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disopyramide

✓ Approved

Ethypharm Corp. · SCN5A · 小分子

什么是 disopyramide？

disopyramide 是一种小分子，由Ethypharm Corp.研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

公司Ethypharm Corp.
药物类别小分子
分子靶点SCN5A
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Ethypharm Corp.

作用机制

分子靶点

disopyramide 作用于 1 个分子靶点：

SCN5Asodium voltage-gated channel alpha subunit 5 (CMD1E, SSS1)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

disopyramide 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Cardiac disordersArrhythmia✓ Approved

相关研究文献

PubMedInternational journal of molecular sciences2026-10-27

Stable Strontium Distribution and Effects on Plants.

Seregin Ilya V IV, Kozhevnikova Anna D AD

Strontium (Sr) is a wide-spread alkaline earth metal that is similar to calcium (Ca) in its chemical properties, although it does not play the physiological role inherent to the latter. At low doses, Sr can stimulate plant growth and development. However, at elevated levels in the environment, it has a negative effect on many processes occurring in plant cells, leading to growth inhibition and reduced productivity. The majority of studies have been focused on the effects of radioactive Sr isotopes which produce additional toxic effects due to ionizing radiation, but the effects of stable Sr have not received enough attention. The current scoping review summarizes the data on the uptake mechanisms and transport pathways of stable Sr and examines the characteristic patterns of its distribution in plant tissues and organs. Available data on the effects of stable Sr on enzyme activity, mineral nutrition, photosynthesis, plant growth, and morphogenesis are analyzed. Understanding the transport pathways of Sr, as well as the factors determining its dual effects on plant growth and development, underlies the development of approaches used in biofortification and phytoremediation technologies. The review may be useful for researchers working on plant mineral nutrition, metal stress, and phytoremediation.

PMID 42942000
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PubMedLife (Basel, Switzerland)2026-10-27

Sex Differences in Freezing Behavior and Extinction Learning Among Wistar Rats Exposed to Social Isolation and 15 cGy GCRsim Space Radiation Both Alone and in Combination.

Luyo Zachary N M ZNM, Heerbrandt Riley S RS, Boden Alea F AF, Keumeni Frederique E E FEE et al.

Long-term space missions traveling beyond the Earth's magnetosphere will expose astronauts to prolonged periods of social isolation (SI) and exposure to space radiation (SR). Throughout these missions, astronauts will have to cope with these stressors and adapt to their environment to carry out mission objectives. It is known that SI and SR can impact mission performance and overall health. Additionally, behavioral stress responses can differ between sexes. However, the independent and interactive effects of SI and SR on fear behavior and extinction learning between sexes is unknown. This study compared freezing behavior and stress-induced hyperthermia (SIH) in female and male Wistar rats using a conditioned fear (CF) paradigm. Comparisons were made in SHAM-treated rats and in ground-based models of SI and SR alone and in combination (dual flight stressors (DFSs)). SHAM and SI females froze significantly more during shock training (ST), context re-exposure (CTX) and extinction learning (EXT) compared to their male counterparts, suggesting sex differences in fear learning and memory. There were minimal changes in freezing behavior between sexes in SR and DFS animals; however, SR and DFS females had significantly lower temperatures than their male counterparts. These findings suggest the presence of sex differences in stress responses, and that stress-based learning and memory can be differentially impacted by spaceflight hazards. Baseline differences suggest that males and female rats may have sex-specific characteristics attuned to their behavioral capacities or needs, whereas differences after exposure to spaceflight hazards suggest differences in stress vulnerability. In general, these data suggest that understanding within-sex alterations will be important for assessing the effects of spaceflight hazards on performance and developing mitigation strategies that may need to be tailored for males and females.

PMID 42942224
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PubMedAnimals : an open access journal from MDPI2026-10-27

Comparative Bioaccumulation of Mineral Elements in Soft Tissues, Shells, and Pearls of Sinohyriopsis cumingii (Lea, 1852) Cultured for Non-Nucleated, Visceral Mass-Nucleated, and Mantle-Nucleated Pearls.

Bah Ibrahim I, Gu Mengying M, Wang Meiyi M, Li Haibo H et al.

The triangle sail mussel Sinohyriopsis cumingii (Lea, 1852) is the world's leading producer of freshwater pearls. Mineral elements are key components of pearls and affect pearl quality, but their bioaccumulation patterns in the soft tissues, shells, and pearls of this species remain unclear. Inductively coupled plasma mass spectrometry was used to compare the bioaccumulation of essential major elements (Na, Mg, K, Ca), essential trace elements (Cr, Mn, Fe, Co, Ni, Cu, Zn, Se, Mo), and non-essential elements (Al, As, Sr, Ag, Cd, Ba, Tl, Pb) in the soft tissues, shells, and pearls of S. cumingii cultured for non-nucleated, visceral mass-nucleated, and mantle-nucleated pearls. Mg, K, Mn, Zn, and Ba were significantly more concentrated in soft tissues than in shells or pearls, whereas Ca and Sr showed the opposite trend (p < 0.05). Principal component analysis based on Zn, Ca, Mg, Sr, and Mn separated soft tissues from shells and pearls, while a second component based on Mo, Fe, Co, and Ni distinguished non-nucleated from visceral mass-nucleated and mantle-nucleated pearl mussels. Ca-Sr and Sr-Ba were consistently positively correlated in soft tissues across all three culture types (p < 0.05). Notably, Na was frequently involved in negative correlations between tissues: in mussels cultured for non-nucleated pearls, shell Na was negatively correlated with soft tissue K and pearl Na with soft tissue Ba (p < 0.05); in those cultured for visceral mass-nucleated pearls, soft tissue Na was negatively correlated with pearl Mn and Zn (p < 0.05); and in those cultured for mantle-nucleated pearls, pearl Na was negatively correlated with shell Zn (p < 0.05). Collectively, these findings elucidate mineral element bioaccumulation in pearl-producing S. cumingii.

PMID 42939162
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PubMedAngewandte Chemie (International ed. in English)2026-10-27

Operando Identification of the Active Phase in Sr-Promoted Lanthanum Cobaltite Perovskite-Derived Catalysts for Ammonia Decomposition.

Alkan Barış B, Duarte-Correa Liseth L, Teschner Detre D, Dembélé Kassiogé K et al.

Storing energy in molecular form, particularly hydrogen in carbon-free carriers such as ammonia, is considered a key strategy for future energy systems. The release of hydrogen via ammonia decomposition is a critical step in this context that requires scalable and economically viable catalysts. In this work, spray-flame synthesis (SFS) was employed to prepare La1- xSrxCoO3- δ (0≤ x ≤ 1) nanoparticles (≈ 10 nm), which serve as precursors for SrO-promoted Co/La2O3 catalysts prepared by exsolution. ESR, operando XRD, and ambient pressure photoelectron spectroscopy (APXPS) provide insights into dynamic interfacial restructuring of the catalysts under the harsh ammonia decomposition conditions. The catalysts contain 25 wt% Co and achieve a maximum hydrogen productivity of 108 mmo l H 2 ·gCo -1·min-1 at 500°C for the La0.75Sr0.25CoO3- δ-derived material. The coverage of La2O3 with SrO/Sr─OH species under reaction conditions inhibits the migration of La-based species, which block active Co sites in the absence of the promoter. An excess of Sr, however, promotes the growth of Co particles and reduces the exposed Co surface area. Beyond its structural role, operando APXPS reveals that SrO also influences reaction kinetics by facilitating NHx decomposition and weakening the binding strength of nitrogen, which is consistent with an electrostatic effect of SrO.

PMID 42935265
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PubMedLife (Basel, Switzerland)2026-10-27

Ultrasound Shear-Wave and Strain Elastography for Differentiating Morton's Neuroma from Intermetatarsal Bursitis.

Sussan Giovanni G, Corso Antonio A, Angelone Raimondo R, Negro Giacomo G et al.

Background: Ultrasound (US) is a well-established imaging modality for the diagnosis of Morton's neuroma (MN), although differentiating MN from intermetatarsal bursitis (IMB) may be challenging in some cases. US elastography, including strain elastography (SE) and shear wave elastography (SWE), enables the assessment of tissue stiffness. Because MN is predominantly composed of fibrotic tissue whereas IMB contains fluid, we hypothesized that elastography could improve the differentiation between these two conditions. Methods: Fifty consecutive patients (43 women) with clinically suspected MN involving 71 feet were prospectively enrolled. All patients underwent both US and MRI, independently interpreted by two radiologists. Patients with imaging findings suspicious for MN on either modality underwent surgery, with histopathology serving as the reference standard. Cases not meeting surgical criteria were classified as IMB based on imaging and clinical follow-up. During US examination, SE and SWE were performed. The Strain Ratio (SR), SWE lesion stiffness, subcutaneous tissue stiffness, and the SWE lesion-to-subcutaneous tissue stiffness ratio (hereafter, SWE ratio) were recorded. Elastographic parameters were compared between MN and IMB, and their diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis. Results: MN demonstrated significantly higher SR and SWE stiffness than IMB. The SWE ratio achieved the highest diagnostic performance, with an AUC significantly greater than those of SWE lesion stiffness (0.915 vs. 0.718, p = 0.004) and SR (0.915 vs. 0.719, p = 0.002). Using a cut-off value >1.5, the SWE ratio yielded 79.2% sensitivity, 88.9% specificity, and 81.7% overall accuracy. Conclusions: US elastography, particularly the SWE ratio, may represent a valuable adjunct to conventional US for differentiating MN from IMB, improving the diagnostic performance of US.

PMID 42942214
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-27

Steric-Pressure-Driven Topological Reconstruction for High-Performance Zintl Phase Thermoelectrics with Machine-Learning Validation.

Kim Siyeon S, Ahmed Aziz A, Lee Juwon J, Lee Jihyun J et al.

The Zintl phase A9M4+ xPn9 (A = Ca, Sr, Eu, Yb; M = transition metal; Pn = pnictogen) family is a promising class of thermoelectric (TE) materials, but conventional optimization has relied on interstitial site tuning rather than structural reconstruction. In this work, we achieve a steric-pressure-driven topological transformation in the quinary Ca9- xSrxZn4+ y - zAgzSb9 system through synergistic Sr and Ag co-doping. Single-crystal X-ray diffraction reveals that substituting larger Sr2+ for Ca2+ progressively drives Zn migration, transforming the parent 2-dimensional (2D) zigzag-shaped anionic layers into a cross-linked 3D polyanionic framework. Density functional theory calculations indicate that Ag incorporation preserves the pseudogap near the Fermi level and reduces bond polarity, optimizing the electronic structure for hole transport. Together with the reconstructed 3D framework, these electronic effects significantly enhance carrier mobility and electrical conductivity without sacrificing a large Seebeck coefficient. As a result, the fully transformed quinary compound Ca7.59(2)Sr1.41Zn4.37(2)Ag0.19Sb9 achieves a maximum ZT of 0.73 at 873 K, doubling the performance of the parent ternary Ca9Zn4.5Sb9. A hybrid transfer machine-learning approach (CrabNet and XGBoost) validates compositional trends and identifies the high-performance region. These findings demonstrate that steric-pressure-induced 2D-to-3D framework reconstruction coupled with electronic optimization offers an effective design principle for high-performance Zintl TE materials.

PMID 42934876
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