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terbinafine hydrochloride (MOB015B / MOB 015 / MOB015)

✓ Approved

DongKoo Bio & Pharma · SQLE · 小分子

什么是 terbinafine hydrochloride？

terbinafine hydrochloride 是一种小分子，由DongKoo Bio & Pharma研发。该药已获批，用于治疗相关适应症，给药途径：Topical。

药物档案

商品名MOB015B, MOB 015, MOB015
公司DongKoo Bio & Pharma
药物类别小分子
分子靶点SQLE
给药途径Topical
状态Approved
来源： ClinicalTrials.gov, DongKoo Bio & Pharma

作用机制

分子靶点

terbinafine hydrochloride 作用于 1 个分子靶点：

SQLEsqualene epoxidase ()
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

terbinafine hydrochloride 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsOnychomycosis✓ Approved

相关研究文献

PubMedAntibiotics (Basel, Switzerland)2026-07-27

Emerging Global Patterns of Terbinafine Resistance in Trichophyton Species: A Systematic Review and Meta-Analysis.

Kilbas Imdat I, Kahraman Kilbas Elmas Pinar EP, Ciftci Ihsan Hakki IH, Varga Norberth-Istvan NI et al.

Background/Objectives: In recent years, reports regarding terbinafine resistance in Trichophyton spp. have increased. The aim of this study is to evaluate the prevalence of terbinafine resistance in Trichophyton spp. species on a regional and species basis and to systematically analyze the antifungal susceptibility testing methods used and the available data. Methods: This systematic review and meta-analysis was conducted in accordance with the PRISMA guideline. Studies published until 1 December 2025 were searched in the PubMed/MEDLINE, Scopus, Web of Science, and Embase databases. Studies reporting antifungal susceptibility test results using species-level identification, standardized, or study-defined methodologies were included. Pooled prevalence estimates were calculated with a random-effects model. Heterogeneity was evaluated with the I2 statistic. Subgroup analyses were performed according to publication period, resistance definition groups, species, and geographic region. SQLE mutation patterns were summarized descriptively. Results: Nineteen studies reported from 13 different countries were included in the meta-analysis. In sensitivity analyses that included surveillance-based studies, the combined prevalence rate was found to be 3.2% (95% confidence interval 1.5-6.7). Higher descriptive resistance levels were observed in T. indotineae and T. mentagrophytes, although species-related differences were not statistically significant. Among studies reporting SQLE mutations, alterations involving codons 393 and 397 were the most frequently described; however, mutation patterns were summarized descriptively because of methodological heterogeneity among studies. Conclusions:Trichophyton spp. terbinafine resistance is an emerging global threat. Standardized susceptibility testing, harmonized epidemiological cut-off values, and enhanced molecular surveillance are essential for accurate detection, resistance monitoring, and effective clinical management.

PMID 42505662
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PubMedJournal of fungi (Basel, Switzerland)2026-07-27

Dermatophytosis: An Update on Global Epidemiology.

Silva Laura Beatriz Borim da LBBD, Oliveira Laríssa Santos de LS, Furlan Thiago Blanco Parra TBP, Almeida Bruna Carolina Teixeira BCT et al.

Dermatophytosis is a cutaneous mycosis caused by keratinolytic fungi, classified as dermatophytes, affecting 20-25% of the global population and representing a significant public health concern. The disease manifests as circular, erythematous, pruritic, and desquamative skin lesions, hair breakage and loss, and nail degradation, leading to considerable morbidity. In addition, dermatophytosis can markedly impair patients' quality of life. Despite the high global prevalence of dermatophytosis, the causative agents are often misdiagnosed, and there is limited data on the epidemiology and genomic surveillance of dermatophytosis worldwide. This review aims to update the global epidemiology of dermatophytosis and dermatophytes while addressing their taxonomy, pathogenesis, virulence factors, clinical manifestations, and antifungal therapy. Consistently, Trichophyton spp., particularly T. rubrum, T. mentagrophytes, and T. interdigitale, remain the predominant pathogens worldwide. Recently, T. indotineae has gained prominence due to its global dissemination, significant terbinafine resistance, extensive lesions, therapeutic failure, and recurrence. Furthermore, studies have reported endogenous cases of T. indotineae infections in Asia and Europe, and exogenous reports in the Americas and Oceania. Among non-Trichophyton dermatophytes, Microsporum canis and M. audouinii stand out as relevant pathogens, particularly in endemic regions and specific clinical settings, such as scalp infections. Overall, these factors emphasize the importance of global vigilance regarding dermatophyte dissemination. This review also highlights a discrepancy between accurate fungal identification and global reporting, raising concerns regarding epidemiological surveillance and underscoring the need for improved strategies to manage dermatophytosis worldwide.

PMID 42506265
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PubMedAntibiotics (Basel, Switzerland)2026-07-27

Resistance and Recalcitrance in Dermatophytosis: Mechanistic and Clinical Considerations for Keratinized Tissues.

Valdez-Martinez Alfredo A, Arenas Roberto R, Moreno-Salinas Andrea A, Perez-Tristan Mariana M et al.

Dermatophytosis remains one of the most prevalent superficial fungal infections worldwide and is increasingly encountered as a persistent or difficult-to-treat syndrome. A major clinical problem is that apparent treatment failure is often attributed to antifungal resistance, although many cases are instead driven by diagnostic uncertainty, corticosteroid-modified disease, reinfection, inadequate exposure, poor adherence, and limited drug delivery within keratinized tissues. This narrative review was developed to clarify the distinction between true antifungal resistance and clinical recalcitrance, with particular attention to terbinafine-resistant Trichophyton species, Trichophyton indotineae, tinea incognito, onychomycosis, dermatophytoma, and high-barrier skin and nail infections. We synthesized peer-reviewed literature and guideline-level evidence addressing epidemiology, molecular mechanisms of resistance, clinical phenotypes of recalcitrance, diagnostic escalation, therapeutic decision-making, and antifungal delivery in keratinized tissues. The review contributes a dermatology-centered conceptual framework in which persistent dermatophytosis is interpreted through both microbiological resistance and modifiable recalcitrance drivers. This approach emphasizes confirmation of fungal disease when indicated, phenotypic and anatomic classification, avoidance of inappropriate corticosteroid combinations, optimization of dose, duration, vehicle, and adherence, measures to improve drug access and reduce protected fungal burden in high-barrier disease, and prevention of reinfection from reservoirs. The proposed framework may support more rational antifungal use and reduce unnecessary escalation; however, it is based on narrative synthesis rather than a systematic review or prospective validation. Additional studies are needed to determine how such structured clinical approaches affect clinical outcomes, relapse rates, antifungal exposure, and resistance emergence in real-world dermatology practice.

PMID 42505597
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PubMedOrganic letters2026-07-27

Divergent Access to Chiral Pyrrolidinone-Fused 4H-Pyrans and Pyridines Via Organocatalytic Asymmetric Decarboxylative Addition-Annulation of β-Keto Acids with 2,3-Dioxopyrrolidines.

Li Tianxing T, He Tianyu T, Meng Weiyue W, Jin Hui H et al.

We disclose an unprecedented organocatalytic asymmetric decarboxylative Michael addition of β-keto acids to 2,3-dioxopyrrolidines, enabling the efficient assembly of chiral pyrrolidinone-fused [3,4-b]-4H-pyrans and [3,4-b]-pyridines. The reaction affords chiral pyrrolidinone-tethered 1,5-dicarbonyl intermediates in high yields with excellent regio- and enantioselectivities. Acid-promoted intramolecular cyclization of these adducts provides enantioenriched pyrrolidinone-fused [3,4-b]-4H-pyrans without erosion of enantiopurity, whereas cyclocondensation with hydroxylamine hydrochloride delivers diverse pyrrolidinone-fused [3,4-b]-pyridines. Notably, this protocol is compatible with a one-pot tandem process and gram-scale synthesis.

PMID 42504541
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PubMedToxins2026-07-27

Enhanced Protection Against Toxicity of Nemopilema nomurai Venom Using a PEG-EGCG/Tetracycline Hydrochloride Micellar Nanocomplex.

Li Jie J, Hu Yanan Y, Qian Yunfeng Y, Luo Sai S et al.

Jellyfish stings are the most common type of marine life injuries. However, at present, the treatment measures against jellyfish stings are mostly empirical and supportive, with uncertain therapeutic outcomes, and there is a lack of specific antidotes based on the toxic mechanism of jellyfish venom in clinical practice. In our previous study, polyphenol epigallocatechin-3-gallate (EGCG) was found to neutralize the toxicity of jellyfish Nemopilema nomurai venom (NnV) in vivo and in vitro. Herein we further demonstrated that EGCG exerted its antagonistic effect against NnV through inhibiting the oxidative stress, pro-apoptotic proteins, and systemic inflammatory responses. Subsequently, we constructed a polyethylene glycol (PEG)-EGCG/tetracycline hydrochloride (HTC) co-loaded micellar nanocomplex in order to enhance the stability and bioavailability of EGCG in vivo, which successfully integrated the membrane-repair function of PEG, the enzyme inhibitory effect of HTC and the antioxidant properties of EGCG. Notably, this micellar nanocomplex demonstrated significant protective effects against both functional damage and pathological alterations in a non-lethal NnV-envenomed mouse model. When administered 1 h after NnV envenomation, EGCG (40 mg/kg), HTC and PEG-EGCG (containing 40 mg/kg EGCG) only partially improved abnormal blood biochemical indicators and moderately alleviated histopathologic damage, and PEG-EGCG/HTC containing merely 8 mg/kg EGCG completely mitigated the toxic reactions in envenomed mice. In the preventive regimen, the administration of EGCG, HTC or PEG-EGCG 30 min before exposure showed no significant improvement in abnormal blood biochemical indicators and histopathologic damage, while PEG-EGCG/HTC could still significantly improve the functional impairments and histopathologic damage of the heart and liver in NnV-envenomed mice. These findings suggest the clinical translational potential of PEG-EGCG/HTC against jellyfish envenomation.

PMID 42506698
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PubMedAnalytical methods : advancing methods and applications2026-07-27

Smartphone-based fluorescence sensing platform for tetracycline determination based on a high quantum yield europium metal-organic framework with a dual-ligand strategy.

Cheng Shuang S, Song Jintian J, Wen Yue Y, Xu Yijia Y et al.

Ultrasensitive and visual detection of tetracyclines (TCs) is of great significance to public health and environmental safety. Herein, we synthesized a dual-ligand europium metal-organic framework (Eu-phen-MOF) via a one-step solvothermal method for the fluorescence detection of TCs. Compared with the Eu-MOF without 1,10-phenanthroline, Eu-phen-MOF exhibits superior stability, lower LOD and higher quantum yield. It delivers superior TC sensing performance and anti-interference, enabling high-accuracy detection with limits of 152.0 nmol L-1, 249.4 nmol L-1, 171.0 nmol L-1 and 277.7 nmol L-1 for tetracycline (TC), oxytetracycline (OTC), doxycycline hydrochloride (DOX), and chlortetracycline (CTC), respectively. Eu-phen-MOF was used for the quantitative detection of TC, OTC, DOX, and CTC in real samples (milk, eggs, and river water) and recoveries ranging from 94.64% to 105.37% were achieved. Finally, a portable fluorescence sensing platform integrating a smartphone and the Eu-phen-MOF fluorescent hydrogel was constructed, enabling convenient, rapid, and low-cost detection of TCs. This work not only highlights the significance of the dual-ligand strategy for fabricating an efficient TC sensor, but also develops a rapid and visual method for TC detection.

PMID 42504902
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