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Factor IX (AlphaNine SD / AlphaNine)

✓ Approved

Mitsubishi Tanabe Pharma Corporation · F9 · 细胞治疗

什么是 Factor IX？

Factor IX 是一种细胞治疗，由Mitsubishi Tanabe Pharma Corporation研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名AlphaNine SD, AlphaNine
公司Mitsubishi Tanabe Pharma Corporation
药物类别细胞治疗
分子靶点F9
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Mitsubishi Tanabe Pharma Corporation

作用机制

分子靶点

Factor IX 作用于 1 个分子靶点：

F9coagulation factor IX (P19, F9 p22)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

Factor IX 针对 3 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersExtravasation blood✓ Approved
Congenital, familial and genetic disordersFactor IX deficiency✓ Approved
Vascular disordersHaemorrhage✓ Approved

相关研究文献

PubMedBulletin of experimental biology and medicine2026-07-27

The Influence of Tumor Necrosis Factor Alpha on the Permeability of Nasal Epithelial Cell Monolayer.

Abalenikhina Yu V YV, Breslavets D I DI, Mylnikov P Yu PY, Builina S G SG et al.

The effect of tumor necrosis factor alpha (TNFα) on the barrier function of the nasal epithelium (RPMI 2650 cell line) was studied in in vitro experiments. It was shown that short-term exposure to the cytokine (6 h) increased transepithelial electrical resistance and decreased paracellular permeability for mannitol, which was accompanied by elevated expression of the tight junction proteins occludin and claudin-1. Prolonged exposure (48 h) caused an opposite effect, i.e., a significant decrease in the barrier function and a decrease in the content of the studied proteins. These results indicate that the proinflammatory cytokine TNFα modulates the permeability of the nasal epithelium, which should be taken into account when developing strategies for intranasal drug delivery.

PMID 42507093
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PubMedNursing reports (Pavia, Italy)2026-07-27

Validity and Internal Consistency of a Rubric for Cervical Collar Placement in Nursing Students.

Diez-Fernandez Jose Miguel JM, Fernandez-Villa Tania T, Rodriguez-Badiola Amaia A, Mauriz Elba E et al.

Background/Objectives: The assessment of clinical competencies in nursing education requires valid and reliable instruments, especially for essential procedures such as the placement of a cervical collar in the care of polytrauma patients. The objective of this study was to analyse the psychometric properties of a rubric designed to assess the placement of cervical collars in nursing students in a low-fidelity clinical simulation environment. Methods: A quasi-experimental, cross-sectional study was conducted with 186 undergraduate nursing students, organised into 61 groups, over three academic years (2021-2024). An eight-item rubric was applied, with a four-level Likert scale (1-4). Interrater reliability was analysed using Cohen's Kappa index (0.418-0.796), internal consistency using Cronbach's alpha (alpha = 0.753), and the internal structure of the instrument using exploratory factor analysis, applying Varimax orthogonal rotation. Results: Inter-rater reliability showed values ranging from moderate to substantial, with greater agreement observed in items related to the selection of the collar and the position of the medical team, and moderate agreement in those related to technical manoeuvres and immobilisation. The rubric showed adequate overall internal consistency (α = 0.76), with good to very good consistency values in six of the eight items. Exploratory factor analysis identified a two-dimensional structure with a dominant procedural factor (four items) and a second factor associated with clinical judgement (four items). Conclusions: The validated rubric has adequate levels of reliability and internal consistency for evaluating the placement of cervical collars by nursing students. Its application can promote more objective and structured evaluation processes in clinical simulation for nursing students, contributing to the development of essential skills in the care of polytrauma patients.

PMID 42506037
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PubMedCranio : the journal of craniomandibular practice2026-07-27

Cytokines and biomarkers of bone resorption and cartilage degeneration in synovial fluid of patients with temporomandibular joint osteoarthritis: A scoping review.

Torres Catalina C, Vera Darco D, Solar Melissa M, Fuentes Del Campo Aler A

Osteoarthritis of the temporomandibular joint is characterized by joint tissue degeneration. However, the synthesized and categorized information regarding biomarkers present in synovial fluid samples from patients who have not been treated for this disease is scarce. This review aims to provide an overview of inflammatory cytokines, bone, and cartilage degeneration biomarkers relevant to this temporomandibular disorder (TMD). Following JBI and PRISMA-ScR guidelines, 26 studies from five databases were analyzed, identifying 45 biomarkers. Inflammatory cytokines (interleukin 1 beta, interleukin 6, tumor necrosis factor alpha), cartilage degeneration markers (matrix metalloproteinases), and bone resorption markers (receptor activator of nuclear factor kappa-B ligand, osteoprotegerin) were most frequently reported. Vascular endothelial growth factor was associated with cartilage degeneration and bone resorption. These biomarkers may aid in disease characterization; however, further standardized clinical studies are required for validation and comparison with other TMDs.

PMID 42504100
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PubMedMetabolites2026-07-27

The Potential Target Value of ADP-Ribosylation Factor 6 in Insulin Secretion Regulation and the Treatment of Metabolic Disorders.

Wang Yangyang Y

Obesity and type 2 diabetes mellitus (T2DM) represent pandemic metabolic illnesses hallmarked by defective pancreatic β-cell function and blunted insulin release. As a conserved small GTPase (guanosine triphosphatase), ADP-ribosylation factor 6 (ARF6) governs fundamental cellular events encompassing vesicle trafficking, cytoskeleton remodeling and lipid metabolic turnover. Emerging data confirm that ARF6 acts as a master rheostat of glucose-stimulated insulin secretion (GSIS) in β-cells through downstream cell division control protein 42/Ras-related C3 botulinum toxin substrate 1 (Cdc42/Rac1) cascades. Pathogenic ARF6 hyperactivation triggers a cascade of β-cell lesions: mitochondrial impairment, autophagic suppression and exacerbated inflammatory signaling, accelerating the progression of obesity and T2DM. First-line therapeutics ranging from GLP-1 (Glucagon-like peptide-1) receptor agonists and metformin to SGLT2 (Sodium-Glucose Cotransporter 2) inhibitors partially restore metabolic homeostasis by rectifying aberrant ARF6-dependent signaling axes. This review comprehensively delineates ARF6's canonical cellular roles, mechanistic bridges connecting ARF6 to β-cell failure and metabolic deterioration, and functional crosstalk between ARF6 and established anti-metabolic pharmacotherapies. We further address unresolved research gaps and prospective translational avenues, offering actionable perspectives to advance ARF6 as a tractable therapeutic target for obesity and T2DM management.

PMID 42506459
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PubMedNursing reports (Pavia, Italy)2026-07-27

Adaptation and Validation of the Parental Stressor Scale: NICU for Spanish Populations.

Sánchez Regina Matey RM, Gómez Mónica Riaza MR, Reina Miguel A MA

Background/Objectives: Parental stress during neonatal intensive care unit (NICU) admission affects parental well-being, bonding, and neonatal outcomes. Reliable assessment requires instruments adapted to the linguistic and cultural context of each population. This study aimed to adapt the Parental Stressor Scale: NICU (PSS:NICU) for use in Spain and evaluate its psychometric properties. Methods: The adaptation comprised forward translation, back-translation, expert review, pilot testing with cognitive debriefing (n = 15), and psychometric evaluation. The adapted scale was administered to 160 parents (80 mothers, 80 fathers) of NICU-admitted neonates; 159 cases were retained for analysis. Internal consistency was assessed with Cronbach's alpha. Exploratory factor analysis (EFA; maximum likelihood, Promax rotation) with parallel analysis examined the factor structure. Confirmatory factor analysis (CFA) tested the original four-factor model, and a second-order model with five first-order factors was subsequently evaluated. Results: Internal consistency was excellent (total α = 0.968; subscales α = 0.866-0.961). Parallel analysis supported a five-factor EFA solution over a four-factor solution. CFA of the original four-factor model yielded poor fit (CFI = 0.755, TLI = 0.737, RMSEA = 0.125). A second-order model with five first-order factors and one general stress factor improved fit (CFI = 0.819, RMSEA = 0.107), though indices remained below conventional thresholds. Standardised factor loadings were moderate to high (0.57-0.96). Conclusions: The Spanish PSS:NICU demonstrates excellent reliability and provides preliminary evidence supporting its use for research and clinical assessment. The original four-factor structure was not replicated; the data suggest a five-factor organisation with evidence of a higher-order stress construct. Structural validity requires confirmation in larger, independent samples.

PMID 42506003
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PubMedCells2026-07-27

Non-Coding and Coding RNAs in Targeted Cancer Therapy.

Silva-Cázares Macrina B MB, López-Camarillo César C

Cancer remains one of the leading causes of morbidity and mortality worldwide despite remarkable advances in molecular biology, precision medicine, and targeted therapeutics [...].

PMID 42505376
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