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Factor VIIIa (LongAte)

✓ Approved

PolyTherics Limited · F8 · 重组蛋白

什么是 Factor VIIIa？

Factor VIIIa 是一种重组蛋白，由PolyTherics Limited研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)、Subcutaneous Injection。

药物档案

商品名LongAte
公司PolyTherics Limited
药物类别重组蛋白, 细胞治疗
分子靶点F8
给药途径Injectable (Others), Intravenous (IV), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, PolyTherics Limited

作用机制

分子靶点

Factor VIIIa 作用于 1 个分子靶点：

F8coagulation factor VIII (AHF, FVIII)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

Factor VIIIa 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Congenital, familial and genetic disordersFactor VIII deficiency✓ Approved

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Li Yuan Y, Chen Ziyu Z, Zhu Shiyu S, Wei Yan Y et al.

Osteoarthritis (OA) is a degenerative joint disease characterized by progressive loss of articular cartilage and an associated decline in its intrinsic mechanoelectrical signaling. Current osteoarthritis treatments relieve symptoms but fail to prevent cartilage degeneration or restore its native biophysical microenvironment. Here, we present an ultrasound-activated, mussel-inspired bio-adhesive hydrogel that addresses these challenges by recreating the cartilage's piezoelectric cues in situ while achieving stable intra-articular retention under synovial conditions. The hydrogel, denoted SFHD-BT@PDA, consists of a silk fibroin (SF) matrix integrated with dopamine-functionalized hyaluronic acid (HADA) and embedded barium titanate nanoparticles coated with polydopamine (BT@PDA). This multi-level design imparts strong interfacial adhesion to wet cartilage (via catechol-mediated bonding to collagen) and piezoelectric sensitivity to external ultrasound. Under ultrasound stimulation, SFHD-BT@PDA generates localized electrical microcurrents that recruit endogenous MSCs via electrotaxis and subsequently promote their chondrogenic differentiation. In vitro, ultrasound-triggered electrical cues upregulated chondrogenic markers (SOX9, collagen II, aggrecan) in MSCs and activated TGF-β signaling, demonstrating restoration of the pro-anabolic bioelectric microenvironment. In a murine DMM model, the adhesive hydrogel exhibited prolonged retention on cartilage surfaces and, with ultrasound, induced robust cartilage regeneration and OA reversal. Treated joints showed preserved proteoglycan and Type II collagen content, inhibited osteophyte formation, and protection of subchondral bone microarchitecture. In summary, this mussel-inspired piezoelectric hydrogel provides an electromechanical stimulation platform that effectively couples physical cues with bio-adhesion to regenerate cartilage.

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Structure and Compressional Behavior of Sillén-Type (BiO)2(CO3) Bismutite Carbonate.

Chuliá-Jordán Raquel R, Santamaría-Pérez David D, Botan-Neto Benedito Donizeti BD, Bera Ganesh G et al.

In this joint experimental/computational work, we study the ambient-conditions structure of bismutite (BiO)2(CO3) and its evolution under high pressure by means of a combination of in situ synchrotron X-ray diffraction (XRD) measurements, Raman spectroscopy, and density-functional theory (DFT) calculations. Using single-crystal XRD, (BiO)2(CO3) is determined to be an orthorhombic Cmcm phase with disorder arising from carbonate rotations at ambient-conditions and DFT confirms the stability of the structure. In situ high-pressure synchrotron powder XRD measurements showed that the Cmcm ambient-pressure structure adequately accounts for the observed diffraction patterns up to 17.7 GPa. The compressibility was determined, obtaining an experimental bulk modulus of 67.2(11) GPa and significant anisotropy in the axial compressibilities: the a and c axes, parallel to the (BiO)22+ layers, are less compressible than the b direction perpendicular to those layers, which we justify on the basis of the bismuth lone electron pair compressibility and the slight reorientation of the carbonate groups. Raman spectroscopy measurements at ambient conditions and under pressure were used to characterize the vibrational properties of this carbonate, unvealing a differentiated behavior of the nonequivalent carbonate units.

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Adaptive Digital Marketing: A Systematic Review of Bio-Inspired Reinforcement Learning, Multi-Agent Systems, and Agentic AI for Intelligent Optimisation.

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