which we justify on the basis of the bismuth lone electron pair compressibility and the slight reorientation of the carbonate groups. Raman spectroscopy measurements at ambient conditions and under pressure were used to characterize the vibrational properties of this carbonate, unvealing a differentiated behavior of the nonequivalent carbonate units.

PMID 42503691
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PubMedDentistry journal2026-07-27

Generalized Developmental Enamel Hypoplasia of the Permanent Dentition Associated with Early Childhood Vitamin D Deficiency Rickets: A Case Report.

Okawa Rena R, Takagi Misato M, Suehiro Yuto Y, Nakano Kazuhiko K

Background: Vitamin D deficiency rickets is a metabolic bone disorder caused by impaired calcium and phosphate homeostasis resulting from insufficient vitamin D. In children, severe vitamin D deficiency can disturb the mineralization of growing bones and teeth. Although the skeletal manifestations are well recognized, reports describing generalized developmental enamel defects affecting nearly all permanent teeth remain limited. Methods: A 6-year-9-month-old Japanese boy with a history of vitamin D deficiency rickets diagnosed at 2 years 5 months of age was referred to our department for evaluation of generalized discoloration and morphological abnormalities affecting multiple permanent teeth. Clinical, radiographic, and medical findings were reviewed. Results: Laboratory examination at diagnosis revealed severe vitamin D deficiency with elevated intact parathyroid hormone levels. Possible contributing factors included exclusive breastfeeding, delayed weaning, avoidance of fish and dairy products, and limited outdoor activity. Following oral alfacalcidol supplementation, skeletal and biochemical findings gradually normalized. However, clinical examination revealed generalized enamel hypoplasia affecting the permanent incisors and first molars, characterized by yellow-brown discoloration, rough enamel surfaces, morphological irregularities, and attrition, whereas the primary dentition showed no obvious abnormalities. Panoramic radiography demonstrated generalized crown malformation involving both erupted and unerupted permanent teeth, particularly the permanent incisors, first molars, and canines, while premolars and second molars were relatively unaffected. Based on the developmental timing of the affected teeth and the patient's medical history, the enamel defects were considered to be associated with systemic mineralization disturbance during early childhood. Restorative treatment, including composite resin restorations and stainless steel crowns, was performed to improve aesthetics and occlusal function. Preventive surgical exposure followed by composite resin restoration was also performed for the permanent canines at the onset of eruption. Conclusions: Severe vitamin D deficiency during critical stages of tooth development may be associated with irreversible developmental enamel defects in the permanent dentition, even after apparent systemic recovery from rickets. Early dental assessment, long-term dental follow-up, and multidisciplinary management should be considered in children with a history of nutritional rickets.

PMID 42505708
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