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ketoprofen spray

✓ Approved

Giuliani · PTGS1 · 小分子

什么是 ketoprofen spray？

ketoprofen spray 是一种小分子，由Giuliani研发。该药已获批，用于治疗相关适应症，给药途径：Transdermal。

药物档案

公司Giuliani
药物类别小分子
分子靶点PTGS1, PTGS2
给药途径Transdermal
状态Approved
来源： ClinicalTrials.gov, Giuliani

作用机制

分子靶点

ketoprofen spray 作用于 2 个分子靶点：

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

ketoprofen spray 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Hepatobiliary disordersHepatitis✓ Approved
Musculoskeletal and connective tissue disordersMusculoskeletal pain✓ Approved

相关研究文献

PubMedJournal of agricultural and food chemistry2026-07-27

Hand-Held Electrostatic Spray Ionization Mass Spectrometry Enables On-Site Metabolomic Analysis of Sophora japonica and Robinia pseudoacacia.

Song Mengyang M, Luo Haiyan H, Ji Zhenyang Z, Ye Zhihao Z et al.

Mass spectrometry plays a key role in agricultural and food chemistry, yet direct ionization of plant samples is complicated by endogenous salts and other matrix components that destabilize conventional direct-current nanoelectrospray ionization (DC-nanoESI). To address this limitation in point-of-need analysis, we developed hand-held electrostatic spray ionization (HESSI), which produces stable ionization from nanoliter sample volumes without direct electrical contact with the solution. A compact pulsed-discharge module and dielectric barrier limit electrochemical reactions and reduce the risk of discharge at the emitter while remaining compatible with salt-containing plant extracts. Approximately 50 nL of the sample sustained MS signals for up to 5 min. In a proof-of-concept application, 208 compounds were tentatively annotated from Sophora japonica and Robinia pseudoacacia extracts in negative-ion mode, and a neural network model distinguished the two groups with an accuracy of 83.3%. These results support HESSI as a compact and sample-efficient platform for the rapid mass-spectrometric characterization of botanical materials.

PMID 42504783
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PubMedGels (Basel, Switzerland)2026-07-27

Effect of Mechanical Homogenization on Nopal Mucilage for the Treatment of a Real Cyanidation Barren Solution.

Valle-Bravo Allison Vianey AV, Camacho-Díaz Brenda Hildeliza BH, Rodrigue Denis D, Pacheco-Vargas Glenda G et al.

This study investigated the effect of brief mechanical homogenization using a household blender on the properties of nopal mucilage and its performance in removing potentially toxic elements (PTEs), specifically Pb, Ni, As, Cd, and Zn, from a real cyanidation barren solution. An aqueous extract from Opuntia ficus-indica cladodes was homogenized for 0, 30, or 60 s before spray drying, yielding powders designated as CA, CB, and CC. The powders and water-reconstituted dispersions were characterized and evaluated in coagulation-flocculation assays. Homogenization reduced water activity and average hydrodynamic diameter and significantly modified the ζ potential, although the effects were not proportional to processing time. At 10% w·v-1, the reconstituted mucilages showed frequency-dependent viscoelastic behavior consistent with a transient gel-like organization. All treatments removed more than 98% of Pb, Ni, and As at doses of 200-800 mg·L-1. Cd removal was more variable and significantly affected by mucilage type, whereas Zn showed lower, non-monotonic removal. ESEM-EDS detected PTE-bearing inorganic domains within the recovered flocs, corroborating transfer from the liquid to the solid phase. Overall, mechanical homogenization modified the colloidal, supramolecular, and gel-related properties of spray-dried nopal mucilage, which showed potential as a multifunctional hydrocolloid for treating chemically complex cyanidation process streams.

PMID 42505253
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PubMedAntibiotics (Basel, Switzerland)2026-07-27

Suppression of Quorum Sensing and Virulence Factors by Meloxicam and Celecoxib in Methicillin-Resistant Staphylococcus aureus Clinical Isolates.

Ali Reham R, El-Domany Ramadan A RA, Shaaban Mona I MI

Background:Staphylococcus aureus is a major cause of life-threatening infections, and increasing antimicrobial resistance necessitates alternative therapeutic strategies. This study evaluated the antiquorum sensing and antivirulence activities of selected nonsteroidal anti-inflammatory drugs (NSAIDs) against S. aureus clinical isolates by targeting the accessory gene regulator (agr). Methods: Antimicrobial susceptibility and virulence factor production were evaluated in 56 S. aureus clinical isolates. The MICs of six NSAIDs (Diclofenac, ketoprofen, ketorolac, meloxicam, indomethacin and celecoxib) were determined by broth microdilution, and the effects of sub-MICs (½ and ¼ MIC) on virulence factors were assessed. The expression of agrA, hlb, and hld was analyzed by qRT-PCR, and molecular docking was performed to evaluate interactions with AgrA receptor. Results: Among the isolates, high resistance rates were accompanied with cefoxitin, ceftazidime, and cefepime. Hemolysin, protease, and lipase production were detected in 42.86%, 89.28%, and 94.64% of isolates, respectively. Meloxicam and celecoxib at sub-MIC levels significantly reduced hemolysin, protease, and lipase activities. Additionally, both drugs markedly downregulated agrA expression by 88.9-95.3% and significantly reduced hlb and hld expression by 90.5-99.9% without affecting bacterial growth. Molecular docking demonstrated favorable binding interactions with AgrA. Conclusions: Meloxicam and celecoxib could be promising adjunctive therapies against S. aureus through suppression of the Agr-regulated virulence traits.

PMID 42505670
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PubMedSmall methods2026-07-27

Dynamic Phase Transition Driven Achievement of Ultra-Broadband Microwave Absorption in FeCoNiCrMo High-Entropy Alloys.

Zhu Ning N, Wang Jianzhao J, Liu Xiaolian X, Zhang Zhenhua Z et al.

Although soft magnetic high-entropy alloys (HEAs) offer the advantage of broadband absorption in microwave absorption materials, it remains challenging to simultaneously enhance their saturation magnetization (Ms) and coercivity (Hc). This trade-off limits further improvements in both the permeability and effective absorption bandwidth (EAB). This work addresses this challenge by regulating the phase composition and tailoring Hc of FeCoNiCr0.4Mo0.1 HEAs through thermal annealing. Precisely controlled annealing induces the precipitation of strongly ferromagnetic α-Fe phase, realizing the phase transformation of HEAs from a single FCC phase to FCC/BCC dual-phase structure. The precipitation of α-Fe not only enhances Ms but also effectively modulates Hc by introducing magnetic domain wall pinning sites at the FCC/BCC interfaces. The optimization, combined with the enhanced magnetic anisotropy and interface polarization effect derived from phase regulation, forms a synergistic magnetic-dielectric loss mechanism. This mechanism enables the A500 HEAs to achieve an ultra-broad EAB of 7.4 GHz at an ultrathin thickness of 1.4 mm. The A500 coating with a thickness of 1.17 mm achieves excellent absorption performance with EAB of 4.2 GHz. After 8 days of salt spray corrosion, the coating still maintains 3.1 GHz, demonstrating immense potential as a new generation of high-performance electromagnetic absorption materials.

PMID 42504983
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PubMedJournal of fungi (Basel, Switzerland)2026-07-27

Etiology, Pathogenicity, and Fungicide Management of Pigeonpea Shoot Dieback Caused by Lasiodiplodia theobromae in China.

Huang Feiyun F, Xu Xi X, Li Yanzhong Y

Pigeonpea (Cajanus cajan) shoot tip dieback was recently observed in Danzhou, Hainan Province, China, with disease incidence of 30-100% in affected fields, but its causal agent and management options remained unclear. This study aimed to isolate and identify the fungal agent associated with the disease, verify its pathogenicity, characterize its biological traits and effects on host growth, and screen candidate fungicides. Fungal isolates were obtained from symptomatic shoot margins and purified by hyphal-tip and single-spore isolation. Representative isolates LYZ0717, LYZ0718, and LYZ0719 were characterized by colony morphology, pycnidial and conidial traits, and combined phylogenetic analysis of ITS and TEF1-α sequences. These analyses identified the isolates as Lasiodiplodia theobromae. Spray inoculation of 20-day-old pigeonpea seedlings reproduced typical shoot tip dieback symptoms within 6 days, and the inoculated fungus was reisolated from symptomatic tissues, fulfilling Koch's postulates. The pathogen grew over a pH range of 3-11 and at temperatures of 5-35 °C, with optimal mycelial growth at 25-30 °C and maximum sporulation under acidic conditions. At 20 days after inoculation, infection reduced plant height, dry weight, and total flavonoid content by 45.21%, 75.88%, and 42.19%, respectively. Among the seven fungicides tested, trifloxystrobin-tebuconazole and thiophanate-methyl showed the strongest in vitro inhibition, with EC50 values of 0.0270 and 0.0614 ppm, respectively. In greenhouse pot experiments, thiophanate-methyl achieved the highest disease control efficacy, reaching 64.35% after the second application. These findings demonstrate that L. theobromae is the causal agent of pigeonpea shoot tip dieback in China and provide a basis for disease diagnosis, biological understanding, and fungicide-based management.

PMID 42506236
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PubMedInorganic chemistry2026-07-27

Ligand-to-Ligand Charge Transfer (LL'CT) Transitions in Square-Planar Metal-Bipyridyl Complexes of Heteroatom-Substituted Maltol Derivatives.

Usman Muhammad Ahsan MA, Adebanjo Joseph O JO, French Kirk A KA, Bruner Britain C BC et al.

A series of square-planar d8-metal complexes that exhibit ligand-to-ligand' charge-transfers (LL'CT) is reported, featuring bipyridines (L') as acceptors and α-hydroxy-thiopyrone (i.e., thiomaltol) derivatives as donors (L). Eleven complexes of the general formula [M(bpy)L]+ were synthesized, where M = Ni(II), Pd(II), or Pt(II); bpy = 2,2'-bipyridine or 4,4'-bis(tert-butyl)-2,2'-bipyridine; and L = 3-hydroxy-2-methyl-4H-pyran-4-thione, 3-hydroxy-2-methyl-4H-thiopyran-4-thione, 3-hydroxy-1,2-dimethylpyridine-4(1H)-thione, and 3-hydroxy-2-methyl-1-phenylpyridine-4(1H)-thione. Structural characterizations include nuclear magnetic resonance (NMR) spectroscopy, electron spray ionization-mass spectrometry (ESI-MS), and single-crystal X-ray diffraction. Photophysical properties were investigated via electronic absorption (UV/vis) and photoluminescence (PL) spectroscopies, and density-functional theory (DFT) computations compared the Frontier Molecular Orbitals (FMOs) for the ground states and Natural Transition Orbitals (NTOs) for CT excited-states. All complexes exhibit donor-to-acceptor LL'CT bands, admixed with metal-to-ligand (bpy) charge transfer (ML'CT). For Pt complexes, excitation into the LL'CT band results in emissions in the yellow-to-red region, attributed to ligand-centered (3LC or 3LL'CT) phosphorescence. In the hydroxypyridine-thione complexes, multiexponential decays suggest that these transitions are admixed with thermally activated delayed fluorescence (1TADF). Excited-state lifetimes fall within the nanosecond regime, with longer-lived components emerging at 77 K, consistent with temperature-suppressed TADF accompanying significant luminescence rigidochromism demonstrated by ∼1700 cm-1 blue-shifted λmax and ∼5-10-fold sensitized PL quantum yields in cryogen-cooled rigid-glassy media vs fluid solutions.

PMID 42503650
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