若生智能
Drug Database
CA

calcium carbonate (Cimascal / Cimascal D Forte)

✓ Approved

CPEX Pharmaceuticals, Inc. · VDR

什么是 calcium carbonate？

calcium carbonate 是一种治疗药物，由CPEX Pharmaceuticals, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Cimascal, Cimascal D Forte
公司CPEX Pharmaceuticals, Inc.
分子靶点VDR
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, CPEX Pharmaceuticals, Inc.

作用机制

分子靶点

calcium carbonate 作用于 1 个分子靶点：

VDRvitamin D receptor (NR1I1, PPP1R163)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

calcium carbonate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

相关研究文献

PubMedCureus2026-07-27

A Case of Severe Hypercalcemia in a Patient Taking Tirzepatide: Potential Risk Factors.

Iqbal Safiah S, Javed Faiza F, Oyibo Samson O SO

Hypercalcemia is commonly caused by hyperparathyroidism and malignancy. Medication-induced hypercalcemia is less common. Tirzepatide is a dual glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide receptor agonist (GLP-1/GIP RA) used to aid weight loss and glycemic control. It is associated with gastrointestinal side effects, but its effect on calcium homeostasis has not been well reported. We report the case of a 75-year-old woman with a history of type 2 diabetes, hypertension, obesity, chronic kidney disease, and post-surgical hypothyroidism and hypoparathyroidism, who presented with severe symptomatic hypercalcemia one month after starting tirzepatide while taking bendroflumethiazide, calcium carbonate, and alfacalcidol. Her serum calcium levels had been in the normal treatment range before the initiation of tirzepatide. All other possible causes of hypercalcemia were ruled out. Her calcium levels returned to normal after intravenous fluid therapy and withholding tirzepatide, bendroflumethiazide, and calcium carbonate. This case highlights the potential occurrence of severe hypercalcemia during the concurrent use of tirzepatide with bendroflumethiazide, a calcium supplement, and vitamin D in the context of chronic kidney disease. With the increasing use of tirzepatide, healthcare workers need to be mindful of the interaction between tirzepatide and these potential risk factors. While further research is required, we suggest serum calcium monitoring during similar clinical scenarios.

PMID 42504310
阅读全文 →
PubMedNanomaterials (Basel, Switzerland)2026-07-27

A Unified Gas-Liquid Carbonation Platform for Habit-Controlled Calcite Nanostructures.

Lee Seungyeol S, Woo Juhwan J, Rhee Chul Woo CW

Calcite habit engineering offers a route to transform CO2 mineralization from bulk sequestration into value-added nanomaterial production. Here, we demonstrate that additive chemistry and seeding strategy can serve as separable, recipe-level levers for directing calcite habit formation within a unified CaO/Ca(OH)2 gas-liquid carbonation platform. This strategy highlights how solution-mediated habit control can bridge fundamental calcite crystallization mechanisms with scalable CO2 utilization and value-added carbonate nanomaterial production. Sodium glutamate yielded ~100 nm rhombohedral nanoparticles, staged MgSO4/ZnSO4 dosing produced whisker-like crystalline nanorods with aspect ratios of 4-7, and two-step seeded carbonation with NH4Cl generated fusiform spindle subunits that assembled into hierarchical rosette architectures. X-ray diffraction confirmed calcite as the only crystalline calcium carbonate phase detected under the present measurement conditions, with no detectable aragonite or vaterite reflections. SEM/TEM revealed distinct primary-subunit architectures, including internal striations in spindle particles indicative of oriented attachment. Thermogravimetry, N2 physisorption, and EDS further distinguished the products and showed that Mg/Zn/S modifiers in the whisker route are retained predominantly at crystal surfaces rather than incorporated into the calcite lattice. These results define calcite habit control through two independent levers: additive-driven facet selectivity and kinetic decoupling of nucleation from growth/assembly. The platform links scalable synthesis, CO2 utilization, and functional carbonate design.

PMID 42506486
阅读全文 →
PubMedFaraday discussions2026-07-27

Understanding the stability of the solid electrolyte interphase formed by vinylene carbonate and fluoroethylene carbonate in sodium-ion batteries.

Schuster Jan Felix JF, Hu Qihan Q, King Laura L, Lapidus Alexandre Linas AL et al.

The formation of a stable solid electrolyte interphase (SEI) in sodium-ion batteries is a challenge which is usually solved by introducing film-forming electrolyte additives. The functions and decomposition of common additives like vinylene carbonate (VC) and fluoroethylene carbonate (FEC) are not fully understood and yield different results in full- and half-cells. This study reveals that the electrochemical reduction of an electrolyte solution based on 1 M NaPF6 dissolved in ethylene carbonate and diethyl carbonate (EC : DEC) with no additive yields a lower charge loss, while electrolytes containing 2 wt% VC or FEC additives suffer from higher charge consumption for the formation and reformation of SEI due to higher solubility. To solely investigate stability and dissolution of the SEI in the absence of other ageing mechanisms, a model cell consisting of a carbon-coated aluminium foil working electrode and Prussian white counter and reference electrodes was used. Additionally, the experiments show a detrimental effect from using sodium metal counter electrodes. This work sheds light on the insufficiency of VC and FEC electrolyte additives in forming a perfect SEI. However, further investigations are required to account for additional ageing mechanisms to provide a comprehensive understanding of the role of VC and FEC in practical sodium-ion batteries.

PMID 42504679
阅读全文 →
PubMedInorganic chemistry2026-07-27

Structure and Compressional Behavior of Sillén-Type (BiO)2(CO3) Bismutite Carbonate.

Chuliá-Jordán Raquel R, Santamaría-Pérez David D, Botan-Neto Benedito Donizeti BD, Bera Ganesh G et al.

In this joint experimental/computational work, we study the ambient-conditions structure of bismutite (BiO)2(CO3) and its evolution under high pressure by means of a combination of in situ synchrotron X-ray diffraction (XRD) measurements, Raman spectroscopy, and density-functional theory (DFT) calculations. Using single-crystal XRD, (BiO)2(CO3) is determined to be an orthorhombic Cmcm phase with disorder arising from carbonate rotations at ambient-conditions and DFT confirms the stability of the structure. In situ high-pressure synchrotron powder XRD measurements showed that the Cmcm ambient-pressure structure adequately accounts for the observed diffraction patterns up to 17.7 GPa. The compressibility was determined, obtaining an experimental bulk modulus of 67.2(11) GPa and significant anisotropy in the axial compressibilities: the a and c axes, parallel to the (BiO)22+ layers, are less compressible than the b direction perpendicular to those layers, which we justify on the basis of the bismuth lone electron pair compressibility and the slight reorientation of the carbonate groups. Raman spectroscopy measurements at ambient conditions and under pressure were used to characterize the vibrational properties of this carbonate, unvealing a differentiated behavior of the nonequivalent carbonate units.

PMID 42503691
阅读全文 →
PubMedMembranes2026-07-27

Selective Separation of Inorganic and Organic Carbonates in Aqueous Solutions by Reverse Osmosis (RO) and Nanofiltration (NF) Membranes.

Al Busaidi Rahma R, Al Umairi Budoor B, Rehan Zulfiqar Ahmad ZA, Al-Abri Mohammed M

This study presents a systematic comparison of commercial reverse osmosis (RO) and nanofiltration (NF) membranes for the separation of inorganic and organic carbonates from aqueous solutions, providing insight into the roles of membrane pore structure and surface charge in governing separation mechanisms. Membrane molecular weight cut-off (MWCO), zeta potential, and thermal stability were characterized and correlated with separation performance. The RO membrane exhibited a lower MWCO and a more negative surface charge than the NF membrane, resulting in superior rejection of both inorganic and organic carbonates. For inorganic carbonates, rejection increased with pH owing to enhanced carbonate ionization and stronger electrostatic repulsion, reaching 91-98% for the RO membrane compared with 60-95% for the NF membrane. In contrast, the rejection of neutral organic carbonates was governed primarily by steric exclusion, with the RO membrane achieving approximately 80% rejection, whereas the NF membrane exhibited negligible removal. These findings demonstrate the combined influence of membrane pore size and surface charge on carbonate separation and provide practical guidance for selecting commercial membranes for efficient carbonate removal in water treatment applications.

PMID 42506213
阅读全文 →
PubMedBiomimetics (Basel, Switzerland)2026-07-27

Long-Term Influence of Endodontic Irrigants on In Vitro Dentin Biomimetic Remineralization.

Taddei Paola P, Di Foggia Michele M, Spinelli Andrea A, Gandolfi Maria Giovanna MG et al.

Endodontic irrigant solutions act as crucial pretreatment conditioning agents in dentin biomimetic remineralization, preparing the collagen scaffold for calcium phosphate infiltration and subsequent tooth structure reconstruction. In this study, root dentin discs were exposed for 10 min to five irrigant solutions: sodium hypochlorite (NaClO, 3%), EDTA (17%), citric acid (CA, 10%), chlorhexidine (CHX, 2%), and an innovative experimental formulation containing citric acid (7%) and surfactants. Samples were then aged in Hank's Balanced Salt Solution (HBSS) at 37 °C for three months to simulate long-term clinical conditions. Physicochemical modifications of the collagen and apatite phases were assessed at each experimental stage using ATR-FTIR spectroscopy, with the ACaP/AAmide I and A870/ACaP absorbance ratios as markers of the degree of mineralization and apatite carbonate content, respectively. Results indicated that CHX- and EDTA-treated dentin exhibited the highest remineralization after ageing, while NaClO impeded remineralization due to collagen degradation. The experimental irrigant produced the most pronounced demineralization, followed by CA; however, it also facilitated significant remineralization, attributed to citrate-collagen binding and surfactant-enhanced apatite nucleation. NaClO selectively degraded collagen and increased apatite crystallinity; CA inhibited apatite nucleation through adsorbed citrate ions, and CHX and EDTA induced minimal alterations. These findings provide molecular-level evidence linking short-term irrigant effects to the long-term potential for dentin biomineralization, with direct implications for irrigant selection in regenerative endodontic protocols. It should be noted that this study was conducted on dentin discs obtained from a single tooth; all findings should therefore be regarded as preliminary and require confirmation in studies with larger, biologically independent sample sizes.

PMID 42505506
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多calcium carbonate