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Fluosol-DA (Fluosol)

✓ Approved

Mitsubishi Tanabe Pharma Corporation · 小分子 · 小分子

什么是 Fluosol-DA？

Fluosol-DA 是一种小分子，由Mitsubishi Tanabe Pharma Corporation研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名Fluosol
公司Mitsubishi Tanabe Pharma Corporation
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Mitsubishi Tanabe Pharma Corporation

治疗适应症

Fluosol-DA 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Blood and lymphatic system disordersAnaemia✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Neoplasm malignant✓ Approved

相关研究文献

PubMedAnalytical and bioanalytical chemistry2026-09-11

A novel multi-aptamer electrospun nanofibrous membrane for simultaneous selective extraction of monoamine neurotransmitters and determination in biological samples by LC-MS.

Zhang Xijia X, Qin Junfeng J, Ma Chen C, Wang Ningning N et al.

Dopamine (DA) and serotonin (5-HT) are key monoamine neurotransmitters, the sensitive determination of which in biological matrices is challenging owing to low concentrations and strong matrix interference. In this study, a multi-aptamer-functionalized electrospun membrane (MA-Au@PVP/PVDF) was developed by simultaneously immobilizing the DA aptamer (Apt-DA) and the 5-HT aptamer (Apt-5-HT) on the membrane surface via Au-S bonds. The membrane combines high specific surface area, good stability, and aptamer-based specificity, enabling simultaneous and selective extraction of DA and 5-HT from complex samples. The enriched analytes were subsequently quantified using liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS). The maximum adsorption capacities of the MA-Au@PVP/PVDF membrane were 190.8 ng/cm2 for 5-HT and 165.1 ng/cm2 for DA, with the adsorption process fitting well to the Langmuir isotherm model (R2 ≥ 0.99). Under optimized extraction conditions, the established method was thoroughly validated in both serum and urine matrices, exhibiting wide linear ranges (2.5-1000 ng/mL, R2 ≥ 0.9905), low limits of quantification (LLOQ 2.5-10 ng/mL), satisfactory intra- and inter-day precision (RSD < 10.54%), and negligible matrix effects (86.37%-108.92%). The recoveries in serum and urine were 88.91%-103.22%, demonstrating its good broad applicability in different matrices. The proposed method was successfully applied to the determination of DA and 5-HT in human urine samples, providing a reliable and efficient pretreatment strategy for trace neurotransmitter analysis.

PMID 42722748
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PubMedACS applied materials & interfaces2026-09-11

Selenium-Functionalized Main-Chain Twisted Molecules with High Melting Points Enable Efficient and Stable Ternary Organic Solar Cells.

Wang Weiping W, Liu Shujuan S, Zhou Yuchen Y, Cong Zhiyuan Z et al.

Although organic solar cells (OSCs) based on Y6 and its derivatives have achieved rapid development, their intrinsically low open-circuit voltage (VOC), which limits the power conversion efficiency (PCE), and the poor long-term stability remain two major obstacles to their application. To address these challenges, two selenium-functionalized main-chain twisted small molecules, i-DA and i-EA, were designed and synthesized. These molecules exhibit strong absorption in the 500-700 nm region and exhibit up-shifted LUMO energy levels, which facilitate cascading energy alignment and enhanced VOC in ternary devices. Notably, they exhibit intrinsically high melting points (Tm) of 312.1 °C (i-DA) and 344.9 °C (i-EA) with large melting enthalpies (ΔHm of 50.02 and 95.61 J g-1), reflecting strong intermolecular cohesion. When incorporated into the PM6:Y6 as the third component, both i-DA and i-EA function as crystallization modulators that optimize the molecular packing and film morphology, leading to improved and more simultaneously balanced hole/electron mobilities. Consequently, the PM6:Y6:i-DA and PM6:Y6:i-EA ternary devices achieve promising PCEs of 19.09% and 19.35%, respectively, with simultaneously enhanced VOC, short-circuit current density (JSC), and fill factor (FF), surpassing the binary device (18.44%). Moreover, the PM6:Y6:i-DA and PM6:Y6:i-EA ternary devices exhibit significantly improved thermal stability (T80 of 840 h and 910 h) compared with the PM6:Y6 control device (T80 of 300 h). The effectiveness of these two molecules is further validated in the D18:L8-BO system, realizing excellent PCEs of 20.33% and 20.50% with i-DA- and i-EA-based ternary devices, respectively. This work demonstrates that high Tm, backbone-twisted small molecular acceptors represent a potential strategy for simultaneously optimizing morphology and charge transport toward high-performance and stable ternary OSCs.

PMID 42723414
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PubMedScandinavian journal of psychology2026-09-11

Self-Esteem Is Associated With Attentional Selection Efficiency: An ERP Study.

Lan Yanwen Y, Liu Xiangyu X, Wang Guiying G, Jing Jingyan J et al.

Self-esteem is a subjective evaluation of one's own worth and serves as a core psychological resource for cognitive processing. This study examined the relationship between self-esteem and attentional selection. High self-esteem (HSE) and low self-esteem (LSE) participants completed a visual search task in which a target was presented with either a salient distractor (distractor-present, DP) or a non-salient distractor (distractor-absent, DA). Behaviorally, both groups showed longer reaction times in DP than DA trials, revealing a reliable attentional capture effect. In addition, this effect was significantly larger in the LSE group. The ERP results showed that, relative to the HSE group, the LSE group exhibited a reduced target-elicited N2pc in DA trials, reflecting weaker target processing, and an enhanced distractor-elicited N2pc in DP trials, suggesting greater susceptibility to attentional capture by salient distractors. These findings suggested that low self-esteem might be associated with reduced attentional selection efficiency.

PMID 42722986
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PubMedFrontiers in surgery2026-09-11

Near-infrared guided robotic partial cystectomy for urachal adenocarcinoma using the da Vinci Xi Firefly platform.

Isherwood L L, Feyissa M M, Muheilan M M, Thandapani K K et al.

Partial cystectomy is considered an optimal bladder-preserving surgical treatment for patients with adenocarcinoma confined to the urachus. This case report describes the use of intraoperative near-infrared fluorescence imaging to fully resect a urachal adenocarcinoma in a partial cystectomy and ensure clear oncological margins while preserving bladder function. The patient described was a male in his 50s who presented to the emergency department with visible haematuria. Both CT and MRI imaging, combined with transurethral resection of the lesion, confirmed a urachal adenocarcinoma. The patient was scheduled for a near-infrared-guided robotic partial cystectomy and pelvic lymph node dissection using Firefly imaging and intraoperative transurethral resection of the bladder tumour. During the procedure, Firefly imaging on the da Vinci Xi robot, combined with cystoscopic transillumination of the tumour, enhanced the surgeon's ability to confidently resect the tumour while sparing the adjacent healthy bladder tissue. The patient recovered well postoperatively and was discharged from hospital after 48 h. A CT cystogram after 4 weeks confirmed that the bladder defect was closed and that the patient was able to void urine without a catheter. Histological analysis confirmed that the tumour had been fully resected and that all pelvic lymph nodes were clear of metastatic disease; however, muscle invasion was present (pT2 disease). This case demonstrates the feasibility of performing a near-infrared-guided robotic partial cystectomy for urachal adenocarcinoma, offering surgeons the ability to confidently resect urachal tumours in a partial cystectomy by providing clear oncological margins and preserving bladder function.

PMID 42723910
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PubMedSurgical endoscopy2026-09-11

Ergonomic impact of closed-console (Da Vinci Xi) versus open-console (Hugo RAS) robotic systems: an ex vivo randomized crossover controlled trial.

Rathod R Sagar RS, Bhattacharjee Hemanga K HK, Kaushik Mohit M, Prakash Prajapati Om O et al.

Robotic technology, based on either open- or closed-console systems, has improved precision, visualization, and ergonomics for surgeons. However, its effects on surgeons' visual health and ocular function have not been studied. A randomized crossover trial was conducted among 20 stereo-enabled surgery residents. They were randomly allocated into closed-console (DaVinci Surgical system) or open-console (HugoTMRAS) groups. Participants did identical simulated tasks for 90 min. Visual strain was assessed subjectively using visual fatigue questionnaire and objectively through near point of accommodation (NPA) and near point of convergence (NPC) using RAF ruler test, stereoacuity using Netherlands Organisation for Applied Scientific Research (TNO) stereopsis test, tear production using Schirmer's test, and tear film stability using Tear Break-Up Time (TBUT). Musculoskeletal strain was measured using SAGES body discomfort and NORDIC musculoskeletal questionnaire (NMSQ). Both groups had comparable demographics and ophthalmic parameters at baseline. After simulated task, open-console group had significant worsening in tearing (p = 0.042), while close console group had significant deterioration in neck stiffness (p=0.018), neck discomfort (p = 0.046), and upper back discomfort (p = 0.019). Within-platform analysis showed post-task increase in pressure around eyes (p = 0.011), dry eyes (p = 0.008), heaviness of eyelids (p = 0.007), headache (p = 0.025), eye pain (p = 0.024), worsened NPC (p = 0.014), and declined TBUT (right: p = 0.044; left: p = 0.022) in open console. Closed-console group had increased pressure around eyes (p = 0.015), dry eyes (p = 0.013), heaviness of eyelids (p = 0.042); worsened NPC (p = 0.009), and declined left-eye TBUT (p = 0.010). Both robotic systems have negative ocular impact, although more with open console. Musculoskeletal discomfort was more on closed console. These findings emphasize the need for ocular and ergonomic training and console design improvements.

PMID 42722909
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PubMedTranslational cancer research2026-09-11

Bone marrow mesenchymal stem cell-derived exosomal miR-93-5p suppresses esophageal squamous cell carcinoma progression and immune escape through targeting PD-L1.

Chen Wenbin W, Fan Fangfang F, Fan Renliang R, Kong Guiju G et al.

Esophageal squamous cell carcinoma (ESCC) is a malignant tumor with poor prognosis, and immune escape and abnormal cell behavior are key factors promoting its progression. Bone marrow mesenchymal stem cell (BMSC)-derived exosomes and microRNAs (miRNAs) play important roles in tumor regulation. This study aimed to explore the regulatory effect and molecular mechanism of BMSC-derived exosomal miR-93-5p on the malignant progression and immune escape of ESCC. The BMSC-derived exosomes were extracted and characterized using transmission electron microscopy, size analysis and marker protein detection. miR-93-5p mimic or negative control was transfected into BMSCs. Cell counting kit-8 (CCK-8), 5-ethynyl-2'-deoxyuridine (EDU) staining, Transwell and 2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA) assays were used to detect the effects of exo-mimic on ESCC cells (KYSE-30, TE-1) viability, proliferation, migration and reactive oxygen species (ROS) accumulation. T cell-ESCC cell co-culture system was established to evaluate immune escape. The luciferase reporter, RNA-pulldown and fluorescence in situ hybridization (FISH) assays verified the targeting relationship between miR-93-5p and programmed death-ligand 1 (PD-L1). Nude mouse xenograft model was used to detect in vivo tumor growth. BMSCs and their exosomes were successfully isolated; miR-93-5p was upregulated in exosomes. Exo-mimic significantly inhibited ESCC cell viability, proliferation, migration, promoted ROS accumulation. Exo-mimic downregulated PD-L1 expression at both messenger ribonucleic acid (mRNA) and protein levels, enhanced T cell-mediated killing efficiency against ESCC cells, and significantly suppressed xenograft tumor growth in nude mice. Luciferase reporter, RNA-pulldown and FISH assays further confirmed that PD-L1 is a direct downstream target of miR-93-5p. BMSC-derived exosomes carrying miR-93-5p can inhibit ESCC progression via PD-L1 suppression and reverse tumor immune evasion in an in vitro T cell co-culture system, which provides a novel potential therapeutic target and strategy for the clinical treatment of ESCC.

PMID 42724838
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