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lamivudine + raltegravir (MK 0518B / Dutrebis / MK0518B)

✓ Approved

Merck & Co. · · 小分子

什么是 lamivudine + raltegravir？

lamivudine + raltegravir 是一种小分子，由Merck & Co.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名MK 0518B, Dutrebis, MK0518B
公司Merck & Co.
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Merck & Co.

作用机制

分子靶点

lamivudine + raltegravir 作用于 1 个分子靶点：

gag-pol, HIV-1 (gag-pol)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

lamivudine + raltegravir 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsAcquired immunodeficiency syndrome✓ Approved

相关研究文献

PubMedInorganic chemistry2026-10-26

Phase-Transition-Induced Co-Fe2O3 Nanosheets from Upcycling Spent LiFePO4 for Oxygen Evolution.

Wang Chang C, Zha Liuyang L, Liu Qiangchun Q, Kong Xiangkai X

Spent LiFePO4 (LFP) batteries were upcycled into Co-modified Fe2O3 nanosheets (sFe2O3@Co) through an oxidative reconstruction, selective acid leaching, and Co incorporation. Phase-transition-induced confined growth generated defect-rich ultrathin Fe2O3 nanosheets, while Co doping reconstructed the local electronic structure and accelerated the charge transfer. As a result, sFe2O3@Co exhibited excellent OER activity, requiring only 265 mV at 10 mA cm-2 with a Tafel slope of 28.6 mV dec-1 and maintaining 72.6% activity after 350 h. An AEM electrolyzer achieved 100 mA cm-2 at 1.62 V. A techno-economic analysis further demonstrated the superior value of this upcycling strategy over conventional recycling routes.

PMID 42929622
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PubMedGels (Basel, Switzerland)2026-10-26

Conetworks and Organogels of Poly(methyl acrylate) Crosslinked with Degradable, Disulfide and β-Thioester Containing Bisacrylate Macromonomer.

Aitkazina Aiman A, Szabó Ákos Á, Trif László L, Verebélyi Klára K et al.

Here, we report, for the first time, on a new class of sulfur-containing double hydrophopbic conetworks, poly(methyl acrylate)-l-poly(3,6-dioxa-1,8-octane-dithiol-co-poly(ethylene glycol) diacrylate) (PMA-l-P(DODT-co-PEGDA). Direct one-pot synthesis of acrylate-telechelic P(DODT-co-PEGDA) macromonomer in a gram-scale for the preparation of the conetworks was obtained by copolymerization of DODT with PEGDA via simultaneous oxidative disulfide formation and thiol-ene Michael addition click reactions. Conetworks with a broad composition range of 20-70 wt% sulfur-rich P(DODT-co-PEGDA) macrocrosslinker contents were obtained by radical copolymerization. High gel fractions and composition near to that of the feed ratios verified successful conetwork synthesis. DSC analysis indicates forced blending of the immiscible PMA and P(DODT-co-PEGDA) in the conetworks by one single Tg, which deviates from both the additive rule and the Fox equation for miscible blends. These novel conetworks exhibit high thermal stability up to ~300 °C and independent decomposition patterns of the components in two separate steps. The PMA-l-P(DODT-co-PEGDA) conetworks behave as organogels by swelling in organic solvents, such as THF, acetone, toluene, with composition dependent swelling degrees up to ~900%. Degradation by breaking the disulfide bonds with thiols followed by hydrolysis with NaOH led to complete disintegration of the PMA-l-P(DODT-co-PEGDA) conetworks. These findings enable establishing a new platform for the rational design of a variety of novel sulfur-containing functional and degradable macromolecular assemblies.

PMID 42929897
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PubMedCells2026-10-26

Decoding Cell-Cell Interactions in Neurovascular Unit Co-Cultures Through Molecular Vibrational Spectroscopy and Biology.

Pragnąca Aleksandra A, Borkowska Agata A, Antolak Anna A, Leśniak Monika M et al.

The blood-brain barrier (BBB) is a coordinated multicellular interface in which intercellular communication shapes responses to injury and metabolic stress. However, the contributions of individual cell types to collective stress adaptation remain poorly understood. Here, we examined molecular and metabolic responses of 2D neurovascular unit (NVU) co-culture models comprising endothelial cells, astrocytes, and pericytes exposed to hypoxia or sublethal HgCl2 toxicity. An integrated platform combining gene and protein expression profiling, label-free vibrational spectroscopic imaging, and machine-learning-based analysis was used to assess stress-induced changes in cell-cycle regulation and metabolism across mono- and co-culture configurations. Hypoxia broadly suppressed G1/S and G2/M regulators, inducing cell-cycle arrest with limited cell death, consistent with an adaptive response. HgCl2 caused heterogeneous, model-dependent changes in viability and proliferative capacity. Spectroscopic phenotyping revealed that the triple co-culture exhibited spectral features resembling those of pericyte monocultures, although the contributions of cell-cell interactions and differences in culture conditions could not be distinguished. Fluorescence imaging further revealed mitochondria-associated signals at cell-cell contact sites, suggesting a possible association of mitochondrial material with regions of close cellular interaction. The presence of pericytes was associated with a more stress-resistant cellular phenotype in the investigated co-culture configurations. The developed spectroscopic-molecular platform provides a label-free framework for characterizing cellular communication and stress responses in multicellular NVU co-culture models.

PMID 42929844
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PubMedDalton transactions (Cambridge, England : 2003)2026-10-26

Unravelling average, local and magnetic structure in Sr-Sc-M-O oxides (M = Co, Fe) by neutron scattering.

Ceretti Monica M, Cuello Gabriel J GJ, Sheptyakov Denis D, Ritter Clemens C et al.

Oxygen-deficient Sr-Sc-M-O oxides (M = Fe, Co) were synthesized and characterized in cubic and brownmillerite forms, with the brownmillerite phase Sr2ScCoO5 reported here for the first time. The cubic phases, described as SrSc0.5M0.5O3-x, and the brownmillerite phases, Sr2ScMO5, exhibit different oxygen contents and distinct degrees of structural ordering. Neutron diffraction and pair distribution function analysis reveal short-range oxygen-vacancy and B-cation ordering at the local scale within the cubic structure. In contrast, the brownmillerite phases exhibit long-range oxygen-vacancy and cation ordering, adopting Imma and I2mb symmetries for Sr2ScFeO5 and Sr2ScCoO5, respectively. Magnetic measurements indicate weak antiferromagnetic interactions, with brownmillerite Sr2ScFeO5 showing only short-range magnetic correlations. In contrast, Sr2ScCoO5 exhibits long-range magnetic ordering at 1.5 K, with the Co magnetic moment aligned along the stacking axis. This represents the first observation of coexisting cation and three-dimensional magnetic ordering in this system, despite the large Co-Co distances of 7.63 Å. These findings highlight the role of oxygen content in driving structural ordering and underscore the need for a multiscale approach to understanding the complex structure-property relationships of oxygen-deficient perovskites.

PMID 42929422
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PubMedNanoscale2026-10-26

Synthesis of Co-H3BTB-4,4'-BiPy MOF and derived cobalt nanocomposite as the catalyst for electrochemical nitrate reduction.

Panda Supriya S, Samanta Monolina M, Manna Biplab Kumar BK, Kempasiddaiah Manjunatha M et al.

The electrochemical reduction of nitrate (e-NO3RR) can be a promising alternative for sustainable ammonia production. Here, we have synthesized a novel Co-based metal-organic framework (MOF) named Co-H3BTB-4,4'-BiPy using 1,3,5-Tris(4-carboxyphenyl)benzene and 4,4'-bipyridine as ligands and Co(NO3)2 as the metal precursor, by a solvothermal method. It was further heated under a reducing atmosphere at 800 °C, which resulted in the formation of the catalyst, CoNP@800, having cobalt nanoparticles embedded in a porous nitrogen doped carbon framework. We have also synthesized cobalt oxide derived from the MOF as well as bare Co nanoparticles to compare their catalytic activity with that of CoNP@800. It proved to be a highly efficient catalyst for nitrate reduction, achieving a faradaic efficiency (FE) of 95.76% and a current density of 10 mA cm-2 at -0.08 V vs. RHE. We also obtained a higher yield rate of 0.57 mmol h-1 cm-2. The experimental study coupled with DFT modeling also provided mechanistic insights into the e-NO3RR. The findings underscore the critical role of MOF-derived cobalt based systems in advancing e-NO3RR technologies for green ammonia production.

PMID 42929302
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PubMedEuropean review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity2026-10-26

Effect of 12-week unstable surfaces resistance training on muscle stiffness, muscle co-activation, and balance in older individuals.

Liu Ping P, Chang Lele L, Shi Yueyue Y, Hao Yaru Y

This randomized controlled trial evaluated the effects of unstable resistance training (URT) and stable resistance training (SRT) on muscle stiffness, co-activation, balance, and pain in older adults. To date, no study has investigated dose-matched instability-based resistance training in this population with prespecified endpoints of co-activation and muscle stiffness. Forty-six older adults were randomly assigned to either the URT (n = 23) or SRT (n = 23) group for a 12-week intervention. Both groups performed seven lower-limb exercises with matched volume and intensity, with the URT group utilizing instability devices. Outcomes included muscle-tendon stiffness in the quadriceps and hamstrings, co-activation during squat-down (SD), stand-up (SU), and transition (SUSD). Balance was assessed using the Y-Balance Test (YBT) and Balance Error Scoring System (BESS), and pain was measured with the visual analogue scale (VAS). Compared with SRT, URT resulted in greater reductions in co-activation during SD (p = 0.035), SU (p = 0.003), and SUSD (p = 0.001). URT also produced larger improvements in balance, as indicated by BESS (p = 0.009), YBT-right (p = 0.008), and YBT-left (p < 0.001). Increases in muscle stiffness with URT were limited to the vastus medialis, quadriceps tendon, and hamstring tendon (all p < 0.05), whereas SRT produced broader increases in muscle-tendon stiffness (all p < 0.05). VAS scores decreased in both groups, with a greater reduction after URT (p = 0.009). In older adults, URT more effectively reduced co-activation and enhanced balance under matched loads, while SRT increased muscle stiffness across a broader range of muscles. Given that both interventions reduced pain, the choice of intervention should depend on whether the primary objective is to improve coordination and balance or to increase muscle stiffness. UMIN Clinical Trials Registry, retrospectively registered. Registration number XXXX.

PMID 42928108
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