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hyaluronic acid (BioHy / Euflexxa / BioLon)

✓ Approved

Johnson & Johnson Services, Inc. · 治疗药物

什么是 hyaluronic acid？

hyaluronic acid 是一种治疗药物，由Johnson & Johnson Services, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intraarticular Injection。

药物档案

商品名BioHy, Euflexxa, BioLon
公司Johnson & Johnson Services, Inc.
给药途径Injectable (Others), Intraarticular Injection
状态Approved
来源： ClinicalTrials.gov, Johnson & Johnson Services, Inc.

治疗适应症

hyaluronic acid 针对 4 个适应症，涉及 3 个治疗领域。

治疗领域疾病/病症分期
Eye disordersGlaucoma✓ Approved
Musculoskeletal and connective tissue disordersOsteoarthritis✓ Approved
Surgical and medical proceduresAdjuvant therapy✓ Approved
Eye disordersDry eyePhase II

相关研究文献

PubMedVeterinary ophthalmology2026-10-26

Novel Therapy for Severe Bilateral Pyogranulomatous Blepharitis Secondary to Hyaluronic Acid Filler in a Dog.

Dacanay-DeFebo Samantha S, Putra Andhika A, Gemensky-Metzler Anne A, Davis Amanda A et al.

A 9-year-old female spayed mixed breed dog was initially examined for severe bilateral entropion secondary to enophthalmos from chronic oral steroid use for immune-mediated thrombocytopenia as well as potential historic masticatory muscle myositis. Surgical intervention with entropion surgery was pursued; however, trichiasis secondary to laxity of the periocular muscles, eyelid tissues, and tarsal plate developed several months later. Hyaluronic acid (HA) filler (Alayna SG 24 Distinct, BSC Medical Devices GmbH, Munich, Germany) was injected into the superior and inferior eyelids of both eyes to correct recurrent ocular irritation. One month later, the patient developed severe, presumed pyogranulomatous blepharitis in both eyes suspected to be a delayed hypersensitivity reaction to the HA filler. The condition worsened despite medical management. Due to the patient's previous, chronic history of oral steroid use, the owners declined administration of oral steroids at that time. Oral Zenrelia (ilunocitinib) and topical neomycin-polymyxin-dexamethasone ointment were instituted, which resulted in a rapid resolution of the patient's clinical signs. This is the first known report of a dog experiencing a severe hypersensitivity reaction to hyaluronic acid used as an eyelid filler and successful treatment with Zenrelia for this purpose.

PMID 42928512
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PubMedGels (Basel, Switzerland)2026-10-26

Comparative Rheological Characterization of Hyaluronic Acid Viscosupplements for Synovial Fluid Restoration in Osteoarthritis and Knee Biomechanics.

Melero Alejandro A, Pino Ander A, Alonso José María JM, Martínez de Cestafe Nagore N et al.

Synovial fluid (SF) rheological properties deteriorate progressively in knee osteoarthritis (OA) due to a reduction in hyaluronic acid (HA) concentration and molecular weight, compromising joint lubrication and load distribution. Restoring these properties through intra-articular viscosupplementation with HA is a widely used therapeutic strategy. However, commercially available linear HA formulations differ substantially in their mechanical behavior, and single-parameter assessments are insufficient for capturing their functional differences. In this study, eight commercially available intra-articular linear HA hydrogels-TrHLINE 1%®, TrHLINE 2%®, Hyalubrix®, Hyalgan Bio®, Pronolis® HD 2.5%, Biolevox™ HA ONE 2.5%, Suplasyn®, and Arthrum H 2%®-were evaluated under standardized conditions using steady-state viscosity, mechanical stress response, first normal stress difference (N1), storage and loss moduli (G', G″), loss factor (tan δ), and elasticity percentage. Results revealed three distinct functional profiles: lubricant-oriented with low to moderate structural organization (Hyalgan Bio®, Suplasyn®, TrHLINE 1%®); balanced viscoelastic with sustained structural persistence (TrHLINE 2%®, Hyalubrix®, Arthrum H 2%®); and high initial rigidity with reduced dynamic persistence (Biolevox™ HA ONE 2.5%, Pronolis® HD 2.5%). These findings demonstrate that multi-parametric rheological benchmarking effectively discriminates functional differences among HA viscosupplements and supports indication-oriented product selection based on OA severity and patient mechanical demand.

PMID 42929916
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PubMedGels (Basel, Switzerland)2026-10-26

Carboxymethylcellulose/Hyaluronic Acid Hybrid Nanoconjugates: Toward Multifunctional Platforms for Melanoma Skin Cancer Theranostics.

Miranda Deborah V DV, Mansur Alexandra A P AAP, Mansur Herman S HS, Carvalho Isadora C IC

Melanoma remains one of the most aggressive forms of skin cancer, characterized by high metastatic potential and risks of tissue trauma and post-surgical recurrence, with limited therapeutic options currently available. While conventional monotherapies often fail to provide comprehensive and efficient treatment, nanoparticle-functionalized hydrogel platforms have emerged as promising multifunctional systems for localized combination cancer therapy, capable of integrating multiple therapeutic modalities, such as chemodynamic therapy (CDT), photodynamic therapy (PDT), and photothermal therapy (PTT), tissue recovery support, antibacterial activity, and image-guided treatment into a single biomaterial. This review examines stimulus-responsive hydrogels based on the anionic polysaccharides carboxymethylcellulose (CMC) and hyaluronic acid (HA), conjugated with nanoparticles for melanoma theranostic applications. It evaluates their design, synergistic mechanisms, and therapeutic potential. It considers how combining CMC and HA overcomes the limitations of individual polymers, such as poor mechanical integrity and rapid degradation, and enhances key functionalities, particularly cell targeting and specificity. It also analyzes how incorporating functional nanoparticles can enable on-demand drug release, diagnostic imaging, immune microenvironment remodeling, and combined phototherapy (PTT/PDT). While HA-based nanotheranostic systems are widely documented, the potential of CMC in melanoma treatment remains largely untapped, despite its proven success in tissue engineering and wound management. Most significantly, the literature currently lacks any bio-nanohybrid platform that integrates CMC and HA, driven by functional hybrid nanoparticles, for targeted melanoma therapy. By identifying this critical gap, this review proposes new research avenues for designing these unified, multifunctional platforms as a highly promising strategy for cutaneous melanoma management.

PMID 42929909
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PubMedJournal of applied biomaterials & functional materials2026-10-26

Arbutin/kojic acid-loaded MHA hydrogel array patches attenuate UVB-induced epidermal hyperplasia and remodeling-associated responses.

Lee Seung-Min SM, Cha Sangryul S, Jeon DooLee D, Choi Wooseok W et al.

Acute ultraviolet B (UVB) exposure induces epidermal hyperplasia, pigmentation-related responses, and early extracellular matrix remodeling. Topical tyrosinase inhibitors, including arbutin and kojic acid, can have limited residence on damaged skin. Here, we evaluated a skin-conformal composite patch comprising aligned polyurethane nanofiber membranes integrated with methacrylated hyaluronic acid (MHA) hydrogel arrays loaded with arbutin or kojic acid. Seven-week-old Hairless Mouse, Strain 2 (HRM2) mice were assigned to six groups: control (CTL), UVB only (UV), UVB plus topical arbutin (UVA), UVB plus topical kojic acid (UVK), UVB plus arbutin-loaded MHA patch (UV-A-MHA), and UVB plus kojic acid-loaded MHA patch (UV-K-MHA). Dorsal skin received a single UVB dose (200 mJ/cm2), was treated immediately, and was analyzed on Day 4. Drug-loaded MHA patch treatment attenuated UVB-induced epidermal thickening and was associated with qualitative differences in dermal matrix organization, while direct comparisons with the corresponding freely applied formulations varied across endpoints. These histological findings were evaluated using hematoxylin and eosin, Masson's trichrome, Picro-Sirius Red, and Fontana-Masson staining. GFP-loaded MHA hydrogels remained detectable in the epidermis and upper dermis through Day 4, supporting local cargo retention under skin-contact conditions. Preliminary HPLC-UV analysis detected arbutin and kojic acid parent peaks in MHA formulations before and after 60 s of UV exposure. Patch treatment was associated with significant reductions in α-smooth muscle actin and vimentin, whereas effects on SMAD phosphorylation differed between the two drug formulations, without detectable changes in body weight or serum TNF-α and IL-6. Because the main experiment lacked drug-free MHA patch and bandage-only controls, scaffold-, occlusion-, and drug-specific effects could not be fully separated. These findings support aligned nanofiber-supported MHA hydrogel arrays as functional biomaterial patches for localized cutaneous delivery and modulation of acute UVB-induced remodeling-associated responses.

PMID 42929246
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PubMedFood & function2026-10-26

Layered glycoprotein nanoparticles co-delivering Meretrix meretrix-derived peptide and astaxanthin attenuate cyclophosphamide-induced immunosuppression.

Wu Wanyi W, Cai Jiamin J, Wu Zhixuan Z, Cao Wenhong W et al.

Marked differences in solubility and stability between hydrophilic bioactive peptides and hydrophobic carotenoids constrain their synergistic oral delivery. Building on the complementary activities of Meretrix meretrix-derived immunomodulatory peptide (MMIP) and astaxanthin (AST), this study developed co-loaded nanoparticles, HLC10, featuring a BSA-dextran glycoprotein core and a composite outer layer of hyaluronic acid (HA) and yeast β-glucan. Hydrogen bonding, hydrophobic interactions, and electrostatic forces collectively drive the multicomponent assembly. By tuning particle interfacial hydration and the dispersion state of the payloads, the formulation improved co-encapsulation capacity, processing and storage stability, and gastrointestinal bioaccessibility of MMIP and AST. The composite polysaccharide outer layer further increased particle accumulation in Peyer's patches-associated regions and increased uptake by RAW264.7 macrophages. Oral HLC10 administration ameliorated cyclophosphamide-induced immunosuppression, restored immune organ and ileal architecture, and produced coordinated shifts in gut microbiota, fecal short-chain fatty acids, and spleen nucleotide-related metabolic profiles. These findings support the immunomodulatory potential of HLC10, but the evidence remains largely limited to endpoint measures in animal models, and direct validation of cellular functions and the underlying mechanisms is still required. Overall, this stratified co-assembly strategy offers a feasible route for the synergistic oral delivery of food-derived active ingredients with markedly different physicochemical properties.

PMID 42929794
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PubMedGels (Basel, Switzerland)2026-10-26

Potential and Safety Assessment of a Hydrogel as a Vitreous Substitute Following Vitrectomy in an Ex Vivo Porcine Model.

Sojdeh Soheil S, Bejandi Zahra Bibak ZB, Castillo Miranda M, Tsougranis Gregory G et al.

To develop and preliminarily evaluate a hyaluronic acid-1,4-butanediol diglycidyl ether (HA-BDDE)/polyethylene glycol-tyramine (PEG-Tyramine) dual-hydrogel designed as a transparent and injectable vitreous substitute with suitable optical, rheological, and cytocompatibility characteristics for potential application following vitrectomy. HA-BDDE and PEG-Tyramine were prepared separately and combined to form a dual-hydrogel formulation. The resulting hydrogel was characterized using attenuated total reflectance Fourier-transform infrared (ATR-FTIR) spectroscopy, proton nuclear magnetic resonance (1H NMR) spectroscopy, oscillatory rheometry, and spectrophotometry to evaluate its chemical, rheological, and optical properties. Cytocompatibility was assessed using retinal pigment epithelial (RPE) cells through the methyl thiazolyl tetrazolium (MTT) assay and Live/Dead fluorescence staining. Ex vivo performance was evaluated following hydrogel injection into porcine eyes after vitrectomy, with assessment of macroscopic transparency, structural integrity, and retention within the vitreous cavity. The HA-BDDE/PEG-Tyramine formulation formed a transparent and macroscopically homogeneous hydrogel phase. Spectroscopic analyses demonstrated the characteristic chemical functionalities and molecular environments associated with the HA- and PEG-containing components. Rheological analysis showed predominantly elastic, gel-like behavior, with the storage modules exceeding the loss modulus across the investigated frequency range. The hydrogel exhibited measurable and relatively stable visible-light transmission across the evaluated wavelength range. RPE cells maintained high metabolic activity during the culture period, while Live/Dead imaging demonstrated predominantly viable cells with limited dead-cell staining. In the ex vivo porcine model, the hydrogel remained within the vitreous cavity and maintained its macroscopic transparency and structural integrity during the observation period. The HA-BDDE/PEG-Tyramine dual-hydrogel exhibited favorable optical, rheological, cytocompatibility, and short-term ex vivo retention characteristics. These findings support further investigation of this dual-hydrogel system as a potential injectable vitreous substitute following vitrectomy.

PMID 42929934
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