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AD-220 (AD 220A / AD 220 / AD220)

✓ Approved

Addpharma · 小分子 · 小分子

什么是 AD-220？

AD-220 是一种小分子，由Addpharma研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名AD 220A, AD 220, AD220
公司Addpharma
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Addpharma

治疗适应症

AD-220 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Metabolism and nutrition disordersHyperlipidaemia✓ Approved
Metabolism and nutrition disordersHypercholesterolaemiaPreclinical

相关研究文献

PubMedAnimals : an open access journal from MDPI2026-10-27

Histopathological Assessment of Diseases in Ornamental Fish from 2019 to 2023 in Minas Gerais State, Brazil.

Marcelino Sóstenes Apolo Correia SAC, Gorza Leonardo Lima LL, Carneiro Sarah Portes SP, Nicolino Rafael Romero RR et al.

The present study aimed to investigate the anatomopathological findings in ornamental fish from multiple sources, submitted to the diagnostic service at the Veterinary School of the Universidade Federal de Minas Gerais (UFMG) between 2019 and 2023. Macroscopic and histopathologic examinations were conducted, and the resulting data regarding disease processes were analyzed through a descriptive observational approach. A total of 635 ornamental fish were studied, with a predominance of exotic fish species. The fish were sourced from ornamental fish farms (37.00%; 235/635), shopkeepers (32.44%; 206/635), facilities (18.43%; 117/635), hobbyists (8.66%; 55/635), and wholesalers (3.46%; 22/635). Among the analyzed cases, 50.39% (320/635) presented relevant anatomopathological findings. The main categories of diseases detected were parasitic (56.25%; 180/320), bacterial (20.31%; 65/320), fungal/oomycete (7.50%; 24/320), viral (7.18%; 23/320), neoplastic (1.88%; 6/320), congenital (2.50%; 8/320), and metabolic (0.94%; 3/320). The main parasites found were unidentified digeneans (15.45%; 34/220), presumed Centrocestus formosanus (14.55%; 32/220), monogeneans (13.18%; 29/220), presumed Tetrahymena spp. (8.18%; 18/220), and presumed Epistylis (6.36%; 14/220). There were diagnoses of undocumented diseases in Brazil, such as the suggestive cases of Ichthyophonus spp. In addition, novel potential pathogen-host associations in the country were documented, such as Pleistophora sp. in Carnegiella strigata. This study presents findings that can contribute to determining disease frequency and identifying pathogens based on microscopic lesions.

PMID 42939095
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PubMedMicromachines2026-10-27

A 220 GHz Integrated Sensing and Communication System Based on Orthogonal-Polarization Multiplexing.

Zhang Jicong J, Tang Zhankun Z, Shi Shuhang S, Liu Ke K et al.

A 220 GHz integrated sensing and communication (ISAC) system based on orthogonal-polarization multiplexing is presented for simultaneous high-speed wireless communication and radar ranging. To achieve broadband operation, low insertion loss, and high polarization isolation, a dual-symmetric reverse-coupled orthomode transducer (OMT) is designed and fabricated. The OMT covers 170-260 GHz, with a measured return loss better than 15 dB and polarization isolation exceeding 45 dB, while relaxing the required fabrication tolerance to 10 μm. The OMT is integrated with solid-state frequency-conversion circuits, amplifiers, waveguide components, and a dual-polarized antenna to construct a dual-polarization transmit front end. The resulting system achieves polarization isolation exceeding 25 dB between the communication and radar channels over 204-222 GHz, together with a receiver noise figure of 9.8 dB at 220 GHz. Using coherent-reference techniques and real-time baseband processing, the system achieves a data rate of 2 Gbit/s over a distance of 0.25 m, with a bit error rate below 5×10-8. Radar ranging experiments using a single corner-reflector target at distances of 0.25 and 0.40 m yielded a maximum observed absolute ranging error of 1 cm. These results demonstrate the feasibility of orthogonal-polarization multiplexing for jointly supporting high-speed THz communication and centimeter-level radar sensing.

PMID 42943866
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PubMedCurrent issues in molecular biology2026-10-27

Integrative Single-Cell Transcriptomic Analysis Identifies Candidate Endothelial Activation Signatures in Atopic Dermatitis.

Cao Fang F, Zhang Hui H, Guo Cui C, Guo Jing J

Background: Endothelial activation is a recognized histological feature of atopic dermatitis (AD), but its transcriptional programs remain incompletely characterized. Methods: We reanalyzed public single-cell RNA-seq data from the skin of five patients with AD and four healthy donors using AD-associated gene set scoring, CellChat, endothelial hdWGCNA and pseudotime ordering, and examined candidate genes with eight machine learning classifiers and SHAP in public bulk transcriptomes of lesional and non-lesional AD skin. Results: Inferred intercellular interactions were more numerous in AD (1348 vs. 1111), with COLLAGEN, CD99 and MIF showing the largest gains in communication strength. Differences in AD-associated gene set scores between AD and healthy endothelial cells were small and inconsistent between scoring approaches. Among seven endothelial modules, Endo7, an NF-κB-responsive immediate-early module containing SELE, ICAM1, IRF1 and NFKBIA, overlapped most strongly with the AD gene set (10 genes; approximately 30-fold enrichment). AD endothelial cells were concentrated at intermediate pseudotime positions (Cohen's d = 0.334). In bulk skin, classifiers based on 14 LASSO-selected genes separated lesional from non-lesional AD skin in a small test set (AUC 0.70-0.98; likely optimistic estimates, as feature selection preceded the training-test split and paired samples from the same patients may span both partitions), with SELE, TOP2A and IRF1 ranked highest by SHAP. Conclusions: This hypothesis-generating analysis identifies AD-associated endothelial activation signatures and candidate genes that require confirmation in independent, clinically characterized cohorts and experimental studies.

PMID 42939577
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PubMedBiomolecules2026-10-27

Integrated Multi-Omics Analysis Reveals ACO2 as an Oxidative-Stress-Related Biomarker in Alzheimer's Disease.

Dou Wenbo W, Chen Xue X, Hong Hang H, Liu Qiong Q et al.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory impairment. Oxidative stress plays an important role in disease progression in AD. However, the molecular mechanisms underlying oxidative stress in AD remain unclear and reliable biomarkers for its detection have not been identified. In this study, bioinformatics analyses integrating differential expression analysis and weighted gene co-expression network analysis were performed to identify oxidative-stress-related differentially expressed genes. Using machine learning algorithms, ACO2 was identified as a significantly downregulated hub gene associated with AD. Single-cell transcriptomic analysis further showed markedly reduced ACO2 expression levels in hippocampal neurons of patients with AD. To validate these findings, proteomic analysis, quantitative real-time polymerase chain reaction (qPCR), and Western blotting were performed in a mouse model of AD. These results confirmed decreased ACO2 mRNA and protein expression levels in the hippocampus. Consistently, qPCR analysis of peripheral blood samples from patients with AD revealed significantly reduced ACO2 expression levels compared to those in healthy controls. Collectively, these findings identified ACO2 as an oxidative-stress-related biomarker associated with AD and suggested its potential value as an AD-related candidate biomarker.

PMID 42939687
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PubMedGenes2026-10-27

Multi-Cohort Transcriptomic Integration Identifies Overlapping Immune and Antigen-Presentation Features in Alzheimer's Disease and Hashimoto's Thyroiditis.

Zhong Shuting S, Xie Guanfeng G, Zhang Zhaohui Z

Thyroid disorders and Alzheimer's disease (AD) have been linked epidemiologically, but whether AD brain tissue and thyroid tissue affected by Hashimoto's thyroiditis (HT) share molecular features remains unclear. Differential expression was estimated in AD (GSE122063) and HT (GSE138198) discovery cohorts using limma, with donor-level blocking and adjustment for age, sex and post-mortem interval where available. Shared genes were tested against chance within the genes measured in both cohorts, separately for each direction of change; characterized by enrichment analysis; related to marker-based cell-state scores; and evaluated in two AD cohorts, three thyroid cohorts including one with concurrently collected normal thyroid (GSE165724), and a single-nucleus AD dataset (GSE138852). The discovery analyses identified 3593 AD- and 3806 HT-associated genes. The overlap was direction-specific: genes upregulated in both diseases exceeded chance (117 vs. 83.2 expected; p = 8.9 × 10-5), whereas the other direction combinations did not. Co-upregulated genes were enriched for MHC class II antigen presentation (FDR = 0.004), complement (FDR = 0.002), microglial activation (FDR = 0.017) and T-cell activation (FDR = 1.7 × 10-4), and recurred in two independent thyroid datasets and the within-study LT+ versus LT- comparison, with less consistent, region-dependent recurrence in AD cohorts. This shared component tracked immune cell-state signals-glial/myeloid activation in AD and lymphocytic infiltration in HT. Fourteen co-upregulated genes, including ITGAX, CD22 and BST2, met prespecified recurrence and detectability criteria. AD brain tissue and thyroid tissue affected by HT exhibit a co-upregulated immune and antigen-presentation transcriptional program that reflects immune activation in both tissues. These overlapping features are associative and do not establish a causal relationship between AD and HT.

PMID 42938377
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PubMedBiomolecules2026-10-27

Deubiquitinating Enzymes in Alzheimer's Disease: From Protein Homeostasis to Diverse Pathological Processes.

Shi Xueying X, Chen Guilin G, Wang Xiufeng X, Ma Rong R et al.

Alzheimer's disease (AD) is a neurodegenerative disorder involving multiple pathological processes, including amyloid-β (Aβ) accumulation, tau pathology, impaired autophagy, mitochondrial dysfunction, neuroinflammation, and synaptic dysfunction. Deubiquitinating enzymes (DUBs) reverse ubiquitination and regulate protein stability, degradation, and cellular signaling. Although studies of DUBs in AD have largely focused on Aβ metabolism and tau homeostasis, accumulating evidence implicates DUBs in a broader range of AD-related processes, including autophagy, neuroinflammation, mitochondrial function, and synaptic function. Several DUBs have also been implicated in more than one of these processes, although these effects have often been identified in different experimental models. In this review, we summarize current knowledge of DUBs in major AD-related pathological processes and discuss the mechanisms through which individual DUBs may influence different aspects of AD pathology. We also discuss the limitations of current studies and the potential and challenges of targeting DUBs in AD.

PMID 42939748
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