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alfuzosin hydrochloride + solifenacin (Solitral)

✓ Approved

Ranbaxy Laboratories Limited · ADRA1A · 小分子

什么是 alfuzosin hydrochloride + solifenacin？

alfuzosin hydrochloride + solifenacin 是一种小分子，由Ranbaxy Laboratories Limited研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Solitral
公司Ranbaxy Laboratories Limited
药物类别小分子
分子靶点ADRA1A, CHRM3
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Ranbaxy Laboratories Limited

作用机制

分子靶点

alfuzosin hydrochloride + solifenacin 作用于 2 个分子靶点：

ADRA1Aadrenoceptor alpha 1A (ALPHA1AAR, ADRA1C)
CHRM3cholinergic receptor muscarinic 3 (HM3, EGBRS)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

alfuzosin hydrochloride + solifenacin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Reproductive system and breast disordersBenign prostatic hyperplasia✓ Approved

相关研究文献

PubMedMolecular therapy : the journal of the American Society of Gene Therapy2026-09-11

D-Amino Acid Prodrug DLMEH Activates mTORC1 via Sestrin2 to Restore Muscle Protein Synthesis in Sarcopenia.

Shim Jae Ho JH, Lee Ji Yeon JY, Ahn Byung Kook BK, Woo Sang Woo SW et al.

Sarcopenia, the age-related loss of skeletal muscle mass and function, lacks FDA-approved pharmacotherapy. The mechanistic target of rapamycin complex 1 (mTORC1), activated by leucine via Sestrin2, is the master regulator of muscle protein synthesis, but L-leucine suffers from rapid catabolism and poor bioavailability. Here, we report D-leucine methyl ester hydrochloride (DLMEH), a metabolically stabilized prodrug incorporating D-stereoisomer conversion, methyl esterification, and hydrochloride salt formation. Three orthogonal biophysical methods demonstrate that DLMEH directly binds Sestrin2 (Kd 28.3 μM), equivalent to L-leucine. Sestrin2 siRNA knockdown and rapamycin co-treatment confirm Sestrin2-dependent, mTORC1-specific activation. In human primary myotubes, DLMEH (100 μM) restores dexamethasone-suppressed protein synthesis by 58.2%, significantly exceeding L-leucine (800 μM, 28.5%). In a rat dexamethasone-induced atrophy model, intravenous DLMEH (100 mg/kg/day, 14 days) preserves gastrocnemius mass (19.3% rescue), grip strength (90% of normal), and treadmill endurance (85% of normal), all superior to oral L-leucine. RNA-seq reveals 41.7% reversal of dexamethasone-induced transcriptomic changes with enrichment in mTOR signaling, ribosome biogenesis, and oxidative phosphorylation. Safety profiling establishes NOAEL at 2000 mg/kg with therapeutic index greater than 30. DLMEH represents a first-in-class Sestrin2-targeting mTORC1 activator for sarcopenia.

PMID 42723280
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PubMedAnnals of medicine and surgery (2012)2026-09-11

Neuroprotective effects of chrysin in a rat model of Parkinson's disease.

Moradi Sana S, Rajaei Farzad F, Darabi Shahram S

Chrysin, or 5,7-dihydroxyflavone, is a flavonoid with antioxidant, anti-inflammatory, and anti-apoptotic effects, which are significant in Parkinson's disease. The objective of the study is to investigate the protective effects of chrysin in Parkinson's disease. Wistar strain rats were divided into three groups: treatment (receiving chrysin before and after OHDA-6 injection), control (injected with 0.9% normal saline into the left striatum), and lesion (injected with 0.9% normal saline and OHDA-6 into the left striatum). Behavioral testing with apomorphine hydrochloride was conducted 1 week before and 4 weeks after surgery. For histological examination, black blocks of tissue were prepared, and Nissl staining was used for neuron counting. Microscopic studies were performed by capturing images of the slides. In the behavioral test conducted after apomorphine injection and before surgery, there was no significant difference in the number of rotations among the control, lesion, and treatment groups. However, after surgery, this difference was significant between the lesion and treatment groups (P ≤ 0.05). In Nissl staining, a significant difference in the number of neurons in the substantia nigra was observed between the treatment and lesion groups. According to the results obtained from this study, chrysin prevented the neurodegeneration caused by OHDA-6, leading to a lower rate of mortality in the neurons of the midbrain substantia nigra.

PMID 42724797
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PubMedPhysical chemistry chemical physics : PCCP2026-09-11

Synergistic non-metal doping and heterojunction engineering in B-doped Bi2MoO6/MIL-88B(Fe) for efficient photocatalytic tetracycline degradation under visible light.

Song Linjie L, Chigan Tonglin T, Ma Jingfang J, Hui Yaguang Y et al.

Among diverse photocatalytic materials, Bi2MoO6 (BMO) has attracted significant attention by virtue of its unique layered structure, narrow bandgap, and tunable energy band configuration. However, its practical application was hindered by inefficient separation of photogenerated carriers and inadequate visible-light utilization. To overcome these limitations, synergistic modification through elemental doping and heterojunction construction was implemented in this study. Herein, boron-doped Bi2MoO6 (B-BMO)/MIL-88B(Fe) composites with Z-scheme heterojunctions were fabricated via a facile solvothermal method. Boron doping effectively modulated the energy band structure, reduced the bandgap, enhanced the light absorption capacity, and induced lattice distortion. Meanwhile, the staggered energy band alignment between MIL-88B(Fe) and B-BMO facilitated Z-scheme heterojunction formation, which strengthened charge carrier separation while maintaining a strong redox capability. Under visible-light irradiation, the B-BMO/MIL-88B(Fe) composite achieved 91.26% degradation efficiency for tetracycline hydrochloride (TCH) within 120 min, with a reaction rate constant of 0.0129 min-1. Compared to pristine B-BMO, the degradation rate improved by 10.2%. The composite maintained over 80% degradation efficiency after three consecutive cycles and retained favorable activity after five successive cycles. Sacrificial agent experiments identified superoxide anion radicals (˙O2-) as the dominant reactive species during the degradation process. Liquid chromatography-mass spectrometry (LC-MS) analysis enabled identification of degradation intermediates, leading to the proposal of a plausible TCH degradation pathway. This study provides insights into subsequent non-metallic element doping and heterojunction engineering strategies for BMO-based photocatalysts.

PMID 42723574
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-09-10

Manipulating the Buried Interfacial Dipole: The Role of Pyridine Acetate-Hydrochloride Isomers in Carbon-Based Perovskite Solar Cells Prepared in Air.

Shi Yifei Y, Gong Jianwen J, Wang Xu X, Hu Shuming S et al.

The buried interface between tin oxide and perovskite is the key factor for non-radiative recombination and energy level mismatch, which limits the performance and stability of perovskite solar cells. This work explores a simple interfacial dipole engineering strategy, where three pyridine acetate-hydrochloride (PAH) isomer molecules (2-PAH, 3-PAH, and 4-PAH) are used to modify the SnO2 electron transport layer. The 3-PAH-modified layer can control the work function of tin oxide, achieve the best energy level alignment, and improve the crystallization quality of the perovskite film, thereby effectively suppressing interface recombination and promoting electron extraction. All the devices are prepared in air, and the device optimized by 3-PAH achieved a champion energy conversion efficiency of 14.31% and demonstrated stability. Subsequent to an 800 h placement in an N2 glove box or a 340 h exposure to an air environment, the unencapsulated target devices that were modified by 3-PAH maintained 80.7% and 81.3% of their initial efficiency.

PMID 42717680
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PubMedAAPS PharmSciTech2026-09-10

Ethosomal Gel-Based Topical Delivery of Albendazole Hydrochloride for Psoriasis: In Vitro and In Vivo Evaluation.

Rençber Seda S, Karpuz Merve M, Ünlü Çakıcı Büşra B, Karayıldırım Çinel Köksal ÇK et al.

This study aimed to develop an albendazole hydrochloride (ALB)-loaded ethosomal gel for topical psoriasis treatment. ALB-loaded ethosomes were prepared and characterized to select the optimal formulation, which was subsequently incorporated into an HPMC-based hydrogel. The ethosomal gel was evaluated through physicochemical, in vitro and in vivo studies. The optimized ethosomal formulation prepared by the film hydration method exhibited a mean vesicle size of 490.00 ± 0.14 nm, polydispersity index of 0.31 ± 0.14, zeta potential of -22.85 ± 2.28 mV and encapsulation efficiency of 23.90 ± 1.43%. After incorporation into the hydrogel matrix, the Gel4-E3/ALB formulation demonstrated appropriate mechanical properties (hardness 8.42 ± 0.70 mN, adhesiveness - 16.85 ± 1.50 mN·s, elasticity 0.89 ± 0.07, cohesiveness 1.14 ± 0.09) and shear-thinning behavior, ensuring ease of application and skin retention. A controlled release pattern was observed, consistent with the controlled-release behavior expected from ethosomal hydrogel systems. Radiolabeling studies demonstrated high labeling efficiency (> 95%). In vitro cytotoxicity evaluation indicated that the optimized ethosomal gel formulation was non-toxic. In vivo studies performed in an imiquimod (IMQ)-induced psoriatic mouse model revealed significant therapeutic improvement in the Gel4-E3/ALB-treated group compared with the IMQ control, with visible reduction in erythema, scaling, and skin thickening after the fifth day of treatment. Hematological analysis showed no adverse effects associated with the formulation. Histopathological evaluation confirmed the reduction in epidermal hyperplasia and inflammatory cell infiltration in the treated group. The developed ALB-loaded ethosomal gel represents a safe and promising topical therapeutic system for psoriasis management.

PMID 42717176
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PubMedFrontiers in pharmacology2026-09-10

Spatial inequalities and contextual correlates of methylphenidate dispensing in Jiangsu Province, China.

Sun Yao Y, Lu Miao M, Zhang Yong Y, Xu Jin J et al.

Understanding geographic inequalities in psychotropic medication dispensing is important for improving health equity and informing place-based pharmaceutical management. This study characterized the spatiotemporal distribution of methylphenidate hydrochloride extended-release tablet dispensing in Jiangsu Province, China, from 2019 to 2023 and examined its socioeconomic and education-related correlates. Annual county-level dispensed tablet volumes were analyzed using Getis-Ord Gi* hot-spot analysis, standard deviational ellipses, and weighted-centroid analysis. Prefecture-level contextual correlates were examined using annual Lasso models interpreted with SHAP. The proportion of county-level units with zero recorded dispensing decreased from approximately 52%-36%, while the proportion with annual volumes exceeding 20,000 tablets increased from 7% to 20%. Southern Jiangsu consistently exhibited higher dispensing volumes than Northern Jiangsu, with Central Jiangsu generally occupying an intermediate position. Getis-Ord Gi* identified localized high-value concentrations mainly in Southern and parts of Central Jiangsu. The standard deviational ellipse area increased by 23.1%, while the weighted centroid remained in south-central Jiangsu. Within the annual Lasso models, predictive importance was allocated mainly to economic-demographic indicators in 2019-2020 and more strongly to education-related indicators in 2021-2023. The findings support geographically differentiated monitoring of medication access, dispensing patterns, and prescribing quality.

PMID 42718491
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