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propafenone hydrochloride (propafenone, SR / propafenone SR / Rythmol SR)

✓ Approved

GSK · SCN5A · 小分子

什么是 propafenone hydrochloride？

propafenone hydrochloride 是一种小分子，由GSK研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名propafenone, SR, propafenone SR, Rythmol SR
公司GSK
药物类别小分子
分子靶点SCN5A
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, GSK

作用机制

分子靶点

propafenone hydrochloride 作用于 1 个分子靶点：

SCN5Asodium voltage-gated channel alpha subunit 5 (CMD1E, SSS1)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

propafenone hydrochloride 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Cardiac disordersAtrial fibrillation✓ Approved
Cardiac disordersVentricular fibrillation✓ Approved

相关研究文献

PubMedJournal of imaging2026-07-27

Vectorial Image Representation on the Texture Space (VIR-TS) Applied to RGB Image Classification: Face Recognition.

Guillen-Bonilla Héctor H, Guillen-Bonilla José Trinidad JT, Jiménez-Rodríguez Maricela M, Guillen-Bonilla Alex A et al.

In this paper, an RGB image with S is separated by its channels, obtaining an image in each color channel SR, SG and SB. The Vectorial Image Representation on the Texture Space (VIR-TS) transform is calculated for each channel; ergo, each image is represented with a given vector, SR→ C→R, SG→C→G and SB→C→B. Employing the C→R, C→G, and C→B vectors in a multi-class classifier, a database of RGB images was identified with the aim of verifying the classification efficiency of the VIR-TS transform. Based on the experimental results, the VIR-TS technique presents high efficiency when the noise is not added to the class and when the signal-to-noise ratio is high. For both instances, the efficiency presented is 100%. Nonetheless, if the class noise is high, the efficiency diminishes from 100%, to 95%, to 90% until it decreases to 10%. Based on the results obtained, the VIR-TS transform can be efficiently applied for the development of security systems and access control and can also be implemented in computer vision systems for medical diagnosis, drones, etc.

PMID 42506141
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PubMedOrganic letters2026-07-27

Divergent Access to Chiral Pyrrolidinone-Fused 4H-Pyrans and Pyridines Via Organocatalytic Asymmetric Decarboxylative Addition-Annulation of β-Keto Acids with 2,3-Dioxopyrrolidines.

Li Tianxing T, He Tianyu T, Meng Weiyue W, Jin Hui H et al.

We disclose an unprecedented organocatalytic asymmetric decarboxylative Michael addition of β-keto acids to 2,3-dioxopyrrolidines, enabling the efficient assembly of chiral pyrrolidinone-fused [3,4-b]-4H-pyrans and [3,4-b]-pyridines. The reaction affords chiral pyrrolidinone-tethered 1,5-dicarbonyl intermediates in high yields with excellent regio- and enantioselectivities. Acid-promoted intramolecular cyclization of these adducts provides enantioenriched pyrrolidinone-fused [3,4-b]-4H-pyrans without erosion of enantiopurity, whereas cyclocondensation with hydroxylamine hydrochloride delivers diverse pyrrolidinone-fused [3,4-b]-pyridines. Notably, this protocol is compatible with a one-pot tandem process and gram-scale synthesis.

PMID 42504541
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PubMedToxins2026-07-27

Enhanced Protection Against Toxicity of Nemopilema nomurai Venom Using a PEG-EGCG/Tetracycline Hydrochloride Micellar Nanocomplex.

Li Jie J, Hu Yanan Y, Qian Yunfeng Y, Luo Sai S et al.

Jellyfish stings are the most common type of marine life injuries. However, at present, the treatment measures against jellyfish stings are mostly empirical and supportive, with uncertain therapeutic outcomes, and there is a lack of specific antidotes based on the toxic mechanism of jellyfish venom in clinical practice. In our previous study, polyphenol epigallocatechin-3-gallate (EGCG) was found to neutralize the toxicity of jellyfish Nemopilema nomurai venom (NnV) in vivo and in vitro. Herein we further demonstrated that EGCG exerted its antagonistic effect against NnV through inhibiting the oxidative stress, pro-apoptotic proteins, and systemic inflammatory responses. Subsequently, we constructed a polyethylene glycol (PEG)-EGCG/tetracycline hydrochloride (HTC) co-loaded micellar nanocomplex in order to enhance the stability and bioavailability of EGCG in vivo, which successfully integrated the membrane-repair function of PEG, the enzyme inhibitory effect of HTC and the antioxidant properties of EGCG. Notably, this micellar nanocomplex demonstrated significant protective effects against both functional damage and pathological alterations in a non-lethal NnV-envenomed mouse model. When administered 1 h after NnV envenomation, EGCG (40 mg/kg), HTC and PEG-EGCG (containing 40 mg/kg EGCG) only partially improved abnormal blood biochemical indicators and moderately alleviated histopathologic damage, and PEG-EGCG/HTC containing merely 8 mg/kg EGCG completely mitigated the toxic reactions in envenomed mice. In the preventive regimen, the administration of EGCG, HTC or PEG-EGCG 30 min before exposure showed no significant improvement in abnormal blood biochemical indicators and histopathologic damage, while PEG-EGCG/HTC could still significantly improve the functional impairments and histopathologic damage of the heart and liver in NnV-envenomed mice. These findings suggest the clinical translational potential of PEG-EGCG/HTC against jellyfish envenomation.

PMID 42506698
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PubMedBiomimetics (Basel, Switzerland)2026-07-27

Enhanced LGMD Model with Adaptive Probabilistic Regulation for Compound Interference.

Luan Hao H, Nie Changmiao C, Chen Weikun W, Yang Bin B et al.

When subjected to compound interference, such as spatial noise and high-frequency jitter, current LGMD-inspired collision detection models for micro-robots are prone to false alarms and perceptual degradation. To address this challenge, this paper proposes an enhanced visual perception model that incorporates adaptive Gaussian random variables and spatial residual feedback (SRF). These random variables filter out discrete spatial noise, while the SRF suppresses global image shifts induced by jitter. Evaluations on synthetic and real-world video sequences validate the proposed mechanisms. Comparative results demonstrate that the model effectively reduces false responses under compound interference, thereby maintaining robust success rate (SR), discrimination ratio (DR), and membrane potential stability index (MPSI) metrics. To explain this robustness, ablation analyses further verify the synergistic benefits of the SRF and the Gaussian random variables. Furthermore, statistical results on the random variables indicate that, under compound interference, the adaptive probabilistic model outperforms fixed probabilistic configurations. By ensuring robust collision perception against such interference, this work enhances the practical viability of LGMD-inspired visual systems.

PMID 42505521
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PubMedAnalytical methods : advancing methods and applications2026-07-27

Smartphone-based fluorescence sensing platform for tetracycline determination based on a high quantum yield europium metal-organic framework with a dual-ligand strategy.

Cheng Shuang S, Song Jintian J, Wen Yue Y, Xu Yijia Y et al.

Ultrasensitive and visual detection of tetracyclines (TCs) is of great significance to public health and environmental safety. Herein, we synthesized a dual-ligand europium metal-organic framework (Eu-phen-MOF) via a one-step solvothermal method for the fluorescence detection of TCs. Compared with the Eu-MOF without 1,10-phenanthroline, Eu-phen-MOF exhibits superior stability, lower LOD and higher quantum yield. It delivers superior TC sensing performance and anti-interference, enabling high-accuracy detection with limits of 152.0 nmol L-1, 249.4 nmol L-1, 171.0 nmol L-1 and 277.7 nmol L-1 for tetracycline (TC), oxytetracycline (OTC), doxycycline hydrochloride (DOX), and chlortetracycline (CTC), respectively. Eu-phen-MOF was used for the quantitative detection of TC, OTC, DOX, and CTC in real samples (milk, eggs, and river water) and recoveries ranging from 94.64% to 105.37% were achieved. Finally, a portable fluorescence sensing platform integrating a smartphone and the Eu-phen-MOF fluorescent hydrogel was constructed, enabling convenient, rapid, and low-cost detection of TCs. This work not only highlights the significance of the dual-ligand strategy for fabricating an efficient TC sensor, but also develops a rapid and visual method for TC detection.

PMID 42504902
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PubMedMolecular neurobiology2026-07-27

Early Rehabilitation Exercise Promotes Vestibular Compensation in UVN Mice by Regulating Microglial Polarization Balance via the PGC-1α/FNDC5/BDNF Pathway.

Wu Junyu J, Zheng Zhihui Z, Lu Gengxin G, Guo Junjie J et al.

Acute unilateral vestibular lesions cause disabling vertigo, postural imbalance, and gait instability. Functional recovery depends on vestibular compensation (VC), a neuroplastic process whose cellular and molecular mechanisms remain incompletely understood. Although vestibular rehabilitation effectively accelerates recovery in clinical practice, the underlying pathways are still elusive. Here, we investigated how exercise-based vestibular rehabilitation modulates neuroinflammation and microglial polarization within the medial vestibular nucleus (MVN) in a mouse model of unilateral vestibular neurectomy (UVN), focusing on the PGC‑1α/FNDC5/BDNF axis in promoting VC. Mice underwent a progressive running-wheel training protocol, and behavioural recovery was assessed using rotarod, beam-walk, and open-field tests. At the molecular and cellular levels, we combined mRNA sequencing, bioinformatic analysis, Western blotting, and immunofluorescence to evaluate pathway activation, inflammatory mediators, and microglial morphology and phenotype. Exercise upregulated the PGC‑1α/FNDC5/BDNF cascade and inhibited NF‑κB/NLRP3-mediated neuroinflammation. It also shifted microglia from a pro-inflammatory M1-like phenotype toward an anti-inflammatory M2-like state, increased microglial process complexity, and improved postural balance recovery. Intracerebroventricular administration of the PGC‑1α inhibitor SR‑18292 abrogated these effects, aggravating inflammation and delaying VC. These findings demonstrate that the PGC‑1α/FNDC5/BDNF pathway is a key mediator of exercise-promoted VC and a promising target for improving rehabilitation strategies for vestibular disorders.

PMID 42503585
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