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alfuzosin hydrochloride + solifenacin (Solitral)

✓ Approved

Ranbaxy Laboratories Limited · ADRA1A · 小分子

什么是 alfuzosin hydrochloride + solifenacin？

alfuzosin hydrochloride + solifenacin 是一种小分子，由Ranbaxy Laboratories Limited研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Solitral
公司Ranbaxy Laboratories Limited
药物类别小分子
分子靶点ADRA1A, CHRM3
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Ranbaxy Laboratories Limited

作用机制

分子靶点

alfuzosin hydrochloride + solifenacin 作用于 2 个分子靶点：

ADRA1Aadrenoceptor alpha 1A (ALPHA1AAR, ADRA1C)
CHRM3cholinergic receptor muscarinic 3 (HM3, EGBRS)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

alfuzosin hydrochloride + solifenacin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Reproductive system and breast disordersBenign prostatic hyperplasia✓ Approved

相关研究文献

PubMedPharmaceuticals (Basel, Switzerland)2026-10-27

Repurposing α-Blockers Alfuzosin and Doxazosin for Cancer Therapy: Integrated Experimental, Mechanistic, and Molecular Docking Studies.

Alanazi Mohammed M MM

Background/Objectives: Drug repurposing represents a promising strategy for determining new anticancer drugs through exploration of new therapeutic applications of clinically used drugs. Alfuzosin and doxazosin are α-adrenergic blockers clinically used for the treatment of benign prostatic hyperplasia (BPH). Growing evidence suggests that α-blockers may have anticancer properties. The purpose of this study was to investigate the potential of alfuzosin and doxazosin as repurposed anticancer medicines and to study their potential mechanisms of action, specifically their effects on apoptosis, cell cycle progression, enzyme panel, and cancer cell proliferation. Methods: The cytotoxicity of alfuzosin and doxazosin was investigated against multiple cancer cell lines using the MTT assay, with sunitinib used as a positive control. The enzyme inhibition effects of both drugs against potential target proteins were investigated, followed by cytometric analysis to determine the effects of the drugs on cell cycle progression and apoptosis in MCF-7 breast cancer cells. Molecular docking studies were also conducted to investigate possible interactions with the active site of EGFR. Results: Both alfuzosin and doxazosin demonstrated promising antiproliferative activity against cancer cells, with alfuzosin showing comparatively lower toxicity toward normal cells. The drugs also revealed potent inhibitory activity against the studied target proteins, pointing to their potential effect as multi-target inhibitors. Cell cycle analysis revealed that both drugs inhibited cell cycle progression at the G2/M phase in MCF-7 cells. Following treatment with alfuzosin and doxazosin, both drugs significantly induced apoptosis, with total apoptotic populations reaching 39.48% and 35.61%, respectively, compared with only 2.77% in untreated MCF-7 cells. Molecular docking studies further indicated the ability to interact with key amino acids within the EGFR active site. Conclusions: The present findings demonstrate the potential repurposing of alfuzosin and doxazosin as anticancer agents and offer a good background for further mechanistic and in vivo investigations.

PMID 42943216
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PubMedInternational journal of molecular sciences2026-10-27

Influence of UV Irradiation Source and of Carboxylic Acid Additives on the Kinetics of Photodegradation of Five Tricyclic Antidepressant Drugs in Aqueous Medium.

Ciuca Maria D MD, Racovita Radu C RC

Use of antidepressant medication has increased substantially nowadays. Investigations of their photostability in aqueous environment are therefore needed both for shelf life assessment of liquid pharmaceutical formulations and for development of wastewater remediation technologies. In this work, the comparative kinetics of photodegradation of five tricyclic antidepressants (TCAs) in aqueous solution was studied under direct photolysis using UVA, UVB, and UVC sources, respectively. A gas chromatography-mass spectrometry (GC-MS) method was developed and validated intra-laboratory for accurate quantification of the five TCAs (amitriptyline hydrochloride AMI, doxepin hydrochloride DOX, imipramine hydrochloride IMI, clomipramine hydrochloride CLO, trimipramine maleate TRI) in the course of photodegradation. UVC photolysis yielded the highest rates of photodegradation, followed by UVB and then UVA. The molecular structure and UV absorption characteristics of individual TCAs were shown to influence photodegradation rates as well. Specifically, heteroatoms (N, O, Cl) present in the molecule and redshifted UV absorption bands increased photosensitivity typically in the order: AMI < IMI < TRI < CLO < DOX. The effect that some mono- and polycarboxylic acids dissolved in the aqueous solutions had on TCA photodegradation kinetics under UVC was also investigated and, for most TCAs, rates were faster and durations required for their complete photodegradation decreased generally in the order: citric > oxalic > maleic > benzoic acid. Furthermore, citric acid was reused for a second round of TCA photodegradation and showed rate enhancement effects very close to those exhibited in the first round.

PMID 42941717
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PubMedPharmaceutics2026-10-27

Impact of Process Parameters on the Quality Attributes of High-Dose Metformin Hydrochloride Film-Coated Tablets.

Duc Nguyen Tan NT, Nguyen Dang-Khoa DK, Liet Huynh Thanh HT, Thiet Nguyen Huynh NH et al.

Background/Objectives: Formulating high-dose metformin hydrochloride film-coated tablets is challenging due to the poor flowability and compressibility inherent to high drug loading. To ensure process robustness and consistent product quality, understanding the impact of manufacturing variables is crucial. This study evaluated the effects of key process parameters on the quality attributes of 1000 mg metformin hydrochloride tablets to establish optimal processing conditions for reliable production. Methods: The manufacturing process, comprising wet granulation, compression, and film coating, was investigated to evaluate the influence of key process parameters on tablet quality attributes. Granules were characterized for bulk density, tapped density, and compressibility index. Core tablets were evaluated for physical appearance, weight variation, hardness, and dissolution at a 45 min sampling point across various compression forces and tableting speeds. Film-coating efficiency was assessed based on coating quality, dissolution behavior, and stability. Favorable manufacturing conditions were empirically identified through single-variable optimization and statistical analysis. Results: Wet granulation conducted at a chopper speed of 1400 rpm for 7 min yielded granules with the lowest compressibility index (11.88%), demonstrating significantly improved flowability. Compression at a force of 10 kN and a speed of 40 rpm produced core tablets with acceptable appearance, robust hardness (7.06-7.37 kP), and complete drug release (100%). Tablet hardness was governed by a strong interaction between compression force and tableting speed (partial η2 = 0.929, p < 0.001) rather than by either factor alone: at 20 kN, hardness collapsed sharply once tableting speed reached 30 rpm, coincident with mild capping, identifying this force-speed combination as a process-failure condition. For the coating process, maintaining a tablet bed surface temperature of 40 °C ensured optimal coating uniformity without compromising product quality. Dissolution profile comparison against a coated reference product in the primary dissolution medium (pH 6.8) yielded f2 similarity values above 50 for all eight core tablet conditions, and stability testing under accelerated/thermal-stress conditions (up to 65 °C) confirmed maintained dissolution, assay, and related-substance (1-cyanoguanidine) compliance for both the test and reference products. The optimized manufacturing conditions successfully produced film-coated tablets that conformed to all predetermined quality specifications. Conclusions: Manufacturing process parameters significantly influenced the quality attributes of high-dose metformin hydrochloride film-coated tablets. Proper selection and control of these processing conditions ensured consistent granule properties, optimal tablet quality, and enhanced manufacturing robustness.

PMID 42942796
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PubMedPharmaceuticals (Basel, Switzerland)2026-10-27

Propolis vs. Chlorhexidine Gluconate and Benzydamine Hydrochloride on Sequelae After Third Molar Surgery: A Randomized Controlled Trial.

Bayramoğlu Zeynep Z, Halıcı Zekai Z, Özakar Emrah E, Sevinç Özakar Rukiye R

Background. Impacted lower third molar surgery is characterized by postoperative sequelae such as pain, edema, and trismus. While chlorhexidine (CHX) is the gold-standard antiseptic, its side effects prompt the search for natural alternatives. The aim of this study is to examine the effects of propolis gargle on wound healing following third molar surgery and to compare it with chlorhexidine gluconate and benzydamine hydrochloride (CHX+BENZ). Methods. In this prospective, randomized, double-blind, active-controlled trial, 52 patients were assigned to 3% Propolis (n = 24) or 0.12% CHX+BENZ (n = 28) groups. Mouthwashes were applied twice daily from postoperative days 2 to 7, and pain (VAS), edema, and trismus were evaluated preoperatively and on days 2 and 7. Statistical significance was set at p < 0.05. Results. No significant differences were found in pain and trismus (p > 0.05). However, the Propolis group exhibited significantly lower edema on day 2 compared to the CHX+BENZ group (p = 0.004), and complication rates were also notably lower in the Propolis group. Conclusions. The novel, non-alcoholic 3% propolis mouthwash demonstrated no statistically significant differences in short-term pain and trismus outcomes compared to CHX+BENZ, alongside a statistically smaller day-2 facial edema measurement. While these findings support its potential as a supportive oral rinse following third molar surgery, adequately powered prospective trials are warranted to validate these preliminary observations before routine clinical adoption.

PMID 42943312
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PubMedPeerJ2026-10-27

Pulsed electric field-mediated elimination of yeast [PSI +] prion is variant dependent and affects cell growth dynamics.

Jonutyte-Trembo Neda N, Versockienė Justina J, Katauskas Gvidas G, Novickij Vitalij V et al.

Yeast Saccharomyces cerevisiae is a widespread model system in which mechanisms of prion induction and elimination have been identified. New and safe substances and methods are being sought to eliminate prions from cells. In this research, we applied guanidinium hydrochloride (GuHCl) alone and in combination with pulsed electric field treatment against [PSI +] prion. The analysis of cell culture optical density and doubling time showed that the method of [PSI +] prion elimination increases cell doubling time, with combined treatment having a more severe impact on cell growth than GuHCl treatment alone. Additionally, we found that both elimination methods can impact the optical culture density achieved by [psi -] cells. However, the cells in which the [PSI +] prion has been eliminated by GuHCl alone are able to reach the same optical density as unaffected [psi -] cells and a higher optical density than the affected [psi -] cells by GuHCl alone. These findings suggest that the presence and subsequent removal of the [PSI +] prion influence early exponential growth, revealing lasting effects on cell growth dynamics that are distinct from previously reported effects on stationary phase survival. This work highlights how prion elimination strategies, including chemical and electric field treatments, can impact post-curing growth behavior in yeast cells.

PMID 42936698
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PubMedAdvanced materials (Deerfield Beach, Fla.)2026-10-27

Threo-Chiral Cation Additive Enables Ordered Lattice Adsorption and Enhanced Operational Stability of Perovskite Photovoltaics.

Gao Yilin Y, Liu Guozhen G, Xu Bingying B, Zhang Yinjuan Y et al.

Chiral molecular engineering is an effective strategy to modulate crystallization and mitigate nonradiative defects in perovskite solar cells (PSCs). However, unconstrained bond rotation often leads to spatial mismatch between chiral molecules and the perovskite lattice, hindering effective defect coordination. Herein, we introduce threo-chiral cation additive of (2S,3R)-2-amino-3-hydroxybutanamide hydrochloride (ThrA) to achieve precise perovskite lattice regulation. Benefiting from methyl‑induced steric hindrance originating from its dual chiral‑center threo‑configuration, ThrA acquires a conformationally locked rigid stereostructure and further facilitates thermodynamically‑favored parallel‑to‑lattice multi‑site synergistic adsorption via hydrogen bonding and Pb coordination. Such stereoselective "lock-and-key" interaction reduces lattice surface energy, guides preferential (100) crystal growth, and simultaneously suppresses lattice distortion and ion migration. Consequently, the ThrA-modified inverted PSCs achieve a champion efficiency of 26.68% (certified 26.31%), while 65 cm2 large-area module delivers a promising PCE of 22.78% (certified 22.12%), representing one of the outstanding certification efficiencies for perovskite modules of comparable size. Unencapsulated devices retain 90% of their initial efficiency after 1000 h thermal aging (ISOS-D-2) and maintain 92% performance after 2000 h continuous maximum power point tracking (ISOS-L-2). This work demonstrates that the stereostructure of additive is decisive for precise perovskite crystallization modulation, providing advanced stereochemical strategy toward high-efficiency and ultra-stable perovskite photovoltaics.

PMID 42935295
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