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calcium carbonate (Cimascal / Cimascal D Forte)

✓ Approved

CPEX Pharmaceuticals, Inc. · VDR

什么是 calcium carbonate？

calcium carbonate 是一种治疗药物，由CPEX Pharmaceuticals, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Cimascal, Cimascal D Forte
公司CPEX Pharmaceuticals, Inc.
分子靶点VDR
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, CPEX Pharmaceuticals, Inc.

作用机制

分子靶点

calcium carbonate 作用于 1 个分子靶点：

VDRvitamin D receptor (NR1I1, PPP1R163)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

calcium carbonate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

相关研究文献

PubMedEnvironmental science and pollution research international2026-09-10

Study on waste eggshell-derived calcium oxide-modified bitumen using response surface methodology.

Debnath Jaba J, Singh Khwairakpam Lakshman KL, Kuity Ambika A

Waste eggshells, composed predominantly of calcium carbonate (> 94%), represent an abundant resource that can be converted into calcium oxide (CaO) for sustainable bitumen modification. This study explores the performance enhancement of bituminous binders modified with CaO produced from calcined waste eggshells. Eggshells were thermally treated at 900 °C to obtain high-purity CaO, and its formation was verified through XRD, FTIR, and SEM-EDX. The modifier was incorporated into 60/70 grade bitumen at dosages ranging from 1% to 4%, and its effects were assessed using a dynamic shear rheometer. The CaO-modified binder exhibited remarkable improvements in high-temperature behavior, with the complex modulus (G*) rising by 540%, phase angle decreasing by 14%, and rutting resistance (G*/sin δ) increasing by 574% as compared to the control binder. Moreover, a response surface methodology (RSM) framework was employed to assess the combined influence of CaO content and temperature, yielding statistically reliable cubic models (R2 > 0.95). Optimization results identified 2.3% CaO at 58 °C as the most effective combination, which was experimentally validated with less than 5% deviation from predicted values. Mixtures prepared using the optimized binder demonstrated enhanced mechanical performance, reflected by increases of 13.76% in Marshall stability, 16% in indirect tensile strength, and 5% in tensile strength ratio, confirming improved stiffness and moisture resistance. Overall, the findings establish waste eggshell-derived CaO as an eco-friendly and technically viable modifier capable of improving both rheological properties and structural performance of bituminous binders and mixes.

PMID 42717172
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PubMedFrontiers in nutrition2026-09-10

Circulating metabolite signatures mediating the association between minerals in domestic water and incident MASLD: a prospective cohort study.

Li Keyang K, Liu Yincheng Y, Li Wenlong W, Qin Li L et al.

Epidemiological evidence on minerals in domestic water and incident metabolic dysfunction-associated steatotic liver disease (MASLD) remains limited, particularly regarding potential mediating roles of circulating metabolites. We evaluated the association between minerals and incident MASLD and characterized metabolomic biomarkers that may mediate this association. We included 218,339 UK Biobank participants without MASLD or other liver disease at baseline. Domestic water hardness (DWH), including calcium (Ca), magnesium (Mg), and calcium carbonate (CaCO3), was obtained from water-utility outputs. MASLD was ascertained using linked health records. One hundred sixty-eight plasma biomarkers were measured using nuclear magnetic resonance profiling. We used Cox models to quantify associations between minerals and MASLD risk, while causal mediation analyses were used to evaluate mediation by these biomarkers. During a median follow-up of 13.7 years, 3,004 participants developed MASLD. Higher Ca in domestic water was positively associated with incident MASLD (Hazard ratio 1.087, 95% confidence interval 1.013-1.166), whereas Mg (1.042, 0.993-1.094) and CaCO3 (1.006, 0.939-1.078) showed no significant associations with MASLD. In mediation analyses, Glutamine, Lactate, and Alanine may mediated the association, with proportions mediated of 21.42, 7.53, and 5.38%, respectively. Ca in domestic water was positively associated with incident MASLD, with partial mediation by metabolites including glutamine, lactate, and alanine. These findings provide insight into the metabolic pathways of minerals-MASLD association and support prevention strategies.

PMID 42718770
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PubMedFrontiers in endocrinology2026-09-10

Pregnancy and lactation-associated osteoporosis in a postpartum woman with twin pregnancy: a 5-year follow-up case report.

Adnan Hussain Muthasim HM, Gao Xiaoyun X, Yu Xiuqi X, Zhang Chunyu C

Pregnancy and lactation-associated osteoporosis (PLO) is a rare but potentially disabling metabolic bone disorder that typically emerges in late pregnancy or the early postpartum period. Because its symptoms often present as common postpartum musculoskeletal complaints, diagnosis is frequently delayed until vertebral fractures are detected. This case report describes a postpartum woman with a twin pregnancy who developed multiple vertebral compression fractures, illustrating the diagnostic challenges, clinical features, and long-term outcomes of PLO. A 32-year-old woman presented with persistent low back pain two weeks after cesarean delivery of twins. She had been exclusively breastfeeding and reported inadequate dietary intake and recent weight loss. Thoracolumbar MRI revealed acute compression fractures at T12, L1, and L5. Laboratory evaluation demonstrated low 25-hydroxyvitamin D and parathyroid hormone levels, markedly elevated β-CTX and P1NP, and elevated prolactin. DXA showed significantly reduced lumbar bone mineral density (Z-score -3.25). Clinically significant secondary causes of osteoporosis were excluded based on available testing, and PLO was diagnosed. She was treated with calcium carbonate, calcitriol, alfacalcidol, calcitonin, and intravenous zoledronic acid (initial 5 mg dose during admission, with a second 5 mg dose administered at 1-year follow-up). Following treatment, biochemical markers normalized. At follow-up, MRI confirmed fracture healing, DXA demonstrated improved bone mineral density, and the patient reported complete resolution of symptoms. Long-term evaluation at 5 years showed sustained clinical stability and continued improvement in BMD. This case highlights the importance of considering PLO in postpartum women with severe back pain, particularly in the presence of risk factors such as low BMI, inadequate calcium intake, vitamin D insufficiency, exclusive breastfeeding, and twin pregnancy. Early recognition and management can prevent prolonged morbidity and support continued improvement in bone health.

PMID 42718481
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PubMedBiophotonics discovery2026-09-10

Transient infrared laser exposure modulates calcium activity in cortical dendritic spines.

Hardenburger Jacob J, Grow George G, Rasiah Pratheepa P, Gerges Mona M et al.

Infrared neural stimulation (INS) is an optical neuromodulation technique that elicits neural activity through photothermal temperature gradients. Photothermal gradients have been shown to alter neuronal excitability, but the effects on the dendritic spine (DS) structure and function have not been characterized. We aim to determine whether INS induces calcium signaling in DS and whether this signaling alters filamentous actin (F-actin). We used confocal imaging of cortical neurons expressing a genetically encoded calcium indicator (GCaMP)8f-Syn1 and mCardinal-LifeAct during laser exposure. Fluorescence signals were measured within regions of interest covering the DS. The resulting fluorescence measurements were baseline-normalized, and transient spiking activity in DS was quantified. Transient thermal gradients induce persistent calcium activity in a fraction of DS, independent of pulse duration but dependent on the absolute temperature and number of laser exposures. There is no relationship between the calcium activity and F-actin. Calcium signaling in DS was not mediated by ionotropic glutamate receptors but depended on extracellular entry. These results indicate that transient thermal gradients elicit calcium activity in DS, but the induced activity does not alter F-actin, suggesting that transient thermal gradients may be a useful tool for studying calcium dynamics in DS without triggering traditional structural plasticity pathways.

PMID 42719458
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PubMedJournal of ginseng research2026-09-10

Direct targeting of ORAI1 by ginsenoside Rg3 modulates calcium signaling and senescence-associated AMPK-NRF2 activation.

Lee Sooyeon S, Ko Minjeong M, Kwon Ho Jeong HJ

20(S)-ginsenoside Rg3 (Rg3(S)), a major saponin derived from red ginseng, exhibits diverse biological activities, including antioxidant and anti-senescence effects. However, the direct molecular targets through which Rg3(S) regulates calcium signaling and its role at membrane contact sites during cellular senescence remain largely unknown. Plasma membrane (PM)-endoplasmic reticulum (ER) contacts and related protein interactions were analyzed using proximity ligation assays and co-immunoprecipitation. Direct binding of Rg3(S) to ORAI1 was validated using cellular thermal shift assays and microscale thermophoresis. Molecular docking simulations followed by site-directed mutagenesis were used to define critical binding residues. Cytosolic calcium levels and cellular senescence were assessed using calcium imaging and senescence-associated β-galactosidase staining. Rg3(S) increased cytosolic calcium levels independently of ER calcium depletion and was accompanied by a reduction in PM-ER contacts. Rg3(S) directly bound to ORAI1 in a dose-dependent manner, identifying ORAI1 as a previously unrecognized molecular target of ginsenoside Rg3. Molecular docking revealed LYS204 and ILE229 within the extracellular loop of ORAI1 as key residues maintaining this interaction. Mutation of these residues abolished Rg3(S)-induced calcium influx, leading to impaired activation of the AMPK-NRF2 pathway and attenuation of the anti-senescence effect of Rg3(S). These findings identify ORAI1 as a key molecular mediator of ginsenoside Rg3(S)-induced calcium signaling linked to cellular senescence. By modulating PM-ER contact sites and cytosolic calcium dynamics, Rg3(S) attenuates senescence, providing new mechanistic insight into the anti-aging potential of ginseng-derived compounds beyond autophagy-centered pathways.

PMID 42718879
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PubMedJACC. Advances2026-09-10

Treating the Denominator: Coronary Artery Calcium and the Measurement Gap in Cardiovascular Prevention.

Ansari Salman S, Razavi Alexander C AC, Blumenthal Roger S RS, Budoff Matthew J MJ

PMID 42720658
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