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caffeine citrate (Cafnea)

✓ Approved

Phebra · 小分子 · 小分子

什么是 caffeine citrate？

caffeine citrate 是一种小分子，由Phebra研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Oral (PO)。

药物档案

商品名Cafnea
公司Phebra
药物类别小分子
给药途径Injectable (Others), Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Phebra

治疗适应症

caffeine citrate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Respiratory, thoracic and mediastinal disordersApnoea✓ Approved

相关研究文献

PubMedPsoriasis (Auckland, N.Z.)2026-10-26

Efficacy and Safety of 5% Topical Caffeine Added to 0.025% Fluocinolone Acetonide Cream for Plaque Psoriasis: A Randomized Controlled Trial.

Mamizadeh Hamed H, Herizchi Ghadim Hamideh H, Pourasghary Sajjad S

To evaluate whether adding topical 5% caffeine to fluocinolone acetonide 0.025% cream (FAC) improves short-term clinical outcomes compared with FAC alone in patients with chronic plaque psoriasis. This randomized, parallel-group, masked, active-controlled clinical trial included 40 patients with chronic plaque psoriasis treated at the dermatology outpatient clinic of Sina Hospital, Tabriz, Iran. Participants were randomly allocated in a 1:1 ratio to receive either topical 5% caffeine plus fluocinolone acetonide 0.025% (intervention group, n=20) or topical fluocinolone acetonide 0.025% alone (control group, n=20). Psoriasis severity was assessed using the Psoriasis Area and Severity Index (PASI) at baseline and weekly for four weeks. Treatment response and adverse events were also recorded. Baseline PASI scores were comparable between the intervention and control groups (3.41 ± 1.86 vs 3.79 ± 1.51, respectively; P=0.484). PASI scores were significantly lower in the intervention group at each post-treatment assessment. At week 4, mean PASI was 0.39 ± 0.17 in the intervention group and 2.29 ± 1.31 in the control group (P=0.001). The mean reduction from baseline to week 4 was 3.01 ± 1.48 with 5% caffeine plus FAC and 1.49 ± 1.01 with FAC alone (P<0.001). Complete clearance, defined as PASI=0, occurred in 14 of 20 patients (70%) in the intervention group compared with 1 of 20 (5%) in the control group (P=0.001). No adverse events were reported during the study. Adding topical 5% caffeine to FAC produced a greater short-term reduction in psoriasis severity than FAC alone. No adverse events were reported during the 4-week treatment period. Larger randomized trials with longer follow-up are warranted to confirm efficacy and characterize longer-term tolerability. Iranian Registry of Clinical Trials (IRCT), IRCT20091012002581N10, registered on October 28, 2023; https://irct.ir/trial/73367.

PMID 42928804
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PubMedCardiovascular research2026-10-26

NOR-1 is an upstream regulator of Ca2+ homeostasis and calmodulin kinase II-dependent arrhythmogenesis.

Vázquez-Sufuentes Paula P, Jiménez-Sábado Verónica V, Ballester-Servera Carme C, Casabella-Ramón Sergi S et al.

Dysregulation of NOR-1 has been reported in cardiovascular diseases associated with altered calcium handling. We therefore investigated how NOR-1 affects calcium homeostasis and arrhythmogenesis to identify the underlying mechanisms. We assessed the expression of NOR-1 and calcium regulatory proteins in myocardial samples from humans and mice that overexpress human NOR-1 in the heart (TgNOR-1). Gene promoter activity was determined by transient co-transfection assays. Calcium imaging, patch-clamp recordings and immunofluorescent labeling was performed in mouse cardiomyocytes. Experimental data were used for mathematical modeling. Arrhythmias were induced in vivo by an epinephrine/caffeine challenge. In human cardiac samples, mRNA levels of genes coding for SERCA2a, CASQ2, TN-C1 and PLB correlated with those of NOR-1, while TgNOR-1 mice exhibited higher cardiac levels of these calcium regulatory proteins than wild-type animals (WT). NOR-1 increased luciferase activity driven by the proximal promoter of both human and mouse genes. Calcium transients were smaller in TgNOR-1 cardiomyocytes while L-type calcium current and SR calcium content were unchanged. Mathematical modeling revealed that more calcium binds to CASQ2 and is released from the SR in TgNOR-1 cardiomyocytes, but the resulting calcium transient is smaller because more calcium is buffered by TN-C1. Furthermore, NOR-1 transgenesis increased the level of reactive oxygen species and CAMKII oxidation, as well as RyR2 phosphorylation at Ser-2814, which led to a higher incidence of calcium waves and afterdepolarizations in resting TgNOR-1 cardiomyocytes. In electrically paced myocytes, NOR-1 transgenesis promoted extra-transients at low frequencies and calcium alternans at high frequencies. Importantly, these derangements in intracellular calcium handling concurred with a dramatic increase in epinephrine/caffeine-induced bidirectional ventricular tachycardia in TgNOR-1 mice. Moreover, the antioxidant N-acetylcysteine and the CAMKII inhibitor KN-93 attenuated arrythmia in TgNOR-1 mice and arrhythmogenic calcium release in isolated myocytes. Our findings highlight NOR-1 as an upstream regulator of CAMKII-oxidation underlying arrhythmia induced by defective calcium homeostasis, pointing to therapies targeting CAMKII as a means to attenuate arrhythmia triggered by pathological upregulation of NOR-1.

PMID 42929040
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-26

Restoring Endothelial Mitochondrial Homeostasis With a Bioactive Nanoshield Promotes Vascular Regeneration on Cardiovascular Implants.

Liu Xiyu X, Zhang Wen W, Liu Lunxin L, Gui Lan L et al.

Defective endothelial regeneration constitutes a fundamental barrier to durable vascular repair. By integrating single cell RNA-sequencing data from rat carotid balloon injury with ultrastructural and histological evidence from rabbit stented arteries, we identified mitochondrial disorganization and dysfunction as common features of injured endothelial cells. Guided by these findings, we developed a poly(citrate-polyglycol-procyanidin) (PCGP) nanoshield to couple mitochondrial protection with anticoagulant and immunoregulatory functions for cardiovascular devices. PCGP preserved mitochondrial integrity, restored endothelial metabolic homeostasis, and rescued the regenerative phenotype of endothelial cells under oxidative stress. In rabbit arterial stent models, this intervention reactivated the PI3K/AKT/eNOS-nitric oxide axis, accelerated functional re-endothelialization, and markedly suppressed neointimal hyperplasia. Collectively, these findings support restoration of endothelial mitochondrial homeostasis as an important mechanistic axis associated with vascular repair.

PMID 42928428
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PubMedParasites, hosts and diseases2026-10-26

Molecular diagnosis of a case of Dibothriocephalus nihonkaiensis infection in Suzu City, Ishikawa Prefecture, Japan.

Kawabata Kohei K, Shimosaki Rin R, Ikku Ryosuke R, Saito Hiroaki H et al.

In this study, we intended to report a case of Dibothriocephalus nihonkaiensis infection diagnosed in Suzu City, Ishikawa Prefecture, Japan. A 23-year-old man from Aichi Prefecture moved to Suzu City, one of the most severely destroyed areas by the 2024 Noto Peninsula earthquake, to engage in reconstructive works. He visited the internal medicine department of Suzu General Hospital by the passage of long slender worm in his stool. Numerous operculated helminth eggs were detected from his stool samples, and a tapeworm strobila with the scolex was found after the treatment of praziquantel (10 mg/kg). Magnesium citrate was administered before and after praziquantel treatment, and stool samples were collected from the patient. The expelled tapeworm measured approximately 1.7 m in length. Morphological examination revealed a relatively small scolex with 2 suckling grooves, suggesting an immature adult specimen. Phylogenetic analysis of the mitochondrial 16S rRNA and cox1 genes identified the parasite as Dibothriocephalus nihonkaiensis. This case highlights the importance of integrating morphological and molecular approaches for accurate species identification in cases with complex epidemiological backgrounds.

PMID 42928461
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PubMedBiosensors2026-10-26

Longitudinal Trajectories of Autonomic Maturation in Preterm Infants Using Serial 24-Hour Heart Rate Variability Monitoring.

Sugino Masashiro M, Kuboi Toru T, Tadatomo Yoko Y, Kawaguchi Nana N et al.

Heart rate variability (HRV) is a non-invasive measure reflecting cardiac autonomic regulation and has been used to investigate developmental changes in preterm infants. Short-term HRV recordings have demonstrated developmental changes with advancing postmenstrual age (PMA), but are highly susceptible to transient physiological conditions, limiting reproducibility. We prospectively performed serial 24 h electrocardiographic recordings in 50 preterm infants born at 24-35 weeks' gestation from postnatal life until before 37 weeks' PMA to characterize longitudinal HRV trajectories. A total of 879 recordings were analyzed using a 24 h single-window approach, and developmental trajectories were evaluated using linear mixed-effects models. All HRV indices increased progressively with advancing PMA. Infants born at ≥32 weeks' gestation exhibited significantly higher HRV values after approximately 33 weeks' PMA than those born at <32 weeks, indicating distinct maturational trajectories according to gestational age. PMA remained independently associated with multiple HRV indices after adjustment for major clinical factors, whereas body weight z-score, respiratory support, oxygen supplementation, and caffeine exposure showed little or no independent association after adjustment. These findings characterize longitudinal 24 h HRV trajectories in preterm infants and suggest that serial 24 h HRV monitoring may provide a framework for assessing developmental changes in cardiac autonomic regulation during neonatal intensive care.

PMID 42930133
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PubMedEnvironmental geochemistry and health2026-10-26

HDL-C as a mediator of PPCP-related kidney function decline in community-dwelling elderly: a mixture analysis approach.

Zhao Yutong Y, Wang Sheng S, Zhou Luoling L, Xu Yuanyuan Y et al.

Pharmaceuticals and personal care products (PPCPs) are widespread environmental contaminants, but their associations with kidney function and lipid metabolism remain incompletely understood. This study included 2758 adults aged ≥ 60 years in Anhui Province, China, during 2022-2023 and used a cross sectional design. Urinary concentrations of 48 PPCPs and two metabolites were measured using high-performance liquid chromatography-tandem mass spectrometry. Estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. Individual associations were assessed using logistic and linear regression, and mixture associations using weighted quantile sum (WQS) regression and Bayesian kernel machine regression. Restricted cubic splines examined nonlinear associations, and exploratory mediation analyses assessed the statistical contribution of high-density lipoprotein cholesterol (HDL-C). Among nine PPCPs with detection frequencies > 50%, doxycycline, enrofloxacin, acetaminophen, metformin, and cotinine were associated with lower eGFR after full adjustment and Benjamini-Hochberg correction. Coefficients ranged from - 3.00 to - 0.93 mL/min/1.73 m2 per tenfold increase in urinary concentration. Tylosin and caffeine were positively associated with eGFR. The WQS index was inversely associated with eGFR, with metformin receiving the largest weight. HDL-C showed a positive nonlinear association with eGFR. Under the mediation model assumptions, HDL-C statistically accounted for 12.21-29.30% of the associations involving enrofloxacin, metformin, and acetaminophen, and 13.78% of the mixture association. The indirect association for cotinine was nonsignificant. These findings remain exploratory. Prospective studies are needed to clarify temporal relationships and address possible reverse causation.

PMID 42928303
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